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公开(公告)号:JPH10251149A
公开(公告)日:1998-09-22
申请号:JP6096198
申请日:1998-03-12
Applicant: BASF AG
Inventor: BERNDL GUNTHER DR , ROSENBERG JOERG DR , BREITENBACH JOERG DR
IPC: A61K9/00 , A61K9/24 , A61K9/52 , A61K31/485
Abstract: PROBLEM TO BE SOLVED: To obtain a preparation capable of satisfying both to rapidly raise the level of an active ingredient and to slowly release the active ingredient by including opioids in two or more solid phases, respectively, and specifying the releasing amounts of the opioids. SOLUTION: A solid material comprising two or more phases is formed, and at least one kind of opioid is added to the matrix of each phase. The releasing amount (measured by the detection of UV light at 270nm by a ph. Eur. paddle method at 100rpm in a 0.1 hydrochloric acid at 37 deg.C) in a test tube is controlled to >=50wt.% after 1hr. The releasing amount is preferably controlled to 55-80wt.% after 1hr, 58-85wt.% after 2hr, 60-95wt.% after 4hr, and 65-100wt.% after 8hr. The two or more phases are preferably divided into rapidly releasing phases and slowly releasing phases in dependence on the differences of the individual matrix compositions. The opioid is preferably hydromorphone, morphine, tramadol, etc.
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公开(公告)号:JPH10314571A
公开(公告)日:1998-12-02
申请号:JP12341798
申请日:1998-05-06
Applicant: BASF AG
Inventor: KOTHRADE STEPHAN DR , MEFFERT HELMUT DR , BERNDL GUNTHER DR , SANNER AXEL DR , STEIN STEFAN DR , SCHEHLMANN VOLKER DR , RUCHATZ FOLKER DR
IPC: A61K8/72 , A61K8/00 , A61K8/81 , A61K47/14 , A61K47/30 , A61K47/32 , A61Q19/00 , B01F17/32 , B01F17/52 , A61K7/00 , A61K7/48
Abstract: PROBLEM TO BE SOLVED: To prepare a solubilization agent for an insoluble action substance. SOLUTION: A copolymer composed of monomers selected out of following items or a mixture of the monomers of 1-40 molar% is used in a prepared material of a water-insoluble substance, and the items are: A) N-vinylpyrrolidone of 60-99% and B) Following groups: b1) monoethylene unsaturated C3 -C8 - carboxylic acid of C8 -C30 -alkylester b2) acrylic acid or methacrylic acid N,N- dialkyl-allyl having C8 -C18 alkyl- or N,N-dialkyl-substituted amide, or b3) aliphatic C8 -C30 -carboxylic acid vinylester.
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公开(公告)号:DE19753298A1
公开(公告)日:1999-06-02
申请号:DE19753298
申请日:1997-12-01
Applicant: BASF AG
Inventor: KOTHRADE STEPHAN DR , MEFFERT HELMUT DR , BERNDL GUNTHER DR , ERNST ANDREAS DR , SANNER AXEL DR
IPC: A61K47/32 , A23K20/10 , A23K40/10 , A23K40/20 , A23L27/00 , A23L33/10 , A61K9/16 , A61K9/20 , A61K9/22 , A61K31/277 , A61K31/421 , A61K31/275 , A23K1/16 , A23L1/29
Abstract: The invention relates to a method for producing solid dosing forms by mixing at least one polymeric binding agent, at least one active substance, and optional common additives while producing a plastic mixture and during shaping, whereby a copolymer from a N-vinyl lactam and from an copolymerizable monomer with a hydrophobic radical is used as a polymeric binding agent. Dosing forms which slowly release the active substance are obtained in a simple and economical manner.
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公开(公告)号:DE19733504A1
公开(公告)日:1999-02-04
申请号:DE19733504
申请日:1997-08-01
Applicant: BASF AG
Inventor: BERNDL GUNTHER DR , BREITENBACH JOERG DR
Abstract: The invention relates to slow sinking, porous granules or pellets with a density of greater than 1 g/cm for use in fish breeding. The inventive granules or pellets are obtained by solvent-free melt extrusion of mixtures consisting of biologically active substances, matrix support substances and a solid gas producer.
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5.
公开(公告)号:ES2260864T3
公开(公告)日:2006-11-01
申请号:ES99104860
申请日:1999-03-11
Applicant: BASF AG
Inventor: MEFFERT HELMUT DR , SANNER AXEL DR , BERNDL GUNTHER DR , RUCHATZ FOLKER DR , KOLTER KARL DR , BAUER KURT HEINZ PROF DR
IPC: A61K8/63 , A61K9/00 , A61K9/107 , A61K9/20 , A61K9/48 , A61K47/32 , C08F220/04 , A61K8/81 , C08F222/04
Abstract: UTILIZACION DE COPOLIMEROS QUE CONTIENEN A) 82 HASTA 99,9 MOLES % DE AL MENOS UN ACIDO CARBOXILICO DE C 3 - C 8 MONOETILENICAMENTE INSATURADO; B) 0,1 HASTA 18 MOL % DE AL MENOS UN MONOMERO ELEGIDO DEL GRUPO B 1 ) AMIDA SUSTITUIDA D EL N - ALQUILO DE C 8 C 30 DE ACIDOS CARBOXILICOS DE C 3 - C 8 MONOETILENICAMENTE INSATURADOS, B 2 ) AMIDAS SUSTITUIDAS DE N, N - DIALQUILO DE C 8 C 30 DE ACIDOS CARBOXILICOS DE C 3 - C 8 MONOETILENICAMENTE INSATURADOS, B 3 ) ALQUILESTERES (EL ALQUILO DE C 8 C 30 ) DE ACIDOS CARBOXILICOS DE C 3 - C 8 MONOE TILENICAMENTE INSATURADOS; C) 0 A 17,9 MOLES % DE AL MENOS UN MONOMERO ELEGIDO DEL GRUPO DE C 1 ) ESTERES VINILICOS DE ACIDOS ALIFATICOS DE C 8 - C 30 , C 2 ) ALQUIL - V INILETER (EL ALQUILO DE C 8 - C 30 ), SUMANDO LAS INDICACIONES EN % EN MOLES DE LOS DIFERENTES COMPONENTES PARA DAR EL 100 %; SE UTILIZA COMO SOLUBILIZANTE.
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公开(公告)号:ES2206782T3
公开(公告)日:2004-05-16
申请号:ES98107386
申请日:1998-04-23
Applicant: BASF AG
Inventor: KOTHRADE STEPHAN DR , MEFFERT HELMUT DR , BERNDL GUNTHER DR , SANNER AXEL DR , STEIN STEFAN DR , SCHEHLMANN VOLKER DR
IPC: A61K8/00 , A61K8/81 , A61K8/72 , A61K47/14 , A61K47/30 , A61K47/32 , A61Q19/00 , C09K23/32 , C09K23/52
Abstract: The use of N-vinyl-pyrrolidone (NVP) copolymers (I) is claimed as surfactants in formulations of water-insoluble materials (II). (I) is derived from (a) 60-99 mol.% NVP, (b) 1-40 mol.% of one or more monomer(s) selected from (b1) 8-30C alkyl esters of mono-ethylenically unsaturated 3-8C carboxylic acids, (b2) N-(8-18C alkyl)- or N,N-di-(8-18C alkyl)-substituted (meth)acrylamides and (b3) vinyl esters of 8-30C aliphatic carboxylic acids and (c) 0-39 mol.% of further radically copolymerisable monomers. The (II) formulations containing (I) as surfactant are also claimed.
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公开(公告)号:DE19629040A1
公开(公告)日:1998-01-22
申请号:DE19629040
申请日:1996-07-19
Applicant: BASF AG
Inventor: BERNDL GUNTHER DR , ROSENBERG JOERG DR , SANNER AXEL DR
Abstract: The invention concerns solid active substance preparations containing as active substances plant extracts, with the exception of extracts of Gingko biloba, Glycyrrhiza glabra and Eucalyptus globulus. The preparations are obtained by extruding a mixture of at least one plant extract and at least one meltable polymer and subsequent shaping.
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公开(公告)号:DE59913213D1
公开(公告)日:2006-05-11
申请号:DE59913213
申请日:1999-03-11
Applicant: BASF AG
Inventor: MEFFERT HELMUT DR , SANNER AXEL DR , BERNDL GUNTHER DR , RUCHATZ FOLKER DR , KOLTER KARL DR , BAUER KURT HEINZ PROF DR
IPC: A61K8/81 , A61K8/63 , A61K9/00 , A61K9/107 , A61K9/20 , A61K9/48 , A61K47/32 , C08F220/04 , C08F222/04
Abstract: The invention relates to the use of copolymers comprising a) 82 to 99.9 mol % of at least one monoethylenically unsaturated C3-C8-carboxylic acid; b) 0.1 to 18 mol % of at least one monomer selected from the group b1) N-C8-C30-alkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids, b2) N,N-C8-C30-dialkyl-substituted amides of mono-ethylenically unsaturated C3-C8-carboxylic acids, b3) C8-C30-alkyl esters of monoethylenically unsaturated C3-C8-carboxylic acids; c) 0 to 17.9 mol % of at least one monomer selected from the group of c1) vinyl esters of aliphatic C8-C30-carboxylic acids, c2) C8-C30-alkylvinyl ethers, the mol % data for the individual components adding up to 100%, as solubilizer.
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公开(公告)号:DE19753300A1
公开(公告)日:1999-06-02
申请号:DE19753300
申请日:1997-12-01
Applicant: BASF AG
Inventor: KOTHRADE STEPHAN DR , BERNDL GUNTHER DR , ERNST ANDREAS DR , SANNER AXEL DR
IPC: A61K9/14 , A61K9/16 , A61K9/20 , A61K47/32 , A61K31/275
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公开(公告)号:DE19710008A1
公开(公告)日:1998-09-17
申请号:DE19710008
申请日:1997-03-12
Applicant: BASF AG
Inventor: BERNDL GUNTHER DR , ROSENBERG JOERG DR , BREITENBACH JOERG DR
IPC: A61K9/00 , A61K9/24 , A61K9/52 , A61K31/485
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