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公开(公告)号：CZ416291A3
公开(公告)日：1993-09-15
申请号：CS416291
申请日：1991-12-30
Applicant: HOECHST AG
Inventor： TEETZ VOLKER DR , GEIGER ROLF PROF DR , URBACH HANSJORG DR , BECKER REINHARD DR , SCHOLKENS BERNWARD DR
IPC: C07C227/08 , A61K31/40 , A61K31/403 , A61K38/00 , A61P9/12 , C07C227/10 , C07C227/16 , C07C229/28 , C07C229/36 , C07C237/06 , C07D209/52 , C07D451/04 , C07K5/02 , C07K5/06
Abstract: Compounds of the formula I (I) in which the carboxyl group on carbon atom 3 is orientated in the endo-position relative to the bicyclic ring system of cis-configuration, and in which R1 denotes hydrogen, allyl, vinyl or a side-chain of a naturally occurring alpha -aminoacid, which may be protected, R2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl and Z denotes hydrogen, or Y and Z together denote oxygen, and X denotes alkyl, alkenyl or cycloalkyl, or aryl which is optionally mono-, di- or tri-substituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or denotes indol-3-yl, a process for their preparation, agents containing these compounds and their use.
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公开(公告)号：DE3586979D1
公开(公告)日：1993-02-25
申请号：DE3586979
申请日：1985-10-04
Applicant: HOECHST AG
Inventor： GEIGER ROLF PROF DR , GERHARDS HERMANN DR , KRUSE HANSJOERG DR
IPC: C07K5/04 , A61K38/00 , A61K38/22 , A61P25/00 , C07K5/00 , C07K5/068 , C07K7/00 , C07K7/06 , C07K14/685 , C07K14/695 , A61K37/02
Abstract: The invention relates to peptides of the formula I R4-A5-A6-A7(I) in which R4 denotes an acyl group, R5 denotes D-Lys or Lys, A6 denotes the radical of phenylalanine, N-methylphenylalanine, 4-alkoxyphenylalanine or 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, and R7 denotes a basic radical, processes for their preparation and their use.
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公开(公告)号：AT84795T
公开(公告)日：1993-02-15
申请号：AT87108184
申请日：1987-06-05
Applicant: HOECHST AG
Inventor： KOENIG WOLFGANG DR , BREIPOHL GERHARD DR , GEIGER ROLF PROF DR , KNOLLE JOCHEN DR , HROPOT MAX DR
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公开(公告)号：AT84544T
公开(公告)日：1993-01-15
申请号：AT85112579
申请日：1985-10-04
Applicant: HOECHST AG
Inventor： GEIGER ROLF PROF DR , GERHARDS HERMANN DR , KRUSE HANSJOERG DR
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公开(公告)号：DE3685177D1
公开(公告)日：1992-06-11
申请号：DE3685177
申请日：1986-08-29
Applicant: HOECHST AG
Inventor： BECKER REINHARD DR , GEIGER ROLF PROF DR , HENNING RAINER DR , TEETZ VOLKER DR , URBACH HANSJOERG DR
Abstract: The preparation contains an angiotensin converting enzyme inhibitor and a loop diuretic.
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Patent Agency Ranking
公开(公告)号：AT75610T
公开(公告)日：1992-05-15
申请号：AT86111973
申请日：1986-08-29
Applicant: HOECHST AG
Inventor： BECKER REINHARD DR , GEIGER ROLF PROF DR , HENNING RAINER DR , TEETZ VOLKER DR , URBACH HANSJOERG DR
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公开(公告)号：CS9104095A3
公开(公告)日：1992-04-15
申请号：CS409591
申请日：1991-12-27
Applicant: HOECHST AG
Inventor： URBACH HANSJORG DR , HENNING RAINER DR , TEETZ VOLKER DR , GEIGER ROLF PROF DR , BECKER REINHARD DR , GAUL HOLGER
IPC: A61K38/55 , A61K31/40 , A61K31/403 , A61K31/404 , A61K38/00 , A61P7/10 , A61P9/08 , A61P9/12 , C07D209/02 , C07D209/08 , C07D209/32 , C07D209/34 , C07D209/42 , C07D209/52 , C07D215/22 , C07D215/227 , C07K1/02 , C07K1/113 , C07K5/02 , C07K5/06
CPC classification number: C07D215/227 , A61K38/00 , C07D209/08 , C07D209/34 , C07D209/42 , C07D209/52 , C07K5/0222
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公开(公告)号：DE3482265D1
公开(公告)日：1990-06-21
申请号：DE3482265
申请日：1984-09-17
Applicant: HOECHST AG
Inventor： GRAU ULRICH DR , GEIGER ROLF PROF DR , OBERMEIER RAINER DR
Abstract: 1. Claims for the Contracting States : BE CH DE FR GB IT LI LU NL SE A medicament having a delayed action for the treatment of diabetes mellitus, comprising at least one insulin derivative of the formula I see diagramm : EP0137361,P16,F1 in which R**1 denotes H or H-Phe R**30 represents the radical of a neutral, genetically codable L-aminoacid whose OH group, where present, can be free or protected by a physiologically acceptable group, and R**31 denotes a physiologically acceptable neutral group blocking the carboxyl group, with the exception of des-B30 human insulin Leu**B30 -NH2 and des-B30 human insulin Gly**B30 -NH2 and des-B30 human insulin Phe**B30 -NH2 and a pharmaceutically acceptable carrier. 1. Claims for the Contracting State : AT A process for the preparation of a medicament having a delayed action for the treatment of diabetes mellitus, which comprises bringing into a suitable dosage form at least one insulin derivative of the formula I see diagramm : EP0137361,P17,F1 in which R**1 denotes H or H-Phe R**30 represents the radical of a neutral, genetically codable L-aminoacid whose OH group, where present, can be free or protected by a physiologically acceptable group, and R**31 denotes a physiologically acceptable neutral group blocking the carboxyl group, with the exception of des-B30 human insulin Leu**B30 -NH2 and des-B30 human insulin Gly**B30 -NH, and des-B30 human insulin Phe**B30 -NH2 Phe**B30 -NH2 and a pharmaceutically acceptable carrier.
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公开(公告)号：AT53590T
公开(公告)日：1990-06-15
申请号：AT84110813
申请日：1984-09-11
Applicant: HOECHST AG
Inventor： OBERMEIER RAINER DR , GEIGER ROLF PROF DR , GRAU ULRICH DR
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公开(公告)号：DE3468031D1
公开(公告)日：1988-01-21
申请号：DE3468031
申请日：1984-01-31
Applicant: HOECHST AG
Inventor： FRIEDRICH AXEL DR , KONIG WOLFGANG DR , TEETZ VOLKER DR , GEIGER ROLF PROF DR , SANDOW JURGEN KURT DR
IPC: C07K7/64 , A61K38/00 , A61K38/04 , A61P5/00 , A61P5/02 , C07C231/00 , C07K1/113 , C07K7/06 , C07K14/575 , C07K14/655 , A61K37/02
Abstract: The invention relates to cyclic hexapeptides of the general formula III in which X represents the radical of an L-aminoacid of the general formula IIIa (IIIa) in which A and B are identical or different and denote alkyl having 1 to 3 carbon atoms, or A and B together represent a saturated, unsaturated or aromatic monocyclic or bicyclic structure having 3 to 6 carbon atoms, n denotes 0 or 1, and Y represents an aliphatic or aromatic L-aminoacid the side chain of which can be hydroxylated, and their salts with physiologically tolerated acids, and to a process for their preparation and their use and their intermediates.
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