公开(公告)号：AU2016282289A1

公开(公告)日：2018-01-04

申请号：AU2016282289

申请日：2016-06-23

Applicant: UNIV HEALTH NETWORK

Inventor： SAMPSON PETER BRENT ,  PATEL NARENDRA KUMAR B ,  PAULS HEINZ W ,  LI SZE-WAN ,  NG GRACE ,  LAUFER RADOSLAW ,  LIU YONG ,  LANG YUNHUI

IPC: C07D495/04 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/551 ,  A61K39/395 ,  A61P35/00

Abstract: Thienopyridinone compounds of Formula (I) and pharmaceutically acceptable salts thereof are described. In these compounds, one of X

公开(公告)号：SMT201600430B

公开(公告)日：2017-01-10

申请号：SM201600430

申请日：2016-11-24

Applicant: UNIV HEALTH NETWORK

Inventor： SAMPSON PETER BRENT ,  LIU YONG ,  LI SZE-WAN ,  FORREST BRYAN T ,  PAULS HEINZ W ,  EDWARDS LOUISE G ,  FEHER MIKLOS ,  PATEL NARENDRA KUMAR B ,  LAUFER RADOSLAW ,  PAN GUOHUA

公开(公告)号：MX2016004963A

公开(公告)日：2016-06-28

申请号：MX2016004963

申请日：2014-10-17

Applicant: UNIV HEALTH NETWORK

Inventor： SAMPSON PETER BRENT ,  PAULS HEINZ W ,  FEHER MIKLOS

IPC: C07D413/14 ,  A61K31/5377 ,  A61P35/00

Abstract: Se describe una sal fumarato y una sal maleato del compuesto (I) representado por la siguiente fórmula estructural, así como sus composiciones farmacéuticas correspondientes; las formas particulares cristalinas sencillas del compuesto (I) fumarato y el compuesto (I) maleato 1:1 se caracterizan por una variedad de propiedades y mediciones físicas; también se describen métodos de preparación de formas específicas cristalinas del compuesto (I) fumarato 1:1 y el compuesto (I) maleato; la presente invención también proporciona métodos de tratamiento de un sujeto con un cáncer. (ver Fórmula).

公开(公告)号：SG11201603102TA

公开(公告)日：2016-05-30

申请号：SG11201603102T

申请日：2014-11-14

Applicant: UNIV HEALTH NETWORK

Inventor： LAUFER RADOSLAW ,  NG GRACE ,  LI SZE-WAN ,  PAULS HEINZ W ,  LIU YONG ,  PATEL NARENDRA KUMAR B

IPC: C07D487/04 ,  A61K31/519 ,  A61P35/00

Abstract: The present teachings provide a compound represented by the following structural formula: (Formula (I)); or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.

公开(公告)号：EA023173B1

公开(公告)日：2016-04-29

申请号：EA201270752

申请日：2011-04-06

Applicant: UNIV HEALTH NETWORK

Inventor： SAMPSON PETER BRENT ,  LIU YONG ,  LI SZE-WAN ,  FORREST BRYAN T ,  PAULS HEINZ W ,  EDWARDS LOUISE G ,  FEHER MIKLOS ,  PATEL NARENDRA KUMAR B ,  LAUFER RADOSLAW ,  PAN GUOHUA

IPC: C07D413/14 ,  A61K31/5377 ,  A61P35/00 ,  C07D403/04

Abstract: Изобретениеотноситсяк соединению, представленномуследующейструктурнойформулой, иегофармацевтическиприемлемымсолям:Указанныесоединенияявляютсяингибиторами polo-подобныхкиназ 4 (PLK4) и Aurora кинази могутбытьиспользованыдлялечениязлокачественнойопухоли.

公开(公告)号：AU2013344716A1

公开(公告)日：2015-05-14

申请号：AU2013344716

申请日：2013-11-15

Applicant: UNIV HEALTH NETWORK

Inventor： LIU YONG ,  PAULS HEINZ W ,  LAUFER RADOSLAW ,  LI SZE-WAN ,  SAMPSON PETER BRENT ,  FEHER MIKLOS ,  NG GRACE ,  PATEL NARENDRA KUMAR B ,  LANG YUNHUI

IPC: C07D487/04 ,  A61K31/519 ,  A61P35/00

Abstract: The present teachings provide a compound represented by structural formula (1-0), or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.

公开(公告)号：AU2011238384B2

公开(公告)日：2015-02-19

申请号：AU2011238384

申请日：2011-04-06

Applicant: UNIV HEALTH NETWORK

Inventor： SAMPSON PETER BRENT ,  LIU YONG ,  LI SZE-WAN ,  FORREST BRYAN T ,  PAULS HEINZ W ,  EDWARDS LOUISE G ,  FEHER MIKLOS ,  PATEL NARENDRA KUMAR B ,  LAUFER RADOSLAW ,  PAN GUOHUA

IPC: C07D403/04 ,  A61K31/5377 ,  A61P35/00 ,  C07D413/14

Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: (I). Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.

公开(公告)号：AU2008340991B2

公开(公告)日：2012-02-23

申请号：AU2008340991

申请日：2008-12-19

Applicant: UNIV HEALTH NETWORK

Inventor： PAN GUOHUA ,  FORREST BRYAN T ,  LAUFER RADOSLAW ,  FEHER MIKLOS ,  PAULS HEINZ W ,  SAMPSON PETER BRENT ,  LI SZE-WAN ,  LIU YONG

IPC: C07D401/14 ,  A61K31/416 ,  A61K31/4192 ,  A61P35/00 ,  C07D403/06 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention is directed to a compound is represented by Structural Formula (A):or a pharmaceutically acceptable salt therof. The present invention is also directed to a pharmaceutical composition comprising a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject having cancer, wherein the method comprises administering a therapeutically effective amount of a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof.

公开(公告)号：AU2008340991A1

公开(公告)日：2009-07-02

申请号：AU2008340991

申请日：2008-12-19

Applicant: UNIV HEALTH NETWORK

Inventor： PAN GUOHUA ,  FORREST BRYAN T ,  LAUFER RADOSLAW ,  FEHER MIKLOS ,  PAULS HEINZ W ,  SAMPSON PETER BRENT ,  LI SZE-WAN ,  LIU YONG

IPC: C07D401/14 ,  A61K31/416 ,  A61K31/4192 ,  A61P35/00 ,  C07D403/06 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention is directed to a compound is represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The present invention is also directed to a pharmaceutical composition comprising a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject having cancer, wherein the method comprises administering a therapeutically effective amount of a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof.

公开(公告)号：PL3322711T3

公开(公告)日：2021-10-25

申请号：PL16813437

申请日：2016-06-23

Applicant: UNIV HEALTH NETWORK

Inventor： SAMPSON PETER BRENT ,  PATEL NARENDRA KUMAR B ,  PAULS HEINZ W ,  LI SZE-WAN ,  NG GRACE ,  LAUFER RADOSLAW ,  LIU YONG ,  LANG YUNHUI

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/551 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  C07K16/28