公开(公告)号：ZA75957B

公开(公告)日：1976-01-28

申请号：ZA75957

申请日：1975-02-14

Applicant: HOECHST AG

Inventor： BECK G ,  LERCH U ,  BABEJ M ,  BARTMANN W

IPC: C07C405/00 ,  C07C ,  A61K ,  C07D

公开(公告)号：ZA747430B

公开(公告)日：1975-12-31

申请号：ZA747430

申请日：1974-11-20

Applicant: HOECHST AG

Inventor： BABEJ M ,  LERCH U ,  BARTMANN W ,  BECK G

IPC: C07D319/08 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D307/935 ,  C07D339/06 ,  C07D493/08 ,  C07C ,  C07D ,  A61K

Abstract: The present invention relates to novel not naturally occuring analogues of prostanoic acids of the formula (I) as well as a process for their preparation. The compounds of the invention have valuable pharmacological properties similar to those of the natural prostaglandins and therefore can be used as medicaments.

公开(公告)号：DK288175A

公开(公告)日：1975-12-27

申请号：DK288175

申请日：1975-06-25

Applicant: HOECHST AG

Inventor： BECK G ,  LERCH U ,  TEUFEL H

IPC: C07D409/06 ,  C07C49/395 ,  C07D317/72 ,  C07D319/08 ,  C07D339/06 ,  C07D339/08 ,  C07D493/10 ,  C07D

公开(公告)号：SE7507096L

公开(公告)日：1975-12-22

申请号：SE7507096

申请日：1975-06-19

Applicant: HOECHST AG

Inventor： TEUFEL H ,  BARTMANN W ,  BECK G ,  GRANZER E

IPC: A61K31/15 ,  A61K20060101 ,  C07C20060101 ,  C07C67/00 ,  C07C239/00 ,  C07C251/66 ,  C07C131/00

Abstract: Procedure for the preparation of substituted 0-acyl acrylaldoximes of the formula I **(See formula)** where X represents a chlorine or bromine atom, R represents an alcoholic, alkoxy or alkylamino group, an alkenyl, alkenoxy or alkenylamino group each having 1 to 12 carbon atoms, or an aryl, aryloxy, arylalkyl group, arylalkoxy, arylamino or arylalkoxylaminos possibly substituted with one or two alcohol groups, each with 1 to 6 carbon atoms-, and R1, R2, R3 and R4 are the same or different and mean in each case a hydrogen atom, a halogen atom or an alcoholic or alkoxy group in each case with 1 to 6 carbon atoms, characterized in that the 2,3-diaryl-3-halogen-acryloxy compounds of formula II are acylated **(See formula)** wherein X, R1, R2, R3 and R4 have the meanings given in the description of formula I, in the presence of aprotic solvents with the aid of acylating agents, to form 0-acyl-2,3-diaryl-3- halogen-acryl-oximes of formula I. (Machine-translation by Google Translate, not legally binding)

公开(公告)号：DK281175A

公开(公告)日：1975-12-22

申请号：DK281175

申请日：1975-06-20

Applicant: HOECHST AG

Inventor： TEUFEL H ,  BARTMANN W ,  BECK G ,  GRANZER E

IPC: A61K31/15 ,  A61K20060101 ,  C07C20060101 ,  C07C67/00 ,  C07C239/00 ,  C07C251/66 ,  C07C

Abstract: Procedure for the preparation of substituted 0-acyl acrylaldoximes of the formula I **(See formula)** where X represents a chlorine or bromine atom, R represents an alcoholic, alkoxy or alkylamino group, an alkenyl, alkenoxy or alkenylamino group each having 1 to 12 carbon atoms, or an aryl, aryloxy, arylalkyl group, arylalkoxy, arylamino or arylalkoxylaminos possibly substituted with one or two alcohol groups, each with 1 to 6 carbon atoms-, and R1, R2, R3 and R4 are the same or different and mean in each case a hydrogen atom, a halogen atom or an alcoholic or alkoxy group in each case with 1 to 6 carbon atoms, characterized in that the 2,3-diaryl-3-halogen-acryloxy compounds of formula II are acylated **(See formula)** wherein X, R1, R2, R3 and R4 have the meanings given in the description of formula I, in the presence of aprotic solvents with the aid of acylating agents, to form 0-acyl-2,3-diaryl-3- halogen-acryl-oximes of formula I. (Machine-translation by Google Translate, not legally binding)

公开(公告)号：SE7503812A

公开(公告)日：1975-10-06

申请号：SE7503812

申请日：1975-04-03

Applicant: HOECHST AG

Inventor： BECK G ,  KUNSTMANN R ,  BABEJ M ,  TEUFEL H

IPC: A61K31/557 ,  A61K31/5575 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D307/935 ,  C07D309/12 ,  C07F9/38 ,  C07F9/40 ,  C07C177/00

CPC classification number: C07D307/935 ,  C07C405/00 ,  C07D309/12

公开(公告)号：SE7414634L

公开(公告)日：1975-05-22

申请号：SE7414634

申请日：1974-11-21

Applicant: HOECHST AG

Inventor： BABEJ M ,  BARTMANN W ,  BECK G ,  LERCH U

IPC: C07D319/08 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D307/935 ,  C07D339/06 ,  C07D493/08 ,  C07C61/36

Abstract: The present invention relates to novel not naturally occuring analogues of prostanoic acids of the formula (I) as well as a process for their preparation. The compounds of the invention have valuable pharmacological properties similar to those of the natural prostaglandins and therefore can be used as medicaments.

公开(公告)号：SE445112B

公开(公告)日：1986-06-02

申请号：SE7910057

申请日：1979-12-06

Applicant: HOECHST AG

Inventor： BARTMANN W ,  BECK G ,  REUSCHLING D-B ,  SEEGER K ,  TEUFEL H

IPC: C07D333/16 ,  A61K31/557 ,  A61K31/5575 ,  A61P1/04 ,  A61P7/02 ,  A61P7/10 ,  A61P9/12 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D307/935 ,  C07D333/00 ,  C07D333/32 ,  C07D333/64 ,  C07D333/78 ,  C07D409/12 ,  C07D409/14 ,  C07F9/54

Abstract: The present invention relates to thienyl-prostaglandin derivatives and to a process for their manufacture. The compounds according to the invention have valuable pharmaceutical properties.

公开(公告)号：NZ196316A

公开(公告)日：1984-08-24

申请号：NZ19631681

申请日：1981-02-20

Applicant: HOECHST AG

Inventor： BECK G ,  KNOLLE J ,  RUPP R H ,  SCHOLKENS B

IPC: A61K31/40 ,  A61K31/403 ,  A61P43/00 ,  C07D209/52 ,  C07D307/93 ,  C07D307/935 ,  C07D309/12 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D209 ,  A61K31/557

公开(公告)号：SE430158B

公开(公告)日：1983-10-24

申请号：SE7606318

申请日：1976-06-03

Applicant: HOECHST AG

Inventor： BARTMANN W ,  BECK G ,  REUSCHLING D-B ,  SEEGER K ,  TEUFEL H

IPC: C07D333/16 ,  A61K31/557 ,  A61K31/5575 ,  A61P1/04 ,  A61P7/02 ,  A61P7/10 ,  A61P9/12 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D307/935 ,  C07D333/00 ,  C07D333/32 ,  C07D333/64 ,  C07D333/78 ,  C07D409/12 ,  C07D409/14 ,  C07F9/54 ,  C07C177/00

Abstract: The present invention relates to thienyl-prostaglandin derivatives and to a process for their manufacture. The compounds according to the invention have valuable pharmaceutical properties.