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公开(公告)号：BR9912523A
公开(公告)日：2001-09-18
申请号：BR9912523
申请日：1999-06-25
Applicant: BAXTER INT , CERUS CORP
Inventor： BOGGS DANIEL R , HEI DEREK J , STERNBERG SCHMUEL , PAULEY ROBIN G , MCLARTY DONNA L
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42.发明专利
公开(公告)号：CA2398247A1
公开(公告)日：2001-08-02
申请号：CA2398247
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： BOGGS DANIEL R , BREILLATT JULIAN , SANDFORD CRAIG , KHARE ATUL , STERNBERG SHMUEL , WOO LECON
Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposu re to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid fl ow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation sourc e (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven b y a roller mechanism (38) in the direction of the fluid flow. As the fluid flo ws through thebelt chamber (22), the flexible vanes (36) provide a squeegee-lik e mechanism to move the fluid through the belt chamber (22) in discrete packet s (40) defined by a pair of vanes (36). As the packets of fluid move through t he belt chamber, they are exposed to sterilizing radiation passing through the plate (32).
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公开(公告)号：DE3750481D1
公开(公告)日：1994-10-06
申请号：DE3750481
申请日：1987-10-13
Applicant: BAXTER INT , AMERICAN NAT RED CROSS
Inventor： LYSAGHT MICHAEL J , BOGGS DANIEL R , RITGER PHILIP L , STROMBERG ROBERT R , FRIEDMAN LEONARD I
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公开(公告)号：HK59893A
公开(公告)日：1993-06-25
申请号：HK59893
申请日：1993-06-17
Applicant: BAXTER INT
Inventor： JOHNSON RICHARD J , CHENOWETH DENNIS E , BOGGS DANIEL R , LYSAGHT MICHAEL J
IPC: A61M1/18 , A61M1/36 , B01D67/00 , B01D69/08 , B01D71/10 , B01D71/82 , D01D5/24 , D01F2/04 , D01F2/28
Abstract: A material is formed into hollow fiber form, and the surface characteristics of the interior bore is selectively modified in a predetermined fashion by a reactive lumen fluid. Nucleophilic materials, such as regenerated cellulose, can be formed into hollow fibers and simultaneously modified to improve their biocompatibility in accordance with the invention.
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Patent Agency Ranking
公开(公告)号：HK1142165A1
公开(公告)日：2010-11-26
申请号：HK10108406
申请日：2010-09-03
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： ANDERLE HEINZ , MATTHIESSEN PETER , SCHWARZ HANS-PETER , TURECEK PETER , KREIL THOMAS , BOGGS DANIEL R
IPC: A61L20060101 , G01J20060101 , G01N20060101
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公开(公告)号：AU2009201269A1
公开(公告)日：2009-04-23
申请号：AU2009201269
申请日：2009-04-01
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： BOGGS DANIEL R , ANDERLE HEINZ , TURECEK PETER , SCHWARZ HANS-PETER , MATTHIESSEN PETER , KREIL THOMAS
Abstract: The present invention relates to a device for calibration in a method for the inactivation of microorganism in a biological fluid, comprising irradiating the biological fluid with an effective dose of monochromatic or polychromatic light from one or more light sources, wherein the effective dose is determined by measuring the effect of the monochromatic or polychromatic light on a dosimetric solution.
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公开(公告)号：AU748068B2
公开(公告)日：2002-05-30
申请号：AU4834499
申请日：1999-06-25
Applicant: BAXTER INT , CERUS CORP
Inventor： BOGGS DANIEL R , HEI DEREK J , STERNBERG SCHMUEL , PAULEY ROBIN G , MCLARTY DONNA L
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公开(公告)号：AT195852T
公开(公告)日：2000-09-15
申请号：AT93908494
申请日：1993-03-25
Applicant: BAXTER INT
Inventor： BRAUKER JAMES H , HILL RONALD S , MARTINSON LAURA A , BOGGS DANIEL R , JOHNSON ROBERT C
IPC: A61B5/00 , A61F2/02 , A61F2/06 , A61K9/00 , A61L27/38 , A61L27/56 , A61L29/00 , A61L29/14 , C08K3/30
Abstract: A method for implanting cells is disclosed which employs a chamber having a wall forming porous boundary between the host and implanted cells. According to the method, a given number of cells (N) is placed within the porous boundary of a given area (A) such that the quantity A/N is less than about 200 mu m2/cell. The porous boundary has a pore size, an ultimate strength, and a metabolic transit value that assures the survival of the cells during the critical ischemic period and afterward.
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49.发明专利
公开(公告)号：CA2132015A1
公开(公告)日：1993-10-14
申请号：CA2132015
申请日：1993-03-25
Applicant: BAXTER INT
Inventor： BRAUKER JAMES H , HILL RONALD S , MARTINSON LAURA A , BOGGS DANIEL R , JOHNSON ROBERT C
IPC: A61B5/00 , A61F2/02 , A61F2/06 , A61K9/00 , A61L27/38 , A61L27/56 , A61L29/00 , A61L29/14 , A61L27/00
Abstract: 2132015 9319700 PCTABS00027 Implant assemblies (10) and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish an improved boundary (34) between the host and the implanted cells. The boundary (34) has a pore size, an ultimate strength, and a metabolic transit value that assures the survival of the cells during the critical ischemic period and afterward. The boundary (34) allows the fabrication and clinical use of implant assemblies (10) and methodologies that can carry enough cells to be of therapeutic value to the host, yet occupy a relatively small, compact area within the host.
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