公开(公告)号：DE19704990A1

公开(公告)日：1997-08-21

申请号：DE19704990

申请日：1997-02-10

Applicant: KAO CORP

Inventor： HOSHINO MASAHIDE ,  SUGIYAMA MITSURU

IPC: A61K8/55 ,  A61K8/00 ,  A61K8/58 ,  A61K8/89 ,  A61Q1/00 ,  A61Q1/12 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/00 ,  C07F7/08 ,  C08G77/38 ,  C08L83/04 ,  C09K3/00 ,  A61K7/06 ,  A61K7/42 ,  C07F7/18 ,  C08G77/04 ,  C08G77/14

Abstract: Benzalmalonate derivative-modified organo(poly)siloxanes of formula (I) are new. R = hydrocarbyl; p = 0-3; R = hydrocarbyl (optionally containing O bonded to C or between two C); A,B = organo(poly)siloxane residues, or together complete an organo(poly)siloxane residue.

公开(公告)号：DE60229460D1

公开(公告)日：2008-12-04

申请号：DE60229460

申请日：2002-03-01

Applicant: KAO CORP

Inventor： HOSHINO MASAHIDE ,  SAITO HIROAKI ,  SUGAI YOSHIYA ,  SUGIYAMA MITSURU ,  NISHIZAWA YOSHINORI ,  KATAYAMA YASUSHI

IPC: A61K31/16 ,  A61Q19/00 ,  A61K8/42 ,  A61Q5/02 ,  A61Q17/00 ,  A61Q17/04

Abstract: The present invention relates to a composition for external application, containing a diamide derivative represented by the following formula (1) : (wherein R 1a and R 1b are the same or different and each represents a C 1-23 hydrocarbon group, R 2a and R 2b are the same or different and each represents a divalent C 1-6 hydrocarbon group, R 3 s are the same or different and each represents a divalent C 2-6 hydrocarbon group and n stands for 1 to 100). The composition for external application basically improves the water retaining ability and barrier functions of the horny layer, is excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.

公开(公告)号：HK1216081A1

公开(公告)日：2016-10-14

申请号：HK16104070

申请日：2016-04-11

Applicant: KAO CORP

Inventor： HORI TAKAAKI ,  HORIUCHI ARISA ,  SUGIYAMA MITSURU ,  NOMURA TOMOKO

IPC: A61K20060101 ,  A61Q20060101

公开(公告)号：EP2502931A4

公开(公告)日：2013-05-22

申请号：EP10831473

申请日：2010-11-08

Applicant: KAO CORP

Inventor： KAWASAKI AKIKO ,  SUGIYAMA MITSURU ,  AMANO YASUKO

IPC: C07J71/00 ,  A61K8/63 ,  A61Q19/02

CPC classification number: C07J71/0021 ,  A61K8/63 ,  A61K8/97 ,  A61Q19/02 ,  A61Q19/10

Abstract: An inhibitor of dopa oxidase activity containing a compound represented by the following Formula (1) as an active ingredient, and a skin-lightening agent containing the compound as an active ingredient: wherein R represents an acyl group having 1 to 5 carbon atom(s).

公开(公告)号：EP2444061A4

公开(公告)日：2015-08-05

申请号：EP10789173

申请日：2010-06-02

Applicant: KAO CORP

Inventor： SUGIYAMA MITSURU ,  KASAMATSU SHINYA

IPC: A61K8/49 ,  A61K8/34 ,  A61K9/00 ,  A61K9/08 ,  A61K31/055 ,  A61K31/353 ,  A61K47/10 ,  A61Q19/02

CPC classification number: A61Q19/02 ,  A61K8/347 ,  A61K8/498 ,  A61K9/0014 ,  A61K9/08 ,  A61K31/055 ,  A61K31/353 ,  A61K47/10 ,  A61K2300/00

Abstract: Provided is a composition which maintains apigenin stably. The present invention provides the composition containing apigenin at 3 ppm or more and dibutylhydroxytoluene, wherein the mass ratio of the content of apigenin relative to the content of dibutylhydroxytoluene is 1 or greater, or the pH value is less than 7. Also provided is a method for preparing an apigenin-containing composition, the method including combining 3 ppm or more of apigenin with dibutylhydroxytoluene so that the mass ratio of the content of apigenin relative to the content of dibutylhydroxytoleune is 1 or greater, or including adjusting the pH of the composition to a value less than 7.

公开(公告)号：EP2995294A4

公开(公告)日：2017-01-18

申请号：EP14794702

申请日：2014-05-09

Applicant: KAO CORP

Inventor： HORI TAKAAKI ,  HORIUCHI ARISA ,  SUGIYAMA MITSURU ,  NOMURA TOMOKO

IPC: A61K8/63 ,  A61K8/19 ,  A61K8/362 ,  A61K8/97 ,  A61Q19/10

CPC classification number: A61K8/362 ,  A61K8/63 ,  A61K8/97 ,  A61K2800/222 ,  A61Q19/10

Abstract: Provided is a bath agent composition capable of sufficiently exhibiting an effect of promoting blood circulation obtained by blending a carbonate and an organic acid, and enhancing appearance stability and skin feeling at the time of bathing. The bath agent composition comprises the following components (A), (B) and (C): (A) a total of 0.00001 mass% ormore and 0. 5 mass% or less of ginsenoside Rg3 and/or ginsenoside Rh2; (B) a carbonate comprising 30 mass% or more of a dialkali metal carbonate; and (C) an organic acid, wherein a mass ratio of ginsenosides Rb2, Rb1, Rc and Rd to ginsenosides Rg3 and Rh2 ((Rb2+Rb1+Rc+Rd)/(Rg3+Rh2)) is 0 or more and 30 or less.

公开(公告)号：JP2014237633A

公开(公告)日：2014-12-18

申请号：JP2014097273

申请日：2014-05-09

Applicant: 花王株式会社 ,  Kao Corp

Inventor： HORI TENMEI ,  HORIUCHI ARISA ,  SUGIYAMA MITSURU ,  NOMURA TOMOKO

IPC: A61K8/63 ,  A61K8/19 ,  A61K8/36 ,  A61Q19/10

CPC classification number: A61K8/362 ,  A61K8/63 ,  A61K8/97 ,  A61K2800/222 ,  A61Q19/10

Abstract: 【課題】炭酸塩及び有機酸の配合による血行促進効果を十分に発揮させつつ、外観上における安定性とともに入浴時における肌感触をも高めることができる浴用剤組成物に関する。【解決手段】次の成分(A)、(B)及び(C):(A)ジンセノシドRg3及び/又はジンセノシドRh2 合計で0.00001質量%以上0.5質量%以下、(B)炭酸塩中の炭酸ジアルカリ金属塩の含有量が30質量%以上である炭酸塩、及び(C)有機酸を含有し、ジンセノシドRb2、Rb1、Rc及びRdと、ジンセノシドRg3及びRh2の質量比((Rb2+Rb1+Rc+Rd)/(Rg3+Rh2))が0以上30以下である浴用剤組成物。【選択図】なし

Abstract translation: 要解决的问题：提供一种能够通过混合碳酸盐和有机酸充分增加血液循环促进作用，提供能够提高外观稳定性和改善洗浴中的皮肤触感的洗浴剂组合物。溶液：提供洗浴剂组合物 其包含以下组分（A），（B）和（C）：（A）人参皂甙Rg3和/或人参皂甙Rh2的总量的0.00001质量％以上且0.5质量％以下，（B） 碳酸酯中的二碱金属碳酸盐的含量为30mass％以上，（C）有机酸，其中人参皂甙Rb2的质量比（（Rb2 + Rb1 + Rc + Rd）/（Rg3 + Rh2） 人参皂苷Rg3和Rh2的Rb1，Rc和Rd为0以上且30以下。

公开(公告)号：JP2014024832A

公开(公告)日：2014-02-06

申请号：JP2013119681

申请日：2013-06-06

Applicant: Kao Corp ,  花王株式会社

Inventor： NOMURA TOMOKO ,  KUSUOKU HIROSHI ,  SUGIYAMA MITSURU ,  WATANABE MANABU

IPC: A61K31/704 ,  A61K31/575 ,  A61K31/7008 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/12 ,  A61P13/12 ,  A61P15/00 ,  A61P15/06 ,  A61P17/02 ,  A61P19/10 ,  A61P25/00 ,  A61P31/04 ,  C12N5/07

Abstract: PROBLEM TO BE SOLVED: To provide a material that can promote the CGRP (calcitonin gene-related peptide) responsiveness of cells.SOLUTION: A CGRP responsiveness promoter for cells includes a compound represented by formula (II) or optical isomer thereof as an active ingredient.

Abstract translation: 要解决的问题：提供可以促进CGRP（降钙素基因相关肽）对细胞的响应性的材料。解决方案：细胞的CGRP反应性启动子包括由式（II）表示的化合物或其旋光异构体作为活性成分 。

公开(公告)号：JP2013053077A

公开(公告)日：2013-03-21

申请号：JP2011190517

申请日：2011-09-01

Applicant: Kao Corp ,  花王株式会社

Inventor： KAWASAKI AKIKO ,  SUGIYAMA MITSURU ,  KIKUCHI MAMIKO

IPC: A61K8/60 ,  A61K8/49 ,  A61Q19/02

Abstract: PROBLEM TO BE SOLVED: To provide a skin whitening agent, a melanogenesis inhibitor and a dopa oxidase activity inhibitor, which have high safety.SOLUTION: A dopa oxidase activity inhibitor includes a compound represented by formula (I) or its salt as an active constituent.

Abstract translation: 要解决的问题：提供具有高安全性的皮肤增白剂，黑素生成抑制剂和多巴氧化酶活性抑制剂。 解决方案：多巴氧化酶活性抑制剂包括由式（I）表示的化合物或其盐作为活性成分。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2011001284A

公开(公告)日：2011-01-06

申请号：JP2009144399

申请日：2009-06-17

Applicant: Kao Corp ,  花王株式会社

Inventor： SUGIYAMA MITSURU ,  KASAMATSU SHINYA

IPC: A61K8/49 ,  A61K8/34 ,  A61Q19/02

Abstract: PROBLEM TO BE SOLVED: To provide a composition stably containing apigenin.SOLUTION: The composition contains not less than 3 ppm apigenin and dibutylhydroxytoluene and has a mass ratio of the apigenin to the dibutylhydroxytoluene of 1 or more. A method for producing an apigenin-containing composition comprises mixing not less than 3 ppm apigenin with dibutylhydroxytoluene so as for the mass ratio of the apigenin to the dibutylhydroxytoluene to come 1 or more.

Abstract translation: 要解决的问题：提供稳定含芹菜素的组合物。溶液：该组合物含有不少于3ppm芹菜素和二丁基羟基甲苯，并且芹菜素与二丁基羟基甲苯的质量比为1以上。 制备含芹菜素的组合物的方法包括将不少于3ppm的芹菜素与二丁基羟基甲苯混合，以使芹菜素与二丁基羟基甲苯的质量比达到1以上。