公开(公告)号：BRPI0512379A

公开(公告)日：2008-03-11

申请号：BRPI0512379

申请日：2005-06-22

Applicant: SOLVAY PHARM GMBH

Inventor： ZIEGLER DIETER ,  WITTE KLAUS ,  STRAUB MATTHIAS ,  FISCHER YVAN ,  THORMAEHLEN DIRK ,  HOELTJE DAGMAR

IPC: A61K31/00 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/55 ,  A61K45/06 ,  A61P9/00 ,  A61P9/12

公开(公告)号：PL195283B1

公开(公告)日：2007-08-31

申请号：PL35016700

申请日：2000-02-10

Applicant: SOLVAY PHARM GMBH

Inventor： WILKINS MARTIN R ,  THORMAEHLEN DIRK ,  WALDECK HARALD

IPC: A61K31/55 ,  C07D223/16 ,  A61P9/00 ,  A61P9/12

Abstract: The present invention relates to the use of benzazepine-N-acetic acid derivatives which contain an oxo-group in the alpha-position to the nitrogen atom and are substituted in position 3 by a 1-(carboxyalkyl)cyclo-entylcarbonylamino radical, and their salts and biolabile esters for the treatment of hypertension, particularly for the treatment of certain forms of secondary hypertension, in larger mammals and particularly humans, and for the production of pharmaceutical compositions suitable for this treatment. The cause of the hypertension to be treated may have a wide variety of origins. The invention particularly relates to the treatment of those forms of secondary hypertension which may occur as a result of various non-cardiac diseases.

公开(公告)号：HK1096293A1

公开(公告)日：2007-06-01

申请号：HK07103420

申请日：2007-03-30

Applicant: SOLVAY PHARM GMBH

Inventor： BAUM DOMINIQUE ,  BIELENBERG G-W ,  BOEDECKER BERND ,  THORMAEHLEN DIRK

IPC: A61K20090101 ,  A61K31/4172 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/506 ,  A61K45/06 ,  A61P20090101

Abstract: Pharmaceutical compositions containing selective imidazoline receptor agonists combined with angiotensin II receptor blockers, particularly, pharmaceutical compositions containing Moxonidine and Eprosartan mesylate, as well as the use of such compositions for the treatment of hypertension, especially in hypertensive patients suffering from type II diabetes or susceptible to developing type II diabetes.

公开(公告)号：AU2004290925A1

公开(公告)日：2005-06-02

申请号：AU2004290925

申请日：2004-11-15

Applicant: SOLVAY PHARM GMBH

Inventor： WALDECK HARALD ,  THORMAEHLEN DIRK ,  HOCHER BERTHOLD

IPC: A61K31/55

公开(公告)号：HU0105491A2

公开(公告)日：2002-06-29

申请号：HU0105491

申请日：2000-02-10

Applicant: SOLVAY PHARM GMBH

Inventor： THORMAEHLEN DIRK ,  WALDECK HARALD ,  WILKINS MARTIN R

IPC: C07D223/16 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12

Abstract: The present invention relates to the use of benzazepine-N-acetic acid derivatives which contain an oxo-group in the alpha-position to the nitrogen atom and are substituted in position 3 by a 1-(carboxyalkyl)cyclo-entylcarbonylamino radical, and their salts and biolabile esters for the treatment of hypertension, particularly for the treatment of certain forms of secondary hypertension, in larger mammals and particularly humans, and for the production of pharmaceutical compositions suitable for this treatment. The cause of the hypertension to be treated may have a wide variety of origins. The invention particularly relates to the treatment of those forms of secondary hypertension which may occur as a result of various non-cardiac diseases.

公开(公告)号：NO20013958L

公开(公告)日：2001-10-15

申请号：NO20013958

申请日：2001-08-15

Applicant: SOLVAY PHARM GMBH

Inventor： WILKINS MARTIN R ,  THORMAEHLEN DIRK ,  WALDECK HARALD

IPC: C07D223/16 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12 ,  A61D9/12

Abstract: The present invention relates to the use of benzazepine-N-acetic acid derivatives which contain an oxo-group in the alpha-position to the nitrogen atom and are substituted in position 3 by a 1-(carboxyalkyl)cyclo-entylcarbonylamino radical, and their salts and biolabile esters for the treatment of hypertension, particularly for the treatment of certain forms of secondary hypertension, in larger mammals and particularly humans, and for the production of pharmaceutical compositions suitable for this treatment. The cause of the hypertension to be treated may have a wide variety of origins. The invention particularly relates to the treatment of those forms of secondary hypertension which may occur as a result of various non-cardiac diseases.

公开(公告)号：NO20013958D0

公开(公告)日：2001-08-15

申请号：NO20013958

申请日：2001-08-15

Applicant: SOLVAY PHARM GMBH

Inventor： WILKINS MARTIN R ,  THORMAEHLEN DIRK ,  WALDECK HARALD

IPC: C07D223/16 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12 ,  A61K

Abstract: The present invention relates to the use of benzazepine-N-acetic acid derivatives which contain an oxo-group in the alpha-position to the nitrogen atom and are substituted in position 3 by a 1-(carboxyalkyl)cyclo-entylcarbonylamino radical, and their salts and biolabile esters for the treatment of hypertension, particularly for the treatment of certain forms of secondary hypertension, in larger mammals and particularly humans, and for the production of pharmaceutical compositions suitable for this treatment. The cause of the hypertension to be treated may have a wide variety of origins. The invention particularly relates to the treatment of those forms of secondary hypertension which may occur as a result of various non-cardiac diseases.

公开(公告)号：HU9802517A2

公开(公告)日：1999-09-28

申请号：HU9802517

申请日：1998-11-02

Applicant: SOLVAY PHARM GMBH

Inventor： MEIL JOERG ,  THORMAEHLEN DIRK ,  WALDECK HARALD ,  WURL MICHAEL

IPC: A61K31/675 ,  A61K31/00 ,  A61K31/55 ,  A61K38/00 ,  A61K38/05 ,  A61P9/00 ,  A61P9/04 ,  A61P9/12 ,  C07D223/16 ,  C07F9/38 ,  C07F9/40 ,  C07F9/553 ,  C07K5/06

Abstract: 3-(1-Phosphonomethyl-cyclopentane-1-carbonylamino)-2,3,4,5-tetrahydro- 2-oxo-1H-1-benzazepine-1-acetic acid derivatives (I) are new. Benzazepine derivatives of formula (I) and their salts are new: R1-R3 = H or biolabile ester residue. An Independent claim relates to the preparation of (I).

公开(公告)号：HU9802517D0

公开(公告)日：1998-12-28

申请号：HU9802517

申请日：1998-11-02

Applicant: SOLVAY PHARM GMBH

Inventor： MEIL JOERG ,  THORMAEHLEN DIRK ,  WALDECK HARALD ,  WURL MICHAEL

IPC: A61K31/675 ,  A61K31/00 ,  A61K31/55 ,  A61K38/00 ,  A61K38/05 ,  A61P9/00 ,  A61P9/04 ,  A61P9/12 ,  C07D223/16 ,  C07F9/38 ,  C07F9/40 ,  C07F9/553 ,  C07K5/06

Abstract: 3-(1-Phosphonomethyl-cyclopentane-1-carbonylamino)-2,3,4,5-tetrahydro- 2-oxo-1H-1-benzazepine-1-acetic acid derivatives (I) are new. Benzazepine derivatives of formula (I) and their salts are new: R1-R3 = H or biolabile ester residue. An Independent claim relates to the preparation of (I).

公开(公告)号：DE602004010172D1

公开(公告)日：2007-12-27

申请号：DE602004010172

申请日：2004-11-15

Applicant: SOLVAY PHARM GMBH

Inventor： THORMAEHLEN DIRK ,  HOCHER BERTHOLD ,  WALDECK HARALD

IPC: A61K31/55 ,  A61P13/12 ,  A61P43/00