公开(公告)号：NO871602A

公开(公告)日：1987-10-19

申请号：NO871602

申请日：1987-04-15

Applicant: HOECHST AG

Inventor： LOHAUS GERHARD ,  DITTMAR WALTER ,  HANEL HEINZ ,  RAETHER WOLFGANG ,  REUSCHLING DIETER ,  GROBEL BENGT-THOMAS

IPC: A61K31/44 ,  C07D213/89 ,  C07D309/38 ,  C07D213/00

CPC classification number: C07D213/89 ,  C07D309/38

公开(公告)号：AU7171787A

公开(公告)日：1987-10-22

申请号：AU7171787

申请日：1987-04-16

Applicant: HOECHST AG

Inventor： LOHAUS GERHARD ,  GROBEL BENGT-THOMAS ,  DITTMAR WALTER ,  HANEL HEINZ ,  RAETHER WOLFGANG ,  REUSCHLING DIETER

IPC: A61K31/44 ,  C07D213/89 ,  C07D309/38 ,  A01N43/40

Abstract: New 1-hydroxy-2-pyridones of the general formula I I in which R1, R2 and R3, which are identical or different, denote hydrogen or lower alkyl having 1-4 carbon atoms, R1 and R3 preferably being hydrogen, and R2 preferably being methyl, X denotes S or, preferably, O, Y denotes hydrogen or up to 2 halogen atoms, namely chlorine and/or bromine, Z denotes a single bond or the bivalent radicals O, S, -CR2- (R=H or C1-C4-alkyl) or other 2-valent radicals with 2-10 carbon and, optionally, oxygen and/or sulfur atoms linked to form a chain, it being obligatory when the radicals contain 2 or more oxygen and/or sulfur atoms for the latter to be separated by at least 2 carbon atoms, and it being possible for 2 adjacent carbon atoms also to be linked together by a double bond, and the free valencies of the carbon atoms being saturated by H and/or C1-C4-alkyl groups, Ar denotes an aromatic ring system which has up to two rings and can be substituted by up to three radicals from the group comprising fluorine, chlorine, bromine, methoxy, C1-C4-alkyl, trifluoromethyl and trifluoromethoxy, are prepared by a variety of process variants. The compounds and their physiologically tolerated salts with inorganic or organic bases mainly have antimycotic, anti-bacterial and antiviral activity. The compounds of the formula V V in which R1, R2, R3, X, Y, Z and Ar have the same meaning as in formula I, which occur in the preparation of the compounds of the formula I, are also new.

公开(公告)号：NO871602L

公开(公告)日：1987-10-19

申请号：NO871602

申请日：1987-04-15

Applicant: HOECHST AG

Inventor： LOHAUS GERHARD ,  DITTMAR WALTER ,  HANEL HEINZ ,  RAETHER WOLFGANG ,  REUSCHLING DIETER ,  GROBEL BENGT-THOMAS

IPC: A61K31/44 ,  C07D213/89 ,  C07D309/38 ,  C07D213/00

Abstract: New 1-hydroxy-2-pyridones of the general formula I I in which R1, R2 and R3, which are identical or different, denote hydrogen or lower alkyl having 1-4 carbon atoms, R1 and R3 preferably being hydrogen, and R2 preferably being methyl, X denotes S or, preferably, O, Y denotes hydrogen or up to 2 halogen atoms, namely chlorine and/or bromine, Z denotes a single bond or the bivalent radicals O, S, -CR2- (R=H or C1-C4-alkyl) or other 2-valent radicals with 2-10 carbon and, optionally, oxygen and/or sulfur atoms linked to form a chain, it being obligatory when the radicals contain 2 or more oxygen and/or sulfur atoms for the latter to be separated by at least 2 carbon atoms, and it being possible for 2 adjacent carbon atoms also to be linked together by a double bond, and the free valencies of the carbon atoms being saturated by H and/or C1-C4-alkyl groups, Ar denotes an aromatic ring system which has up to two rings and can be substituted by up to three radicals from the group comprising fluorine, chlorine, bromine, methoxy, C1-C4-alkyl, trifluoromethyl and trifluoromethoxy, are prepared by a variety of process variants. The compounds and their physiologically tolerated salts with inorganic or organic bases mainly have antimycotic, anti-bacterial and antiviral activity. The compounds of the formula V V in which R1, R2, R3, X, Y, Z and Ar have the same meaning as in formula I, which occur in the preparation of the compounds of the formula I, are also new.

公开(公告)号：PT84702B

公开(公告)日：1989-11-30

申请号：PT8470287

申请日：1987-04-16

Applicant: HOECHST AG

Inventor： RAETHER WOLFGANG ,  LOHAUS GERHARD ,  DITTMAR WALTER ,  HANEL HEINZ ,  REUSCHLING DIETER ,  GROBEL BENGT-THOMAS

IPC: A61K31/44 ,  C07D213/89 ,  C07D309/38

Abstract: New 1-hydroxy-2-pyridones of the general formula I I in which R1, R2 and R3, which are identical or different, denote hydrogen or lower alkyl having 1-4 carbon atoms, R1 and R3 preferably being hydrogen, and R2 preferably being methyl, X denotes S or, preferably, O, Y denotes hydrogen or up to 2 halogen atoms, namely chlorine and/or bromine, Z denotes a single bond or the bivalent radicals O, S, -CR2- (R=H or C1-C4-alkyl) or other 2-valent radicals with 2-10 carbon and, optionally, oxygen and/or sulfur atoms linked to form a chain, it being obligatory when the radicals contain 2 or more oxygen and/or sulfur atoms for the latter to be separated by at least 2 carbon atoms, and it being possible for 2 adjacent carbon atoms also to be linked together by a double bond, and the free valencies of the carbon atoms being saturated by H and/or C1-C4-alkyl groups, Ar denotes an aromatic ring system which has up to two rings and can be substituted by up to three radicals from the group comprising fluorine, chlorine, bromine, methoxy, C1-C4-alkyl, trifluoromethyl and trifluoromethoxy, are prepared by a variety of process variants. The compounds and their physiologically tolerated salts with inorganic or organic bases mainly have antimycotic, anti-bacterial and antiviral activity. The compounds of the formula V V in which R1, R2, R3, X, Y, Z and Ar have the same meaning as in formula I, which occur in the preparation of the compounds of the formula I, are also new.

公开(公告)号：AU602684B2

公开(公告)日：1990-10-25

申请号：AU7171787

申请日：1987-04-16

Applicant: HOECHST AG

Inventor： LOHAUS GERHARD ,  DITTMAR WALTER ,  HANEL HEINZ ,  RAETHER WOLFGANG ,  REUSCHLING DIETER ,  GROBEL BENGT-THOMAS

IPC: A61K31/44 ,  C07D213/89 ,  C07D309/38 ,  A01N43/40

Abstract: New 1-hydroxy-2-pyridones of the general formula I I in which R1, R2 and R3, which are identical or different, denote hydrogen or lower alkyl having 1-4 carbon atoms, R1 and R3 preferably being hydrogen, and R2 preferably being methyl, X denotes S or, preferably, O, Y denotes hydrogen or up to 2 halogen atoms, namely chlorine and/or bromine, Z denotes a single bond or the bivalent radicals O, S, -CR2- (R=H or C1-C4-alkyl) or other 2-valent radicals with 2-10 carbon and, optionally, oxygen and/or sulfur atoms linked to form a chain, it being obligatory when the radicals contain 2 or more oxygen and/or sulfur atoms for the latter to be separated by at least 2 carbon atoms, and it being possible for 2 adjacent carbon atoms also to be linked together by a double bond, and the free valencies of the carbon atoms being saturated by H and/or C1-C4-alkyl groups, Ar denotes an aromatic ring system which has up to two rings and can be substituted by up to three radicals from the group comprising fluorine, chlorine, bromine, methoxy, C1-C4-alkyl, trifluoromethyl and trifluoromethoxy, are prepared by a variety of process variants. The compounds and their physiologically tolerated salts with inorganic or organic bases mainly have antimycotic, anti-bacterial and antiviral activity. The compounds of the formula V V in which R1, R2, R3, X, Y, Z and Ar have the same meaning as in formula I, which occur in the preparation of the compounds of the formula I, are also new.

公开(公告)号：PH24106A

公开(公告)日：1990-03-05

申请号：PH35156

申请日：1987-04-20

Applicant: HOECHST AG

Inventor： LOHAUS GERHARD ,  DITTMAR WALTER ,  HANEL HEINZ ,  RAETHER WOLFGANG ,  REUSCHLING DIETER ,  GROBEL BENGT-THOMAS

IPC: A61K31/44 ,  C07D213/89 ,  C07D309/38 ,  C07D211/86

Abstract: New 1-hydroxy-2-pyridones of the general formula I I in which R1, R2 and R3, which are identical or different, denote hydrogen or lower alkyl having 1-4 carbon atoms, R1 and R3 preferably being hydrogen, and R2 preferably being methyl, X denotes S or, preferably, O, Y denotes hydrogen or up to 2 halogen atoms, namely chlorine and/or bromine, Z denotes a single bond or the bivalent radicals O, S, -CR2- (R=H or C1-C4-alkyl) or other 2-valent radicals with 2-10 carbon and, optionally, oxygen and/or sulfur atoms linked to form a chain, it being obligatory when the radicals contain 2 or more oxygen and/or sulfur atoms for the latter to be separated by at least 2 carbon atoms, and it being possible for 2 adjacent carbon atoms also to be linked together by a double bond, and the free valencies of the carbon atoms being saturated by H and/or C1-C4-alkyl groups, Ar denotes an aromatic ring system which has up to two rings and can be substituted by up to three radicals from the group comprising fluorine, chlorine, bromine, methoxy, C1-C4-alkyl, trifluoromethyl and trifluoromethoxy, are prepared by a variety of process variants. The compounds and their physiologically tolerated salts with inorganic or organic bases mainly have antimycotic, anti-bacterial and antiviral activity. The compounds of the formula V V in which R1, R2, R3, X, Y, Z and Ar have the same meaning as in formula I, which occur in the preparation of the compounds of the formula I, are also new.