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公开(公告)号：CA2784837C
公开(公告)日：2017-10-10
申请号：CA2784837
申请日：2010-12-15
Applicant: TORAY INDUSTRIES
Inventor： KURODA TOSHIHIKO , NOMURA OSAMU , NOBUMASA HITOSHI
IPC: C12Q1/68 , G01N27/447 , G06F17/30
Abstract: Information on expression of a gene in a tissue or cell(s) fixed with a fixative , or whether or not the gene is expressed therein, is analyzed by a method for analyzing RNA extracted from a tissue or cell(s) fixed with a fixative, the method comprising a step wherein whether the RNA satisfies the following equation: Equation: B/A
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公开(公告)号：CA2671866C
公开(公告)日：2014-03-25
申请号：CA2671866
申请日：2008-01-23
Applicant: TORAY INDUSTRIES
Inventor： NOMURA OSAMU , KURODA TOSHIHIKO , NOBUMASA HITOSHI , MURAO YASUO
IPC: C40B60/12 , C12Q1/68 , C40B30/04 , C40B40/00 , G01N33/543
Abstract: An analysis chip which has a baseboard having a selectively binding substance immobilized on the surface thereof, a covering member bonded to this baseboard and fine particles contained or injected in a movable state within a space that is formed between the baseboard and the covering member, wherein the surface of the fine particles is coated with a surfactant. Owing to this construction, it is possible to prevent the formation of bubbles inhibiting a selective reaction between a test substance and the selectively binding substance having been immobilized so that data variation and lowering in the sensitivity can be regulated and the reproducibility of the measurement can be elevated.
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公开(公告)号：CA2553234A1
公开(公告)日：2005-08-04
申请号：CA2553234
申请日：2005-01-20
Applicant: TORAY INDUSTRIES
Inventor： JUNG GIMAN , WADA SHIGEHISA , YAMADA SATOKO , KUROKI NOBUYUKI , KURODA TOSHIHIKO , SUGAYA HIROYUKI , SEKIGUCHI SHUJI , TANAHASHI KAZUHIRO , KUMO ICHIRO
Abstract: The following is disclosed: (1) a membrane fractionator including a filtrati on section, a concentrating section, a recovery section and a liquid feed pump, wherein a flow channel connecting the filtration section, concentrating section and recovery section to each other constitutes a closed circuitry; ( 2) a method of biocomponent separation, characterized in that a sample derived from biocomponents is fed into an antibody adsorption membrane separation system having an antibody capable of adsorbing specified protein internally accommodated in the middle or a rear part of a membrane separation system th at in the absence of antibodies adsorbing proteins, exhibits a permeation ratio between human .alpha.1-microglobulin and human albumin of 1.5 to 1000, there by separating part of the biocomponents; and (3) a method of protein fractionation, comprising bringing a solution containing two or more types o f proteins and water into contact with a hollow yarn separation membrane to thereby attain protein fractionation, characterized in that the fractionatio n solution contains an organic solvent.
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公开(公告)号：ES2623098T3
公开(公告)日：2017-07-10
申请号：ES13755655
申请日：2013-02-27
Applicant: TORAY INDUSTRIES
Inventor： KURODA TOSHIHIKO , NOBUMASA HITOSHI
IPC: G01N35/02 , G01N33/53 , G01N33/543 , G01N37/00
Abstract: Procedimiento para remover una solución que contiene una sustancia a ensayar, inyectada en un chip de análisis, en el que: dicho chip de análisis comprende un hueco en el que se inyecta dicha solución que contiene una sustancia a ensayar; y una sustancia de unión selectiva, que se une selectivamente a dicha sustancia a ensayar, se inmoviliza en la totalidad o en una parte de la superficie inferior de dicho hueco, comprendiendo dicho procedimiento: inyectar dicha solución que contiene la sustancia a ensayar en el espacio de dicho hueco de dicho chip de análisis, de tal modo que dicho espacio queda parcialmente sin llenar; y hacer girar dicho chip de análisis al que se ha inyectado dicha solución que contiene la sustancia a ensayar, aplicando una aceleración centrífuga no menor de 1×g, en el que dicho chip de análisis al que se ha inyectado dicha solución que contiene la sustancia a ensayar se hace girar con un radio de rotación de 0,1 mm a 10 mm, y en el que dicha solución que contiene la sustancia a ensayar es inyectada en dicho hueco, de tal modo que queda sin llenar del 10 % al 70 % de dicho espacio.
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公开(公告)号：CA2795436A1
公开(公告)日：2011-10-27
申请号：CA2795436
申请日：2011-04-21
Applicant: TORAY INDUSTRIES
Inventor： KURODA TOSHIHIKO , NOMURA OSAMU , NOBUMASA HITOSHI
Abstract: Provided is a method for preparing, from an RNA sample extracted from tissue or cells fixed by a fixative, aRNA used in gene expression assay. During the step for RNA sample amplification by means of reverse transcription and in vitro transcription, the ratio of aminoallyl uridine-5'-triphosphate (AA-UTP) in the nucleotide reagent used for in vitro transcription is brought to 5 mol% or greater but less than 25 mol% per the total of uridine-5'-triphosphate (UTP) and AA-UTP.
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Patent Agency Ranking
公开(公告)号：CA2671866A1
公开(公告)日：2008-07-31
申请号：CA2671866
申请日：2008-01-23
Applicant: TORAY INDUSTRIES
Inventor： NOMURA OSAMU , MURAO YASUO , NOBUMASA HITOSHI , KURODA TOSHIHIKO
Abstract: An analysis chip which has a baseboard having a selectively binding subst ance immobilized on the surface thereof, a covering member bonded to this ba seboard and fine particles contained or injected in a movable state within a space that is formed between the baseboard and the covering member, wherein the surface of the fine particles is coated with a surfactant. Owing to thi s construction, it is possible to prevent the formation of bubbles inhibitin g a selective reaction between a test substance and the selectively binding substance having been immobilized so that data variation and lowering in the sensitivity can be regulated and the reproducibility of the measurement can be elevated.
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公开(公告)号：AU2008208342A1
公开(公告)日：2008-07-31
申请号：AU2008208342
申请日：2008-01-23
Applicant: TORAY INDUSTRIES
Inventor： KURODA TOSHIHIKO , NOBUMASA HITOSHI , MURAO YASUO , NOMURA OSAMU
Abstract: This invention is directed to an analysis chip comprising a substrate having a surface on which a selective binding substance is immobilized; a cover member adhered to the substrate; and particles movably contained or injected in a void between the substrate and the cover member; wherein the surfaces of the particles are coated with a surfactant. By this invention, generation of bubbles which inhibit the selective reaction between the test substance and the immobilized selective binding substance is suppressed, thereby reducing the deviation of data, suppressing the lowering of sensitivity, and promoting the reproducibility of the measurement.
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公开(公告)号：CA2861288C
公开(公告)日：2019-10-01
申请号：CA2861288
申请日：2013-02-27
Applicant: TORAY INDUSTRIES
Inventor： KURODA TOSHIHIKO , NOBUMASA HITOSHI
Abstract: The present invention provides a means for accelerating selective binding reaction between a selective binding substance immobilized on an analysis chip and a test substance, particularly a means for enabling to analyze a test substance in a short time. The present invention relates to a method of stirring a test substance solution, the method comprising: injecting a test substance-containing solution to a space in a recess of an analysis chip such that the space is partially left unfilled; and rotating the analysis chip applying a centrifugal acceleration of not less than 1×g.
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公开(公告)号：DK2821794T3
公开(公告)日：2017-06-06
申请号：DK13755655
申请日：2013-02-27
Applicant: TORAY INDUSTRIES
Inventor： KURODA TOSHIHIKO , NOBUMASA HITOSHI
IPC: G01N35/02 , G01N33/53 , G01N33/543 , G01N37/00
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公开(公告)号：ES2605406T3
公开(公告)日：2017-03-14
申请号：ES05703866
申请日：2005-01-20
Applicant: TORAY INDUSTRIES
Inventor： TANAHASHI KAZUHIRO , KUMO ICHIRO , KUROKI NOBUYUKI , SUGAYA HIROYUKI , YAMADA SATOKO , WADA SHIGEHISA , JUNG GIMAN , KURODA TOSHIHIKO , SEKIGUCHI SHUJI
Abstract: Un dispositivo de fraccionamiento para separar solutos en un liquido bruto mediante una membrana, que comprende 1) una parte de suministro (2b) para cargar el liquido bruto; 2) una parte de filtracion con una membrana (5a; 5b; 5c) para filtrar algo de los solutos en el liquido bruto enviado desde la parte de suministro; 3) una parte de concentracion (5d) para concentrar el filtrado procedente de la parte de filtracion; 4) una parte de recuperacion (10) para recuperar la solucion concentrada obtenida en la parte de concentracion; 5) una bomba de flujo para el envio de una fase movil; en el que la bomba de flujo es una bomba de tubo provista de un rotor giratorio y de un rodillo (9) instalado de manera giratoria en la circunferencia exterior del rotor; caracterizado por que la parte de suministro, la parte de filtracion, la parte de concentracion, la parte de recuperacion y un canal de flujo que conecta las partes respectivas, forman un circuito cerrado y estan ensamblados en un cartucho desechable (14) en el que al menos las porciones de los canales de flujo estan expuestas a la pared exterior del cartucho desde el exterior del cartucho, y por que el cartucho se puede separar del rodillo de la bomba de flujo y esta dispuesto de manera que una parte de la pared exterior del cartucho funciona como un miembro de compresion mediante el acoplamiento de la bomba de rodillos para comprimir las porciones expuestas de los canales de flujo cuando el rodillo se hace girar para hacer circular los liquidos en las partes respectivas del cartucho.
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