Patent search ap:("VERTEX PHARMA") AND inv:"TRUDEAU MARTIN" Page 1

1.

发明公开
낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법 审中-公开

公开(公告)号：KR20180043408A

公开(公告)日：2018-04-27

申请号：KR20187011145

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR

IPC: C07D215/233 , A61K31/4704 , C07C68/02 , C07C69/96 , C07C201/08 , C07C213/02 , C07C229/66 , C07D215/56

CPC classification number: C07C205/43 , C07C68/02 , C07C69/96 , C07C201/08 , C07C213/02 , C07C229/66 , C07D215/233 , C07D215/56 , G01N33/5041 , G01N33/6872 , Y02P20/55

Abstract: 본발명은하기화학식 2의카르복실산을커플링제의존재하에하기화학식 3의아닐린과커플링시키는것을포함하는, 하기화학식 1의화합물의제조방법을제공한다.

2.

发明申请
PROCESSES AND INTERMEDIATES 审中-公开
Title translation: 过程和中间

公开(公告)号：WO2005090334A2

公开(公告)日：2005-09-29

申请号：PCT/US2005008251

申请日：2005-03-11

Applicant: VERTEX PHARMA , TANOURY GERALD J , CHEN MINZHANG , JONES ANDREW D , NYCE PHILIP L , TRUDEAU MARTIN , GUERIN DAVID J , SNOONIAN JOHN R

Inventor： TANOURY GERALD J , CHEN MINZHANG , JONES ANDREW D , NYCE PHILIP L , TRUDEAU MARTIN , GUERIN DAVID J , SNOONIAN JOHN R

IPC: C07B43/04 , C07B57/00 , C07D405/12 , C07D405/00

CPC classification number: C07D207/16 , C07D209/52 , C07D211/60 , C07D405/12 , C07D417/06 , C07D417/12 , C07D417/14 , Y02P20/55

Abstract: The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.

Abstract translation: 本发明涉及可用于生产改性天冬氨酸衍生物如天冬氨酸醛部分的方法和化合物。天冬氨酸衍生物可用于制备半胱天冬酶抑制剂和/或其前药。

3.

发明申请
CASPASE INHIBITORS AND USES THEREOF 审中-公开
Title translation: CASPASE抑制剂及其用途

公开(公告)号：WO2005085236A3

公开(公告)日：2005-10-20

申请号：PCT/US2005006540

申请日：2005-02-28

Applicant: VERTEX PHARMA , CHARRIER JEAN-DAMIEN , DURRANT STEVEN , MORTIMORE MICHAEL , O'DONNELL MICHAEL , RUTHERFORD ALISTAIR , RAMAYA SHARN , STUDLEY JOHN R , TRUDEAU MARTIN , LOOKER ADAM

Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , MORTIMORE MICHAEL , O'DONNELL MICHAEL , RUTHERFORD ALISTAIR , RAMAYA SHARN , STUDLEY JOHN R , TRUDEAU MARTIN , LOOKER ADAM

IPC: A61K38/04 , A61K38/06 , C07D207/16 , C07D209/52 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/06 , C07D417/12 , C07K5/02 , C07K5/04 , A61K31/401 , A61K31/4025 , A61K31/403 , A61K31/443 , A61P37/00

CPC classification number: C07D405/12 , A61K38/06 , C07D207/16 , C07D209/52 , C07D401/12 , C07D401/14 , C07D417/06 , C07D417/12 , C07K5/0202

Abstract: The present invention provides a compound of formula (I): wherein the variables are as defined herein. The present invention also provides processes for preparing the compounds of formula (I), and intermediates thereof, pharmaceutical compositions comprising those compounds, and methods of using the compounds and compositions.

Abstract translation: 本发明提供式（I）的化合物：其中变量如本文所定义。本发明还提供制备式（I）化合物及其中间体，包含那些化合物的药物组合物的方法，以及使用该化合物和组合物的方法。

4.

发明申请
SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 审中-公开
Title translation: N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体形式

公开(公告)号：WO2007079139A9

公开(公告)日：2007-11-29

申请号：PCT/US2006049421

申请日：2006-12-28

Applicant: VERTEX PHARMA , HURTER PATRICIA , ROWE WILLIAM , YOUNG CHRISTOPHER R , COSTACHE ADRIANA , CONNELLY PATRICK , KRAWIEC MARIUSZ , GONG YUCHUAN , FENG YUSHI , TRUDEAU MARTIN

Inventor： HURTER PATRICIA , ROWE WILLIAM , YOUNG CHRISTOPHER R , COSTACHE ADRIANA , CONNELLY PATRICK , KRAWIEC MARIUSZ , GONG YUCHUAN , FENG YUSHI , TRUDEAU MARTIN

IPC: A01N43/40 , A61K31/445

CPC classification number: A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982

Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.

Abstract translation: 本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物及其方法。

5.

发明申请
BACTERIAL GYRASE INHIBITORS AND USES THEREOF 审中-公开
Title translation: 细菌GYRASE抑制剂及其用途

公开(公告)号：WO02060879A3

公开(公告)日：2003-03-27

申请号：PCT/US0148855

申请日：2001-12-12

Applicant: VERTEX PHARMA , GRILLOT ANNE-LAURE , CHARIFSON PAUL , STAMOS DEAN , LIAO YUSHENG , BADIA MICHAEL , TRUDEAU MARTIN

Inventor： GRILLOT ANNE-LAURE , CHARIFSON PAUL , STAMOS DEAN , LIAO YUSHENG , BADIA MICHAEL , TRUDEAU MARTIN

IPC: C07D235/32 , A61K31/00 , A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/437 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , A61P31/00 , A61P31/04 , A61P43/00 , C07D213/00 , C07D221/00 , C07D235/00 , C07D235/30 , C07D263/58 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/056 , C07D498/04 , C07D521/00 , C07F9/6558 , C07F9/6561

CPC classification number: C07D403/12 , A61K31/00 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/12 , C07D233/56 , C07D235/30 , C07D249/08 , C07D263/58 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D471/04 , C07D471/14 , C07D491/04 , C07F9/65583 , C07F9/6561 , A61K2300/00

Abstract: The present invention relates to compounds of the formula (I): or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to methods for decreasing bacterial quantity in a biological sample.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的衍生物或前药。该化合物可用作细菌回旋酶活性的抑制剂。本发明还涉及用于治疗哺乳动物细菌感染的方法。本发明还涉及生物样品中细菌数量减少的方法。

6.

发明公开
INHIBITORS OF IMPDH ENZYME 有权
Title translation: IMPDH酶的抑制剂

公开(公告)号：EP1178797A4

公开(公告)日：2003-05-02

申请号：EP00916479

申请日：2000-03-17

Applicant: VERTEX PHARMA

Inventor： STAMOS DEAN , TRUDEAU MARTIN , BETHIEL SCOTT , BADIA MICHAEL , SAUNDERS JEFFREY

IPC: C07D307/20 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07C275/40 , C07C275/42 , C07D263/32 , C07D413/12 , C07D417/12 , C07F9/653 , A61K31/277 , C07C275/34

CPC classification number: C07C275/40 , C07B2200/07 , C07C275/42 , C07D263/32 , C07F9/653

7.

发明公开
SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 有权
Title translation: FESTE FORMEN VON N- [2,4-BIS（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧杂环辛烷-3-羧酸

公开(公告)号：EP1993360A4

公开(公告)日：2010-12-01

申请号：EP06848237

申请日：2006-12-28

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN

IPC: C07D215/56 , A61K31/445

CPC classification number: A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982

Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.

Abstract translation: 本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物及其方法。