公开(公告)号：JP2013031436A

公开(公告)日：2013-02-14

申请号：JP2012145090

申请日：2012-06-28

Applicant: Ube Industries Ltd ,  宇部興産株式会社

Inventor： YOSHIDA YOICHI ,  TOKUYASU KAZUYA ,  YAMAMOTO YASUHITO

IPC: C12P13/00

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a carbamate compound, which is simple and industrially suitable.SOLUTION: The method includes reacting an amine compound and a carbonate compound in the presence of a hydrolytic enzyme catalyst and in the absence of a solvent. According to this, an intended carbamate compound can be industrially suitably produced in good yield.

Abstract translation: 待解决的问题：提供一种简单且工业上合适的氨基甲酸酯化合物的制造方法。 解决方案：该方法包括在水解酶催化剂存在下和不存在溶剂的情况下使胺化合物和碳酸酯化合物反应。 据此，目的氨基甲酸酯化合物可以在工业上以良好的收率生产。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2012161332A

公开(公告)日：2012-08-30

申请号：JP2012097936

申请日：2012-04-23

Applicant: Ube Industries Ltd ,  宇部興産株式会社

Inventor： KONEGAWA TADAYASU ,  MIYATA HIROYUKI ,  YAMAMOTO YASUHITO

IPC: C12P41/00

Abstract: PROBLEM TO BE SOLVED: To provide a method for industrial production of an (R or S)-N-substituted-β-amino acid and its ester having a reverse absolute steric configuration while suppressing autohydrolysis of a β-amino acid ester liable to be hydrolyzed with water, and improving yield, selectivity, operability, etc., of an optically active N-substituted-β-amino acid difficult to obtain in an isolated state.SOLUTION: An optically active (R or S)-N-substituted-β-amino acid is formed and an unreacted optically active (S or R)-N-substituted-β-amino acid alkyl ester is obtained by selectively reacting one enantiomer of an N-substituted-β-amino acid alkyl ester (racemic mixture) expressed by general formula (I) (in the formula, P is a protecting group; Ris alkyl, alkenyl, cycloalkyl, aralkyl or aryl; and R is alkyl) with water in an organic solvent in the presence of a hydrolase.

Abstract translation: 待解决的问题：为了提供工业生产（R或S）-N-取代的-β-氨基酸的方法及其具有反向绝对立体构型的酯，同时抑制β-氨基酸酯的自动水解 易于水解，提高了在孤立状态下难以获得的光学活性N-取代-β-氨基酸的产率，选择性，可操作性等。 解决方案：形成光学活性的（R或S）-N-取代的-β-氨基酸，通过选择性地反应制得未反应的光学活性的（S或R）-N-取代的-β-氨基酸烷基酯 由通式（I）表示的N-取代-β-氨基酸烷基酯（外消旋混合物）的一种对映异构体（在该式中，P是保护基; R 1 是烷基，烯基，环烷基，芳烷基或芳基; R是烷基）与水在有机溶剂中在水解酶存在下反应。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2011207975A

公开(公告)日：2011-10-20

申请号：JP2010075885

申请日：2010-03-29

Applicant: Ube Industries Ltd ,  宇部興産株式会社

Inventor： YOSHIDA YOICHI ,  YAMAMOTO YASUHITO ,  HIROTSU KENJI

IPC: C08G64/42

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a polycarbonate diol diacrylate compound from polycarbonate diol and an acrylic ester compound without using a protonic acid and a metal component.SOLUTION: In the method for producing a polycarbonate diol diacrylate compound, polycarbonate diol represented by formula (I) is reacted with an acrylic ester compound represented by formula (II) in the presence of lipase. In formula (I), each Ris the same or different and a divalent group composed of one or more straight chain, branched chain, or cyclic alkylene groups, wherein the divalent group may have a substituent and/or one or more non-terminal carbon atoms substituted with a divalent aromatic group, a divalent heterocyclic group, an oxygen atom, or a sulfur atom, or is a divalent group of a crosslinking carbocyclic ring; and n represents an average degree of polymerization and is a number of 1-50. In formula (II), Ris a hydrogen atom or a 1-4C straight chain or branched chain alkyl group; and Ris a 1-12C straight chain, branched chain or cyclic alkyl group, a 7-10C aralkyl group or a 6-10C aryl group.

Abstract translation: 要解决的问题：提供一种不使用质子酸和金属成分的聚碳酸酯二醇和丙烯酸酯化合物的聚碳酸酯二醇二丙烯酸酯化合物的制造方法。溶液：在聚碳酸酯二醇二丙烯酸酯化合物的制造方法中， 通过式（I）与式（II）表示的丙烯酸酯化合物在脂肪酶的存在下反应。 在式（I）中，每个R 1相同或不同，由一个或多个直链，支链或环状亚烷基组成的二价基团，其中二价基团可以具有取代基和/或一个或多个非末端碳 被二价芳族基团，二价杂环基，氧原子或硫原子取代的原子，或是交联性碳环的二价基团; n表示平均聚合度，为1-50。 式（II）中，R为氢原子或1-4C直链或支链烷基; 并且R 1为1-12C直链，支链或环状烷基，7-10C芳烷基或6-10C芳基。

公开(公告)号：JPH0931059A

公开(公告)日：1997-02-04

申请号：JP18537995

申请日：1995-07-21

Applicant: UBE INDUSTRIES

Inventor： YONEDA YASUHIRO ,  YAMAMOTO YASUHITO ,  OKAMURA SHINJI ,  ATAKA KIKUO

IPC: C07D215/12 ,  C07D215/18

Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound capable of readily industrializing and useful as an antiallergic agent having antileukotriene action without using a solvent affecting adverse influence on environment by using an ester-based solvent or amide-based solvent as an organic solvent. SOLUTION: When (A) a quinaldine derivative (e.g. quinaldine) of formula I (R to R are each H or a halogen) is reacted with (C) a brominating agent (e.g. N-bromosuccinimide) in the presence of (B) a free radical initiator (e.g. N,N'-azobisisobutyronitrile), the reaction is carried out in a solvent expressed by the formula R COR [R is H, an alkyl or an alkoxy; R is an alkoxy or NR 2 (R is an alkyl)], preferably an ester-based solvent or an amide-based solvent, especially ethyl acetate or dimethylformamide to provide the objective compound of formula II [e.g. 2-(bromomethyl)quinoline].

公开(公告)号：EP1493819A4

公开(公告)日：2010-12-22

申请号：EP03715786

申请日：2003-04-08

Applicant: UBE INDUSTRIES

Inventor： MIYATA HIROYUKI ,  YAMAMOTO YASUHITO ,  KONEGAWA TADAYOSHI ,  SAKATA KAZUMA

IPC: C12P13/04 ,  C12P41/00

CPC classification number: C12P41/005 ,  C12P13/04

公开(公告)号：EP1840218A4

公开(公告)日：2009-11-11

申请号：EP05793727

申请日：2005-10-11

Applicant: UBE INDUSTRIES

Inventor： KONEGAWA TADAYOSHI ,  MIYATA HIROYUKI ,  YAMAMOTO YASUHITO

IPC: C12P41/00 ,  C07B53/00 ,  C07C227/18 ,  C07C229/34

CPC classification number: C12P41/005 ,  C07C227/18 ,  C07C229/34 ,  C12P13/04 ,  C12P13/222

公开(公告)号：EP1408047A4

公开(公告)日：2004-09-29

申请号：EP02738658

申请日：2002-06-12

Applicant: UBE INDUSTRIES ,  CHUGAI PHARMACEUTICAL CO LTD

Inventor： MIYATA HIROYUKI ,  TAKAMA AKIRA ,  YAMAMOTO YASUHITO ,  ATAKA KIKUO

IPC: C07H17/08

CPC classification number: C07H17/08

Abstract: A process for the preparation of erythromycin compounds by alkylating 2’−O−acetyl−4”−O−formyl−11−oxo−8,9−anhydro− erythromycin A 6,9−hemiketal compound (1), characterized by reacting compound (1) with an alkylating agent in a mixed solvent consisting of 0.18 to 1.05 times as much water as compound (1) by equivalent and an organic solvent to thereby obtain a 2’ −O−acetyl−4”−O−formyl−11−oxo−12−alkoxy−8,9−anhydroerythro− mycin A 6,9−hemiketal compound (3).

Abstract translation: 通过烷基化2'-O-乙酰基-4“-O-甲酰基-11-氧代-8,9-脱水红霉素A 6,9-半缩酮化合物（1）制备红霉素化合物的方法，其特征在于使化合物 （1）与烷基化剂在由化合物（1）的0.18-1.05倍的水和相当的有机溶剂组成的混合溶剂中反应，从而获得2'-O-乙酰基-4“-O-甲酰基-11 - 氧-12-烷氧基-8,9-脱水红霉素6,9-半缩酮化合物（3）。

公开(公告)号：EP0785205A4

公开(公告)日：1999-12-15

申请号：EP95933605

申请日：1995-10-04

Applicant: UBE INDUSTRIES

Inventor： ATAKA KIKUO UBE ,  MIYATA HIROYUKI ,  KONO MASAHIKO ,  YOKOTA NAOYUYKI ,  YAMAMOTO YASUHITO

IPC: C07F7/18

CPC classification number: C07F7/1856

Abstract: 2-Silyloxy-4,5,6,7-tetrahydrothieno[3,2-c]-pyridines represented by general formula (I), salts thereof, a process for producing the same, (wherein R , R and R each independently represent C1-C10 alkyl or aryl), 5-alkyl-2-silyloxy-4,5,6,7-tetrahydrothieno[3,2-c]pyridines represented by general formula (IV) and useful as intermediates in the synthesis of antithrombocytic agents or esterase inhibitors, and a process for producing the same, wherein R , R and R are each as defined above; R represents hydrogen, C2-C10 alkoxycarbonyl, C2-C10 aryl or C4-C10 cycloalkylcarbonyl; and R represents halogeno, C1-C4 alkyl or C1-C4 alkoxy.

公开(公告)号：JPH11349539A

公开(公告)日：1999-12-21

申请号：JP15767698

申请日：1998-06-05

Applicant: UBE INDUSTRIES

Inventor： YAMAMOTO YASUHITO ,  FUJIMURA HITOSHI ,  ATAKA KIKUO

IPC: C07C201/12 ,  C07B61/00 ,  C07C205/50 ,  C07C205/51

Abstract: PROBLEM TO BE SOLVED: To produce a 4-nitro ester compound in a high yield and in a high selectivity under mild conditions by reacting a nitroolefin compound with a ketene silyl acetal compound in the presence of a catalyst comprising the salt of an alkylpyridine compound with a superacid. SOLUTION: This method for producing a 4-nitro ester compound of formula IV comprises reacting a nitroolefin compound of formula II (R to R are each H, an alkyl or the like, or form a methylene chain between R and R ) (for example, nitroethylene) with a ketal silyl acetal compound of formula III (R and R are each H, an alkyl or the like, or form a methylene group between R and R ; R and R are each an alkyl, an aryl or a halogen; R is an alkyl, an alkenyl or the like) [for example, methyl(trimethylsily)dimethylketene acetal] in the presence of a 2-alkylpyridinium salt catalyst obtained by mixing a 2-alkylpyridine compound of formula I (R is an alkyl; R to R are each H, an alkyl or the like, or form methylene chains between R and R , between R and R , and between R and R , respectively) (for example, 2-methylpyridine) with a superacid.

公开(公告)号：JPH1067706A

公开(公告)日：1998-03-10

申请号：JP22284696

申请日：1996-08-23

Applicant: UBE INDUSTRIES

Inventor： YAMAMOTO YASUHITO ,  YONEDA YASUHIRO ,  ATAKA KIKUO

IPC: C07C51/363 ,  C07B61/00 ,  C07C63/70 ,  C07C67/08 ,  C07C69/78

Abstract: PROBLEM TO BE SOLVED: To produce a 2,4,5-trifluoro-3-iodobenzoic acid and its ester which are useful as a material for 2,4,5-trifluoro-3-trifluoromethyl benzoic acids used as a starting material for production of antimicrobial and antiviral agents, easily and at a high yield. SOLUTION: This 2,4,5-trifluoro-3-iodobenzoic acid of formula I (R is an alkyl, cycloalkyl or aralkyl) is produced by making a 2,4,5-trifluoroiodobenzoic acid of formula II with a N-iodosuccinimide of formula III in the presence of trifluoromethane sulfonic acid. Furthermore, a 2,4,5-trifluoro-3-iodobenzoic ester of formula IV is obtained by reaction of a reactant mixture that contains a compound of formula I with an alcohol of the formula of R-OH.