公开(公告)号：FI93697C

公开(公告)日：1995-05-26

申请号：FI892690

申请日：1989-06-01

Applicant: HOECHST AG

Inventor： BONIN WERNER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  WOEHNER ELISABET

IPC: A61K38/55 ,  A61K35/56 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K14/81 ,  A61K35/64 ,  A61K38/57

公开(公告)号：HU210528A9

公开(公告)日：1995-04-28

申请号：HU9400042

申请日：1994-11-09

Applicant: HOECHST AG

Inventor： WOEHNER ELISABET ,  BONIN WERNER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE

IPC: A61K38/55 ,  A61K35/56 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K14/81 ,  C07K15/00 ,  A61K37/64

Abstract: The invention relates to a new active substance-amblyommin-for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-, Lys-Ile-Leu-Phe-X-Gln-Gly- and Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid.

公开(公告)号：NO175900B

公开(公告)日：1994-09-19

申请号：NO892266

申请日：1989-06-02

Applicant: HOECHST AG

Inventor： BONIN WERNER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  WOEHNER ELISABET

IPC: A61K38/55 ,  A61K35/56 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K14/81 ,  C07K3/02 ,  C07K3/28 ,  C07K13/00 ,  A61K35/78 ,  A61K37/64

Abstract: The invention relates to a new active substance-amblyommin-for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-, Lys-Ile-Leu-Phe-X-Gln-Gly- and Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid.

公开(公告)号：ZA931774B

公开(公告)日：1993-09-30

申请号：ZA931774

申请日：1993-03-12

Applicant: HOECHST AG

Inventor： SCHAPER WOLFGANG ,  PREUSS RAINER ,  BRAUN PETER ,  SALBECK GERHARD ,  KNAUF WERNER ,  SACHSE BURKHARD ,  WALTERSDORFER ANNA ,  LUEMMEN PETER ,  BONIN WERNER ,  KERN MANFRED

IPC: A01N43/54 ,  A01N43/90 ,  A01P3/00 ,  A01P7/02 ,  A01P7/04 ,  C07D239/34 ,  C07D239/42 ,  C07D239/46 ,  C07D239/52 ,  C07D239/60 ,  C07D239/88 ,  C07D239/94 ,  C07D401/12 ,  C07D405/12 ,  C07D491/048 ,  C07D495/04 ,  C07D ,  A61K ,  A01N

Abstract: The invention relates to compounds of the formula defined in the description, X is NH or oxygen and E is a bond or a 1- to 4-membered carbon chain, to a process for their preparation, to agents containing them, and to their use in the control of pests and as fungicides.

公开(公告)号：NZ232345A

公开(公告)日：1992-07-28

申请号：NZ23234590

申请日：1990-02-02

Applicant: HOECHST AG

Inventor： KRATT GUNTER ,  SALBECK GERHARD ,  BONIN WERNER ,  DUWEL DIETER

IPC: C07D239/557 ,  A01N43/54 ,  A01N57/36 ,  C07C217/84 ,  C07C265/12 ,  C07C323/36 ,  C07D239/54 ,  C07D239/545 ,  C07D239/553 ,  C07D239/60 ,  C07D239/62 ,  C07D319/12 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07F9/6584 ,  C07D239/28 ,  A61K31/505 ,  A61K31/675 ,  C07D213/73 ,  C07F9/6512

公开(公告)号：HU205148B

公开(公告)日：1992-03-30

申请号：HU282089

申请日：1989-06-02

Applicant: HOECHST AG

Inventor： BONIN WERNER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  WOEHNER ELISABET

IPC: A61K38/55 ,  A61K35/56 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K14/81 ,  C07K15/08 ,  A61K37/02

Abstract: The invention relates to a new active substance-amblyommin-for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-, Lys-Ile-Leu-Phe-X-Gln-Gly- and Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid.

公开(公告)号：NZ227171A

公开(公告)日：1991-06-25

申请号：NZ22717188

申请日：1988-12-02

Applicant: HOECHST AG

Inventor： KOCH VOLKER ,  SCHNATTERER STEFAN ,  BONIN WERNER ,  KERN MANFRED ,  KNAUF WERNER ,  WALTERSDORFER ANNA

IPC: A01N43/88 ,  A01N47/30 ,  A01N47/34 ,  A01P7/02 ,  A01P7/04 ,  C07C317/24 ,  C07C317/42 ,  C07C323/22 ,  C07C323/27 ,  C07C323/44 ,  C07C335/26 ,  C07D273/04 ,  C07C149/437 ,  A01N41/02 ,  C07C143/38 ,  C07C147/06 ,  C07D273/02

公开(公告)号：ZA9000830B

公开(公告)日：1991-02-27

申请号：ZA9000830

申请日：1990-02-05

Applicant: HOECHST AG

Inventor： KRATT GUENTER ,  GUENTER KRATT ,  SALBECK GERHARD ,  GERHARD SALBECK ,  BONIN WERNER ,  WERNER BONIN ,  DUEWEL DIETER ,  DIETER DUEWEL

IPC: C07D239/557 ,  A01N43/54 ,  A01N57/36 ,  C07C217/84 ,  C07C265/12 ,  C07C323/36 ,  C07D239/54 ,  C07D239/545 ,  C07D239/553 ,  C07D239/60 ,  C07D239/62 ,  C07D319/12 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07F9/6584 ,  C07D ,  A01N ,  A61K ,  C07C

CPC classification number: C07D239/545 ,  A01N43/54 ,  C07C217/84 ,  C07C265/12 ,  C07C323/36 ,  C07D239/62 ,  C07D401/12

公开(公告)号：ZA8909722B

公开(公告)日：1990-09-26

申请号：ZA8909722

申请日：1989-12-19

Applicant: HOECHST AG

Inventor： STARK HERBERT ,  HERBERT STARK ,  SALBECK GERHARD ,  GERHARD SALBECK ,  BONIN WERNER ,  WERNER BONIN

IPC: A61K31/415 ,  A61P33/00 ,  C07D233/20 ,  C07D233/22 ,  C07D233/24 ,  C07D ,  A01N

CPC classification number: C07D233/20 ,  C07D233/22 ,  C07D233/24

公开(公告)号：HUT52117A

公开(公告)日：1990-06-28

申请号：HU282089

申请日：1989-06-02

Applicant: HOECHST AG

Inventor： BONIN WERNER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  WOEHNER ELISABET

IPC: A61K38/55 ,  A61K35/56 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K14/81 ,  C07K15/08 ,  A61K37/02

Abstract: The invention relates to a new active substance-amblyommin-for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-, Lys-Ile-Leu-Phe-X-Gln-Gly- and Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid.