公开(公告)号：NO177143B

公开(公告)日：1995-04-18

申请号：NO903952

申请日：1990-09-11

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  LINZ WOLFGANG ,  NICKEL WOLF-ULRICH ,  RUPPERT DIETER ,  URBACH HANSJORG

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P9/12 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07K5/02

Abstract: The invention relates to renin-inhibiting amino-acid derivatives of the formula in which R is a radical of a substituted nitrogen-containing heterocycle such as piperidine, X is CO, CS, SO2 or SO, Y is CH2, O or S, B is the residue of an amino acid of the formula H-B-OH, and R , R and R are as defined in the description, process for their preparation, agents containing them and their use.

公开(公告)号：NZ240693A

公开(公告)日：1993-07-27

申请号：NZ24069391

申请日：1991-11-22

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  HENNING RAINER ,  NICKEL WOLF-ULRICH

IPC: A61K31/41 ,  A61K31/425 ,  A61P9/12 ,  A61P43/00 ,  C07D263/06 ,  C07D417/04 ,  C07D417/06 ,  C12N9/99 ,  C07D263/04 ,  C07D413/06

Abstract: The invention relates to compounds of the formula in which W represents -CO-, -O-CO-, -SO2- or -NH-CO-, R , R , R , R , R and R represent hydrogen or an organic radical and R denotes alkyl, cycloalkyl or cycloalkylalkyl, processes for their preparation, intermediates and their use in the preparation of inhibitors of renin and HIV protease.

公开(公告)号：PH27210A

公开(公告)日：1993-05-04

申请号：PH35073

申请日：1987-03-25

Applicant: HOECHST AG

Inventor： HOCK FRANZ ,  URBACH HANSJORG ,  HENNING RAINER ,  LERCH ULRICH ,  NICKEL WOLF-ULRICH ,  RUGER WOLFGANG

IPC: C07K14/81 ,  A61K38/00 ,  A61P9/12 ,  A61P25/28 ,  C07C235/02 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  A61K37/02 ,  A61K37/64

Abstract: The invention relates to novel compounds having a nootropic activity, the use of ACE inhibitors as medicaments having nootropic activity, agents containing them, and their use in the treatment and prophylaxis of cognitive malfunctions.

公开(公告)号：ZA919245B

公开(公告)日：1992-07-29

申请号：ZA919245

申请日：1991-11-22

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  ADALBERT WAGNER ,  HENNING RAINER ,  RAINER HENNING ,  NICKEL WOLF-ULRICH ,  WOLF-ULRICH NICKEL

IPC: A61K31/41 ,  A61K31/425 ,  A61P9/12 ,  A61P43/00 ,  C07D263/06 ,  C07D417/04 ,  C07D417/06 ,  C12N9/99 ,  C07D ,  A61K

Abstract: The invention relates to compounds of the formula in which W represents -CO-, -O-CO-, -SO2- or -NH-CO-, R , R , R , R , R and R represent hydrogen or an organic radical and R denotes alkyl, cycloalkyl or cycloalkylalkyl, processes for their preparation, intermediates and their use in the preparation of inhibitors of renin and HIV protease.

公开(公告)号：HU205770B

公开(公告)日：1992-06-29

申请号：HU250590

申请日：1990-04-20

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH ,  LINZ WOLFGANG ,  RUPPERT DIETER ,  URBACH HANSJOERG ,  WAGNER ADALBERT

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  C07K5/02 ,  A61K37/64

Abstract: The present invention relates to compounds of the formula I in which A and B are, independently of one another, an amino acid, and W, R , R , R and R are as defined in the description, to processes for the preparation thereof, to the use thereof and to pharmaceutical compositions containing them.

公开(公告)号：NO914584L

公开(公告)日：1992-05-25

申请号：NO914584

申请日：1991-11-22

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  HENNING RAINER ,  NICKEL WOLF-ULRICH

IPC: A61K31/41 ,  A61K31/425 ,  A61P9/12 ,  A61P43/00 ,  C07D263/06 ,  C07D417/04 ,  C07D417/06 ,  C12N9/99 ,  C07D413/06

Abstract: The invention relates to compounds of the formula in which W represents -CO-, -O-CO-, -SO2- or -NH-CO-, R , R , R , R , R and R represent hydrogen or an organic radical and R denotes alkyl, cycloalkyl or cycloalkylalkyl, processes for their preparation, intermediates and their use in the preparation of inhibitors of renin and HIV protease.

公开(公告)号：NZ231435A

公开(公告)日：1992-01-29

申请号：NZ23143589

申请日：1989-11-17

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH ,  RUGER WOLFGANG ,  URBACH HANSJORG ,  HOCK FRANZ

IPC: A61K31/40 ,  A61K31/403 ,  A61K38/00 ,  A61P25/00 ,  A61P25/18 ,  A61P25/28 ,  C07D207/16 ,  C07D209/52 ,  C07K5/06 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D209/26 ,  C07D207/09 ,  A61K31/405

Abstract: The present invention relates to compounds of the formula I (I) in which R1 to R4 are defined in the description, processes for their preparation, their use for the treatment and prophylaxis of cognitive dysfunctions and pharmaceuticals containing them and processes for their preparation.

公开(公告)号：HU203117B

公开(公告)日：1991-05-28

申请号：HU130887

申请日：1987-03-25

Applicant: HOECHST AG

Inventor： HENNING RAINER ,  HOCK FRANZ ,  LERCH ULRICH ,  NICKEL WOLF-ULRICH ,  RUEGER WOLFGANG ,  SCHOLTHOLT JOSEF ,  URBACH HANSJOERG

IPC: C07K14/81 ,  A61K38/00 ,  A61P9/12 ,  A61P25/28 ,  C07C235/02 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  A61K37/02

Abstract: The invention relates to novel compounds having a nootropic activity, the use of ACE inhibitors as medicaments having nootropic activity, agents containing them, and their use in the treatment and prophylaxis of cognitive malfunctions.

公开(公告)号：HU905859D0

公开(公告)日：1991-03-28

申请号：HU585990

申请日：1990-09-11

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  LINZ WOLFGANG ,  NICKEL WOLF-ULRICH ,  RUPPERT DIETER ,  URBACH HANSJOERG

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P9/12 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07K5/02

Abstract: The invention relates to renin-inhibiting amino-acid derivatives of the formula in which R is a radical of a substituted nitrogen-containing heterocycle such as piperidine, X is CO, CS, SO2 or SO, Y is CH2, O or S, B is the residue of an amino acid of the formula H-B-OH, and R , R and R are as defined in the description, process for their preparation, agents containing them and their use.

公开(公告)号：PT93797A

公开(公告)日：1990-11-20

申请号：PT9379790

申请日：1990-04-19

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  RUPPERT DIETER ,  LINZ WOLFGANG ,  NICKEL WOLF-ULRICH ,  URBACH HANSJORG

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  A61K37/64

Abstract: The present invention relates to compounds of the formula I in which A and B are, independently of one another, an amino acid, and W, R , R , R and R are as defined in the description, to processes for the preparation thereof, to the use thereof and to pharmaceutical compositions containing them.