公开(公告)号：WO2005033326A3

公开(公告)日：2005-05-19

申请号：PCT/JP2004015094

申请日：2004-10-06

Applicant: SONY CORP ,  MATSUMOTO SAYOKO ,  MAMINE TAKAYOSHI ,  WASHIZU MASAO ,  KUROSAWA OSAMU

Inventor： MATSUMOTO SAYOKO ,  MAMINE TAKAYOSHI ,  WASHIZU MASAO ,  KUROSAWA OSAMU

IPC: G01N33/53 ,  C12M1/00 ,  C12N15/00 ,  C12N15/09 ,  C12Q20060101 ,  C12Q1/68 ,  G01N37/00

CPC classification number: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6832 ,  C12Q2523/301 ,  C12Q2523/307

Abstract: The action of high-frequency AC electric field on a single-stranded nucleic acid being present in an aqueous solution is verified, and the action is utilized for enhancement of the efficiency of hybridization for conversion of the single-stranded nucleic acid to a companion complementary strand. There are provided, for example, a method of nucleic acid extension and nucleic acid extending apparatus, wherein high-frequency AC electric field is applied to a single-stranded nucleic acid being present in liberated form in pure water or an aqueous solution of 5 to 11 pH (R), or to a single-stranded nucleic acid fixed onto the surface (f) of one or both (E) of counter electrodes (E,E) provided so as to face the aqueous solution (R), thereby extending the single-stranded nucleic acid.

Abstract translation: 证实了高频AC电场对存在于水溶液中的单链核酸的作用，并且该作用被用于提高单链核酸转化为伴侣互补的杂交效率 链。 例如，提供了一种核酸延伸和核酸延伸装置的方法，其中将高频AC电场施加到以游离态形式存在的单链核酸在纯水或5至 （或E）对电极（E，E）的一个或两个表面（f）上固定的单链核酸，以便面对水溶液（R），从而延伸 单链核酸。

公开(公告)号：DE60329384D1

公开(公告)日：2009-11-05

申请号：DE60329384

申请日：2003-05-21

Applicant: SONY CORP

Inventor： MAMINE TAKAYOSHI ,  YAMAMOTO TAKURO

IPC: G01N33/53 ,  C12Q1/68 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N33/543 ,  G01N37/00

Abstract: Disclosed is a bioassay method in which, by controlling the electric field formation in the reaction region where an interaction between substances, such as a hybridization, is performed, the efficiency of the interaction can be improved. Also disclosed is a bioassay apparatus in which the method can be favorably carried out. In the method, an interaction between substances is detected by a detecting element 1 (10), the detecting element including at least a detection surface S (S') which is surface-treated for immobilizing a detecting substance D, a reaction region R (R') which provides a field for interaction between the detecting substance D immobilized on the detection surface S (S') and a target substance T, and an electric field-forming means E which forms an electric field in the reaction region R (R') by applying a potential difference in the reaction region R (R'), and the method includes at least a step of turning on/off the electric field formation by the electric field-forming means E at a predetermined timing.

公开(公告)号：FR2568064A1

公开(公告)日：1986-01-24

申请号：FR8511015

申请日：1985-07-18

Applicant: SONY CORP

Inventor： MAMINE TAKAYOSHI ,  OKADA TSUNEKAZU ,  CHIBA MICHIRO

IPC: H01S5/00 ,  H01S5/223 ,  H01S3/18

Abstract: A semiconductor laser comprises a substrate (31) in which there are formed, in turn, a first cladding layer (32), an active layer (33), a second cladding layer (34) and a light absorbing layer (35) for limiting a current path and for absorbing light emitted from the active layer (33). The light absorbing layer (35) is provided with a stripe-shaped removed portion (35a) for forming the current path. The width (W) of the removed portion (35a) is selected to be in a range of from 1 to 4 microns, the thickness (d1) of the active layer (33) is selected to be not less than approximately 500 Angstroms, and the distance (d2) between the active layer (33) and the light absorbing layer (35) is selected to be in a range of from 0.2 to 0.7 microns.

公开(公告)号：AU8570175A

公开(公告)日：1977-04-21

申请号：AU8570175

申请日：1975-10-14

Applicant: SONY CORP

Inventor： MATSUSHITA TAKESHI ,  MAMINE TAKAYOSHI

IPC: H01L31/04 ,  H01L31/06 ,  H01L31/068 ,  H01L31/0687 ,  H01L31/10 ,  H01L21/36 ,  H01L21/38

Abstract: A semiconductor photovoltaic device is comprised of 2n layers of alternating p-type and n-type material having respective PN junctions between adjacent layers, wherein n is an integer greater than 1. Each layer has a thickness which is less than the diffusion length of a minority carrier therein. The PN junctions are excited by light which is incident on the device to thereby cause majority carriers to be accumulated in the respective layers so as to forward bias all of the PN junctions. As a result of this forward biasing, minority carriers are injected across a first PN junction fr0m one layer into an adjacent layer and then traverse the next PN junction into the next succeeding layer. The photovoltaic device thus is adapted to supply a voltage and a current to a load.

公开(公告)号：DE3525703A1

公开(公告)日：1986-02-20

申请号：DE3525703

申请日：1985-07-18

Applicant: SONY CORP

Inventor： MAMINE TAKAYOSHI ,  OKADA TSUNEKAZU ,  CHIBA MICHIRO

IPC: H01S5/00 ,  H01S5/223 ,  H01S3/05 ,  H01S3/19

Abstract: A semiconductor laser comprises a substrate (31) in which there are formed, in turn, a first cladding layer (32), an active layer (33), a second cladding layer (34) and a light absorbing layer (35) for limiting a current path and for absorbing light emitted from the active layer (33). The light absorbing layer (35) is provided with a stripe-shaped removed portion (35a) for forming the current path. The width (W) of the removed portion (35a) is selected to be in a range of from 1 to 4 microns, the thickness (d1) of the active layer (33) is selected to be not less than approximately 500 Angstroms, and the distance (d2) between the active layer (33) and the light absorbing layer (35) is selected to be in a range of from 0.2 to 0.7 microns.

公开(公告)号：CA1045235A

公开(公告)日：1978-12-26

申请号：CA236812

申请日：1975-10-01

Applicant: SONY CORP

Inventor： MAMINE TAKAYOSHI ,  MATSUSHITA TAKESHI

IPC: H01L31/04 ,  G02B1/11 ,  G02B1/113 ,  H01L21/314 ,  H01L31/02 ,  H01L31/0216 ,  H01L31/068 ,  H01L31/10 ,  H01L27/14

Abstract: A polycrystalline silicon layer provides an antireflective coating on a semiconductor surface of a photo-sensitive detector, the polycrystalline silicon layer containing from 25 to 45 atomic percent of oxygen and having a refractive index intermediate that of the semiconductor crystal and the exterior environment.

公开(公告)号：EP1507146A4

公开(公告)日：2005-08-24

申请号：EP03752936

申请日：2003-05-21

Applicant: SONY CORP

Inventor： MAMINE TAKAYOSHI ,  YAMAMOTO TAKURO

IPC: C12Q1/68 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N33/543 ,  G01N33/53 ,  G01N37/00

CPC classification number: G01N33/543 ,  B01J2219/0036 ,  B01J2219/00362 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N33/54366 ,  G01N33/54373 ,  G01N33/54393

Abstract: A bioassay method in which the efficiency of an interaction between substances such as hybridization is enhanced by controlling the production of an electric field in a reaction region where the interaction occurs, and a bioassay device for preferably implementing the method are disclosed. The method is conducted to detect an interaction between substances by using a detector (1(10)) at least having a detection surface (S(S')) subjected to a surface treatment for fixing a substance D for detection, a reaction region (R(R')) for providing a field where an interaction between the detection substance D fixed to the detection surface (S(S')) and an added target substance T occurs, and electric field producing means (E) for producing an electric field in the reaction region (R(R')) by causing a potential difference in the reaction region (R(R')). The method comprises a procedure of turning on/off the electric field producing means (E) at a predetermined timing so as to produce/extinguish an electric field.

公开(公告)号：EP1864997A4

公开(公告)日：2009-02-25

申请号：EP06730113

申请日：2006-03-27

Applicant: SONY CORP

Inventor： YAMAMOTO TAKURO ,  MAMINE TAKAYOSHI ,  TAKUMI TORU ,  AKASHI MAKOTO

IPC: C07K14/47 ,  A61K31/7088 ,  A61K31/7105 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P25/00 ,  A61P25/20 ,  A61P35/00 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566

CPC classification number: A61K31/7105 ,  A61K31/7088 ,  C07K14/4702 ,  C07K14/70567 ,  G01N33/743 ,  G01N2333/70567 ,  G01N2500/00

Abstract: It is intended to clarify the undisclosed part of the mechanism controlling the circadian rhythm. It is newly found out that RORa (retinoic acid binding-receptor alpha, the same applies hereinafter) promotes the induction of Bmal1 expression and that the induction of Bmal1 expression is promoted under hypoxic conditions. These facts strongly suggest the presence of the mechanism controlling the circadian rhythm wherein, when RORa expression is promoted under hypoxic conditions etc., the induction of Bmal1 expression is promoted and the promotion of the induction of Bmal1 expression promotes the binding of BMAL1 to CLOCK to thereby promote the induction of the expression of the Per gene or the Cry gene. Accordingly, the above findings are likely applicable to agents for regulating jet lag and anticancer drugs.

公开(公告)号：DE60323517D1

公开(公告)日：2008-10-23

申请号：DE60323517

申请日：2003-09-24

Applicant: SONY CORP

Inventor： MAMINE TAKAYOSHI ,  KINOSHITA TAKASHI

IPC: G01N33/53 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/68 ,  G01N27/00 ,  G01N37/00 ,  G01Q10/00 ,  G01Q60/24 ,  G01Q80/00

Abstract: In a cell detecting part (2), an end face (13a) of a cantilever (13) is previously surface treated so that a detecting nucleotide chain D can be fixed thereto. In a reaction area (10), an electric field is generated by a cathode (11) and an anode (12). A target nucleotide chain T dripped from a nozzle (3) moves to the end face (13a) while the target nucleotide chain T is stretched. When the detecting nucleotide chain D and the target nucleotide chain T are hybridized, the mass of the cantilever (13) is increased to lower a natural frequency. Thus, ac voltage is applied to the cantilever (13) to measure the change of the natural frequency. Thus, whether or not there is the hybridization is detected and the number of the hybridized target nucleotide chains T is quantitatively detected.

公开(公告)号：AU2003266583A1

公开(公告)日：2004-04-23

申请号：AU2003266583

申请日：2003-09-24

Applicant: SONY CORP

Inventor： MAMINE TAKAYOSHI ,  KINOSHITA TAKASHI

IPC: C12M1/00 ,  C12N15/09 ,  C12Q1/68 ,  G01N27/00 ,  G01N33/53 ,  G01N37/00 ,  G01Q10/00 ,  G01Q60/24 ,  G01Q80/00 ,  G01N13/16 ,  G01N33/566 ,  C12N15/00

Abstract: In a cell detecting part (2), an end face (13a) of a cantilever (13) is previously surface treated so that a detecting nucleotide chain D can be fixed thereto. In a reaction area (10), an electric field is generated by a cathode (11) and an anode (12). A target nucleotide chain T dripped from a nozzle (3) moves to the end face (13a) while the target nucleotide chain T is stretched. When the detecting nucleotide chain D and the target nucleotide chain T are hybridized, the mass of the cantilever (13) is increased to lower a natural frequency. Thus, ac voltage is applied to the cantilever (13) to measure the change of the natural frequency. Thus, whether or not there is the hybridization is detected and the number of the hybridized target nucleotide chains T is quantitatively detected.