公开(公告)号：CA2894687A1

公开(公告)日：2014-06-26

申请号：CA2894687

申请日：2013-12-16

Applicant: GENOMATICA INC

Inventor： BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  VAN DIEN STEPHEN J ,  TRACEWELL CARA ANN ,  PHARKYA PRITI ,  ANDRAE STEFAN

IPC: C12N1/21 ,  A23L27/10 ,  A23L29/269 ,  C12N1/15 ,  C12N1/19 ,  C12N15/52 ,  C12N15/53 ,  C12N15/54 ,  C12N15/55 ,  C12P1/00 ,  C12P7/24 ,  C12P7/44 ,  C12P13/00 ,  C12P17/10

Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as adipate, 6-aminocaproate, hexamethylenediamine or caprolactam. Also provided herein are methods for using such an organism to produce adipate, 6-aminocaproate, hexamethylenediamine or caprolactam.

公开(公告)号：AU2018244459A1

公开(公告)日：2019-10-10

申请号：AU2018244459

申请日：2018-03-29

Applicant: GENOMATICA INC

Inventor： HOFF KEVIN ,  TRACEWELL CARA ANN ,  CHAN KUI ,  SHAH AMIT ,  WARNER JOSEPH ,  NOBLE MICHAEL

IPC: C12N9/02

Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3 -butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.

公开(公告)号：MY175370A

公开(公告)日：2020-06-23

申请号：MYPI2015701936

申请日：2013-12-16

Applicant: GENOMATICA INC

Inventor： BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  VAN DIEN STEPHEN J ,  TRACEWELL CARA ANN ,  PHARKYA PRITI ,  ANDRAE STEFAN

IPC: A23L27/10 ,  A23L29/269

Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as adipate, 6-aminocaproate, hexamethylenediamine or caprolactam. Also provided herein are methods for using such an organism to produce adipate, 6-aminocaproate, hexamethylenediamine or caprolactam.

公开(公告)号：CA3058219A1

公开(公告)日：2018-10-04

申请号：CA3058219

申请日：2018-03-29

Applicant: GENOMATICA INC

Inventor： HOFF KEVIN ,  TRACEWELL CARA ANN ,  CHAN KUI ,  SHAH AMIT ,  WARNER JOSEPH ,  NOBLE MICHAEL

IPC: C12N9/02

Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3 -butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.

公开(公告)号：CA2882896A1

公开(公告)日：2014-03-06

申请号：CA2882896

申请日：2013-08-27

Applicant: GENOMATICA INC

Inventor： BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  VAN DIEN STEPHEN J ,  TRACEWELL CARA ANN ,  PHARKYA PRITI ,  ANDRAE STEFAN

IPC: C12P7/18 ,  C07C31/04 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N15/52 ,  C12N15/53 ,  C12N15/54 ,  C12N15/55 ,  C12N15/60 ,  C12P7/14 ,  C12P7/16

Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.

公开(公告)号：EP2909325A4

公开(公告)日：2016-05-25

申请号：EP13848548

申请日：2013-10-21

Applicant: GENOMATICA INC

Inventor： BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  VAN DIEN STEPHEN J ,  TRACEWELL CARA ANN ,  PHARKYA PRITI ,  ANDRAE STEFAN

IPC: C12P1/04 ,  C12N15/00 ,  C12P7/24 ,  C12P7/46

CPC classification number: C12P7/46 ,  C07C55/10 ,  C07C59/235 ,  C08G63/00 ,  C12N9/0006 ,  C12N9/0028 ,  C12N9/1007 ,  C12N15/70 ,  C12N15/74 ,  C12N15/77 ,  C12N15/81 ,  C12N15/815 ,  C12P7/24 ,  C12Y101/01244 ,  C12Y105/0102

Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as succinate. Also provided herein are methods for using such an organism to produce succinate.

公开(公告)号：EP2888369A4

公开(公告)日：2016-08-10

申请号：EP13832246

申请日：2013-08-27

Applicant: GENOMATICA INC

Inventor： BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  VAN DIEN STEPHEN J ,  TRACEWELL CARA ANN ,  PHARKYA PRITI ,  ANDRAE STEFAN

IPC: C12P7/18 ,  C12N1/21 ,  C12N9/04 ,  C12N9/06 ,  C12N9/10

CPC classification number: C12P7/18 ,  C07D207/12 ,  C08G18/3206 ,  C08G63/06 ,  C08G63/12 ,  C08G63/66 ,  C08G69/26 ,  C12N9/0006 ,  C12N9/0028 ,  C12N9/1007 ,  C12N9/88 ,  C12P7/24 ,  C12P19/02 ,  C12Y101/01224 ,  C12Y101/01244 ,  C12Y101/02007 ,  C12Y105/0102 ,  C12Y201/01 ,  C12Y201/0109 ,  C12Y402/01 ,  Y02P20/52

Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.

公开(公告)号：EP2931874A4

公开(公告)日：2016-09-28

申请号：EP13865674

申请日：2013-12-16

Applicant: GENOMATICA INC

Inventor： BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  VAN DIEN STEPHEN J ,  TRACEWELL CARA ANN ,  PHARKYA PRITI ,  ANDRAE STEFAN

IPC: C12N1/21 ,  A23L27/10 ,  A23L29/269 ,  C08G63/78 ,  C08G69/08 ,  C08G69/16 ,  C08G73/02 ,  C12N9/04 ,  C12N15/52 ,  C12P7/24 ,  C12P7/44 ,  C12P13/00 ,  C12P17/10

CPC classification number: C12P17/10 ,  A23L29/065 ,  C08G63/78 ,  C08G69/08 ,  C08G69/16 ,  C08G73/0213 ,  C12N9/0006 ,  C12N15/52 ,  C12P7/24 ,  C12P7/44 ,  C12P13/001 ,  C12P13/005 ,  C12Y101/01244

Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as adipate, 6-aminocaproate, hexamethylenediamine or caprolactam. Also provided herein are methods for using such an organism to produce adipate, 6-aminocaproate, hexamethylenediamine or caprolactam.