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    41.
    发明专利
    未知

    公开(公告)号：DE19511131A1

    公开(公告)日：1996-10-02

    申请号：DE19511131

    申请日：1995-03-27

    Applicant: BASF AG

    Inventor： SPENGLER REINHARD DR ,  ROSENBERG JOERG DR ,  BREITENBACH JOERG DR

    IPC: A61K9/28 ,  A61K9/16 ,  A61K9/24 ,  A61K31/485 ,  A61K31/60

    Abstract: The invention concerns mechanically stable solid formulations of active substances, containing at least one active substance and at least one polymer and provided with a coating containing a proportion of softener equal to 0-16 wt. %. With the formulations of active substances proposed, it is possible to achieve mechanical stabilisation of moulded articles such as tablets, granules or pellets based on the above polymers when the latter are treated to produce solid solutions with the above active substances or when those polymers are treated with softening active substances such as acetylsalicylic acid, fenofibrate, naftidrofuryl, furosemide, ibuprofen, anipamil, benzoic acid, or indomethacin.

    42.
    发明专利
    未知

    公开(公告)号：DE4446470A1

    公开(公告)日：1996-06-27

    申请号：DE4446470

    申请日：1994-12-23

    Applicant: BASF AG

    Inventor： ROSENBERG JOERG DR ,  MAIER WERNER ,  FRICKE HELMUT DR ,  BREITENBACH JOERG DR

    IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

    Abstract: The present invention concerns a method of producing divisible tablets by melt calendering: two form cylinders are combined, one of the cylinders having at least one recess with at least one ridge which extends as far as the surface line of the cylinder and forms a break groove.

    44.
    发明专利
    未知

    公开(公告)号：DE4413350A1

    公开(公告)日：1995-10-19

    申请号：DE4413350

    申请日：1994-04-18

    Applicant: BASF AG

    Inventor： GRABOWSKI SVEN DR ,  ROSENBERG JOERG DR ,  SANNER AXEL DR

    IPC: A61K9/16 ,  A61K9/22

    Abstract: Disclosed are sustained-release matrix pellets of spherical to lenticular shape and uniform maximum diameter in the range of 0-5 to 4 mm, consisting of a) 0.1 to 87 wt % of at least one biologically active compound, b) 5 to 50 wt % of at least one water-insoluble polymer, c) 5-45 wt % of at least one lipophilic component as plasticizer for the b) polymer, d) 3 to 40 wt % of a natural or semisynthetic gelling agent, e) 0 to 50 wt% of one or more common formulation auxiliaries.

    45.
    发明专利
    未知

    公开(公告)号：DK0596203T3

    公开(公告)日：2000-03-13

    申请号：DK93112464

    申请日：1993-08-04

    Applicant: BASF AG

    Inventor： SANNER AXEL DR ,  GRABOWSKI SVEN DR ,  ROSENBERG JOERG DR

    IPC: A01N25/10 ,  A01N25/12 ,  A61K9/14 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26

    Abstract: Preparations in solid particle form containing active compounds, obtainable by intimate mixing of the active compound with a water-soluble melt of a) 10 to 90% by weight of a water-soluble polymer A of a viscosity Va of 1,000 to 120,000 cps and b) 10 to 90% by weight of a water-soluble polymer B of a viscosity Vb of 1 to 500 cps as a carrier substance, the viscosities Va and Vb being those of a 2% strength by weight aqueous solution at 20@C, measured by the capillary method ASTM D 2363-72 (European Pharmacopoeia, Vol. III, p. 37), and processing of the melt with shaping to give the particles.

    47.
    发明专利
    未知

    公开(公告)号：AT186638T

    公开(公告)日：1999-12-15

    申请号：AT93112464

    申请日：1993-08-04

    Applicant: BASF AG

    Inventor： GRABOWSKI SVEN DR ,  SANNER AXEL DR ,  ROSENBERG JOERG DR

    IPC: A01N25/10 ,  A01N25/12 ,  A61K9/14 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26

    Abstract: Preparations in solid particle form containing active compounds, obtainable by intimate mixing of the active compound with a water-soluble melt of a) 10 to 90% by weight of a water-soluble polymer A of a viscosity Va of 1,000 to 120,000 cps and b) 10 to 90% by weight of a water-soluble polymer B of a viscosity Vb of 1 to 500 cps as a carrier substance, the viscosities Va and Vb being those of a 2% strength by weight aqueous solution at 20@C, measured by the capillary method ASTM D 2363-72 (European Pharmacopoeia, Vol. III, p. 37), and processing of the melt with shaping to give the particles.

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