公开(公告)号：DE69214365D1

公开(公告)日：1996-11-14

申请号：DE69214365

申请日：1992-07-17

Applicant: KAO CORP

Inventor： OHASHI YUKIHIRO ,  KAWAMATA AKIRA

IPC: A61K8/72 ,  A61K8/89 ,  A61K8/893 ,  A61K8/897 ,  A61Q1/00 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q1/06 ,  A61Q1/12 ,  A61Q19/00 ,  C07F7/08 ,  C08G77/04 ,  C08G77/14 ,  C08G77/22 ,  C08G77/38 ,  C08G77/42 ,  C08G77/44 ,  C08L83/04 ,  C08L83/06 ,  C08L83/10 ,  A61K7/06 ,  A61K7/48

公开(公告)号：HK116296A

公开(公告)日：1996-07-12

申请号：HK116296

申请日：1996-07-04

Applicant: KAO CORP

Inventor： OHASHI YUKIHIRO ,  SUDA MITUO ,  YANO SHINJI ,  KAWAMATA AKIRA ,  OKUDA MINEHIRO ,  OMOKAWA GENJI

IPC: A61K8/68 ,  A61Q19/00 ,  C07C233/18 ,  C07C235/08 ,  A61K31/16 ,  A61K31/23

公开(公告)号：DE3854275T2

公开(公告)日：1996-04-11

申请号：DE3854275

申请日：1988-03-02

Applicant: KAO CORP

Inventor： YANO SHINJI ,  KAWAMATA AKIRA ,  MINEMATSU YOSHIHIRO ,  AKAZAKI SHUICHI ,  ZAMA MITSUKO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE ,  OHTOMO TSUYOSHI ,  KOMORI TAKASHI

IPC: A61K8/42 ,  A61K8/68 ,  A61Q5/00 ,  A61Q19/00 ,  C07H15/04 ,  A61K7/48

Abstract: An external skin care preparation comprising a compound represented by the following general formula (II), or a salt thereof: General formula (II): wherein R6 and R7 mean individually an aliphatic hydrocarbon group having 10-26 carbon atoms and R8 denotes a group -CH CH OH, -CH COOH or -COCH , and further comprising a surfactant.p

公开(公告)号：DE69115602D1

公开(公告)日：1996-02-01

申请号：DE69115602

申请日：1991-07-03

Applicant: KAO CORP

Inventor： KAWASE JIRO ,  OGURA YOSHIKO ,  YOSHINO KOJI ,  KAWAMATA AKIRA

IPC: A61K8/893 ,  A61K8/899 ,  A61Q5/12 ,  A61K7/06

公开(公告)号：DE3854275D1

公开(公告)日：1995-09-07

申请号：DE3854275

申请日：1988-03-02

Applicant: KAO CORP

Inventor： YANO SHINJI ,  KAWAMATA AKIRA ,  MINEMATSU YOSHIHIRO ,  AKAZAKI SHUICHI ,  ZAMA MITSUKO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE ,  OHTOMO TSUYOSHI ,  KOMORI TAKASHI

IPC: A61K8/42 ,  A61K8/68 ,  A61Q5/00 ,  A61Q19/00 ,  C07H15/04 ,  A61K7/48

Abstract: An external skin care preparation comprising a compound represented by the following general formula (II), or a salt thereof: General formula (II): wherein R6 and R7 mean individually an aliphatic hydrocarbon group having 10-26 carbon atoms and R8 denotes a group -CH CH OH, -CH COOH or -COCH , and further comprising a surfactant.p

公开(公告)号：HK33591A

公开(公告)日：1991-05-10

申请号：HK33591

申请日：1991-05-02

Applicant: KAO CORP

Inventor： KAWAMATA AKIRA ,  YANO SHINJI ,  HATTORI MICHIHIRO ,  AKAZAKI SHUICHI ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE

IPC: A61K8/68 ,  A61Q19/00 ,  C09K23/22 ,  F16K31/18 ,  C07C103/38 ,  C07C103/60 ,  A61K31/16

Abstract: An external medicament comprises a novel amide derivative represented by the following formula (I).wherein R 1 and R 2 are long chain alkyl groups.The external medicament is applicable to both a pharmaceutical external medicament and a cosmetic composition, and it provides excellent improving and preventing effects for chapping of the skin.

公开(公告)号：DE3665580D1

公开(公告)日：1989-10-19

申请号：DE3665580

申请日：1986-12-10

Applicant: KAO CORP

Inventor： KAWAMATA AKIRA ,  YANO SHINJI ,  HATTORI MICHIHIRO ,  AKAZAKI SHUICHI ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE

IPC: A61K8/68 ,  A61Q19/00 ,  C09K23/22 ,  F16K31/18 ,  C07C103/38 ,  C07C103/60 ,  A61K31/16

Abstract: An external medicament comprises a novel amide derivative represented by the following formula (I).wherein R 1 and R 2 are long chain alkyl groups.The external medicament is applicable to both a pharmaceutical external medicament and a cosmetic composition, and it provides excellent improving and preventing effects for chapping of the skin.

公开(公告)号：JP2004189740A

公开(公告)日：2004-07-08

申请号：JP2003408899

申请日：2003-12-08

Applicant: Kao Corp ,  花王株式会社

Inventor： OHASHI YUKIHIRO ,  FUJIMORI TAKETOSHI ,  KAWAMATA AKIRA ,  YADA YUKIHIRO ,  HIGUCHI KAZUHIKO ,  TAKEMA YOSHINORI ,  FUJIMURA TSUTOMU ,  IMOKAWA GENJI

IPC: A61K8/30 ,  A61K8/02 ,  A61K8/06 ,  A61K8/40 ,  A61K8/41 ,  A61K8/44 ,  A61K8/55 ,  A61K8/58 ,  A61K8/60 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To provide an external preparation for skin, having an excellent effect of preventing/improving wrinkles, making the skin maintain its normal function, and excellent in a dandruff-resisting effect and an effect of improving the skin after sunburned.
SOLUTION: This external preparation for skin contains an amine derivative expressed by general formula (1) (R
1 is a 1-40C hydrocarbon radical which may contain one or more hetero atoms; R
2 and R
3 are each a 1-3C bivalent hydrocarbon radical; R
4 is H or a 1-3C hydrocarbon radical; R
5 is H, a 1-3C hydrocarbon radical or -P(O)(OH)
2 ; R
6 is H or a 1-3C hydrocarbon radical which may have one or more hydroxy group; and Y is a 1-10C hydrocarbon radical which has one or more radicals, such as hydroxy group, alkoxy group, phosphate and carboxyl group) or general formula (2) (R
7 and R
8 are each a 1-3C hydrocarbon radical which may have one to three hydroxy groups).
COPYRIGHT: (C)2004,JPO&NCIPI

公开(公告)号：JPH07330743A

公开(公告)日：1995-12-19

申请号：JP12874294

申请日：1994-06-10

Applicant: KAO CORP

Inventor： HOSHINO TADAHIDE ,  SUGIYAMA MITSURU ,  KAWAMATA AKIRA ,  JOKURA HIROKO ,  IMOKAWA GENJI

IPC: C07D251/34 ,  A61K8/00 ,  A61K8/49 ,  A61Q1/00 ,  A61Q1/12 ,  A61Q17/04 ,  C09K3/00 ,  A61K7/42

Abstract: PURPOSE:To obtain the subject new compound useful for a cosmetic, showing excellent ultraviolet light absorbing action in a wide wavelength region, having excellent stability, light stability and oil solubility. CONSTITUTION:A compound of formula I (R and R are each a hydrocarbon). The compound is obtained by condensing 2,4,6-tri(4-formylphenoxy)-striazine of formula II with a malonate derivative of formula III in the presence of a catalyst (e.g. piperidine-acetic acid) in a solvent (e.g. benzene). Since the compound of formula I absorbs ultraviolet light in a wide wavelength region from UV-A to UV-B and is hardly decomposed with an amount of sunlight to which human is daily exposed, it hardly has an influence on skin caused by a decomposition product, etc. It has no problem in terms of stability, toxicity, irritation, etc. The compound of formula I has excellent affinity for other cosmetic bases and an ultraviolet light absorber and a cosmetic containing the compound of formula I show an excellent feeling of use and durability of ultraviolet light screening action.

公开(公告)号：JPH07330693A

公开(公告)日：1995-12-19

申请号：JP12874594

申请日：1994-06-10

Applicant: KAO CORP

Inventor： HOSHINO TADAHIDE ,  SUGIYAMA MITSURU ,  KAWAMATA AKIRA ,  JOKURA HIROKO ,  IMOKAWA GENJI

IPC: A61K8/00 ,  A61K8/40 ,  A61K8/41 ,  A61K8/46 ,  A61Q1/00 ,  A61Q1/12 ,  A61Q17/04 ,  C07C69/00 ,  C07C69/593 ,  C07C217/08 ,  C09K3/00 ,  A61K7/42

Abstract: PURPOSE:To obtain a benzalmalonate derivative which is excellent in hydrophilic properties, UV absorption and light stability, thus is useful as a starting material for cosmetics. CONSTITUTION:A benzalmalonate derivative of formula I (R and R are each a hydrocarbon; R -R are each an alkyl; A is an alkylene; n is 0-2) is allowed react with a quaternizing agent for an tertiary amino group to provide this derivative of formula II {Y' is formula III, formula IV [R is (CH2)pSO3 , (CH2)pCO2 , (p is 1-4); X is a halogen, an alkylsulfate, an alkylsulfonate, an arylsulfonate]}.