公开(公告)号：DE4003094A1

公开(公告)日：1991-08-08

申请号：DE4003094

申请日：1990-02-02

Applicant: BASF AG

Inventor： DEESSEN ULRICH VON DR ,  PAUST JOACHIM DR ,  KAISER KLAUS DR ,  INDEST HELMUT DR

IPC: C07H15/18 ,  C07H15/10 ,  C07H15/26

Abstract: (A) 4-Glycopyranosyloxy-2-methyl -2-buten-1-al derivs. of formula (IVa) and (Va) are new: R4 = CH2OAc or COOMe; Ac = acetyl. (B) Prodn. of retinyl glycosides of formula (I) is effected by (a) reacting an acylated glycoside deriv. of formula (II) with a 4-hydroxy-2-methyl-2 -buten-1-al acetal of formula (III); (b) treating the prod. (IV) with an acid, (c) reacting the resulting aldehdye (V) with a beta-ionylidene -ethyl-triphenyl phosphonium salt of formula (VI) under Wittig conditions; and (d) removing the acyl gps. from the prod.: Z= a linear or branched glycoside gp. comprising 1-20 glycoxide units; Z'=Z in which all OH gps. are replaced by OCOR1; R1 = 1-10C alkyl or aralkyl, R2 and R3 = 1-10C alkyl or 7-10C aralkyl, or R2+R3 = ethylene or propylene opt. substd. by 1-4C alkyl; Y = a leaving gp.; X = a monovalent anion. (C) The use of cpds. (IV) and (V) for prodn. of medicaments is also new.

公开(公告)号：DE3938468A1

公开(公告)日：1991-05-23

申请号：DE3938468

申请日：1989-11-18

Applicant: BASF AG

Inventor： GUEMBEL HELMUT DR ,  PAUST JOACHIM DR ,  SPERLING-VIETMEIER KARIN DR ,  BECKER RAINER DR

IPC: A61K8/00 ,  A61K8/35 ,  A61K8/41 ,  A61K8/49 ,  A61Q17/04 ,  C07C49/255 ,  C07C69/618 ,  C07D317/26 ,  C07D317/44 ,  C07D319/06 ,  C07D321/00 ,  C07D407/06

Abstract: 1,1-Dialkoxy-2-oxo-6-aryl-3,5-alkadienes of the general formula I I where Ar is a phenyl, biphenyl or naphthyl radical which may be substituted by one, two or three C1-C4-alkyl groups, C1-C4-alkoxy groups, hydroxyl groups, phenoxy groups, amino groups which may be mono- or di-C1-C4-alkyl-substituted, halogen atoms or a methylenedioxy group, the substituents being identical or different, R1 is hydrogen or C1-C8-alkyl, R2 is hydrogen, C1-C4-alkyl, C1-C10-alkoxycarbonyl or C1-C10-acyl, the radicals R3 are C1-C8-alkyl groups which may be bonded to one another with formation of a five-membered or six-membered ring and R4 is hydrogen or C1-C4-alkyl, are used as sunscreen agents in cosmetic preparations.

公开(公告)号：DE3906632A1

公开(公告)日：1990-09-06

申请号：DE3906632

申请日：1989-03-02

Applicant: BASF AG

Inventor： DOBLER WALTER DR ,  SCHUL WOLFGANG DR ,  PAUST JOACHIM DR ,  MITSCHKER ALFRED DR

IPC: C07F9/6558 ,  G01N30/02

Abstract: In a process for separating thiamine monophosphate from a solution of thiamine phosphates, the solution of thiamine phosphates, which contains the thiamine monophosphate and cocarboxylase is used at a pH of 2 to 7 and a cationic exchanger resin is used having a pKa of 1.0 to 4.5.

公开(公告)号：DE3578179D1

公开(公告)日：1990-07-19

申请号：DE3578179

申请日：1985-04-23

Applicant: BASF AG

Inventor： ERNST HANSGEORG DR ,  ECKHARDT HEINZ DR ,  PAUST JOACHIM DR

IPC: C07C67/00 ,  C07C241/00 ,  C07C245/08 ,  C07D475/14

Abstract: An improved process for the preparation of riboflavin by condensation of a 4,5-dimethyl-N-(D)-ribityl-2-phenylazoaniline derivative with barbituric acid in the presence of an acidic condensing agent in an organic solvent, wherein a 4,5-dimethyl-N-(D)-ribityl-2-(o-alkoxyphenylazo)-aniline of the formula IIa where R is alkyl of 1 to 4 carbon atoms, in particular methyl, is reacted with barbituric acid, as well as the novel intermediates of the formula IIa.

公开(公告)号：DE3829850A1

公开(公告)日：1990-03-15

申请号：DE3829850

申请日：1988-09-02

Applicant: BASF AG

Inventor： PAUST JOACHIM DR ,  ERNST HANSGEORG DR

IPC: C07D239/42

Abstract: In an improved process for the preparation of 2-n-propyl-4-amino-5-methoxymethyl-pyrimidine of the formula I I by reacting butyramidine II II with alpha -methoxymethyl- beta -methoxyacrylonitrile III III the butyramidine II is reacted with a 0.4-5 molar excess of alpha -methoxymethyl- beta -methoxyacrylonitrile III at from -10 DEG to +20 DEG C.

公开(公告)号：DE3705785A1

公开(公告)日：1988-09-01

申请号：DE3705785

申请日：1987-02-24

Applicant: BASF AG

Inventor： KNAUS GUENTER H DR ,  PAUST JOACHIM DR

IPC: B01J31/30 ,  C07B61/00 ,  C07C45/00 ,  C07C45/38 ,  C07C47/21 ,  C07C47/225 ,  C07C47/267 ,  C07C47/277 ,  C07C49/757 ,  C07C67/00 ,  C07C67/31 ,  C07C67/313 ,  C07C69/73 ,  C07C69/738 ,  C07C401/00 ,  C07C403/00 ,  C07C403/08 ,  C07C403/14 ,  C07D317/26 ,  C07D319/06 ,  C07C175/00

Abstract: A process for the preparation of polyene aldehydes of the formula I … … in which R represents … … where R' has the meaning alkyl, aryl, aralkyl or cycloalkyl and, if desired, can be further substituted and the radicals R'' represent C1-C4-alkyl or together denote -CH2-CH2- or -CH2-CH2-CH2- bridges which, if desired, can be further substituted by C1-C4-alkyl,… by catalytic oxidation of the corresponding polyene alcohol with oxygen or an oxygen-containing gas is proposed, characterised in that the oxidation is carried out in the presence of the catalyst system 2,2,6,6-tetramethylpiperidin-1-oxyl or 4-oxo- 2,2,6,6-tetramethylpiperidin-1-oxyl and copper(I) chloride.

公开(公告)号：DE3465992D1

公开(公告)日：1987-10-15

申请号：DE3465992

申请日：1984-03-07

Applicant: BASF AG

Inventor： ERNST HANSGEORG DR ,  GEHRKEN HENNING-PETER DR ,  PAUST JOACHIM DR

IPC: C07D317/60 ,  B01J31/16 ,  C07B61/00 ,  C07D311/72

Abstract: A process for the preparation of alpha -tocopherol of the formula I (I) by reacting a chroman derivative with a C14-Grignard reagent using a di-alkali metal tetrahalocuprate catalyst in a Schlosser-Fouquet reaction, wherein a chroman derivative of the general formula II (II) where Y is a leaving group, especially Br, is used and is reacted, at from -70 DEG to 0 DEG C., first with a solution of about 1 equivalent of a Grignard compound of the general formula III X-Mg-R (III) where X is Cl, Br or I and R is straight-chain or branched alkyl of 1 to 14 carbon atoms, preferably methyl, ethyl or and then with a solution of a Grignard reagent of the formula IIIa (IIIa) in an ether solvent and a solution of a di-alkali metal tetrahalocuprate in an ether solvent. The novel process simplifies the preparation of 2RS,4'RS,8'RS-, 2R,4'RS,8'RS- or 2R,4'R,8'R- alpha -tocopherol by reacting a chroman structural unit, containing a C2 side-chain in the 2-position, with the corresponding C14-Grignard compound.

公开(公告)号：DE3433959A1

公开(公告)日：1986-03-27

申请号：DE3433959

申请日：1984-09-15

Applicant: BASF AG

Inventor： LEININGER HARTMUT DR ,  LITTMANN WOLFGANG DR ,  PAUST JOACHIM DR ,  TRAUTMANN WALTER DR

IPC: C07D241/20 ,  C07D403/04 ,  C07D209/48

Abstract: 2-Amino-3,5-di-(halomethyl)-pyrazines of the general formula I (I) where X is either chlorine or bromine, m and n may each be 0, 1, 2 or 3 and R1 and R2 are each hydrogen or a protective group or may furthermore be bonded to one another, in particular those compounds of the formula I in which m is 1 and n is 2 and/or R1 and R2 together form a phthaloyl radical, are useful intermediates for the pteridine building block of folic acid or folic acid analogs. They are obtained by a method in which a 2-amino-3,5-dimethylpyrazine of the general formula II (II) is treated with a chlorinating or brominating agent and, where R1 and/or R2 are protective groups, these are, if desired, eliminated when the chlorination or bromination is complete.

公开(公告)号：DE3362209D1

公开(公告)日：1986-03-27

申请号：DE3362209

申请日：1983-11-23

Applicant: BASF AG

Inventor： WEITZ HANS-MARTIN DR ,  FISCHER ROLF DR ,  PAUST JOACHIM DR

IPC: C07C67/00 ,  C07C69/16

公开(公告)号：DE3417944A1

公开(公告)日：1985-11-21

申请号：DE3417944

申请日：1984-05-15

Applicant: BASF AG

Inventor： ERNST HANSGEORG DR ,  ECKHARDT HEINZ DR ,  PAUST JOACHIM DR

IPC: C07C67/00 ,  C07C241/00 ,  C07C245/08 ,  C07D475/14

Abstract: An improved process for the preparation of riboflavin by condensation of a 4,5-dimethyl-N-(D)-ribityl-2-phenylazoaniline derivative with barbituric acid in the presence of an acidic condensing agent in an organic solvent, wherein a 4,5-dimethyl-N-(D)-ribityl-2-(o-alkoxyphenylazo)-aniline of the formula IIa where R is alkyl of 1 to 4 carbon atoms, in particular methyl, is reacted with barbituric acid, as well as the novel intermediates of the formula IIa.