中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

186 records (took 0.024 seconds)

    MICROORGANISM EXPRESSING EXOGENOUS CROTONASE FOR PRODUCING 1,3-BUTANEDIOL
    41.
    发明专利
    MICROORGANISM EXPRESSING EXOGENOUS CROTONASE FOR PRODUCING 1,3-BUTANEDIOL 未知

    公开(公告)号：CA3042565A1

    公开(公告)日：2010-11-04

    申请号：CA3042565

    申请日：2010-04-30

    Applicant: GENOMATICA INC

    Inventor： BURGARD ANTHONY P ,  BURK MARK J ,  OSTERHOUT ROBIN E ,  PHARKYA PRITI

    IPC: C12N1/21 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88 ,  C12N15/52 ,  C12N15/53 ,  C12N15/54 ,  C12N15/60 ,  C12P7/18

    Abstract: A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxpentanoate aminotransferase, a 2-amino-4-hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2-one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacetyl-CoA reductase (CoA-dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase (aldehyde forming), a 3-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl-CoA dehydratase, and a crotonase. A method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.

    ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL
    42.
    发明专利
    ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL 未知

    公开(公告)号：CA2759994A1

    公开(公告)日：2010-11-04

    申请号：CA2759994

    申请日：2010-04-30

    Applicant: GENOMATICA INC

    Inventor： BURGARD ANTHONY P ,  BURK MARK J ,  OSTERHOUT ROBIN E ,  PHARKYA PRITI

    IPC: C12N1/21 ,  C12N1/20 ,  C12N15/00 ,  C12N15/52 ,  C12P7/18

    Abstract: A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3- BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4- hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2- one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacetyl-CoA reductase (CoA- dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent, alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase (aldehyde forming), a 3-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl- CoA dehydratase, and a crotonase. A method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.

    MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF FUMARATE, MALATE, AND ACRYLATE
    43.
    发明专利
    MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF FUMARATE, MALATE, AND ACRYLATE 未知

    公开(公告)号：CA2725549A1

    公开(公告)日：2009-12-23

    申请号：CA2725549

    申请日：2009-06-17

    Applicant: GENOMATICA INC

    Inventor： BURK MARK J ,  BURGARD ANTHONY P ,  PHARKYA PRITI

    IPC: C12N1/19 ,  C12N1/15 ,  C12N1/21 ,  C12N15/00 ,  C12P7/40 ,  C12P7/46

    Abstract: A non-naturally occurring eukaryotic or prokaryotic organism includes one or more gene disruptions occurring in genes encoding enzymes imparting increased fumarate, malate or acrylate production in the organism when the gene disruption reduces an activity of the enzyme. The one or more gene disruptions confers increased production of acrylate onto the organism. Organisms that produce acrylate have an acrylate pathway that at least one exogenous nucleic acid encoding an acrylate pathway enzyme expressed in a sufficient amount to produce acrylate, the acrylate pathway comprising a decarboxylase. Methods of producing fumarate, malate or acrylate include culturing these organisms.

    MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID
    46.
    发明专利
    MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID 未知

    公开(公告)号：AU2021204276A1

    公开(公告)日：2021-07-22

    申请号：AU2021204276

    申请日：2021-06-24

    Applicant: GENOMATICA INC

    Inventor： BURK MARK J ,  BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  PHARKYA PRITI

    IPC: C12N1/21 ,  C12P7/44 ,  C12P13/04

    Abstract: The invention provides a non-naturally occurring microbial organism having a 6 aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the 5 respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic 0 acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.

    MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID
    48.
    发明专利
    MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID 未知

    公开(公告)号：AU2018204702B2

    公开(公告)日：2021-03-25

    申请号：AU2018204702

    申请日：2018-06-28

    Applicant: GENOMATICA INC

    Inventor： BURK MARK J ,  BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  PHARKYA PRITI

    IPC: C12N1/21 ,  C12P7/44 ,  C12P13/04

    Abstract: The invention provides a non-naturally occurring microbial organism having a 6 aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the 5 respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic 0 acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.

Patent Agency Ranking