公开(公告)号：AU715681B2

公开(公告)日：2000-02-10

申请号：AU5936096

申请日：1996-05-28

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K47/24 ,  A61K9/127 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61B8/13 ,  C07D265/30

Abstract: Stabilized compositions comprising, in combination with a gas, a fluorinated amphiphilic compound. The compositions are particularly suitable for use in diagnostic applications, including ultrasound. The compositions can take the form of vesicular compositions, such as micelles and liposomes.

公开(公告)号：BR9609343A

公开(公告)日：1999-12-28

申请号：BR9609343

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  YELLOWHAIR DAVID ,  BARRETTE TERRENCE R

IPC: A61K49/00 ,  A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00 ,  A61B5/00 ,  A61K9/133

Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3 DEG . The total length of travel around the figure-8 pattern is at least 0.7 cm.

公开(公告)号：HK1013625A1

公开(公告)日：1999-09-03

申请号：HK98114978

申请日：1998-12-23

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61B20060101 ,  A61K20060101 ,  B01J20060101 ,  A61K ,  A61B ,  B01J

公开(公告)号：AT180170T

公开(公告)日：1999-06-15

申请号：AT91902857

申请日：1990-12-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61B8/00 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  B01J13/02 ,  B01J13/12 ,  A61B8/14

Abstract: The present invention relates to a method for synthesizing a liposome having encapsulated therein a gas comprising contacting the liposomes in the liquid medium with gas under elevated pressure. The liposomes so produced and are useful in ultrasonic imaging techniques.

公开(公告)号：AU1390699A

公开(公告)日：1999-06-07

申请号：AU1390699

申请日：1998-11-11

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  SADEWASSER DAVID

IPC: A61K41/00 ,  A61K48/00 ,  A61N7/00 ,  A61H1/00

公开(公告)号：AU696056B2

公开(公告)日：1998-08-27

申请号：AU6953794

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61K8/14 ,  A61K9/127 ,  A61K9/14 ,  A61K41/00 ,  A61K47/48 ,  A61K49/04 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B28B1/54

公开(公告)号：BR9604786A

公开(公告)日：1998-07-07

申请号：BR9604786

申请日：1996-03-27

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/133 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/30 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  A61K9/14

公开(公告)号：AU5161298A

公开(公告)日：1998-06-22

申请号：AU5161298

申请日：1997-11-03

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K49/22 ,  A61K49/04 ,  C07C19/08 ,  C07C41/00

公开(公告)号：DE69128422T2

公开(公告)日：1998-04-09

申请号：DE69128422

申请日：1991-05-31

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  WU GUANLI

IPC: A61K49/00 ,  A61K49/22 ,  A61K31/70 ,  A61K31/695 ,  A61K31/715 ,  A61K31/73

公开(公告)号：AU4089897A

公开(公告)日：1998-04-02

申请号：AU4089897

申请日：1997-08-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K49/22 ,  A61K49/04 ,  A61B8/14

Abstract: A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator and performing ultrasound imaging of the region. Renal disease, including renal arterial stenosis, may be diagnosed using the method.