公开(公告)号：JP2006020524A

公开(公告)日：2006-01-26

申请号：JP2004199122

申请日：2004-07-06

Applicant: Sony Corp ,  ソニー株式会社

Inventor： YAMAMOTO TAKUO ,  SOMA ATSUHIKO ,  MAMINE TAKAYOSHI ,  TAKUMI TORU ,  NAKAHATA YASUKAZU

IPC: C12N15/09 ,  C12M1/00 ,  C12Q1/68 ,  G01N33/53 ,  G01N37/00

CPC classification number: C07K14/4702

Abstract: PROBLEM TO BE SOLVED: To provide an expression timing and expressing order of a circadian rhythm-regulating gene group in a normal time, a method for detecting the irregularity of the circadian rhythm by using the expression timing and expressing order and further, a method of screening by using the expression timing and expressing order. SOLUTION: This circadian rhythm-regulating gene group (Bmal1 gene, Npas2 gene, Rev-erbα gene, Dbp gene, Per3 gene, Per2 gene and Per1 gene) having a prescribed expression timing and expressing order in the normal time is provided. Also, a DNA chip arranged at least with the circadian rhythm-regulating gene group is provided. Further, a method for forecasting the irregularity of the expression timing of the circadian rhythm-regulating gene group, a method for detecting the irregularity of the circadian rhythm, a method for selecting a circadian rhythm-adjusting agent, a method for screening the circadian rhythm-adjusting agent and a method for screening a substance accompanied with the irregularity of the circadian rhythm as an adverse effect, by using the DNA chip are provided. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 待解决的问题：为了在正常时间提供昼夜节律调节基因组的表达定时和表达顺序，通过使用表达定时和表达顺序来检测昼夜节律的不规则性的方法， 通过使用表达时间和表达顺序进行筛选的方法。 解决方案：提供具有规定的表达时间并在正常时间表达顺序的这种昼夜节律调节基因组（Bmal1基因，Npas2基因，Rev-erbα基因，Dbp基因，Per3基因，Per2基因和Per1基因） 。 此外，提供了至少与昼夜节律调节基因组排列的DNA芯片。 另外，用于预测昼夜节律调节基因组的表达时机的不规则性的方法，用于检测昼夜节律的不规则性的方法，选择昼夜节律调节剂的方法，筛选昼夜节律的方法 提供了调整剂和通过使用DNA芯片筛选伴有昼夜节律不规则的物质作为不利影响的方法。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2005345365A

公开(公告)日：2005-12-15

申请号：JP2004167404

申请日：2004-06-04

Applicant: Sony Corp ,  ソニー株式会社

Inventor： IIDA TOMOKO ,  SEGAWA YUJI ,  ONISHI MICHIHIRO ,  MAMINE TAKAYOSHI

IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  G01N27/00 ,  G01N27/447 ,  G01N37/00

Abstract: PROBLEM TO BE SOLVED: To achieve the enhancement of the efficiency (speedup) of hybridization and the enhancement of the detection precision of hybridization under a condition using electrodynamic technique. SOLUTION: The bioassay method is constituted so that an electric field is applied to a reaction field 2 wherein detecting nucleic acid D, target nucleic acid T having a complementary base sequence with respect to detecting nucleic acid D and mismatch nucleic acid M having an unproper base in the complementary base sequence are mixed to predominantly advance the normal hybridization H 1 between detecting nucleic acid D and target nucleic acid T. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：在使用电动力学技术的条件下，实现杂交效率（加速）的提高和杂交检测精度的提高。 解决方案：生物测定方法构成为使得电场施加到反应场2，其中检测核酸D，相对于检测核酸D具有互补碱基序列的靶核酸T和具有错配核酸M的核酸 在互补碱基序列中的非完全碱基被混合以主要推进检测核酸D和靶核酸T之间的正常杂交H SB SBI。（C）2006，JPO和NCIPI

公开(公告)号：JP2005149196A

公开(公告)日：2005-06-09

申请号：JP2003386708

申请日：2003-11-17

Applicant: Sony Corp ,  ソニー株式会社

Inventor： YAMAMOTO TAKUO ,  MAMINE TAKAYOSHI ,  YAMADA TAKAYUKI

IPC: C12N15/00 ,  G06F19/00 ,  G06F19/12 ,  G06F19/26

Abstract: PROBLEM TO BE SOLVED: To facilitate understanding of interaction mechanism and metabolic system of biological material. SOLUTION: A visualization method for biological material is disclosed in which a computer system is used to display information on the biological material such as genes and protein on a computer display picture and visualize the information. wherein on the basis of classification information for each biological material stored in a storage means beforehand which constitutes the computer system, the biological material belonging to the same classification and the interaction among the biological materials are displayed on the same layer on the computer display screen. COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：促进对生物材料的相互作用机制和代谢系统的理解。 解决方案：公开了一种用于生物材料的可视化方法，其中使用计算机系统在计算机显示图像上显示诸如基因和蛋白质的生物材料的信息并且可视化信息。 其特征在于，根据预先构成计算机系统的存储装置中存储的每种生物材料的分类信息，将属于相同分类的生物材料和生物材料之间的相互作用显示在计算机显示屏上的同一层上。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2005114603A

公开(公告)日：2005-04-28

申请号：JP2003350553

申请日：2003-10-09

Applicant: Sony Corp ,  ソニー株式会社

Inventor： SEGAWA YUJI ,  YUBI HIROSHI ,  MAMINE TAKAYOSHI ,  SAKAMOTO YASUHIRO

IPC: G01N33/53 ,  C12M1/00 ,  C12N15/09 ,  G01N33/566 ,  G01N37/00

Abstract: PROBLEM TO BE SOLVED: To supply an aqueous solution to a minute reaction region that is a field for detecting the interaction between substances, and to prevent the evaporation of the aqueous solution.
SOLUTION: The detection part of the interaction between substances is constituted so as to provide a reaction region 11 that is a field for detecting the interaction between substances and the detection part 1 for the interaction between the substances equipped with at least water absorbable gel G housed in the reaction region 11 and electrodes 12 and 13 arranged in opposed relation to the reaction region 11 to arrange the detection part 1.
COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：将水溶液供给到作为用于检测物质之间的相互作用的场的微小反应区域，并且防止水溶液的蒸发。 解决方案：物质之间的相互作用的检测部分构成为提供反应区域11，反应区域11是用于检测物质与检测部分1之间的相互作用的场，用于至少配备吸水性物质 凝胶G容纳在反应区域11中，电极12和13与反应区域11相对设置，以布置检测部分1.版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2005110539A

公开(公告)日：2005-04-28

申请号：JP2003346779

申请日：2003-10-06

Applicant: Sony Corp ,  ソニー株式会社

Inventor： MATSUMOTO SAYOKO ,  MAMINE TAKAYOSHI ,  WASHIZU MASAO ,  KUROSAWA OSAMU

IPC: G01N33/53 ,  C12M1/00 ,  C12N15/00 ,  C12N15/09 ,  C12Q20060101 ,  C12Q1/68 ,  G01N37/00

CPC classification number: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6832 ,  C12Q2523/301 ,  C12Q2523/307

Abstract: PROBLEM TO BE SOLVED: To verify the action of a high frequency AC electric field on a single strand nucleic acid existing in an aqueous solution never containing an ingredient such as a nucleic acid material, an enzyme, or a primer for synthesizing DNA, and to use the action for improving the efficiency of a hybridization using the single strand nucleic acid as a complementary chain for the other nucleic acid.
SOLUTION: This method for elongating the single strand nucleic acid, comprises making a high frequency AC electric field to act on a single strand nucleic acid existing in pure water or an aqueous solution (R) of pH 15 to 11, or a single strand nucleic acid immobilized on the surface or surfaces (f) of one or both of counter electrodes (E, E) adjacently disposed to the aqueous solution (R). And an apparatus for elongating the single strand nucleic acid, and the like are provided.
COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：为了验证高频AC电场对存在于不含有诸如用于合成DNA的核酸材料，酶或引物的成分的水溶液中的单链核酸的作用 并且使用该作用来提高使用单链核酸作为其它核酸的互补链的杂交效率。 解决方案：用于延长单链核酸的方法包括使高频AC电场作用于存在于纯水或pH 15至11的水溶液（R）中的单链核酸，或 单链核酸固定在相邻设置于水溶液（R）的相对电极（E，E）中的一个或两个的表面或表面（f）上。 并且提供了用于延长单链核酸的装置等。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2004135512A

公开(公告)日：2004-05-13

申请号：JP2002300924

申请日：2002-10-15

Applicant: Sony Corp ,  ソニー株式会社

Inventor： SEGAWA YUJI ,  MAMINE TAKAYOSHI

IPC: G01N33/483 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/68 ,  G01N27/00 ,  G01N27/416 ,  G01N27/447 ,  G01N33/53 ,  G01N37/00

CPC classification number: G01N27/3276

Abstract: PROBLEM TO BE SOLVED: To improve the hybridization efficiency by adopting a device so as to arrange and fix a nucleotide chain for sensing an elongated state.
SOLUTION: A hybridization sensing part 1a, etc., are composed so as to fix a reaction region R to be a site for hybridization between a nucleotide chain X for sensing and a target nucleotide chain Y having a base sequence complementary to the nucleotide chain X for sensing to an end of a scanning electrode C by dielectrophoretic actions while elongating the nucleotide chain X for sensing with an electric field. Thereby, a sensor chip equipped with the sensing part 1a, etc. and a method for hybridization using the hybridization sensing part and sensor chip are provided.
COPYRIGHT: (C)2004,JPO

公开(公告)号：JPH10260300A

公开(公告)日：1998-09-29

申请号：JP6329497

申请日：1997-03-17

Applicant: AGENCY IND SCIENCE TECHN ,  SONY CORP ,  OGAKI HIDEAKI

Inventor： OGAKI HIDEAKI ,  MAMINE TAKAYOSHI

IPC: G21K5/02 ,  H01L21/027

Abstract: PROBLEM TO BE SOLVED: To provide an optical device that can obtain more or the order of 10 photons with shortened wavelengths by the collision of an electron beam and a laser beam and easily obtain an electromagnetic wave (ultraviolet rays) with a desired wavelength. SOLUTION: An optical device is equipped with an electron beam source consisting of a linear accelerator 10 and a laser light source 20. The optical device gives the energy possessed by electrons in an electron beam to photons in a laser beam by colliding the electrons in the electron beam emitted from the electron beam source and moving at a relativistic velocity with the photons in the laser beam emitted from the laser light source 20 in order to shorten a wavelength of scattered light. When the cross sectional area of the colliding electron beam or laser beam, whichever is larger, is set at A (unit: cm ), A should satisfy 1×10 .

公开(公告)号：JPS6397030A

公开(公告)日：1988-04-27

申请号：JP24224286

申请日：1986-10-13

Applicant: SONY CORP

Inventor： MAMINE TAKAYOSHI ,  YONEYAMA OSAMU ,  OTOBE TAKASHI

IPC: H04B10/60 ,  H01S5/06 ,  H04B10/2507 ,  H04B10/40 ,  H04B10/50

Abstract: PURPOSE:To obtain a stable digital communication and to evade the degrading in the reliability and service life of a laser diode by using a laser diode whose optical output-current characteristic has a super linear characteristic area for a light emitting element. CONSTITUTION:As the light emitting element, a gain guide type semiconductor laser diode is constituted by using the laser diode whose optical output-current L-I characteristic curve shown by the full line curve 1 of the figure has the super linear characteristic area. This means that a current limited area is provided for that a current collectively flows within the oscillation area of an active layer. In this case, as the degree of light excitation increases, a dip in gain occurs in a gain distribution curve 3A. As a result, a virtually positive refraction factor distribution is generated in the middle of a refraction distribution curve 3B, accordingly, the light shifts to a wave-guided state from a non- wave-guided state, and thus the super linear characteristic area in which the optical output is increased in proportion to the aggregation of input current. Since the modulation is executed by using this area, the degrading of differential efficiency can be improved, therefore, the temperature rise is suppressed, as a result, the life and the reliability of the titled equipment can be improved.

公开(公告)号：JPS62137892A

公开(公告)日：1987-06-20

申请号：JP27977185

申请日：1985-12-12

Applicant: SONY CORP

Inventor： MAMINE TAKAYOSHI ,  ODA TATSUJI ,  IMAI TOSHIHIRO

IPC: H01L21/265 ,  H01S5/00

Abstract: PURPOSE:To obtain a semiconductor device which is long-lived and has uniform characteristics by forming a non-current injection region by ion-implanting one of He, Be, Li and B in the semiconductor. CONSTITUTION:The formation of a non-current region for a semiconductor, such as a GaAs compound semiconductor, is formed by ion-implanting at least one kind out of the following specified light elements other than without using protons: helium He, beryllium Be, lithium Li and boron B: When this forming technigue applies to a gain guide type semiconductor laser of a stripe structure, an N-type AlxGa1-xAs first clad layer 2 and a P-type or N-type AlyGa1-yAs active layer, for example, and moreover, a P-type AlxGa10xAs second clad layer 4 and a P low-resistivity cap layer 5 are epitaxially grown in order on an N-type GaAs substrate 1 and the active layer and thereafter, a metal masking layer or a mask 20 of wire or so on to be extended in one direction is arranged on the cap layer 5 and boron B is implanted with a specific accelerating energy in such a depth that it intrudes from a top of the cap layer 5 into part of the thickness of the second clad layer 4.

公开(公告)号：JPS59154089A

公开(公告)日：1984-09-03

申请号：JP2837983

申请日：1983-02-22

Applicant: Sony Corp

Inventor： MAMINE TAKAYOSHI ,  YONEYAMA OSAMU

IPC: H01S5/00 ,  H01S5/042 ,  H01S5/10 ,  H01S5/16 ,  H01S5/20 ,  H01S5/22

CPC classification number: H01S5/20 ,  H01S5/10 ,  H01S5/1064 ,  H01S5/16 ,  H01S5/22 ,  H01S2301/185

Abstract: PURPOSE: To contrive to improve the astigmatism, threshold current, etc. by increasing or reducing the stripe width S
1 and then reducing the width S
2 , in a planar stripe structure wherein said width is S
1 at a distance from an optical end surface and S
2 at the optical end surface, and varies gently therebetween.
CONSTITUTION: Each semiconductor layer is epitaxially grown on a GaAs substrate 1. For the pattern of the electrode window 7a of an insulation layer 7, the widths S
1 and S
2 are joined to each other with a tapered part 13. When the distance to the imaginary light source of a light parallel with a junction surface from the optical end surface 12 is D, the curvature radius of the cophasal surface of an emitted light is R, and the half power width of the near field image of light at said surface 12 is W, D becomes maximum at some value of R with W as the parameter; therefore the larger the parameter W, the larger the distance D. Besides, the larger the width S
1 almost independently, the larger the radius R, and the larger the width S
2 , the larger the parameter W. Accordingly, S
1 is set large or small with the maximum value as a boundary, and S
2 small, R large, and W small, in order to reduce D. Thereby, the threshold current, astigmatism, etc. improve.
COPYRIGHT: (C)1984,JPO&Japio

Abstract translation: 目的：通过增加或减少条纹宽度S1并随后减小宽度S2来改进散光，阈值电流等，其平面条纹结构中，其中所述宽度为距离光学端面一定距离的S1，而S2 光学端面，并且在它们之间轻微变化。 构成：在GaAs衬底1上外延生长每个半导体层。对于绝缘层7的电极窗口7a的图案，宽度S1和S2通过锥形部分13彼此接合。当到虚拟的距离 与光端面12的接合面平行的光的光源为D，发射光的相面的曲率半径为R，所述表面12的光的近场像的半功率宽度为 W，D在某些R值为最大值，W为参数; 因此，参数W越大，距离D越大。此外，宽度S1几乎独立地越大，半径R越大，宽度S2越大，参数W越大。因此，S1设定为大或小 以最大值作为边界，S2为小，R大，W为小，以减少D.因此，阈值电流，像散等提高。