公开(公告)号：CA2578202A1

公开(公告)日：2006-03-09

申请号：CA2578202

申请日：2005-08-30

Applicant: TORAY INDUSTRIES

Inventor： TANAHASHI KAZUHIRO ,  WADA SHIGEHISA ,  SUGAYA HIROYUKI ,  TAKAHASHI HIROSHI

IPC: C07K1/22 ,  A61J3/00 ,  A61L31/00 ,  A61M1/18 ,  A61M25/00 ,  C07K1/34 ,  C08J7/12 ,  C08L101/00 ,  C12M1/00

Abstract: The present invention discloses a fractionation device used for proteins and/or peptides, which has any of the following features: 1) At least one portion of a substrate surface with which proteins or the like are made in contact has an amount of adsorption of bovine serum albumin of 50 ng/cm 2 or less with respect to the substrate surface, when a bovine serum albumin solution is made in contact therewith. 2) At least one portion of a substrate surface with which proteins or the like are made in contact has an amount of adsorption of human ²2-microglobulin of 3 ng/cm 2 or less with respect to the substrate surface, when a protein aqueous solution consisting of human ²2-microglobulin and bovine serum albumin is made in contact with the substrate surface. 3) The fractionation device is provided with: a means for supplying a solution containing proteins or the like; a means for separating proteins or the like from the solution; and a means for concentrating proteins or the like in the solution, and in the fractionation device, at least one portion of the substrate surface with which proteins or the like are made in contact is subj ected to a grafting process by using a hydrophilic polymer. By using the above-mentioned device, it becomes possible to reduce non-peculiar adsorption of protein onto the substrate, and consequently to easily provide a sample from which proteins having high-molecular weights have been removed, and which is advantageously used for an analysis.

公开(公告)号：DE69327578T2

公开(公告)日：2000-08-24

申请号：DE69327578

申请日：1993-09-28

Applicant: TORAY INDUSTRIES

Inventor： SUGAYA HIROYUKI ,  MINAGA MASAHIRO ,  TERADA RYOZO ,  TAYAMA TOSHIKAZU ,  TANAKA KAZUMI ,  FUKUI FUMIAKI

IPC: B01D67/00 ,  B01D71/28 ,  B01D71/40 ,  C08F283/06 ,  C08F290/06 ,  C08F299/02 ,  A61M1/16 ,  C08F220/28 ,  C08F212/14 ,  A61L33/00

Abstract: A hydrophilic material comprising a copolymer composed of a monomer (A) having a polyalkylene oxide unit and a polymerizable carbon-carbon double bond in its molecule, a methacrylate or acrylate monomer (B) and another monomer (C) having a polymerizable carbon-carbon double bond in its molecule, which material is characterized by containing the monomer (C) in the proportion of 10 to 90 % by weight. The invention provides a hydrophilic material which is soluble, readily moldable, and excellent in antithrombotic and antifouling properties, and further provides an antithrombotic material and a semipermeable membrane. These materials can be appropriately used in the medical field and as water-absorbent and antifouling materials.

公开(公告)号：EP2286902A4

公开(公告)日：2015-09-16

申请号：EP09727576

申请日：2009-03-30

Applicant: TORAY INDUSTRIES

Inventor： UENO YOSHIYUKI ,  FUJITA MASAKI ,  SUGAYA HIROYUKI

IPC: B01D69/02 ,  A61M1/16 ,  B01D67/00 ,  B01D69/08 ,  B01D71/38 ,  B01D71/40 ,  B01D71/44 ,  B01D71/68

CPC classification number: B01D71/48 ,  A61M1/16 ,  B01D63/02 ,  B01D67/0093 ,  B01D69/02 ,  B01D69/087 ,  B01D71/38 ,  B01D71/40 ,  B01D71/44 ,  B01D71/68 ,  B01D2323/02 ,  B01D2323/385 ,  B01D2325/36 ,  B01D2325/38

Abstract: Provided is a separation membrane module suffering from little sticking of organic matters, proteins, platelets and so on. A separation membrane which is a membrane comprising a polymer, characterized in that a functional layer is formed on the surface in one side of the membrane, the peak area percentage of carbon derived from ester group measured by the electron spectroscopy for chemical analysis (ESCA) on the surface of the preceding functional layer is 0.1% (by atomic number) or more but not more than 10 (% by atomic number), and the peak area percentage of carbon derived from ester group measured by the electron spectroscopy for chemical analysis (ESCA) on the surface opposite to the functional layer is not more than 10 (% by atomic number); and a separation membrane module provided with the same as a built-in membrane.

公开(公告)号：EP2119494A4

公开(公告)日：2013-01-09

申请号：EP08704057

申请日：2008-01-29

Applicant: TORAY INDUSTRIES

Inventor： OSABE MASAHIRO ,  NAKAMATSU OSAMU ,  SUGAYA HIROYUKI

IPC: B01D69/08 ,  A61M1/18 ,  B01D63/02 ,  B01D71/38 ,  B01D71/44 ,  B01D71/52 ,  B01D71/68

CPC classification number: B01D63/02 ,  A61M1/16 ,  A61M1/34 ,  A61M1/3403 ,  A61M2205/3331 ,  B01D69/081 ,  B01D69/084 ,  B01D71/68 ,  D02G1/0286 ,  Y10T29/49826

公开(公告)号：EP2468389A4

公开(公告)日：2018-04-04

申请号：EP09848497

申请日：2009-08-21

Applicant: TORAY INDUSTRIES

Inventor： OSABE MASAHIRO ,  TANAKA KAZUMI ,  SUGAYA HIROYUKI

IPC: B01D69/08 ,  B01D63/02 ,  B01D65/10 ,  F24F3/14 ,  F24F6/00 ,  F24F6/04 ,  H01M8/04119

CPC classification number: F24F6/00 ,  B01D65/10 ,  B01D69/08 ,  B01D2325/02 ,  B01D2325/24 ,  B01D2325/40 ,  F24F2003/1435 ,  H01M8/04149

Abstract: The invention provides a water vapor permeable membrane comprising a dense layer and a support layer that are adjacent to each other, wherein said dense layer contains voids with a void length of 0.1 µm or less and said layer has a thickness of 0.1 µm or more and 2 µm or less while in said support layer, void (a), i.e. the void with the largest length in the 2 µm thick region measured from the boundary between the dense layer and the support layer into the support layer, has a length of 0.3 µm or more and void (b), i.e. the void with the largest length in the region ranging between 2 µm and 4 µm measured from said boundary into the support layer, has a length of 0.5 µm or more, the length of said void (b) being larger than that of said void (a). The invention provides a water vapor permeable membrane having both a high water vapor permeability and a low air leakage.

公开(公告)号：EP1707573A4

公开(公告)日：2010-07-07

申请号：EP05703866

申请日：2005-01-20

Applicant: TORAY INDUSTRIES

Inventor： TANAHASHI KAZUHIRO ,  KUMO ICHIRO ,  KUROKI NOBUYUKI ,  SUGAYA HIROYUKI ,  YAMADA SATOKO ,  WADA SHIGEHISA ,  JUNG GIMAN ,  KURODA TOSHIHIKO ,  SEKIGUCHI SHUJI

IPC: C07K1/34 ,  B01D61/00 ,  B01D61/14 ,  B01D63/02 ,  B01D63/04 ,  C07K1/22 ,  C07K14/435

CPC classification number: B01D63/04 ,  B01D61/142 ,  B01D61/20 ,  B01D63/08 ,  B01D2313/243 ,  B01D2319/022 ,  C07K1/22 ,  C07K1/34 ,  C07K1/36

公开(公告)号：EP2659914A4

公开(公告)日：2014-09-10

申请号：EP11854069

申请日：2011-12-27

Applicant: TORAY INDUSTRIES

Inventor： UENO YOSHIYUKI ,  FUJITA MASAKI ,  SUGAYA HIROYUKI ,  HASHIMOTO KAZUYUKI ,  TERASAKA HIROYUKI ,  KOGANEMARU RYO

IPC: A61L33/00 ,  A61M1/18 ,  B01D63/02 ,  B01D65/08 ,  B01D67/00

CPC classification number: A61M1/16 ,  A61L33/062 ,  A61M1/1623 ,  A61M1/1625 ,  A61M1/1627 ,  A61M1/3672 ,  A61M1/3673 ,  B01D63/02 ,  B01D67/0088 ,  B01D69/02 ,  B01D69/084 ,  B01D71/68 ,  B01D71/76 ,  B01D2323/02 ,  C08L81/06 ,  C08L39/06

Abstract: The purpose of the invention of the present application is to provide a medical material and a blood purification apparatus each having high anti-thrombotic properties and high safety. The apparatus is produced by incorporating therein a medical material which has a hydrophilic copolymerization polymer present on a surface thereof which is to be in contact with blood, wherein particulate protuberances each having a particle diameter of 50 nm or more are present on the surface which is to be in contact with blood at a density of 3 particles/µm 2 or less and the relaxation time of adsorbed water in the hydrophilic copolymerization polymer is 2.5 × 10 -8 seconds or shorter and 5.0 × 10 -10 seconds or longer at -40°C.

公开(公告)号：EP1785431A4

公开(公告)日：2011-06-08

申请号：EP05781472

申请日：2005-08-30

Applicant: TORAY INDUSTRIES

Inventor： TANAHASHI KAZUHIRO ,  TAKAHASHI HIROSHI ,  SUGAYA HIROYUKI ,  WADA SHIGEHISA

IPC: C07K1/22 ,  A61J3/00 ,  A61L31/00 ,  A61M1/18 ,  A61M25/00 ,  C07K1/34 ,  C08J7/12 ,  C08L101/00 ,  C12M1/00

CPC classification number: C07K1/22

公开(公告)号：EP1535657A4

公开(公告)日：2010-04-28

申请号：EP03792729

申请日：2003-08-20

Applicant: TORAY INDUSTRIES

Inventor： UENO YOSHIYUKI ,  TAKAHASHI HIROSHI ,  SUGAYA HIROYUKI

IPC: A61L33/00 ,  B01D67/00 ,  B01D63/02 ,  B01D65/02 ,  B01D69/08 ,  B01D71/40 ,  C08J7/00 ,  C08J7/18

CPC classification number: B01D67/0093 ,  A61L33/0082 ,  B01D71/68 ,  B01D2323/02 ,  B01D2323/12 ,  B01D2323/14 ,  B01D2323/16 ,  B01D2323/30 ,  B01D2323/34 ,  B01D2323/36

Abstract: The present invention provides a modified substrate including a hydrophilic polymer wherein the soluble hydrophilic polymer ratio is 15 weight percent or less and the number of adhered human blood platelets is 10/4.3x10 mu m or less. In addition, the present invention provides a method for producing a modified substrate including a step of irradiating the substrate with radiation while the substrate is brought into contact with an aqueous solution containing a hydrophilic polymer and an antioxidant. The present invention provides a modified substrate having high hematologic compatibility wherein the hydrophilic polymer is immobilized on the surface of the substrate, and a method for producing the same.

公开(公告)号：EP1894965A4

公开(公告)日：2008-06-18

申请号：EP06730152

申请日：2006-03-28

Applicant: TORAY INDUSTRIES

Inventor： ARAKI MIHO ,  UENO YOSHIYUKI ,  SUGAYA HIROYUKI

IPC: C08J7/00 ,  A61L31/00 ,  A61L33/00 ,  A61M1/18 ,  B01D65/02 ,  B01D69/08 ,  B01D71/40 ,  D06M10/00 ,  D06M13/144 ,  D06M101/26

CPC classification number: B01D71/40 ,  A61M1/16 ,  B01D67/0093 ,  B01D71/48 ,  B01D2323/385 ,  C08J7/16 ,  D06M10/08 ,  D06M2101/26

Abstract: The present invention is characterized in that a base material comprises ester groups in the main chain and/or in the side chain(s), and comprises a polymer having hydrophobic groups. Particularly, the hydrophobic groups can be introduced by irradiating the base material with a radiation during the base material contacts an aqueous solution of a monohydric alcohol or an aqueous solution of an alcohol having not less than 2 hydroxyl groups, which is a monomer or a polymer, and which has one or more carbon atoms between the carbon atoms to each of which the hydroxyl group is bound in the monomer or in each monomer constituting the polymer.