公开(公告)号：NO930817D0

公开(公告)日：1993-03-05

申请号：NO930817

申请日：1993-03-05

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  WAGNER ADALBERT ,  GERHARDS HERMANN ,  BECKER REINHARD ,  SCHOELKENS BERNWARD

IPC: A61K31/4164 ,  A61K31/415 ,  A61K31/64 ,  A61P9/10 ,  A61P9/12 ,  C07D233/84 ,  C07D233/86 ,  C07D233/90 ,  C07D

Abstract: Compounds of the formula (I) in which R is, for example, ethyl, R is, for example, methyl, n is, for example, zero, R is, for example, COOH and R is, for example, SO2NHCONHCH3 are highly active antagonists of angiotensin II receptors.

公开(公告)号：ZA919245B

公开(公告)日：1992-07-29

申请号：ZA919245

申请日：1991-11-22

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  ADALBERT WAGNER ,  HENNING RAINER ,  RAINER HENNING ,  NICKEL WOLF-ULRICH ,  WOLF-ULRICH NICKEL

IPC: A61K31/41 ,  A61K31/425 ,  A61P9/12 ,  A61P43/00 ,  C07D263/06 ,  C07D417/04 ,  C07D417/06 ,  C12N9/99 ,  C07D ,  A61K

Abstract: The invention relates to compounds of the formula in which W represents -CO-, -O-CO-, -SO2- or -NH-CO-, R , R , R , R , R and R represent hydrogen or an organic radical and R denotes alkyl, cycloalkyl or cycloalkylalkyl, processes for their preparation, intermediates and their use in the preparation of inhibitors of renin and HIV protease.

公开(公告)号：NO920048L

公开(公告)日：1992-07-06

申请号：NO920048

申请日：1992-01-03

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  ENGLERT HEINRICH ,  KLEEMANN HEINZ-WERNER ,  GERHARDS HERMANN ,  SCHOELKENS BERNWARD ,  BECKER REINHARD ,  LINZ WOLFGANG

IPC: A61K31/415 ,  A61K31/40 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00 ,  C07D233/64

Abstract: Azole derivative of the general formula (I) in which A, L, O, R , X, Y, Z and q have the meanings given, a process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have, for example, the following meanings: R = (C2-C10)-alkyl Z = nitrogen X and Y = independently of one another CR L = -CH2- q = zero or 1 A = biphenyl radical which is substituted, for example, by R R = halogen or hydrogen R = SO2-NH-CO-OR and R = phenyl, are highly active antagonists of angiotensin II receptors.

公开(公告)号：HU205770B

公开(公告)日：1992-06-29

申请号：HU250590

申请日：1990-04-20

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH ,  LINZ WOLFGANG ,  RUPPERT DIETER ,  URBACH HANSJOERG ,  WAGNER ADALBERT

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  C07K5/02 ,  A61K37/64

Abstract: The present invention relates to compounds of the formula I in which A and B are, independently of one another, an amino acid, and W, R , R , R and R are as defined in the description, to processes for the preparation thereof, to the use thereof and to pharmaceutical compositions containing them.

公开(公告)号：AU624579B2

公开(公告)日：1992-06-18

申请号：AU2295988

申请日：1988-09-29

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  KLEEMANN HEINZ-WERNER ,  RUPPERT DIETER ,  SCHOLKENS BERNWARD ,  URBACH HANSJORG

IPC: A61K38/55 ,  A61K38/00 ,  A61P9/12 ,  C07C67/00 ,  C07C231/00 ,  C07C237/06 ,  C07C237/08 ,  C07C237/14 ,  C07C237/20 ,  C07C237/22 ,  C07C273/10 ,  C07C301/00 ,  C07C303/22 ,  C07C303/40 ,  C07C309/14 ,  C07C309/70 ,  C07C313/00 ,  C07C317/48 ,  C07C323/60 ,  C07D413/06 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  C07K5/08 ,  A61K37/64 ,  C07D233/64 ,  C07D333/24 ,  C07D401/12 ,  C07D409/14

Abstract: The compounds have the formula in which R is absent or is hydrogen, alkyl or acyl, A is an acyl radical or an amino acid residue, B is an amino acid residue, R , R and R are as defined in the description, and R is -OH or -F, and they and their salts are used as pharmaceuticals.

公开(公告)号：NO914584L

公开(公告)日：1992-05-25

申请号：NO914584

申请日：1991-11-22

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  HENNING RAINER ,  NICKEL WOLF-ULRICH

IPC: A61K31/41 ,  A61K31/425 ,  A61P9/12 ,  A61P43/00 ,  C07D263/06 ,  C07D417/04 ,  C07D417/06 ,  C12N9/99 ,  C07D413/06

Abstract: The invention relates to compounds of the formula in which W represents -CO-, -O-CO-, -SO2- or -NH-CO-, R , R , R , R , R and R represent hydrogen or an organic radical and R denotes alkyl, cycloalkyl or cycloalkylalkyl, processes for their preparation, intermediates and their use in the preparation of inhibitors of renin and HIV protease.

公开(公告)号：ZA915683B

公开(公告)日：1992-04-29

申请号：ZA915683

申请日：1991-07-19

Applicant: HOECHST AG

Inventor： HENNING RAINER ,  RAINER HENNING ,  GERHARDS HERMANN ,  HERMANN GERHARDS ,  WAGNER ADALBERT ,  ADALBERT WAGNER ,  SCHOELKENS BERNWARD ,  BERNWARD SCHOELKENS

IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/495 ,  A61K31/505 ,  A61P1/16 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P43/00 ,  C07D233/56 ,  C07D233/90 ,  C07D403/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D ,  A61K

Abstract: Substd. azole derivs. of formula (I) and their physiologically acceptable salts are new. In (I) X, Y and Z are each N or CR2 R1 is 2-10C alkyl, 3-10C alkenyl, 3-10C alkynyl, -(CH2)mB(CH2nR4 (these 4 gps. opt. monosubstd. with CO2R3 and opt. have 1-all H atoms replaced by F), OR3, 3-8C cycloalkyl, 5-10C cycloalkylalkynyl, or benzyl (opt. mono or disubstd. on the Ph ring with halogen, 1-4C alkoxy and/or NO2), R2 = H, halogen, CvF2v+1, SF5, pentafluoro phenyl CN, phenyl, -(CH2)nF, -(CH2)nONO2, -CH2N3, -(CH2)nNO2, phthalimido (CH2)n-, R3 = H, 1-8C alkyl (in which 1 to all H are replaced by F), 3-8C cycloalkyl, Ph or benzyl, R4 = H, 1-6C alkyl, 3-8C cycloalkyl, 2-4C alkenyl, or 2-4C alkynyl, A = a mono or bicyclic unsatd. or partially hydrogenated heterocycle gp. with 5-10 ring atom of which up to 9 are C, and opt. substd. with up to 3 opt. different R14 gps. or -(CH2)n-1-(CHR6CH2)0-1, R14 where R14 = halogen, oxo, nitroso, NO2, amino, CN, OH, 1-6C alkyl, 1-4C alkanoyl, 1-4C alkanoyloxy. B = O, NR7 or S, W = O or S, L = 1-3C alkanediyl, R26 and R27 are each H, halogen, NO2, 1-4C alkyl or 1-2C alkoxy, n = 1-5, o = 1-10, q = 0-1.

公开(公告)号：HU9200021D0

公开(公告)日：1992-03-30

申请号：HU9200021

申请日：1992-01-03

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  ENGLER HEINRICH ,  KLEEMANN HEINZ-WERNER ,  GERHARDS HERMANN ,  SCHOELKENS BERNWARD ,  BECKER REINHARD ,  LINZ WOLFGANG

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00

Abstract: Azole derivative of the general formula (I) in which A, L, O, R , X, Y, Z and q have the meanings given, a process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have, for example, the following meanings: R = (C2-C10)-alkyl Z = nitrogen X and Y = independently of one another CR L = -CH2- q = zero or 1 A = biphenyl radical which is substituted, for example, by R R = halogen or hydrogen R = SO2-NH-CO-OR and R = phenyl, are highly active antagonists of angiotensin II receptors.

公开(公告)号：AU622014B2

公开(公告)日：1992-03-26

申请号：AU5371190

申请日：1990-04-23

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  URBACH HANSJORG ,  RUPPERT DIETER ,  LINZ WOLFGANG ,  SCHOLKENS BERNWARD

IPC: A61K38/55 ,  A61K38/00 ,  A61P9/00 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  A61K37/64

Abstract: The present invention relates to compounds of the formula I in which A and B are, independently of one another, an amino acid, and R , R , R and R are as defined in the description, to processes for the preparation thereof, to their use as medicines and to pharmaceutical agents containing them.

公开(公告)号：AU8112991A

公开(公告)日：1992-01-23

申请号：AU8112991

申请日：1991-07-19

Applicant: HOECHST AG

Inventor： HENNING RAINER ,  WAGNER ADALBERT ,  GERHARDS HERMANN ,  SCHOLKENS VERNWARD

IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/495 ,  A61K31/505 ,  A61P1/16 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P43/00 ,  C07D233/56 ,  C07D233/90 ,  C07D403/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

Abstract: Substd. azole derivs. of formula (I) and their physiologically acceptable salts are new. In (I) X, Y and Z are each N or CR2 R1 is 2-10C alkyl, 3-10C alkenyl, 3-10C alkynyl, -(CH2)mB(CH2nR4 (these 4 gps. opt. monosubstd. with CO2R3 and opt. have 1-all H atoms replaced by F), OR3, 3-8C cycloalkyl, 5-10C cycloalkylalkynyl, or benzyl (opt. mono or disubstd. on the Ph ring with halogen, 1-4C alkoxy and/or NO2), R2 = H, halogen, CvF2v+1, SF5, pentafluoro phenyl CN, phenyl, -(CH2)nF, -(CH2)nONO2, -CH2N3, -(CH2)nNO2, phthalimido (CH2)n-, R3 = H, 1-8C alkyl (in which 1 to all H are replaced by F), 3-8C cycloalkyl, Ph or benzyl, R4 = H, 1-6C alkyl, 3-8C cycloalkyl, 2-4C alkenyl, or 2-4C alkynyl, A = a mono or bicyclic unsatd. or partially hydrogenated heterocycle gp. with 5-10 ring atom of which up to 9 are C, and opt. substd. with up to 3 opt. different R14 gps. or -(CH2)n-1-(CHR6CH2)0-1, R14 where R14 = halogen, oxo, nitroso, NO2, amino, CN, OH, 1-6C alkyl, 1-4C alkanoyl, 1-4C alkanoyloxy. B = O, NR7 or S, W = O or S, L = 1-3C alkanediyl, R26 and R27 are each H, halogen, NO2, 1-4C alkyl or 1-2C alkoxy, n = 1-5, o = 1-10, q = 0-1.