公开(公告)号：JPH01139572A

公开(公告)日：1989-06-01

申请号：JP20819088

申请日：1988-08-24

Applicant: MITSUI PHARMACEUTICALS ,  MITSUI PETROCHEMICAL IND

Inventor： AWAYA AKIRA ,  HORIGOME KAZUTOSHI ,  SASAKI TADAYUKI ,  KOBAYASHI AKIRA ,  MIZUCHI AKIRA ,  NAKANO TAKUO ,  TOMINO IKUO ,  ARAKI SHINTARO ,  TAKEI MITSUSACHI ,  KATOU KOUJI ,  YOKOYAMA KEIICHI

IPC: C07D239/48 ,  A61K31/505 ,  A61K31/535 ,  A61P25/00 ,  A61P25/02 ,  A61P25/28 ,  C07D401/04 ,  C07D487/04

Abstract: NEW MATERIAL:A compound expressed by formula I [X is NR R (R is H or alkyl; R is phenethyl, phenyl, piperidyl, alkyl, etc.) or SR (R is alkyl); Y is amino or mono- or dialkylamino; Z is methyl substituted by alkoxycarbonyl, alkoxycarbonyl or forms formula II (R is alkyl which may be substituted with an alkoxy) or formula III (R is alkyl) together with Y] or salt thereof together with Z. EXAMPLE:2-Isopropylamino-5,6-dihydro-7-methyl-6-oxo(7H)pyrolo[2,3-d] pyrimidine. USE:A treating agent for nerve disease of peripheral nervous system and central nervous system. PREPARATION:For example, a compound expressed by formula IV (R is alkyl) is reacted with an amine expressed by the formula R NH2 to provide the compound expressed by formula I (X is NR R ; Y and Z are formula II).

公开(公告)号：JPS6267077A

公开(公告)日：1987-03-26

申请号：JP20446385

申请日：1985-09-18

Applicant: MITSUI PETROCHEMICAL IND ,  MITSUI PHARMACEUTICALS

Inventor： YOKOYAMA KEIICHI ,  ONO HIROYASU ,  KATOU KOUJI ,  KITAHARA TAKUMI ,  NISHINA TAKASHI ,  WATANABE KAZUYUKI ,  SARUTA SAKAE ,  KUMAKURA MIKIO ,  AWAYA AKIRA ,  NAKANO TAKUO

IPC: C07D401/12 ,  A61K31/505 ,  A61K31/517 ,  A61P9/12 ,  C07D213/00 ,  C07D215/00 ,  C07D239/00 ,  C07D239/95 ,  C07D487/04

Abstract: NEW MATERIAL:The compound of formula I [Het is group of formula II (R is alkyl, cycloalkyl, OH-substituted lower alkyl, aralkyl, etc.), formula III (R and R are lower lakoxy, OH, lower alkylamino, etc.), formula IV, formula V, etc.] or its pharmacologically permissible salt. EXAMPLE:4-Amino-6, 7-dimethoxy-2-[ 4-( 2-methyl-3-oxo-2, 3-dihydro-1 H-pyrazolo[3,4- d]pyrimidin-6-yl) piperazino] quinazoline hydrochloride. USE:Medicine. Hypotensor. It has strong and long-acting hypotensive effect. The orthostatic hypotension which is an undesirable side effect caused by rapid lowering of blood tension is alleviated or suppressed almost completely in the present hypotensor. the agent is expected to have a remedying effect to cardiac insufficiency. PREPARATION:The objective compound of formula I can be produced by reacting the compound of formula IV with the compound of formula VII in a solvent such as isoamyl alcohol at 100-150 deg.C for 1-6 hr under refluxing.

公开(公告)号：JPH09309857A

公开(公告)日：1997-12-02

申请号：JP12669796

申请日：1996-05-22

Applicant: MITSUI PETROCHEMICAL IND

Inventor： KATOU KOUJI ,  TSUKAMOTO KOJI

IPC: B01J27/232 ,  C07B61/00 ,  C07C45/45 ,  C07C45/51 ,  C07C45/56 ,  C07C47/21 ,  C07C47/232

Abstract: PROBLEM TO BE SOLVED: To produce 4-unsaturated aldehydes useful as an intermediate for unsaturated alcohols, unsaturated carboxylic acids, saturated aldehydes, etc., in high yield by reacting enamines with specific olefins in the coexistence of an alkali metallic carbonate. SOLUTION: Compounds of formula I [R1 is H, an alkyl or an aryl; R2 and R3 are each a lower alkyl or an aryl; R2 and R3 may mutually be bonded together to form a ring (which may contain a hetero-atom such as N, O or S)] are brought into contact with a compound of formula II (R4 to R8 are each H, an alkyl or an aryl; X is a halogen or a sulfonate) and an alkali metallic carbonate to afford an unsaturated aldehyde of formula III. A compound of formula IV is preferred as the compound of formula I and a compound of formula V is preferred as the compound of formula II. For example, N,N- dimethyl-N-vinylamine is cited as the enamines of formula I and, e.g. acryloyl chloride is cited as the compound of formula II. For example, potassium carbonate is cited as the alkali metallic carbonate.

公开(公告)号：JPH06321930A

公开(公告)日：1994-11-22

申请号：JP11152393

申请日：1993-05-13

Applicant: MITSUI PETROCHEMICAL IND

Inventor： ISAYAMA SHIGERU ,  KATOU KOUJI ,  FUKUHARA HIROSHI ,  KUWABARA MASAHIRO

IPC: B01J23/40 ,  C07B61/00 ,  C07D307/33 ,  C07D309/30 ,  C07D313/00 ,  C07D313/04 ,  C07D313/16

Abstract: PURPOSE:To provide a method for producing lactones in which the lactones are obtained in high yield and separation thereof from a catalyst can readily be carried out while suppressing the formation of a cyclic ketone and an oxidation by-product of the lactones. CONSTITUTION:The characteristic of this method for producing lactones comprises catalytically reacting a mixture of a cyclic ketone with a >=2C aldehyde with an oxygen-containing gas in the presence of a solid catalyst supporting at least one noble metal.

公开(公告)号：JPH05163224A

公开(公告)日：1993-06-29

申请号：JP32867491

申请日：1991-12-12

Applicant: MITSUI PETROCHEMICAL IND

Inventor： MUKOYAMA MITSUAKI ,  YOROZU KIYOTAKA ,  KATOU KOUJI ,  YAMADA TORU

IPC: C07D207/16 ,  C07B61/00 ,  C07C231/02 ,  C07C231/12 ,  C07C231/18 ,  C07C237/04 ,  C07C237/22 ,  C07D295/18 ,  C07K5/062

Abstract: PURPOSE:To obtain the subject compound which is an optically active dipeptide, an optically active amino acid, etc., useful as a synthetic intermediate for medicines and agricultural chemicals according to simple operation by carrying out new reaction using an inexpensive and readily handleable samarium iodide as a reducing agent. CONSTITUTION:Samarium iodide expressed by the formula SmI2 is reacted with an oxime compound expressed by formula I (R to R are H, alkyl or aryl; R and R or R and R may mutually be bonded to form a ring) in the presence of an alcohol expressed by the ROH (R is hydrocarbon) to afford an amino group-containing compound expressed by formula II, which is then made to react, with an acyl halide compound expressed by the formula R X (R is acyl; X is halogen) to provide an amino group-containing compound expressed by formula III. N-(D)-Alanyl-(L)-proline methyl ester, N-(D)-alanyl-(L)- alanylpiperidinoamide, etc., are obtained by this method.

公开(公告)号：JPH02209855A

公开(公告)日：1990-08-21

申请号：JP3076489

申请日：1989-02-09

Applicant: MITSUI PETROCHEMICAL IND

Inventor： MUKOYAMA MITSUAKI ,  ISAYAMA SHIGERU ,  KATOU KOUJI ,  INOKI SATORU ,  YAMADA TORU ,  TAKAI TOSHIHIRO

IPC: C07D295/18 ,  C07C235/72

Abstract: NEW MATERIAL:A compound expressed by the formula (R , R and R are lower alkyl, R and R may form a ring directly or through O). EXAMPLE:1-dimethyl aminocarbamoyl-4,4-dimethyl-1,3-pentanedione. USE:Raw material of catalyst. Forms stable complex together with cobalt, has excellent oxidation activity and e.g. useful as catalyst in production of hydroxyl group-containing compound or ketone, etc., from olefins. PREPARATION:For instance, ethyl formate having carbamoyl group corresponding to R and R such as 1-morpholinocarbamoyl ethyl formate is reacted with acetone compound having alkyl group corresponding to R in the presence of alkali metal component substance to obtain alkali metal salt of beta-diketone compound. Then, said salt is neutralized by using mineral acid to afford a compound expressed by the formula.

公开(公告)号：JPH02157241A

公开(公告)日：1990-06-18

申请号：JP31359788

申请日：1988-12-12

Applicant: MITSUI PETROCHEMICAL IND

Inventor： MUKOYAMA MITSUAKI ,  ISAYAMA SHIGERU ,  KATOU KOUJI ,  INOKI SATORU ,  YAMADA TORU ,  TAKAI TOSHIHARU

IPC: C07C45/29 ,  B01J31/20 ,  C07B61/00 ,  C07C49/04 ,  C07C49/29 ,  C07C49/76

Abstract: PURPOSE:To enable easy production of ketones in high conversion and high yield by using a specific bis-cobalt complex as a catalyst to effect the oxidation reaction of a secondary alcohol with an oxygen-containing gas CONSTITUTION:In the presence of a cobalt complex catalyst of formula I [R , R , R , R are H, alkyl, aryl, perfluoroalkyl, CO2R (R is alkyl, aryl), CONR R (R , R are H, alkyl); R , R are H, alkyl, -COOR (R is H, alkyl), halogen] such as bis(2,4-pentanedionato)cobalt (II)], a secondary alcohol of formula II (R , R are alkyl, aryl, cycloalkyl, arylalkyl) such as 2-decanol is allowed to react with an oxygen-containing gas to give a ketone such as 2-decanone.