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公开(公告)号：DE3025367A1
公开(公告)日：1982-01-28
申请号：DE3025367
申请日：1980-07-04
Applicant: HOECHST AG
Inventor： MUSCHAWECK ROMAN DR , FUELBERTH WERNER DR , SICKMUELLER ALFRED DR
IPC: C07D295/14 , A61K31/13 , A61K31/135 , A61K31/275 , A61K31/34 , A61K31/341 , A61K31/40 , A61K31/402 , A61K31/635 , A61P9/12 , C07D295/08 , C07D295/155 , C07D307/52
Abstract: Salts formed between penbutolol and furosemide or piretanide, pharmaceutical compositions containing such salts, and methods for treating diseases of the coronary and circulatory systems with such salts.
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公开(公告)号：DE3009229A1
公开(公告)日：1981-10-15
申请号：DE3009229
申请日：1980-03-11
Applicant: HOECHST AG
Inventor： STURM KARL DIPL CHEM DR , MUSCHAWECK ROMAN DR
IPC: A61K31/18 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/63 , A61P7/10 , C07C67/00 , C07C301/00 , C07C303/32 , C07C303/40 , C07C311/39 , C07D307/52 , C07D333/20 , C07C143/80 , A61K31/255
Abstract: The present invention relates to compounds of the formula I wherein R is furyl, thienyl or phenyl, to physiologically acceptable salts thereof, to a process for their manufacture, to a composition comprising said compounds and to their use as a medicament.
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43.发明专利
公开(公告)号：CH621776A5
公开(公告)日：1981-02-27
申请号：CH1059479
申请日：1979-11-28
Applicant: HOECHST AG
Inventor： BORMANN DIETER DR , MERKEL WULF DR , MUSCHAWECK ROMAN DR , MANIA DIETER DR
IPC: C07D207/00 , A61K31/395 , A61K31/40 , A61K31/445 , C07D207/06 , C07D207/10 , C07D207/20 , C07D207/32 , C07D207/327 , C07D207/40 , C07D207/404 , C07D207/44 , C07D207/452 , C07D209/14 , C07D209/44 , C07D209/48 , C07D209/52 , C07D211/14 , C07D211/30 , C07D211/34 , C07D211/88 , C07D265/32 , C07D265/33 , C07D295/00 , C07D295/155 , C07D295/18 , C07D207/04 , C07D207/18 , C07D211/06 , C07D227/00
Abstract: Novel heterocyclically substituted 5-sulphamoylbenzoic acid derivatives of the accompanying formula I, in which the symbols R , R , X and A have the meaning given in Patent Claim 1, are prepared by introducing the radical X into appropriate 3-nitro-5-sulphamoylbenzoic acids or their esters, which carry a halogen atom in the 4-position and whose 5-sulphamoyl group is protected, reducing the reaction product to the corresponding 3-amino compound, reacting this with dicarboxylic acid derivatives, reducing the 3-imido or 3-amido compounds thus obtained and hydrolysing the reaction product thus obtained to remove the protective group B and the ester group R . The alkyl radicals R can then be introduced by alkylation. Starting from the compounds of the formula I prepared according to the invention, in which X denotes a -SR group, the corresponding compounds in which X denotes a -SOR or -SO2R group are obtained by oxidation. The novel compounds are highly active saluretics and diuretics. They are used mainly for the treatment of oedematous diseases of various origins.
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公开(公告)号：DE2849646A1
公开(公告)日：1980-06-04
申请号：DE2849646
申请日：1978-11-16
Applicant: HOECHST AG
Inventor： MERKEL WULF DIPL CHEM DR , BORMANN DIETER DIPL CHEM DR , MANIA DIETER DIPL CHEM DR , MUSCHAWECK ROMAN DR
IPC: A61K31/38 , A61K31/381 , A61P7/10 , A61P9/12 , C07D333/20 , C07D333/24 , C07D333/28 , C07D409/12
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公开(公告)号：CH612168A5
公开(公告)日：1979-07-13
申请号：CH1091274
申请日：1974-08-09
Applicant: HOECHST AG
Inventor： SIEGEMUND GUENTHER DR , MUSCHAWECK ROMAN DR
Abstract: 1,2,2,2-Tetrafluoroethyl ethers and process for preparing them; the compounds are useful inhalation anesthetics which are distinguished by shorter recovery times.
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Patent Agency Ranking
公开(公告)号：DE2533821A1
公开(公告)日：1977-02-17
申请号：DE2533821
申请日：1975-07-29
Applicant: HOECHST AG
Inventor： LANG HANS-JOCHEN DIPL CHEM DR , MUSCHAWECK ROMAN DR
IPC: A61K31/425 , A61K31/426 , A61P7/10 , C07D277/18 , C07D513/04
Abstract: The invention relates to thiazolidine derivatives having in 4-position a hydroxy group and a 3'-sulphamyl-phenyl substituent the phenyl ring of which is di-substituted by halogen or methyl, in 2 position an imino group and in 1-position an aliphatic or cycloaliphatic substituent. Said thiazolidines have diuretic activity.
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47.发明专利
公开(公告)号：DE2524956A1
公开(公告)日：1976-12-16
申请号：DE2524956
申请日：1975-06-05
Applicant: HOECHST AG
Inventor： MUFFLER HERBERT DR , MUSCHAWECK ROMAN DR , SIEGEMUND GUENTER DR
Abstract: The fluoroether of formula (I) is new: CF3.CHF.CF2.OCH2F (I). It is prepd. from CF3.CHF.CF2.OCH3 by partial photochlorination to CF3.CHF.CF2.OCH2Cl then conventional fluorination. Cpd. (I) is an inhalation anaesthetic opt. used in conjunction with N2O, ether etc. It is non-flammable, extremely stable towards NaOH-Ca(OH)2 mixts.; easily miscible with other org. liquids and since it has a relatively low b. pt. easily and controllably introduced into breathing mixts. It is also useful as a solvent for fluorinated olefins, other fluorinated cpds., fats and oils, and may be used to clean metal surfaces.
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公开(公告)号：DE2340561A1
公开(公告)日：1975-02-27
申请号：DE2340561
申请日：1973-08-10
Applicant: HOECHST AG
Inventor： SIEGEMUND GUENTHER DR , MUSCHAWECK ROMAN DR
IPC: A61K31/075 , A61P23/00 , C07C41/00 , C07C43/12 , C07C43/174 , C07C67/00 , A61K31/045
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公开(公告)号：DE2340560A1
公开(公告)日：1975-02-27
申请号：DE2340560
申请日：1973-08-10
Applicant: HOECHST AG
Inventor： SIEGEMUND GUENTHER DR , MUSCHAWECK ROMAN DR
Abstract: 1,2,2,2-Tetrafluoroethyl ethers and process for preparing them; the compounds are useful inhalation anesthetics which are distinguished by shorter recovery times.
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公开(公告)号：DE2339714A1
公开(公告)日：1975-02-27
申请号：DE2339714
申请日：1973-08-06
Applicant: HOECHST AG
Inventor： STURM KARL DR , MUSCHAWECK ROMAN DR , NAHM HELMUT DR
IPC: A61K31/18 , C07C143/80 , A61K31/19 , A61K31/34 , A61K31/44 , C07D213/63 , C07D307/42
Abstract: Cpds. (I):- (where R' is 1-6C alkyl opt. branched and opt. contng. one unsatd. bond; or an aralkyl group contng. up to 9C or 2-, 3- or 4- pyridylmethyl) may be prepd. either by reacting 3-butylamino-4-phenoxy-5-sulphamoyl benzoic acid (II) with R'OH and HCHO; or hydrogenating a (I)-benzyl ester, or reacting (I; R' = Me) with R'OH to give (I; R' = 2-6C alkyl). Thus (I; R' = Me) is prepd. by refluxing (II), HCHO and MeOH.
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