公开(公告)号：DE4132013A1

公开(公告)日：1993-04-01

申请号：DE4132013

申请日：1991-09-26

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/165 ,  A61K31/18 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4418 ,  A61P9/06 ,  C07C217/58 ,  C07C233/80 ,  C07C255/54 ,  C07C255/57 ,  C07C311/08 ,  C07C311/21 ,  C07D213/30 ,  C07D213/38 ,  C07D213/71 ,  C07D213/81 ,  C07D233/60 ,  C07D233/61 ,  C07D295/096 ,  C07D295/135

公开(公告)号：CZ300895A3

公开(公告)日：1996-02-14

申请号：CZ300895

申请日：1994-05-09

Applicant: BASF AG

Inventor： GRABOWSKI SVEN DR ,  MUELLER WINFRIED DR ,  ROSENBERG JOERG DR ,  BINDER RUDOLF DR ,  SANNER AXEL DR

IPC: A61K47/32 ,  A61K9/14 ,  A61K31/37 ,  A61K31/41 ,  A61K31/425 ,  A61K31/433 ,  A61K47/30 ,  A61K47/38

Abstract: PCT No. PCT/EP94/01489 Sec. 371 Date Nov. 7, 1995 Sec. 102(e) Date Nov. 7, 1995 PCT Filed May 9, 1994 PCT Pub. No. WO94/26267 PCT Pub. Date Nov. 24, 1994Compositions in the form of solid solutions containing a) 1-90% by weight of a coumarin derivative A from the group of alkoxycoumarins with a heterocyclic substituent or of hydroxycoumarins esterified with a sulfonic acid as active substance and b) 10-99% by weight of at least one water-soluble polymer B as carrier substance.

公开(公告)号：DE4316537A1

公开(公告)日：1994-11-24

申请号：DE4316537

申请日：1993-05-18

Applicant: BASF AG

Inventor： GRABOWSKI SVEN DR ,  MUELLER WINFRIED DR ,  ROSENBERG JOERG DR ,  BINDER RUDOLF DR ,  SANNER AXEL DR

IPC: A61K47/32 ,  A61K9/14 ,  A61K31/37 ,  A61K31/41 ,  A61K31/425 ,  A61K31/433 ,  A61K47/30 ,  A61K47/38 ,  A61K31/35

Abstract: PCT No. PCT/EP94/01489 Sec. 371 Date Nov. 7, 1995 Sec. 102(e) Date Nov. 7, 1995 PCT Filed May 9, 1994 PCT Pub. No. WO94/26267 PCT Pub. Date Nov. 24, 1994Compositions in the form of solid solutions containing a) 1-90% by weight of a coumarin derivative A from the group of alkoxycoumarins with a heterocyclic substituent or of hydroxycoumarins esterified with a sulfonic acid as active substance and b) 10-99% by weight of at least one water-soluble polymer B as carrier substance.

公开(公告)号：DK0481299T3

公开(公告)日：1994-09-12

申请号：DK91116915

申请日：1991-10-04

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4427 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58 ,  C07D401/12 ,  A61K31/44

Abstract: Phenylpiperidylamines of the formula I I R1 is H, NO2, R4SO2NH, N=C, CF3, CF3O, F, Cl, Br, C1-C4-alkyl, R3O, CO2R3, CHO, CH=NOR3, CH3OR3 and R2 is H, F, Cl, Br, C1-C4-alkyl or R4O, where R1 and R2 are not both H, R3 is H or R4, R4 is C1-C4-alkyl or phenyl, n is 1, 2, 3 or 4 and Ar is and the physiologically tolerated salts thereof, are used as active ingredients in drugs.

公开(公告)号：DE4112353A1

公开(公告)日：1992-10-22

申请号：DE4112353

申请日：1991-04-16

Applicant: BASF AG

Inventor： STEINER GERD DR ,  UNGER LILIANE DR ,  HOFMANN HANS PETER DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  BEHL BERTHOLD DR ,  BINDER RUDOLF DR

IPC: A61K31/445 ,  A61K31/4433 ,  A61K31/451 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D211/22 ,  C07D211/46 ,  C07D211/48 ,  C07D211/52 ,  C07D211/70 ,  C07D409/04

Abstract: The description relates to compounds of formula (I) in which A-B-D, R , R , R and n have the meanings given in the specification, and their production. The compounds are suitable for the treatment of diseases.

公开(公告)号：ES2058174T3

公开(公告)日：1994-11-01

申请号：ES88107762

申请日：1988-05-13

Applicant: BASF AG

Inventor： STEINER GERD DR ,  PFISTER JUERGEN DR ,  TESCHENDORF HANS-JUERGEN DR ,  UNGER LILIANE DR ,  BINDER RUDOLF DR

IPC: A61K31/55 ,  A61P21/02 ,  A61P25/00 ,  A61P25/02 ,  A61P25/20 ,  C07D487/04

Abstract: Compounds of the formula where R1, R2, R3, R4 and A have the meanings stated in the specification, as well as the use thereof for controlling diseases, are described.

公开(公告)号：DE59102245D1

公开(公告)日：1994-08-25

申请号：DE59102245

申请日：1991-10-04

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4427 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58 ,  C07D401/12

Abstract: Phenylpiperidylamines of the formula I I R1 is H, NO2, R4SO2NH, N=C, CF3, CF3O, F, Cl, Br, C1-C4-alkyl, R3O, CO2R3, CHO, CH=NOR3, CH3OR3 and R2 is H, F, Cl, Br, C1-C4-alkyl or R4O, where R1 and R2 are not both H, R3 is H or R4, R4 is C1-C4-alkyl or phenyl, n is 1, 2, 3 or 4 and Ar is and the physiologically tolerated salts thereof, are used as active ingredients in drugs.

公开(公告)号：DE3717068A1

公开(公告)日：1988-12-08

申请号：DE3717068

申请日：1987-05-21

Applicant: BASF AG

Inventor： STEINER GERD DR ,  PFISTER JUERGEN DR ,  TESCHENDORF HANS-JUERGEN DR ,  UNGER LILIANE DR ,  BINDER RUDOLF DR

IPC: A61K31/55 ,  A61P21/02 ,  A61P25/00 ,  A61P25/02 ,  A61P25/20 ,  C07D487/04

Abstract: Compounds of the formula where R1, R2, R3, R4 and A have the meanings stated in the specification, as well as the use thereof for controlling diseases, are described.

公开(公告)号：DK0481288T3

公开(公告)日：1995-09-11

申请号：DK91116812

申请日：1991-10-02

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58

Abstract: Phenylpiperidinylamines of the formula I I where R1 is -NHSO2R4 or R2 and R3 are each, independently of one another, H or C1-C4-alkyl or together are a (CH2)n chain with n=4 or 5, and R4 is C1-C4-alkyl or phenyl, and the physiologically tolerated salts thereof, and pharmaceutical compositions containing these are described.

公开(公告)号：AT108775T

公开(公告)日：1994-08-15

申请号：AT91116915

申请日：1991-10-04

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4427 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58 ,  C07D401/12

Abstract: Phenylpiperidylamines of the formula I I R1 is H, NO2, R4SO2NH, N=C, CF3, CF3O, F, Cl, Br, C1-C4-alkyl, R3O, CO2R3, CHO, CH=NOR3, CH3OR3 and R2 is H, F, Cl, Br, C1-C4-alkyl or R4O, where R1 and R2 are not both H, R3 is H or R4, R4 is C1-C4-alkyl or phenyl, n is 1, 2, 3 or 4 and Ar is and the physiologically tolerated salts thereof, are used as active ingredients in drugs.