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    41.
    发明专利
    未知

    公开(公告)号：PT84702B

    公开(公告)日：1989-11-30

    申请号：PT8470287

    申请日：1987-04-16

    Applicant: HOECHST AG

    Inventor： RAETHER WOLFGANG ,  LOHAUS GERHARD ,  DITTMAR WALTER ,  HANEL HEINZ ,  REUSCHLING DIETER ,  GROBEL BENGT-THOMAS

    IPC: A61K31/44 ,  C07D213/89 ,  C07D309/38

    Abstract: New 1-hydroxy-2-pyridones of the general formula I I in which R1, R2 and R3, which are identical or different, denote hydrogen or lower alkyl having 1-4 carbon atoms, R1 and R3 preferably being hydrogen, and R2 preferably being methyl, X denotes S or, preferably, O, Y denotes hydrogen or up to 2 halogen atoms, namely chlorine and/or bromine, Z denotes a single bond or the bivalent radicals O, S, -CR2- (R=H or C1-C4-alkyl) or other 2-valent radicals with 2-10 carbon and, optionally, oxygen and/or sulfur atoms linked to form a chain, it being obligatory when the radicals contain 2 or more oxygen and/or sulfur atoms for the latter to be separated by at least 2 carbon atoms, and it being possible for 2 adjacent carbon atoms also to be linked together by a double bond, and the free valencies of the carbon atoms being saturated by H and/or C1-C4-alkyl groups, Ar denotes an aromatic ring system which has up to two rings and can be substituted by up to three radicals from the group comprising fluorine, chlorine, bromine, methoxy, C1-C4-alkyl, trifluoromethyl and trifluoromethoxy, are prepared by a variety of process variants. The compounds and their physiologically tolerated salts with inorganic or organic bases mainly have antimycotic, anti-bacterial and antiviral activity. The compounds of the formula V V in which R1, R2, R3, X, Y, Z and Ar have the same meaning as in formula I, which occur in the preparation of the compounds of the formula I, are also new.

    PROCESS FOR PRODUCING 1-HYDROXY-2-PYRIDON DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    42.
    发明专利
    PROCESS FOR PRODUCING 1-HYDROXY-2-PYRIDON DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 未知

    公开(公告)号：HU198020B

    公开(公告)日：1989-07-28

    申请号：HU168387

    申请日：1987-04-16

    Applicant: HOECHST AG

    Inventor： LOHAUS GERHARD ,  HAENEL HEINZ ,  REUSCHLING DIETER ,  DITTMAR WALTER ,  RAETHER WOLFGANG ,  GROEBEL BENGT-THOMAS

    IPC: A61K31/44 ,  C07D213/89 ,  C07D309/38

    Abstract: New 1-hydroxy-2-pyridones of the general formula I I in which R1, R2 and R3, which are identical or different, denote hydrogen or lower alkyl having 1-4 carbon atoms, R1 and R3 preferably being hydrogen, and R2 preferably being methyl, X denotes S or, preferably, O, Y denotes hydrogen or up to 2 halogen atoms, namely chlorine and/or bromine, Z denotes a single bond or the bivalent radicals O, S, -CR2- (R=H or C1-C4-alkyl) or other 2-valent radicals with 2-10 carbon and, optionally, oxygen and/or sulfur atoms linked to form a chain, it being obligatory when the radicals contain 2 or more oxygen and/or sulfur atoms for the latter to be separated by at least 2 carbon atoms, and it being possible for 2 adjacent carbon atoms also to be linked together by a double bond, and the free valencies of the carbon atoms being saturated by H and/or C1-C4-alkyl groups, Ar denotes an aromatic ring system which has up to two rings and can be substituted by up to three radicals from the group comprising fluorine, chlorine, bromine, methoxy, C1-C4-alkyl, trifluoromethyl and trifluoromethoxy, are prepared by a variety of process variants. The compounds and their physiologically tolerated salts with inorganic or organic bases mainly have antimycotic, anti-bacterial and antiviral activity. The compounds of the formula V V in which R1, R2, R3, X, Y, Z and Ar have the same meaning as in formula I, which occur in the preparation of the compounds of the formula I, are also new.

    44.
    发明专利
    未知

    公开(公告)号：FI871699A

    公开(公告)日：1987-10-19

    申请号：FI871699

    申请日：1987-04-16

    Applicant: HOECHST AG

    Inventor： LOHAUS GERHARD ,  DITTMAR WALTER ,  HAENEL HEINZ ,  RAETHER WOLFGANG ,  REUSCHLING DIETER ,  GROEBEL BENGT-THOMAS

    IPC: A61K31/44 ,  C07D213/89 ,  C07D309/38 ,  C07D

    Abstract: New 1-hydroxy-2-pyridones of the general formula I I in which R1, R2 and R3, which are identical or different, denote hydrogen or lower alkyl having 1-4 carbon atoms, R1 and R3 preferably being hydrogen, and R2 preferably being methyl, X denotes S or, preferably, O, Y denotes hydrogen or up to 2 halogen atoms, namely chlorine and/or bromine, Z denotes a single bond or the bivalent radicals O, S, -CR2- (R=H or C1-C4-alkyl) or other 2-valent radicals with 2-10 carbon and, optionally, oxygen and/or sulfur atoms linked to form a chain, it being obligatory when the radicals contain 2 or more oxygen and/or sulfur atoms for the latter to be separated by at least 2 carbon atoms, and it being possible for 2 adjacent carbon atoms also to be linked together by a double bond, and the free valencies of the carbon atoms being saturated by H and/or C1-C4-alkyl groups, Ar denotes an aromatic ring system which has up to two rings and can be substituted by up to three radicals from the group comprising fluorine, chlorine, bromine, methoxy, C1-C4-alkyl, trifluoromethyl and trifluoromethoxy, are prepared by a variety of process variants. The compounds and their physiologically tolerated salts with inorganic or organic bases mainly have antimycotic, anti-bacterial and antiviral activity. The compounds of the formula V V in which R1, R2, R3, X, Y, Z and Ar have the same meaning as in formula I, which occur in the preparation of the compounds of the formula I, are also new.

    46.
    发明专利
    未知

    公开(公告)号：NO139861C

    公开(公告)日：1979-05-23

    申请号：NO120573

    申请日：1973-03-23

    Applicant: HOECHST AG

    Inventor： LOHAUS GERHARD ,  DITTMAR WALTER

    IPC: C07D221/04 ,  A61K31/4412 ,  A61P31/04 ,  C07D213/64 ,  C07D213/89 ,  C07D221/10 ,  C07D221/20 ,  C07D405/04 ,  C07D405/06

    Abstract: 1416397 Process for 1-hydroxy-2-pyridones HOECHST AG 21 March 1973 [25 March 1972] 13587/73 Heading C2C The invention comprises making compounds in which R 1 represents an alkyl radical of 1 to 17 carbon atoms which may be branched; an alkenyl radical of 2 to 17 carbon atoms; a cycloalkyl radical of 3 to 8 carbon atoms; a cyclohexylalkyl radical; a phenyl, phenylalkyl, phenylalkenyl, benzhydryl, phenoxymethyl; phenylmercaptomethyl or phenyl-sulphonylmethyl radical which may be substituted in the aromatic nucleus by one or more alkyl, alkoxy, amino, nitro, alkoxycarbonyl or cyano groups or halogen atoms; or a furyl or furylalkenyl radical; R 2 represents a hydrogen atom or an alkyl, alkenyl or alkynyl radical or a benzyl group or R 2 together with R 1 or R 3 forms a 5- or 6- membered carbocyclic ring; R 3 represents a hydrogen atom, an alkyl radical or a phenyl group and R 4 represents a hydrogen atom, an alkyl or alkenyl radical, a methoxymethyl or benzyl radical, or a chlorine or bromine atom, by reacting a 2-pyrone of the general Formula (II) with NH 2 OH or its salt in the presence of an optionally substituted aminopyridine or imidazole. Pharmaceutical preparations showing antibacterial and antimycotic actions contain (I) as active ingredient.

    47.
    发明专利
    未知

    公开(公告)号：RO62622A

    公开(公告)日：1978-05-15

    申请号：RO7428073

    申请日：1973-03-23

    Applicant: HOECHST AG

    Inventor： LOHAUS GERHARD ,  DITTMAR WALTER

    IPC: C07D221/04 ,  A61K31/4412 ,  A61P31/04 ,  C07D213/64 ,  C07D213/89 ,  C07D221/10 ,  C07D221/20 ,  C07D405/04 ,  C07D405/06

    Abstract: 1416397 Process for 1-hydroxy-2-pyridones HOECHST AG 21 March 1973 [25 March 1972] 13587/73 Heading C2C The invention comprises making compounds in which R 1 represents an alkyl radical of 1 to 17 carbon atoms which may be branched; an alkenyl radical of 2 to 17 carbon atoms; a cycloalkyl radical of 3 to 8 carbon atoms; a cyclohexylalkyl radical; a phenyl, phenylalkyl, phenylalkenyl, benzhydryl, phenoxymethyl; phenylmercaptomethyl or phenyl-sulphonylmethyl radical which may be substituted in the aromatic nucleus by one or more alkyl, alkoxy, amino, nitro, alkoxycarbonyl or cyano groups or halogen atoms; or a furyl or furylalkenyl radical; R 2 represents a hydrogen atom or an alkyl, alkenyl or alkynyl radical or a benzyl group or R 2 together with R 1 or R 3 forms a 5- or 6- membered carbocyclic ring; R 3 represents a hydrogen atom, an alkyl radical or a phenyl group and R 4 represents a hydrogen atom, an alkyl or alkenyl radical, a methoxymethyl or benzyl radical, or a chlorine or bromine atom, by reacting a 2-pyrone of the general Formula (II) with NH 2 OH or its salt in the presence of an optionally substituted aminopyridine or imidazole. Pharmaceutical preparations showing antibacterial and antimycotic actions contain (I) as active ingredient.

    COSMETIC COMPOSITION COMPRISING A 1-HYDROXY-2-PYRIDONE
    48.
    发明专利
    COSMETIC COMPOSITION COMPRISING A 1-HYDROXY-2-PYRIDONE 未知

    公开(公告)号：CA1013675A

    公开(公告)日：1977-07-12

    申请号：CA176021

    申请日：1973-07-09

    Applicant: HOECHST AG

    Inventor： DITTMAR WALTER ,  FUTTERER EBERHARD ,  LOHAUS GERHARD

    IPC: A61K8/00 ,  A61K20060101 ,  A61K8/33 ,  A61K8/37 ,  A61K8/49 ,  A61K8/92 ,  A61K31/12 ,  A61K31/44 ,  A61P17/08 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q7/00 ,  C07D20060101 ,  C07D207/26 ,  C07D213/89 ,  C11D3/28 ,  C11D3/48

    Abstract: A cosmetic composition comprising a content of an 1-hydroxy-2-pyridone of the general formula in which R1 stands for hydrogen, alkyl of 1 to 17 carbon atoms, alkenyl of 2 to 17 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, bicycloalkyl of 7 to 9 carbon atoms, cycloalkyl-alkyl of 1 to 4 alkyl carbon atoms, the cycloalkyl groups being optionally substituted by alkyl groups of 1 to 4 carbon atoms, aryl, aralkyl of 1 to 4 alkyl carbon atoms, aryl-alkenyl of 2 to 4 alkenyl carbon atoms, aryloxy-alkyl or arylthio-alkyl of 1 to 4 alkyl carbon atoms, benzhydryl, phenylsulfonyl-alkyl of 1 to 4 alkyl carbon atoms, furyl or furyl-alkenyl of 2 to 4 alkenyl carbon atoms, the aryl groups being optionally substituted by alkyl of 1 to 4 carbon atoms, by alkoxy of 1 to 4 carbon atoms, by nitro, cyano or halogen atoms, R2 stands for hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl or alkinyl of 2 to 4 carbon atoms, halogen atoms or benzyl, R3 stands for hydrogen, alkyl of 1 to 4 carbon atoms or phenyl, and R4 stands for hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms, methoxy-methyl, halogen or benzyl, and/or salt thereof, which may be used as an anti-dandruff agent.

    1-HYDROXY-2-PYRIDONES
    50.
    发明专利
    1-HYDROXY-2-PYRIDONES 未知

    公开(公告)号：AU5363073A

    公开(公告)日：1974-09-26

    申请号：AU5363073

    申请日：1973-03-22

    Applicant: HOECHST AG

    Inventor： DITTMAR WALTER ,  LOHAUS GERHARD

    IPC: C07D221/04 ,  A61K31/4412 ,  A61P31/04 ,  C07D213/64 ,  C07D213/89 ,  C07D221/10 ,  C07D221/20 ,  C07D405/04 ,  C07D405/06 ,  C07D29/42

    Abstract: 1416397 Process for 1-hydroxy-2-pyridones HOECHST AG 21 March 1973 [25 March 1972] 13587/73 Heading C2C The invention comprises making compounds in which R 1 represents an alkyl radical of 1 to 17 carbon atoms which may be branched; an alkenyl radical of 2 to 17 carbon atoms; a cycloalkyl radical of 3 to 8 carbon atoms; a cyclohexylalkyl radical; a phenyl, phenylalkyl, phenylalkenyl, benzhydryl, phenoxymethyl; phenylmercaptomethyl or phenyl-sulphonylmethyl radical which may be substituted in the aromatic nucleus by one or more alkyl, alkoxy, amino, nitro, alkoxycarbonyl or cyano groups or halogen atoms; or a furyl or furylalkenyl radical; R 2 represents a hydrogen atom or an alkyl, alkenyl or alkynyl radical or a benzyl group or R 2 together with R 1 or R 3 forms a 5- or 6- membered carbocyclic ring; R 3 represents a hydrogen atom, an alkyl radical or a phenyl group and R 4 represents a hydrogen atom, an alkyl or alkenyl radical, a methoxymethyl or benzyl radical, or a chlorine or bromine atom, by reacting a 2-pyrone of the general Formula (II) with NH 2 OH or its salt in the presence of an optionally substituted aminopyridine or imidazole. Pharmaceutical preparations showing antibacterial and antimycotic actions contain (I) as active ingredient.

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