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公开(公告)号：US20140301986A1
公开(公告)日：2014-10-09
申请号：US14291256
申请日：2014-05-30
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
CPC classification number: A61K35/28 , A01N1/0221 , A61K35/50 , A61K38/1825 , A61K38/1841 , A61K38/39 , A61K38/57 , C12N5/0605 , C12N2500/02 , C12N2501/115 , C12N2502/025
Abstract: Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
Abstract translation: 本文提供了包含免疫兼容性绒毛膜的胎盘产品。 这样的胎盘产物可以冷冻保存并且解冻后含有可行的治疗细胞。 本发明的胎盘产品可用于通过将胎盘产品应用于损伤来治疗患有组织损伤（例如伤口或烧伤）的患者。 类似的应用可用于韧带和腱修复以及植入手术如骨移植。
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42.发明申请公开(公告)号：US20140140966A1
公开(公告)日：2014-05-22
申请号：US14069894
申请日：2013-11-01
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin Qiang Kuang , Jennifer Michelle Marconi
IPC: A61K35/50
CPC classification number: A61K35/28 , A01N1/0221 , A61K35/50 , A61K38/1825 , A61K38/1841 , A61K38/39 , A61K38/57 , C12N5/0605 , C12N2500/02 , C12N2501/115 , C12N2502/025
Abstract: Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
Abstract translation: 本文提供了包含免疫兼容性绒毛膜的胎盘产品。 这样的胎盘产物可以冷冻保存并且解冻后含有可行的治疗细胞。 本发明的胎盘产品可用于通过将胎盘产品应用于损伤来治疗患有组织损伤（例如伤口或烧伤）的患者。 类似的应用可用于韧带和腱修复以及植入手术如骨移植。
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公开(公告)号：US20140030309A1
公开(公告)日：2014-01-30
申请号：US13939981
申请日：2013-07-11
Applicant: Osiris Therapeutics, Inc.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
CPC classification number: A61L27/3612 , A61K35/32 , A61K38/014 , A61L27/24 , A61L27/3608 , A61L27/3654 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/3817 , A61L27/3852 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/64 , A61L2430/06
Abstract: This invention provides disrupted cartilage products, methods of manufacturing disrupted cartilage products, and methods of treating a subject comprising administering a cartilage product. The cartilage products are manufactured by a method comprising disrupting a collagen matrix, e.g. to produce a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
Abstract translation: 本发明提供破坏软骨产品，制造破坏性软骨产品的方法以及治疗受试者的方法，包括施用软骨产品。 软骨产品通过包括破坏胶原蛋白基质的方法制备。 以产生柔性软骨产品。 任选地，软骨产品包括活的软骨细胞，生物活性因子如软骨形成因子和II型胶原蛋白。 任选地，软骨产品是非免疫原性的。
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公开(公告)号：US12268797B2
公开(公告)日：2025-04-08
申请号：US17681064
申请日：2022-02-25
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
Abstract: This invention provides porated cartilage products and methods of producing porated cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
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45.发明公开公开(公告)号：US20240050482A1
公开(公告)日：2024-02-15
申请号：US18101727
申请日：2023-01-26
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
CPC classification number: A61K35/28 , A01N1/0221 , A61K35/50 , A61K38/1825 , A61K38/1841 , A61K38/39 , A61K38/57 , C12N5/0605 , C12N2500/02 , C12N2502/025 , C12N2501/115
Abstract: This invention provides a fluid therapeutic placental product comprising placental cells and a placental dispersion comprising placental factors. The placental cells and the placental dispersion are derived from placental tissue. A placental tissue can optionally be an amnion, chorion, or a trophoblast-depleted chorion. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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Patent Agency Ranking
公开(公告)号：US11590172B2
公开(公告)日：2023-02-28
申请号：US16296463
申请日：2019-03-08
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana YOo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：US11406735B2
公开(公告)日：2022-08-09
申请号：US14485210
申请日：2014-09-12
Applicant: Osiris Therapeutics, Inc.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
Abstract: This invention provides porated cartilage products and methods of producing porated cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
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公开(公告)号：US10828395B2
公开(公告)日：2020-11-10
申请号：US15298142
申请日：2016-10-19
Applicant: Osiris Therapeutics, Inc.
Inventor： Thomas E. Uveges , Jin-Qiang Kuang , Alla Danilkovitch , S. Michael Sinclair , Sandra D. Geraghty
Abstract: Provided herein is a bone repair composition that is composed of periosteum containing an angiogenic growth factor(s), cancellous bone chips containing viable osteogenic cells, and, optionally, demineralized bone matrix (DBM) chips. Also provided herein are articles of manufacture and methods of use thereof to treat bone defects.
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公开(公告)号：US10603174B2
公开(公告)日：2020-03-31
申请号：US15079867
申请日：2016-03-24
Applicant: Osiris Therapeutics, Inc.
Inventor： Alla Danilkovitch , Jinqiang Kuang , Steven Michael Sinclair
Abstract: Disclosed are compositions comprising a meniscal tissue. For example, disclosed are compositions comprising a meniscal tissue, wherein the meniscal tissue comprises one or more engineered channels. Disclosed are compositions comprising a meniscal tissue comprising viable cells native to the meniscal tissue and devitalized blood vessels. Disclosed are compositions comprising a previously cryopreserved meniscal tissue, wherein after cryopreservation and subsequent thawing the meniscal tissue comprises a) cells native to the meniscal tissue and greater than 30% of the cells are viable, b) extracellular matrix that is native to the meniscal tissue, c) one or more growth factors that are native to the meniscal tissue, and d) depleted amounts of one or more types of functional immunogenic cells. Also disclosed are methods of producing and using these compositions comprising meniscal tissue.
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公开(公告)号：US20200069739A1
公开(公告)日：2020-03-05
申请号：US16296475
申请日：2019-03-08
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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