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    MICROORGANISMS AND METHODS FOR IMPROVING PRODUCT YIELDS ON METHANOL USING ACETYL-COA SYNTHESIS
    41.
    发明申请
    MICROORGANISMS AND METHODS FOR IMPROVING PRODUCT YIELDS ON METHANOL USING ACETYL-COA SYNTHESIS 审中-公开
    使用乙酰辅酶A合成改善甲醇产品的微生物和方法

    公开(公告)号：WO2015084633A1

    公开(公告)日：2015-06-11

    申请号：PCT/US2014/067287

    申请日：2014-11-25

    Applicant: GENOMATICA, INC.

    Inventor： OSTERHOUT, Robin, E. ,  BURGARD, Anthony, P. ,  PHARKYA, Priti ,  ANDRAE, Stefan

    IPC: C12N1/19 ,  C12N1/15 ,  C12N1/13 ,  C12N1/11

    CPC classification number: C12P5/026 ,  C12N1/14 ,  C12N1/20 ,  C12N15/70 ,  C12N15/81 ,  C12P7/02 ,  C12P7/04 ,  C12P7/18 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P13/001 ,  C12P13/005 ,  C12P17/10 ,  Y02E50/343

    Abstract: The invention provides non-naturally occurring microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA. In some embodiments, the microbial organisms having such pathways also include pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation. The enhanced carbon flux through acetyl-CoA, in combination with pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation can, in some embodiments, be used for production of a bioderived compound. Accordingly, in some embodiments, the microbial organisms of the invention can include a pathway capable of producing a bioderived compound of the invention. The invention still further provides a bioderived compound produced by a microbial organism of the invention, culture medium having the bioderived compound of the invention, compositions having the bioderived compound of the invention, a biobased product comprising the bioderived compound of the invention, and a process for producing a bioderived compound of the invention.

    Abstract translation: 本发明提供了非天然存在的微生物，其含有通过乙酰辅酶A的碳通量的酶途径和/或代谢修饰。 在一些实施方案中，具有这种途径的微生物生物体还包括产生还原当量的途径，甲醛固定和/或甲酸盐同化。 在一些实施方案中，通过乙酰辅酶A增强的碳通量与产生还原当量的途径，甲醛固定和/或甲酸盐同化可用于生产生物活性化合物。 因此，在一些实施方案中，本发明的微生物体可以包括能够产生本发明生物活性化合物的途径。 本发明还提供了由本发明的微生物生物产生的生物活性化合物，具有本发明的生物活性化合物的培养基，具有本发明的生物活性化合物的组合物，包含本发明的生物活性化合物的生物基产物和一种方法 用于生产本发明的生物活性化合物。

    MICROORGANISMS AND METHODS FOR THE PRODUCTION OF CAPROLACTONE
    44.
    发明申请
    MICROORGANISMS AND METHODS FOR THE PRODUCTION OF CAPROLACTONE 审中-公开
    用于生产CAPROLACTONE的微生物和方法

    公开(公告)号：WO2013067432A1

    公开(公告)日：2013-05-10

    申请号：PCT/US2012/063424

    申请日：2012-11-02

    Applicant: GENOMATICA, INC.

    Inventor： BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  PHARKYA, Priti ,  BURK, Mark, J.

    IPC: C12P17/02

    CPC classification number: C12P17/08 ,  C07D313/04 ,  C08G18/4277 ,  C08G63/08 ,  C12N5/0018 ,  C12N15/52 ,  C12N15/63 ,  C12N15/70 ,  C12P17/02

    Abstract: The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce caprolactone. The invention additionally provides methods of using such microbial organisms to produce caprolactone by culturing a non-naturally occurring microbial organism containing caprolactone pathways as described herein under conditions and for a sufficient period of time to produce caprolactone.

    Abstract translation: 本发明提供了含有己内酯途径的非天然存在的微生物，其具有至少一种编码丁二烯途径酶的外源核酸，其以足够的量表达以产生己内酯。 本发明另外提供了使用这种微生物生物体制备己内酯的方法，通过在条件和足够的时间内培养含有本文所述的己内酯途径的非天然存在的微生物生物体以制备己内酯。

    MICROORGANISMS FOR PRODUCING 1,4-BUTANEDIOL AND METHODS RELATED THERETO
    46.
    发明申请
    MICROORGANISMS FOR PRODUCING 1,4-BUTANEDIOL AND METHODS RELATED THERETO 审中-公开
    用于生产1,4-丁二醇的微生物及其相关方法

    公开(公告)号：WO2012177943A1

    公开(公告)日：2012-12-27

    申请号：PCT/US2012/043638

    申请日：2012-06-21

    Applicant: GENOMATICA, INC. ,  BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  SUN, Jun ,  PHARKYA, Priti

    Inventor： BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  SUN, Jun ,  PHARKYA, Priti

    IPC: C12P7/04 ,  C12N1/12

    CPC classification number: C12N15/52 ,  C12N9/0008 ,  C12P7/16 ,  C12P7/18 ,  C12P7/42 ,  C12Y102/99006 ,  Y02E50/10

    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4- hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.

    Abstract translation: 本发明提供了包含1,4-丁二醇（BDO），4-羟基丁酰辅酶A，4-羟基丁醛或腐胺途径的非天然存在的微生物，其包含至少一种编码BDO，4-羟基丁酰辅酶A， - 羟基丁醛或腐胺通路酶以足够的量表达以产生BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺，并进一步优化BDO的表达。 本发明另外提供了使用这些微生物生产BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺的方法。

    METHODS FOR INCREASING PRODUCT YIELDS
    48.
    发明申请
    METHODS FOR INCREASING PRODUCT YIELDS 审中-公开
    增加产品线的方法

    公开(公告)号：WO2012099621A1

    公开(公告)日：2012-07-26

    申请号：PCT/US2011/044223

    申请日：2011-07-15

    Applicant: GENOMATICA, INC. ,  BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  SUN, Jun ,  PHARKYA, Priti

    Inventor： BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  SUN, Jun ,  PHARKYA, Priti

    IPC: C12P7/00

    CPC classification number: C12P7/00 ,  C12N9/0006 ,  C12N9/001 ,  C12N9/0095 ,  C12N9/1029 ,  C12N9/1217 ,  C12N9/88 ,  C12N9/93 ,  C12P7/04 ,  C12P7/18 ,  C12P7/42 ,  C12P19/42

    Abstract: A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing theses non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a building block. Another non-naturally occurring microbial organism includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock. A method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen includes culturing this organism for a sufficient period of time to produce a product.

    Abstract translation: 非天然存在的微生物体包括具有还原性TCA或Wood-Ljungdahl途径的微生物生物体，其中至少一种编码这些途径酶的外源核酸以足够的量表达以增强通过乙酰辅酶A的碳通量。 通过乙酰辅酶A增强碳通量的方法包括在条件和足够的时间段内培养这些非天然存在的微生物，以产生具有乙酰辅酶A作为结构单元的产物。 另一种非天然存在的微生物生物体包括至少一种编码以足够量表达的酶的外源核酸，以增强在一氧化碳或氢气存在下还原当量的可用性，从而通过碳水化合物 - 碳原料。 在一氧化碳或氢气存在下增强还原当量的可用性的方法包括在足够的时间内培养该生物体以产生产物。

    MICROORGANISMS AND METHODS FOR THE PRODUCTION OF 1.4- CYCLOHEXANEDIMETHANOL
    49.
    发明申请
    MICROORGANISMS AND METHODS FOR THE PRODUCTION OF 1.4- CYCLOHEXANEDIMETHANOL 审中-公开
    用于生产1,4-环己烷二甲醇的微生物和方法

    公开(公告)号：WO2012082978A1

    公开(公告)日：2012-06-21

    申请号：PCT/US2011/065048

    申请日：2011-12-15

    Applicant: GENOMATICA, INC. ,  PHARKYA, Priti ,  BURK, Mark, J.

    Inventor： PHARKYA, Priti ,  BURK, Mark, J.

    IPC: C12P7/18

    CPC classification number: C12P7/02 ,  C12N15/52 ,  C12N15/70 ,  C12N15/74 ,  C12N15/75 ,  C12N15/76 ,  C12N15/78 ,  C12N15/81 ,  C12N15/815 ,  C12P7/18

    Abstract: A non-naturally occurring microbial organism includes a microbial organism having a 1,4-cyclohexanedimethanol pathway that includes at least one exogenous nucleic acid encoding a 1,4-cyclohexanedimethanol pathway enzyme expressed in a sufficient amount to produce 1,4- cyclohexanedimethanol. A method for producing 1,4-cyclohexanedimethanol includes culturing a non-naturally occurring microbial organism having a 1,4-cyclohexanedimethanol pathway. The pathway includes at least one exogenous nucleic acid encoding a 1,4- cyclohexanedimethanol pathway enzyme expressed in a sufficient amount to produce 1,4- cyclohexanedimethanol, under conditions and for a sufficient period of time to produce 1,4- cyclohexanedimethanol.

    Abstract translation: 非天然存在的微生物体包括具有1,4-环己烷二甲醇途径的微生物生物体，其包含至少一种编码1,4-环己烷二甲醇途径酶的外源核酸，其以足够的量表达以产生1,4-环己烷二甲醇。 生产1,4-环己烷二甲醇的方法包括培养具有1,4-环己烷二甲醇途径的非天然存在的微生物。 所述途径包括至少一种编码1,4-环己烷二甲醇途径酶的外源核酸，其在足以在足够的时间内产生1,4-环己烷二甲醇以足够量产生1,4-环己烷二甲醇。

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