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公开(公告)号：US20150140057A1
公开(公告)日：2015-05-21
申请号：US14464123
申请日：2014-08-20
Applicant: Osiris Therapeutics, Inc.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
CPC classification number: A61L27/3612 , A61K35/32 , A61K38/014 , A61L27/24 , A61L27/3608 , A61L27/3654 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/3817 , A61L27/3852 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/64 , A61L2430/06
Abstract: This invention provides porated cartilage products, methods of producing porated cartilage products, and methods of treating subjects by administering cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
Abstract translation: 本发明提供了开放的软骨产品，生产门软骨产品的方法，以及通过施用软骨制品治疗受试者的方法。 任选地，软骨产品的尺寸，开口和消化以提供柔性软骨产品。 任选地，软骨产品包括活的软骨细胞，生物活性因子如软骨形成因子和II型胶原蛋白。 任选地，软骨产品是非免疫原性的。
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公开(公告)号：US20150017222A1
公开(公告)日：2015-01-15
申请号：US14498394
申请日：2014-09-26
Applicant: Osiris Therapeutics, Inc.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
CPC classification number: A61L27/3612 , A61K35/32 , A61K38/014 , A61L27/24 , A61L27/3608 , A61L27/3654 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/3817 , A61L27/3852 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/64 , A61L2430/06
Abstract: This invention provides disrupted cartilage products, methods of manufacturing disrupted cartilage products, and methods of treating a subject comprising administering a cartilage product. The cartilage products are manufactured by a method comprising disrupting a collagen matrix, e.g. to produce a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
Abstract translation: 本发明提供破坏软骨产品，制造破坏性软骨产品的方法以及治疗受试者的方法，包括施用软骨产品。 软骨产品通过包括破坏胶原蛋白基质的方法制备。 以产生柔性软骨产品。 任选地，软骨产品包括活的软骨细胞，生物活性因子如软骨形成因子和II型胶原蛋白。 任选地，软骨产品是非免疫原性的。
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公开(公告)号：US20220331485A1
公开(公告)日：2022-10-20
申请号：US17854688
申请日：2022-06-30
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
Abstract: A cryopreserved cartilage product is disclosed. The cryopreserved cartilage product can include a partially digested cryopreserved natural cartilage collagen matrix isolated from a subject. The collagen matrix can include viable cells embedded within the collagen matrix that are native to the collagen matrix and that were embedded in the collagen matrix when the collagen matrix was isolated from the subject, at least 70% of the embedded cells native to the collagen matrix can be viable in the cryopreserved cartilage product, and the partially digested collagen matrix can retain interaction between the collagen matrix and the native cells.
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公开(公告)号：US11413373B2
公开(公告)日：2022-08-16
申请号：US14498394
申请日：2014-09-26
Applicant: Osiris Therapeutics, Inc.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
Abstract: This invention provides disrupted cartilage products, methods of manufacturing disrupted cartilage products, and methods of treating a subject comprising administering a cartilage product. The cartilage products are manufactured by a method comprising disrupting a collagen matrix, e.g. to produce a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
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公开(公告)号：US20150004211A1
公开(公告)日：2015-01-01
申请号：US14485210
申请日：2014-09-12
Applicant: Osiris Therapeutics, Inc.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
IPC: A61K35/32
CPC classification number: A61L27/3612 , A61K35/32 , A61K38/014 , A61L27/24 , A61L27/3608 , A61L27/3654 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/3817 , A61L27/3852 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/64 , A61L2430/06
Abstract: This invention provides porated cartilage products and methods of producing porated cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
Abstract translation: 本发明提供了有价软骨产品和生产门软骨产品的方法。 任选地，软骨产品的尺寸，开口和消化以提供柔性软骨产品。 任选地，软骨产品包括活的软骨细胞，生物活性因子如软骨形成因子和II型胶原蛋白。 任选地，软骨产品是非免疫原性的。
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Patent Agency Ranking
公开(公告)号：US20140030309A1
公开(公告)日：2014-01-30
申请号：US13939981
申请日：2013-07-11
Applicant: Osiris Therapeutics, Inc.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
CPC classification number: A61L27/3612 , A61K35/32 , A61K38/014 , A61L27/24 , A61L27/3608 , A61L27/3654 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/3817 , A61L27/3852 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/64 , A61L2430/06
Abstract: This invention provides disrupted cartilage products, methods of manufacturing disrupted cartilage products, and methods of treating a subject comprising administering a cartilage product. The cartilage products are manufactured by a method comprising disrupting a collagen matrix, e.g. to produce a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
Abstract translation: 本发明提供破坏软骨产品，制造破坏性软骨产品的方法以及治疗受试者的方法，包括施用软骨产品。 软骨产品通过包括破坏胶原蛋白基质的方法制备。 以产生柔性软骨产品。 任选地，软骨产品包括活的软骨细胞，生物活性因子如软骨形成因子和II型胶原蛋白。 任选地，软骨产品是非免疫原性的。
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公开(公告)号：US12268797B2
公开(公告)日：2025-04-08
申请号：US17681064
申请日：2022-02-25
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
Abstract: This invention provides porated cartilage products and methods of producing porated cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
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公开(公告)号：US11406735B2
公开(公告)日：2022-08-09
申请号：US14485210
申请日：2014-09-12
Applicant: Osiris Therapeutics, Inc.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
Abstract: This invention provides porated cartilage products and methods of producing porated cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
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公开(公告)号：US20140017292A1
公开(公告)日：2014-01-16
申请号：US13939991
申请日：2013-07-11
Applicant: Osiris Therapeutics, Inc.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
CPC classification number: A61L27/3612 , A61K35/32 , A61K38/014 , A61L27/24 , A61L27/3608 , A61L27/3654 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/3817 , A61L27/3852 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/64 , A61L2430/06
Abstract: This invention provides porated cartilage products and methods of producing porated cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
Abstract translation: 本发明提供了有价软骨产品和生产门软骨产品的方法。 任选地，软骨产品的尺寸，开口和消化以提供柔性软骨产品。 任选地，软骨产品包括活的软骨细胞，生物活性因子如软骨形成因子和II型胶原蛋白。 任选地，软骨产品是非免疫原性的。
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公开(公告)号：US20140017283A1
公开(公告)日：2014-01-16
申请号：US13939969
申请日：2013-07-11
Applicant: Osiris Therapeutics, Inc.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
IPC: A61K35/32
CPC classification number: A61L27/3612 , A61K35/32 , A61K38/014 , A61L27/24 , A61L27/3608 , A61L27/3654 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/3817 , A61L27/3852 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/64 , A61L2430/06
Abstract: This invention provides porated cartilage products, methods of producing porated cartilage products, and methods of treating subjects by administering cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
Abstract translation: 本发明提供了开放的软骨产品，生产门软骨产品的方法，以及通过施用软骨制品治疗受试者的方法。 任选地，软骨产品的尺寸，开口和消化以提供柔性软骨产品。 任选地，软骨产品包括活的软骨细胞，生物活性因子如软骨形成因子和II型胶原蛋白。 任选地，软骨产品是非免疫原性的。
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