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公开(公告)号：KR20180043408A
公开(公告)日：2018-04-27
申请号：KR20187011145
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233 , A61K31/4704 , C07C68/02 , C07C69/96 , C07C201/08 , C07C213/02 , C07C229/66 , C07D215/56
CPC classification number: C07C205/43 , C07C68/02 , C07C69/96 , C07C201/08 , C07C213/02 , C07C229/66 , C07D215/233 , C07D215/56 , G01N33/5041 , G01N33/6872 , Y02P20/55
Abstract: 본발명은하기화학식 2의카르복실산을커플링제의존재하에하기화학식 3의아닐린과커플링시키는것을포함하는, 하기화학식 1의화합물의제조방법을제공한다.
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公开(公告)号：WO2007109080A3
公开(公告)日：2007-11-15
申请号：PCT/US2007006493
申请日：2007-03-14
Applicant: VERTEX PHARMA , PERNI ROBERT B , CHEN MINZHANG , JUNG YOUNG CHUN , FORSLUND RAYMOND E , TANOURY GERALD J , BENNANI YOUSSEF , ZLOKARNIK GREGOR , MALTAIS FRANCOIS
Inventor： PERNI ROBERT B , CHEN MINZHANG , JUNG YOUNG CHUN , FORSLUND RAYMOND E , TANOURY GERALD J , BENNANI YOUSSEF , ZLOKARNIK GREGOR , MALTAIS FRANCOIS
IPC: C07C231/20 , A61K31/403 , A61K31/422 , A61K31/498 , A61P31/12 , C07C237/04 , C07D209/52 , C07D403/12 , C07D403/14 , C07D498/10
CPC classification number: C07C231/20 , C07B2200/05 , C07B2200/07 , C07C237/04 , C07C2601/02 , C07D209/52 , C07D301/14 , C07D303/48 , C07D401/14 , C07D403/12 , C07D403/14 , C07D498/10 , C07K5/0202 , C07K7/02
Abstract: A deuterated a-ketoamido steric specific compound of the formula (I), wherein D denotes a deuterium atom on a steric specific carbon atom.
Abstract translation: 式（I）的氘代α-酮酰胺基空间特异性化合物，其中D表示空间特异性碳原子上的氘原子。
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公开(公告)号：WO2009023509A3
公开(公告)日：2009-07-09
申请号：PCT/US2008072446
申请日：2008-08-07
Applicant: VERTEX PHARMA , SINGH ASHVANI , WORLEY JENNINGS FRANKLIN III , ZLOKARNIK GREGOR
Inventor： SINGH ASHVANI , WORLEY JENNINGS FRANKLIN III , ZLOKARNIK GREGOR
IPC: A61K31/137 , A61K31/138 , A61K31/343 , A61K31/351 , A61K31/4184 , A61K31/4545 , A61K31/517 , A61K31/5415 , A61K31/553 , A61P11/00
CPC classification number: A61K31/137 , A61K31/138 , A61K31/343 , A61K31/351 , A61K31/4184 , A61K31/4545 , A61K31/517 , A61K31/5415 , A61K31/553
Abstract: The present invention relates to therapeutic combinations and kits useful in treating CFTR-related diseases, such as cystic fibrosis.
Abstract translation: 本发明涉及可用于治疗CFTR相关疾病如囊性纤维化的治疗组合和试剂盒。
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公开(公告)号：DK2464337T4
公开(公告)日：2024-07-22
申请号：DK10708442
申请日：2010-02-18
Applicant: VERTEX PHARMA
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公开(公告)号：SI3330255T1
公开(公告)日：2021-03-31
申请号：SI201032047
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROPER STEFANIE , RYAN MICHAEL , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GROOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/00 , C07C229/00
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Patent Agency Ranking
公开(公告)号：PL2464337T3
公开(公告)日：2019-07-31
申请号：PL10708442
申请日：2010-02-18
Applicant: VERTEX PHARMA
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公开(公告)号：HUE042437T2
公开(公告)日：2019-07-29
申请号：HUE10708442
申请日：2010-02-18
Applicant: VERTEX PHARMA
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公开(公告)号：AU2018204671B2
公开(公告)日：2019-05-02
申请号：AU2018204671
申请日：2018-06-27
Applicant: VERTEX PHARMA
Inventor： GROOTENHUIS PETER D J , VAN GOOR FREDRICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR , DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA J , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP GUERETTE DAHRIKA MILFRED LAO , KRUEGER BRIAN R
IPC: C07D215/233
Abstract: The invention provides a process for the preparation of a compound of Formula 1, N H (Rx-X Formula 1 comprising coupling a carboxylic acid of Formula 2 (Rx-X OH Formula 2 with an aniline of Formula 3 Formula 3 in the presence of a coupling agent.
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公开(公告)号：SI2821400T1
公开(公告)日：2018-02-28
申请号：SI201031604
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT LANGILLE BOBBIANA , TRUDEAU MARTIN , ROPER STEFANIE , RYAN MICHAEL , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GROOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/00
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公开(公告)号：AU2010226393B2
公开(公告)日：2016-08-11
申请号：AU2010226393
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： YANG XIAOQING , HADIDA RUAH SARA S , GROOTENHUIS PETER D J , VAN GOOR FREDRICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233 , A61K31/47 , A61P3/00
Abstract: This invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R is COOH or CH
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