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公开(公告)号：US11986498B2
公开(公告)日：2024-05-21
申请号：US14056101
申请日：2013-10-17
Applicant: Osiris Therapeutics, Inc.
Inventor： Timothy Jansen , Samson Tom , Alla Danilkovitch , Dana Yoo , Jaime Zerhusen
CPC classification number: A61K35/28 , A01N1/0221 , A61K35/50 , A61K38/1825 , A61K38/1841 , A61K38/39 , A61K38/57 , C12N5/0605 , C12N2500/02 , C12N2501/115 , C12N2502/025
Abstract: This invention provides a fluid therapeutic placental product comprising placental cells and a placental dispersion comprising placental factors. The placental cells and the placental dispersion are derived from placental tissue. A placental tissue can optionally be an amnion, chorion, or a trophoblast-depleted chorion. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：US20230128936A1
公开(公告)日：2023-04-27
申请号：US17971980
申请日：2022-10-24
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：US11510947B2
公开(公告)日：2022-11-29
申请号：US16736066
申请日：2020-01-07
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：US10994913B2
公开(公告)日：2021-05-04
申请号：US16279413
申请日：2019-02-19
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Yi Duan-Arnold , Alla Danilkovitch , Alexandra Gyurdieva , Jin-Qiang Kuang , Steven Michael Sinclair
IPC: B65D77/26 , B65D65/02 , B65D85/00 , B65B5/04 , B65B55/22 , A61F2/00 , A61F15/00 , A61F2/10 , A61B90/00
Abstract: A support assembly for supporting a biological product (e.g., membrane) in an operative position. The support assembly has a base and a cover. A membrane receiving portion of the base defines a plurality of perforations that extend between top and bottom surfaces of the product receiving portion. The cover is releasably coupled to the base in a product-covering position in which the cover overlies the product receiving portion of the base. In the operative position, the biological product engages the top surface of the product receiving portion and the bottom surface of the cover.
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公开(公告)号：US10272116B2
公开(公告)日：2019-04-30
申请号：US14172940
申请日：2014-02-05
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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Patent Agency Ranking
公开(公告)号：US20150017222A1
公开(公告)日：2015-01-15
申请号：US14498394
申请日：2014-09-26
Applicant: Osiris Therapeutics, Inc.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
CPC classification number: A61L27/3612 , A61K35/32 , A61K38/014 , A61L27/24 , A61L27/3608 , A61L27/3654 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/3817 , A61L27/3852 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/64 , A61L2430/06
Abstract: This invention provides disrupted cartilage products, methods of manufacturing disrupted cartilage products, and methods of treating a subject comprising administering a cartilage product. The cartilage products are manufactured by a method comprising disrupting a collagen matrix, e.g. to produce a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
Abstract translation: 本发明提供破坏软骨产品，制造破坏性软骨产品的方法以及治疗受试者的方法，包括施用软骨产品。 软骨产品通过包括破坏胶原蛋白基质的方法制备。 以产生柔性软骨产品。 任选地，软骨产品包括活的软骨细胞，生物活性因子如软骨形成因子和II型胶原蛋白。 任选地，软骨产品是非免疫原性的。
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7.发明申请公开(公告)号：US20150010506A1
公开(公告)日：2015-01-08
申请号：US14272339
申请日：2014-05-07
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Timothy Jansen , Samson Tom , Alla Danilkovitch , Dana Yoo , Jaime Zerhusen , Gabriele Putz Todd , Amy Elizabeth Johnson
CPC classification number: A61K35/50 , A01N1/0221 , A61K38/1754 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/193 , A61K38/212 , A61K38/22 , A61K38/57 , C12N5/0605 , C12N2501/115
Abstract: This invention provides a therapeutic placental composition comprising placental cells and other placental components derived from placental tissue. A cryopreserved placental composition is also provided. The placental compositions can be used to stimulate and promote angiogenesis, reduce inflammation, and to reduce scar formation, among others. The placental tissue can optionally be an amnion, chorion, a trophoblast-depleted chorion, umbilical cord, Wharton's jelly, placental cotyledon, and/or maternal decidua. The placental composition of the present invention is useful in treating a patient with a tissue injury (e.g., wound or burn) by applying the placental composition to the injury or in close proximity. Placental compositions may also be used to promote or increase regeneration of tissue. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
Abstract translation: 本发明提供包含胎盘细胞和源自胎盘组织的其它胎盘组分的治疗性胎盘组合物。 还提供了一种冷冻保存的胎盘组合物。 胎盘组合物可用于刺激和促进血管发生，减少炎症，并减少瘢痕形成等。 胎盘组织可以任选地是羊膜，绒毛膜，滋养层细胞的绒毛膜，脐带，沃顿的果冻，胎盘子叶和/或母体的蜕膜。 本发明的胎盘组合物可用于通过将胎盘组合物施用于损伤或紧邻来治疗患有组织损伤（例如伤口或烧伤）的患者。 胎盘组合物也可用于促进或增加组织再生。 类似的应用可用于韧带和腱修复以及植入手术如骨移植。
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公开(公告)号：US20140294777A1
公开(公告)日：2014-10-02
申请号：US14172940
申请日：2014-02-05
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
CPC classification number: A61K35/28 , A01N1/0221 , A61K35/50 , A61K38/1825 , A61K38/1841 , A61K38/39 , A61K38/57 , C12N5/0605 , C12N2500/02 , C12N2501/115 , C12N2502/025
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
Abstract translation: 本文提供了包含免疫兼容的羊膜的胎盘产品。 这样的胎盘产物可以冷冻保存并且解冻后含有可行的治疗细胞。 本发明的胎盘产品可用于通过将胎盘产品应用于损伤来治疗患有组织损伤（例如伤口或烧伤）的患者。 类似的应用可用于韧带和腱修复以及植入手术如骨移植。
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公开(公告)号：US20140037598A1
公开(公告)日：2014-02-06
申请号：US14056101
申请日：2013-10-17
Applicant: Osiris Therapeutics, Inc.
Inventor： Timothy Jansen , Samson Tom , Alla Danilkovitch , Dana Yoo , Jaime Zerhusen
CPC classification number: A61K35/28 , A01N1/0221 , A61K35/50 , A61K38/1825 , A61K38/1841 , A61K38/39 , A61K38/57 , C12N5/0605 , C12N2500/02 , C12N2501/115 , C12N2502/025
Abstract: This invention provides a fluid therapeutic placental product comprising placental cells and a placental dispersion comprising placental factors. The placental cells and the placental dispersion are derived from placental tissue. A placental tissue can optionally be an amnion, chorion, or a trophoblast-depleted chorion. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
Abstract translation: 本发明提供了包含胎盘细胞的流体治疗性胎盘产物和包含胎盘因子的胎盘分散体。 胎盘细胞和胎盘分散体来源于胎盘组织。 胎盘组织可以任选地是羊膜，绒毛膜或消化滋养层的绒毛膜。 本发明的胎盘产品可用于通过将胎盘产品应用于损伤来治疗患有组织损伤（例如伤口或烧伤）的患者。 类似的应用可用于韧带和腱修复以及植入手术如骨移植。
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公开(公告)号：US11318168B2
公开(公告)日：2022-05-03
申请号：US15631707
申请日：2017-06-23
Applicant: Osiris Therapeutics, Inc.
Inventor： Steven Michael Sinclair , Alla Danilkovitch , Malathi Sathyamoorthy , Jin-Qiang Kuang , Sandeep Dhall , Yishan Liu , Anthony John Melchiorri , Matthew Robert Moorman , Mena Schiano Lo Moriello , Anne Allgood Lerch
IPC: A61K35/50 , A61K35/51 , A01N1/02 , A61K9/00 , A61K9/06 , A61K9/19 , A61K35/33 , A61P19/00 , A61P19/04 , A61P17/02 , A61P29/00 , A61P19/10 , A61P19/02 , A61L27/36 , A61L27/38 , A61L26/00
Abstract: Disclosed are compositions comprising a non-homogenized chorionic matrix, a homogenized amniotic matrix and a homogenized UC (UC) matrix, wherein the non-homogenized chorionic matrix comprises viable cells. Disclosed are methods of making the compositions disclosed herein comprising preparing a non-homogenized chorionic matrix, preparing a homogenized amniotic matrix, preparing a homogenized UC matrix, and combining the non-homogenized chorionic matrix, the non-homogenized chorionic matrix, and the homogenized UC matrix. Disclosed are methods of treating a tissue injury or chronic pain comprising administering any of the disclosed compositions to an area of a subject comprising a tissue injury.
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