公开(公告)号：CY1116954T1

公开(公告)日：2017-04-05

申请号：CY151101043

申请日：2015-11-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDERICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/233

Abstract: ΗεφεύρεσηπαρέχειμίαμέθοδογιατηνπαρασκευήμίαςένωσηςΤύπου 1•πουπεριλαμβάνεισύζευξηενόςκαρβοξυλικούοξέοςΤύπου 2 μεμίαανιλίνηΤύπου 3•παρουσίαενόςπαράγοντασύζευξης.

公开(公告)号：SI2408750T1

公开(公告)日：2015-11-30

申请号：SI201031042

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDERICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/00

公开(公告)号：HRP20151137T1

公开(公告)日：2015-11-20

申请号：HRP20151137

申请日：2015-10-27

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDERICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/233

公开(公告)号：BRPI1011506A2

公开(公告)日：2015-08-25

申请号：BRPI1011506

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  GOOR FREDERICK F VAN ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/233

公开(公告)号：NZ595153A

公开(公告)日：2014-05-30

申请号：NZ59515310

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR ,  VAN GOOR FREDRICK F

IPC: C07D215/233 ,  A61K31/365 ,  C07D215/56 ,  C07D307/83

Abstract: The disclosure provides a process for the preparation of a substituted 4-Hydroxy-N-phenylquinoline-3-carboxamide derivative of Formula 1; comprising coupling a substituted 4-Hydroxyquinoline-3-carboxylic acid derivative of Formula 2; with an substituted aniline of Formula 3; in the presence of a coupling agent. The compounds of formula I being useful as cystic fibrosis transmembrane conductance regulators.

公开(公告)号：CA2984994A1

公开(公告)日：2010-09-23

申请号：CA2984994

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/56

Abstract: The invention provides a process for the preparation of a compound of Formula 1; (See Formula 1) comprising coupling a carboxylic acid of Formula 2; (See Formula 2) with an aniline of Formula 3; (See Formula 3) in the presence of a coupling agent.