公开(公告)号：ZA89432B

公开(公告)日：1989-09-27

申请号：ZA89432

申请日：1989-01-19

Applicant: HOECHST AG

Inventor： RUEGER WOLFGANG ,  WOLFGANG RUEGER ,  URBACH HANSJOERG ,  HANSJOERG URBACH ,  BECKER REINHARD ,  REINHARD BECKER ,  HOCK FRANZ ,  FRANZ HOCK

IPC: A61K38/55 ,  A61K38/00 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81 ,  C07K ,  A61K

Abstract: The invention relates to amino acid esters of the formula (I) in which n=1 or 2, R, R1, R2 and R3 denote hydrogen or a defined radical, R4 together with R5 and the atoms carrying them form a heterocyclic ring system, processes for their preparation, agents containing them and their use.

公开(公告)号：DD272035A5

公开(公告)日：1989-09-27

申请号：DD30742787

申请日：1987-09-30

Applicant: HOECHST AG

Inventor： BECKER REINHARD ,  HENNING RAINER ,  RUEGER WOLFGANG ,  TEETZ VOLKER ,  URBACH HANSJOERG

IPC: A61K31/40 ,  A61K31/401 ,  A61K31/435 ,  A61K31/44 ,  A61K38/05 ,  A61K38/55 ,  A61K45/06 ,  A61P3/00 ,  A61P3/14 ,  A61P9/12 ,  A61P43/00 ,  A61K37/64

Abstract: The combinations are produced as described and used as medicines.

公开(公告)号：FI78684B

公开(公告)日：1989-05-31

申请号：FI834593

申请日：1983-12-14

Applicant: HOECHST AG

Inventor： URBACH HANSJOERG ,  HENNING RAINER ,  TEETZ VOLKER ,  BECKER REINHARD

IPC: A61K31/40 ,  A61K31/403 ,  A61K38/00 ,  A61P9/12 ,  A61P43/00 ,  C07D209/52 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81

Abstract: The invention relates to derivatives of cis,endo-2-azabicyclo[5.3.0]decane-3-carboxylic acid of the formula I (I) in which R denotes hydrogen, alkyl, alkenyl or aralkyl, R1 denotes hydrogen, allyl, vinyl or a side chain of an optionally protected naturally occurring alpha -aminoacid, R2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen, or Y and Z together denote oxygen, X denotes alkyl, alkenyl, cycloalkyl, aryl which can be substituted once, twice or three times by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or denotes indol-3-yl, and their physiologically acceptable salts, a process for their preparation, agents containing them and their use.

公开(公告)号：NO892125D0

公开(公告)日：1989-05-26

申请号：NO892125

申请日：1989-05-26

Applicant: HOECHST AG

Inventor： BECKER REINHARD ,  HENNING RAINER ,  URBACH HANSJOERG ,  TETZ VOLKER ,  ENGLERT HEINRICH CHRISTIAN ,  MANIA DIETER

IPC: A61K31/40 ,  A61K38/55 ,  A61K45/06 ,  A61P25/02 ,  A61K37/00

Abstract: The invention relates to combinations of angiotensin converting enzyme inhibitors with potassium channel modulators, process for the preparation thereof and their use as medicines.

公开(公告)号：ZA8806840B

公开(公告)日：1989-04-26

申请号：ZA8806840

申请日：1988-09-14

Applicant: HOECHST AG

Inventor： RUEGER WOLFGANG ,  WOLFGANG RUEGER ,  URBACH HANSJOERG ,  HANSJOERG URBACH ,  BECKER REINHARD ,  REINHARD BECKER ,  HOCK FRANZ ,  FRANZ HOCK

IPC: C07D317/34 ,  A61K38/00 ,  A61K38/55 ,  A61P25/28 ,  A61P29/00 ,  C07D317/36 ,  C07D317/40 ,  C07D405/12 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81 ,  C07K ,  A61K

CPC classification number: C07K5/0222 ,  A61K38/00

公开(公告)号：AU1167288A

公开(公告)日：1988-08-18

申请号：AU1167288

申请日：1988-02-12

Applicant: HOECHST AG

Inventor： URBACH HANSJORG ,  HENNING RAINER ,  SCHOLKENS BERNWARD ,  BECKER REINHARD

IPC: C07D223/32 ,  A61K31/395 ,  A61K31/445 ,  A61K31/55 ,  A61K38/00 ,  A61P9/00 ,  A61P9/12 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  C07D225/04 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07K5/02 ,  C07K5/06

Abstract: Cyclopenta-azocine and -azepine derivs. of formula (I) and their salts are new. In (I) m = 1 or 2; n = 0-2; R1 and R2 = H; 1-6C alkyl (opt. substd. once by OH, SH, 1-2C alkoxy, 1-2C alkylthio, COOH, 1-2C alkoxycarbonyl, 3-indolyl, imidazolyl, CONH2, amino or guanidino); 2-6C alkenyl; 3-9C cycloalkyl or cycloalkenyl; 3-7C cycloalkyl (1-4C) alkyl; 6-12C aryl (opt. partially hydrogenated) or 6-12C aryl (1-4C) alkyl (opt. OH substd. in aryl); R3 and R4 = H, 1-6C alkyl, 2-6C alkenyl or 6-12C aryl (1-4C) alkyl, opt. substd. in aryl by one MeO or NO2; Y = H or OH; Z = H; or Y and Z are together oxo; X = 1-6C alkyl (opt. substd. by NH2, acylamino, 1-6C alkylamino and/or di(1-4C)alkylamino); 2-6C alkenyl; 5-9C cycloalkyl, 1-R1-piperidin-4-yl, 6-12C aryl (opt. substd. by 1-3 of 1-4C alkyl or alkoxy, OH, halo, NO2, NH2 (itself opt. substd. by 1 or 2 1-4C alkyl) and/or methylenedioxy) or 3-indolyl; any free OH, SH, COOH, amino or guanidino can be protected conventionally.

公开(公告)号：FI883456A

公开(公告)日：1988-07-21

申请号：FI883456

申请日：1988-07-21

Applicant: HOECHST AG

Inventor： URBACH HANSJOERG ,  HENNING RAINER ,  TEETZ VOLKER ,  GEIGER ROLF ,  BECKER REINHARD ,  GAUL HOLGER

IPC: C07D20060101 ,  C07D209/42 ,  C07D209/52 ,  C07D

Abstract: The invention relates to azabicycloalkane carboxylic acid derivatives of the formula III" wherein n is an integer number of 0-10, W' is hydrogen, alkyl with 1-18 C atoms, or aralkyl with 7-10 C atoms, and R3, R4 and R5 are hydrogen or R3 and R4 taken together or R4 and R5 taken together are a chemical bond, not taking into account such compounds of the formula III", wherein a) R3, R4 and R5 are hydrogen, n=0, W' is hydrogen, (C1-C6) alkyl or (C7 or C8) aralkyl, nitrobenzyl included, R4 and R5 are in the cis configuration relative to one another and COOW' is directed towards the same side as the cyclopentane ring, or b) R3, R4 and R5 are as described above in point a), n=1, W' is hydrogen or (C1-C4) alkyl and COOW' is directed towards the same side as the cyclohexane ring, or c) R3 is hydrogen and R4 and R5 taken together are a chemical bond, n=0 and W' is hydrogen, and a process for the preparation of these compounds. Compounds of the formula III" can be used as intermediates in the preparation of therapeutically active N-substituted azabicycloalkane carboxylic acid derivatives.

公开(公告)号：ZA877303B

公开(公告)日：1988-05-25

申请号：ZA877303

申请日：1987-09-29

Applicant: HOECHST AG

Inventor： BECKER REINHARD ,  REINHARD BECKER ,  GEIGER ROLF ,  ROLF GEIGER ,  HENNING RAINER ,  RAINER HENNING ,  TEETZ VOLKER ,  VOLKER TEETZ ,  URBACH HANSJOERG ,  HANSJOERG URBACH

IPC: A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61K

Abstract: The pharmaceutical preparation consists of an angiotensin converting enzyme inhibitor and of a diuretic of the thiazide type.

公开(公告)号：AU7907987A

公开(公告)日：1988-04-14

申请号：AU7907987

申请日：1987-09-29

Applicant: HOECHST AG

Inventor： BECKER REINHARD ,  GEIGER ROLF ,  HENNING RAINER ,  TEETZ VOLKER ,  URBACH HANSJORG

IPC: A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61K31/54 ,  A61K31/44 ,  A61K31/47 ,  A61K31/40

Abstract: The pharmaceutical preparation consists of an angiotensin converting enzyme inhibitor and of a diuretic of the thiazide type.

公开(公告)号：NO157138C

公开(公告)日：1988-01-27

申请号：NO831594

申请日：1983-05-05

Applicant: HOECHST AG

Inventor： TEETZ VOLKER ,  GEIGER ROLF ,  URBACH HANSJORG ,  BECKER REINHARD ,  SCHOLKENS BERWARD

IPC: C07D20060101 ,  C07D209/52