公开(公告)号：AU783709B2

公开(公告)日：2005-11-24

申请号：AU5421300

申请日：2000-06-23

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROGER BURKHARD ,  SCHRODER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: C07K14/34 ,  C12N1/21 ,  C12N9/90 ,  C12N15/31 ,  C12N15/61 ,  C12P13/08 ,  C12Q1/68

公开(公告)号：AU783708B2

公开(公告)日：2005-11-24

申请号：AU5559000

申请日：2000-06-23

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROGER BURKHARD ,  SCHRODER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: G01N33/53 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/12 ,  C12N9/18 ,  C12N9/88 ,  C12N15/09 ,  C12N15/31 ,  C12N15/55 ,  C12P20060101 ,  C12P13/04 ,  C12P13/08 ,  C12P21/02 ,  C12Q20060101 ,  C12Q1/68 ,  C12R1/15 ,  G01N33/566 ,  G01N33/569

Abstract: Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SMP genes in this organism.

公开(公告)号：AU783703B2

公开(公告)日：2005-11-24

申请号：AU5836900

申请日：2000-06-23

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROGER BURKHARD ,  SCHRODER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR ,  LEE HEUNG-SHICK ,  KIM HYUNG-JOON

IPC: G01N33/53 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/18 ,  C12N15/09 ,  C12N15/31 ,  C12P20060101 ,  C12P1/04 ,  C12P13/04 ,  C12P21/02 ,  C12Q20060101 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/13 ,  C12R1/15 ,  C12R1/16 ,  G01N33/569 ,  G01N37/00

Abstract: Isolated nucleic acid molecules, designated SRT nucleic acid molecules, which encode novel SRT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SRT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SRT proteins, mutated SRT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SRT genes in this organism.

公开(公告)号：CA2548125A1

公开(公告)日：2005-06-30

申请号：CA2548125

申请日：2004-12-17

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  KIEFER PATRICK ,  KROGER BURKHARD ,  KLOPPROGGE CORINNA ,  HAEFNER STEFAN ,  WITTMANN CHRISTOPH ,  SCHROEDER HARTWIG ,  HEINZLE ELMAR

IPC: C12P13/08 ,  C12N1/21 ,  C12N9/04 ,  C12N15/53

Abstract: The present invention features methods of increasing the production of a fin e chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., lactate dehydrogenase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of the expression of lactate dehydrogenase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides method s for the production of lysine by way of utilizing fructose or sucrose as a carbon source.

公开(公告)号：AU2004299259A1

公开(公告)日：2005-06-30

申请号：AU2004299259

申请日：2004-12-16

Applicant: BASF AG

Inventor： HAEFNER STEFAN ,  GRAEF CLAUDIA ISABELLA ,  KROGER BURKHARD ,  HABERHAUER GREGOR ,  KLOPPROGGE CORINNA ,  RUFFER UWE ,  SCHRODER HARTWIG ,  ZELDER OSKAR

IPC: C07K14/34

Abstract: The present invention relates to mutated nucleic acids and proteins of the metabolic pathway of fine chemicals, to processes for preparing genetically modified producer organisms, to processes for preparing fine chemicals by culturing genetically modified organisms, and to genetically modified organisms themselves.

公开(公告)号：AU2003238385A8

公开(公告)日：2003-12-12

申请号：AU2003238385

申请日：2003-05-23

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  KROGER BURKHARD ,  SCHRODER HARTWIG ,  HAFNER STEFAN ,  KLOPPROGGE CORINNA

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/10 ,  C12P13/12 ,  C12R1/15

Abstract: The invention relates to methods for the production of sulfur-containing fine chemicals, in particular L-methionine, by fermentation using bacteria in which a nucleotide sequence encoding an S-adenosylmethionine synthase (metK) gene is expressed.

公开(公告)号：AU2003229691A1

公开(公告)日：2003-10-27

申请号：AU2003229691

申请日：2003-04-16

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  SCHRODER HARTWIG ,  HAFNER STEFAN

IPC: A23K1/00 ,  A23K1/16 ,  C12N1/15 ,  C12N9/10 ,  C12N15/09 ,  C12P11/00 ,  C12P13/12 ,  C12R1/15 ,  C12N15/63

Abstract: The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metH) gene.

公开(公告)号：AU2002361951A1

公开(公告)日：2003-05-19

申请号：AU2002361951

申请日：2002-10-31

Applicant: BASF AG

Inventor： SCHRODER HARTWIG ,  ZELDER OSKAR ,  KROGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR ,  POMPEJUS MARKUS

IPC: C07K14/34 ,  C12N1/21 ,  C12N9/00 ,  C12P13/08 ,  C12R1/15 ,  C12N15/77 ,  C12Q1/68 ,  C12P1/04 ,  C12N15/63

Abstract: Isolated nucleic acid (I) that encodes any of 50 amino acid sequences (II) that have, at specific positions, an amino acid (aa) alteration. The specification includes (i) a table identifying the function of (II) and the nature/position of the amino acid exchange and (ii) sequences for (I) and (II). Independent claims are also included for the following: (1) vector that contains at least one (I); (2) host cell transfected with at least one vector of component (1); and (3) preparing fine chemicals by culturing cells of component (2).

公开(公告)号：AU2002361950A1

公开(公告)日：2003-05-19

申请号：AU2002361950

申请日：2002-10-31

Applicant: BASF AG

Inventor： HABERHAUER GREGOR ,  SCHRODER HARTWIG ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  KROGER BURKHARD ,  POMPEJUS MARKUS

IPC: C12N1/21 ,  C12N15/52 ,  C12P13/04 ,  C12N15/77 ,  C12N15/00

Abstract: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.

公开(公告)号：AU1393702A

公开(公告)日：2002-04-02

申请号：AU1393702

申请日：2001-09-19

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  SCHRODER HARTWIG DR ,  KROGER BURKHARD ,  ZELDER OSKAR

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/10 ,  C12N15/54 ,  C12N15/77 ,  C12P1/04 ,  C12P13/04 ,  C12P13/08 ,  C12P13/12 ,  C12P13/14 ,  C12N15/52

Abstract: Preparation of corynebacteria (A) with one or more altered genomic sequences by using a vector (B) that is not replicable in (A) and whose nucleic acid is not recognized as foreign by (A). Independent claims are also included for the following: (1) method for preparing fine chemicals (II) by using (A); and (2) vectors that are not replicable in (A) but have an (A)-specific pattern of methylation.