公开(公告)号：NO844422L

公开(公告)日：1985-07-22

申请号：NO844422

申请日：1984-11-06

Applicant: HOECHST AG

Inventor： VERTESY LASZLO ,  TRIPIER DOMINIQUE ,  RITZEL HARALD

IPC: C12N1/20 ,  A61K35/74 ,  A61K38/00 ,  A61K38/55 ,  C07K7/00 ,  C07K7/64 ,  C07K14/00 ,  C07K14/195 ,  C07K14/36 ,  C07K14/41 ,  C12N9/99 ,  C12P7/64 ,  C12P13/00 ,  C12P21/02 ,  C12P21/04 ,  C12R1/485 ,  C12P ,  C12N ,  C07K

Abstract: Cyclic polypeptides of the formula I I in which Z, S, Y and AS have the meanings given, a process for their preparation and their use are described. The compounds have an alpha -amylase-inhibiting action.

公开(公告)号：FI851521A0

公开(公告)日：1985-04-16

申请号：FI851521

申请日：1985-04-16

Applicant: HOECHST AG

Inventor： TRIPIER DOMINIQUE

IPC: C07K1/113 ,  A61K35/56 ,  A61K35/62 ,  A61K38/00 ,  A61K38/46 ,  A61K38/55 ,  A61P7/02 ,  C07C20060101 ,  C07G20060101 ,  C07K1/20 ,  C07K14/00 ,  C07K14/815 ,  C07K

Abstract: The invention relates to polypeptides of the formula I (I) in which m denotes 0-50, n denotes 0-100 and R denotes the phenolic hydrogen or a phenol ester group, X represents identical or different residues of naturally occurring alpha -amino acids, Y denotes Val, Ile, Thr, Leu or Phe, and Z represents identical or different residues of naturally occurring alpha -amino acids, and in which the Cys residues are linked pairwise via disulfide bridges, to a process for preparing or obtaining them and to agents containing them.

公开(公告)号：DK173509B1

公开(公告)日：2001-01-15

申请号：DK338486

申请日：1986-07-16

Applicant: HOECHST AG

Inventor： KRAMER MARTIN ,  TRIPIER DOMINIQUE

IPC: C07K1/06 ,  A61K35/62 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K1/00 ,  C07K1/12 ,  C07K1/14 ,  C07K1/20 ,  C07K1/22 ,  C07K14/00 ,  C07K14/435 ,  C07K14/81 ,  C07K14/815

Abstract: The invention relates to a polypeptide of the formula (I) +TR in which R represents phenoloic hydrogen or a phenolic ester group and m, n, X, Z, A, B, C, D, E, F, G, I and J have the meanings given, and in which the 6 Cys radicals are linked in pairs via disulfide bridges, processes for the preparation or isolation thereof, their use and agents containing them.

公开(公告)号：HK1006024A1

公开(公告)日：1999-02-05

申请号：HK98105201

申请日：1998-06-11

Applicant: HOECHST AG

Inventor： CRAUSE PETER ,  HABERMANN PAUL ,  KRAMER MARTIN ,  OBERMEIER RAINER ,  SAUBER KLAUS ,  TRIPIER DOMINIQUE

IPC: C12N9/99 ,  A61K38/00 ,  A61K38/55 ,  A61K47/00 ,  A61K47/48 ,  A61P7/02 ,  C07K1/113 ,  C07K1/20 ,  C07K1/22 ,  C07K14/81 ,  C07K14/815 ,  C07K17/10 ,  C12P21/02 ,  C12R1/645 ,  C07K ,  A61K

Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or its physiologically acceptable salt and of a carrier, to a process for the preparation thereof and to the use thereof as thrombin inhibitor.

公开(公告)号：NO303452B1

公开(公告)日：1998-07-13

申请号：NO923252

申请日：1992-08-19

Applicant: HOECHST AG

Inventor： MUELLER GUENTER ,  TRIPIER DOMINIQUE ,  MUELLNER STEFAN

IPC: A61K38/28 ,  A61K31/715 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K1/22 ,  C07K5/08 ,  C07K5/093 ,  C07K5/10 ,  C07K9/00 ,  C07K14/37 ,  C07K14/41 ,  C07K14/475 ,  C07K14/575 ,  C07K14/62 ,  C07K14/65 ,  C12P19/26 ,  C12P21/00 ,  C12P21/02 ,  C12R1/865

Abstract: Phosphoinositolglycan peptides, obtainable by cleavage of adenosine-3%,5%-cyclic monophosphate binding protein, which contain glucosamine, galactose, mannose, inositol, phosphoric acid, ethanolamine and a peptide containing the sequence Asn-Cys-Tyr, their preparation and use for the treatment of diabetes mellitus and non-insulin-dependent diabetes are described.

公开(公告)号：CA1339189C

公开(公告)日：1997-07-29

申请号：CA601594

申请日：1989-06-02

Applicant: HOECHST AG

Inventor： BONIN WERNER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  WOEHNER ELISABET

IPC: A61K38/55 ,  A61K35/56 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K14/81 ,  A61K38/57

Abstract: Amblyommin, a new active substance for anticoagulant therapy The invention relates to a new active substance amblyommin - for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences - Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn- X-Phe-Glu-, - Lys-Ile-Leu-Phe-X-Gln-Gly- and - Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu- X-Leu-Ser-Glu-Gly-Ile-in which each radical X can be identical or different and each represents a naturally occurring amino acid.

公开(公告)号：DK171824B1

公开(公告)日：1997-06-23

申请号：DK173985

申请日：1985-04-17

Applicant: HOECHST AG

Inventor： TRIPIER DOMINIQUE

IPC: C07K1/113 ,  A61K35/56 ,  A61K35/62 ,  A61K38/00 ,  A61K38/46 ,  A61K38/55 ,  A61P7/02 ,  C07C20060101 ,  C07G20060101 ,  C07K1/20 ,  C07K14/00 ,  C07K14/815 ,  C07K14/435

Abstract: The invention relates to polypeptides of the formula I (I) in which m denotes 0-50, n denotes 0-100 and R denotes the phenolic hydrogen or a phenol ester group, X represents identical or different residues of naturally occurring alpha -amino acids, Y denotes Val, Ile, Thr, Leu or Phe, and Z represents identical or different residues of naturally occurring alpha -amino acids, and in which the Cys residues are linked pairwise via disulfide bridges, to a process for preparing or obtaining them and to agents containing them.

公开(公告)号：FI98309C

公开(公告)日：1997-05-26

申请号：FI925497

申请日：1992-12-03

Applicant: HOECHST AG

Inventor： CRAUSE PETER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  ULMER WOLFGANG ,  SCHMID GERHARD

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K14/00 ,  C07K14/815 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12R1/19 ,  C12N15/15 ,  C12N15/81

公开(公告)号：FI98703B

公开(公告)日：1997-04-30

申请号：FI892686

申请日：1989-06-01

Applicant: HOECHST AG

Inventor： CRAUSE PETER ,  HABERMANN PAUL ,  KRAMER MARTIN ,  OBERMEIER RAINER ,  SAUBER KLAUS ,  TRIPIER DOMINIQUE

IPC: C12N9/99 ,  A61K38/00 ,  A61K38/55 ,  A61K47/00 ,  A61K47/48 ,  A61P7/02 ,  C07K1/113 ,  C07K1/20 ,  C07K1/22 ,  C07K14/81 ,  C07K14/815 ,  C07K17/10 ,  C12P21/02 ,  C12R1/645 ,  A61K38/58 ,  A61K47/26 ,  A61K47/38

Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or its physiologically acceptable salt and of a carrier, to a process for the preparation thereof and to the use thereof as thrombin inhibitor.

公开(公告)号：IE72201B1

公开(公告)日：1997-04-09

申请号：IE181589

申请日：1989-06-12

Applicant: HOECHST AG

Inventor： CRAUSE PETER ,  HABERMANN PAUL ,  KRAMER MARTIN ,  OBERMEIER RAINER ,  SAUBER KLAUS ,  TRIPIER DOMINIQUE

IPC: C12N9/99 ,  A61K38/00 ,  A61K38/55 ,  A61K47/00 ,  A61K47/48 ,  A61P7/02 ,  C07K1/113 ,  C07K1/20 ,  C07K1/22 ,  C07K14/81 ,  C07K14/815 ,  C07K17/10 ,  C12P21/02 ,  C12R1/645 ,  A61K37/46 ,  A61K47/36 ,  C07K7/00

Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or its physiologically acceptable salt and of a carrier, to a process for the preparation thereof and to the use thereof as thrombin inhibitor.