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    OPIOID ANALGESIC PREPARATION OF SOLID AND AT LEAST TWO-PHASE AND ITS PRODUCTION
    1.
    发明专利
    OPIOID ANALGESIC PREPARATION OF SOLID AND AT LEAST TWO-PHASE AND ITS PRODUCTION 失效

    公开(公告)号：JPH10251149A

    公开(公告)日：1998-09-22

    申请号：JP6096198

    申请日：1998-03-12

    Applicant: BASF AG

    Inventor： BERNDL GUNTHER DR ,  ROSENBERG JOERG DR ,  BREITENBACH JOERG DR

    IPC: A61K9/00 ,  A61K9/24 ,  A61K9/52 ,  A61K31/485

    Abstract: PROBLEM TO BE SOLVED: To obtain a preparation capable of satisfying both to rapidly raise the level of an active ingredient and to slowly release the active ingredient by including opioids in two or more solid phases, respectively, and specifying the releasing amounts of the opioids. SOLUTION: A solid material comprising two or more phases is formed, and at least one kind of opioid is added to the matrix of each phase. The releasing amount (measured by the detection of UV light at 270nm by a ph. Eur. paddle method at 100rpm in a 0.1 hydrochloric acid at 37 deg.C) in a test tube is controlled to >=50wt.% after 1hr. The releasing amount is preferably controlled to 55-80wt.% after 1hr, 58-85wt.% after 2hr, 60-95wt.% after 4hr, and 65-100wt.% after 8hr. The two or more phases are preferably divided into rapidly releasing phases and slowly releasing phases in dependence on the differences of the individual matrix compositions. The opioid is preferably hydromorphone, morphine, tramadol, etc.

    4.
    发明专利
    未知

    公开(公告)号：DE19733504A1

    公开(公告)日：1999-02-04

    申请号：DE19733504

    申请日：1997-08-01

    Applicant: BASF AG

    Inventor： BERNDL GUNTHER DR ,  BREITENBACH JOERG DR

    IPC: A23K40/10 ,  A23K40/20 ,  A23K50/80 ,  A23K1/18 ,  A23K1/16 ,  A23P1/12 ,  A23P1/02

    Abstract: The invention relates to slow sinking, porous granules or pellets with a density of greater than 1 g/cm for use in fish breeding. The inventive granules or pellets are obtained by solvent-free melt extrusion of mixtures consisting of biologically active substances, matrix support substances and a solid gas producer.

    8.
    发明专利
    未知

    公开(公告)号：DE59913213D1

    公开(公告)日：2006-05-11

    申请号：DE59913213

    申请日：1999-03-11

    Applicant: BASF AG

    Inventor： MEFFERT HELMUT DR ,  SANNER AXEL DR ,  BERNDL GUNTHER DR ,  RUCHATZ FOLKER DR ,  KOLTER KARL DR ,  BAUER KURT HEINZ PROF DR

    IPC: A61K8/81 ,  A61K8/63 ,  A61K9/00 ,  A61K9/107 ,  A61K9/20 ,  A61K9/48 ,  A61K47/32 ,  C08F220/04 ,  C08F222/04

    Abstract: The invention relates to the use of copolymers comprising a) 82 to 99.9 mol % of at least one monoethylenically unsaturated C3-C8-carboxylic acid; b) 0.1 to 18 mol % of at least one monomer selected from the group b1) N-C8-C30-alkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids, b2) N,N-C8-C30-dialkyl-substituted amides of mono-ethylenically unsaturated C3-C8-carboxylic acids, b3) C8-C30-alkyl esters of monoethylenically unsaturated C3-C8-carboxylic acids; c) 0 to 17.9 mol % of at least one monomer selected from the group of c1) vinyl esters of aliphatic C8-C30-carboxylic acids, c2) C8-C30-alkylvinyl ethers, the mol % data for the individual components adding up to 100%, as solubilizer.

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