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公开(公告)号：US20230128936A1
公开(公告)日：2023-04-27
申请号：US17971980
申请日：2022-10-24
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：US11510947B2
公开(公告)日：2022-11-29
申请号：US16736066
申请日：2020-01-07
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：US10994913B2
公开(公告)日：2021-05-04
申请号：US16279413
申请日：2019-02-19
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Yi Duan-Arnold , Alla Danilkovitch , Alexandra Gyurdieva , Jin-Qiang Kuang , Steven Michael Sinclair
IPC: B65D77/26 , B65D65/02 , B65D85/00 , B65B5/04 , B65B55/22 , A61F2/00 , A61F15/00 , A61F2/10 , A61B90/00
Abstract: A support assembly for supporting a biological product (e.g., membrane) in an operative position. The support assembly has a base and a cover. A membrane receiving portion of the base defines a plurality of perforations that extend between top and bottom surfaces of the product receiving portion. The cover is releasably coupled to the base in a product-covering position in which the cover overlies the product receiving portion of the base. In the operative position, the biological product engages the top surface of the product receiving portion and the bottom surface of the cover.
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公开(公告)号：US10272116B2
公开(公告)日：2019-04-30
申请号：US14172940
申请日：2014-02-05
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：US20150017222A1
公开(公告)日：2015-01-15
申请号：US14498394
申请日：2014-09-26
Applicant: Osiris Therapeutics, Inc.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
CPC classification number: A61L27/3612 , A61K35/32 , A61K38/014 , A61L27/24 , A61L27/3608 , A61L27/3654 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/3817 , A61L27/3852 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/64 , A61L2430/06
Abstract: This invention provides disrupted cartilage products, methods of manufacturing disrupted cartilage products, and methods of treating a subject comprising administering a cartilage product. The cartilage products are manufactured by a method comprising disrupting a collagen matrix, e.g. to produce a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
Abstract translation: 本发明提供破坏软骨产品，制造破坏性软骨产品的方法以及治疗受试者的方法，包括施用软骨产品。 软骨产品通过包括破坏胶原蛋白基质的方法制备。 以产生柔性软骨产品。 任选地，软骨产品包括活的软骨细胞，生物活性因子如软骨形成因子和II型胶原蛋白。 任选地，软骨产品是非免疫原性的。
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Patent Agency Ranking
公开(公告)号：US20140294777A1
公开(公告)日：2014-10-02
申请号：US14172940
申请日：2014-02-05
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
CPC classification number: A61K35/28 , A01N1/0221 , A61K35/50 , A61K38/1825 , A61K38/1841 , A61K38/39 , A61K38/57 , C12N5/0605 , C12N2500/02 , C12N2501/115 , C12N2502/025
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
Abstract translation: 本文提供了包含免疫兼容的羊膜的胎盘产品。 这样的胎盘产物可以冷冻保存并且解冻后含有可行的治疗细胞。 本发明的胎盘产品可用于通过将胎盘产品应用于损伤来治疗患有组织损伤（例如伤口或烧伤）的患者。 类似的应用可用于韧带和腱修复以及植入手术如骨移植。
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公开(公告)号：US11318168B2
公开(公告)日：2022-05-03
申请号：US15631707
申请日：2017-06-23
Applicant: Osiris Therapeutics, Inc.
Inventor： Steven Michael Sinclair , Alla Danilkovitch , Malathi Sathyamoorthy , Jin-Qiang Kuang , Sandeep Dhall , Yishan Liu , Anthony John Melchiorri , Matthew Robert Moorman , Mena Schiano Lo Moriello , Anne Allgood Lerch
IPC: A61K35/50 , A61K35/51 , A01N1/02 , A61K9/00 , A61K9/06 , A61K9/19 , A61K35/33 , A61P19/00 , A61P19/04 , A61P17/02 , A61P29/00 , A61P19/10 , A61P19/02 , A61L27/36 , A61L27/38 , A61L26/00
Abstract: Disclosed are compositions comprising a non-homogenized chorionic matrix, a homogenized amniotic matrix and a homogenized UC (UC) matrix, wherein the non-homogenized chorionic matrix comprises viable cells. Disclosed are methods of making the compositions disclosed herein comprising preparing a non-homogenized chorionic matrix, preparing a homogenized amniotic matrix, preparing a homogenized UC matrix, and combining the non-homogenized chorionic matrix, the non-homogenized chorionic matrix, and the homogenized UC matrix. Disclosed are methods of treating a tissue injury or chronic pain comprising administering any of the disclosed compositions to an area of a subject comprising a tissue injury.
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公开(公告)号：US11207353B2
公开(公告)日：2021-12-28
申请号：US16296475
申请日：2019-03-08
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：US20200281981A1
公开(公告)日：2020-09-10
申请号：US16736066
申请日：2020-01-07
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：US10729809B2
公开(公告)日：2020-08-04
申请号：US14849509
申请日：2015-09-09
Applicant: Osiris Therapeutics, Inc.
Inventor： Thomas E. Uveges , Jin-Qiang Kuang , Alla Danilkovitch , S. Michael Sinclair , Sandra D. Geraghty
Abstract: Provided herein is a bone repair composition that is composed of periosteum containing an angiogenic growth factor(s), cancellous bone chips containing viable osteogenic cells, and, optionally, demineralized bone matrix (DBM) chips. Also provided herein are articles of manufacture and methods of use thereof to treat bone defects.
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