公开(公告)号：US4863689A

公开(公告)日：1989-09-05

申请号：US126857

申请日：1987-11-30

Applicant: Merlin L. Leong ,  John S. Hayward ,  Glyn R. Fox

Inventor： Merlin L. Leong ,  John S. Hayward ,  Glyn R. Fox

IPC: C12Q1/26 ,  C12Q1/66 ,  G01N21/76 ,  G01N33/58

CPC classification number: C12Q1/66 ,  C12Q1/26 ,  G01N21/76 ,  G01N33/582 ,  G01N2021/1768 ,  G01N21/763 ,  G01N2201/0648 ,  Y10T436/206664

Abstract: Apparatus is provided for the detection of chemiluminescence, e.g., the luminescent assay of an analyte in a sample. Sample, namely the production of a permanent photographic record of such chemiluminescence, e.g., by the use of a POLAROID film. The apparatus includes three interrelated elements. The first element comprises a film holder for holding a photographic film sensitive to a chemiluminescent reaction of the sample, the film holder defining a window in registry with any photographic film which may be held in the film holder. The second element comprises a sample holder for holding the sample in registry with the window and any photographic film which may be held in the film holder, and for allowing movements of the sample relative to any photographic film which may be held in the film holder between (i) a raised position, wherein the sample holder, and thus the sample is in spaced relation to any photographic film which may be held in the film holder and (ii) a lowered position, wherein said sample holder is in sufficiently close proximity to any photogarphic film which may be held in the film holder means to allow the sample held thereby directly to contact any photographic film which may be held in the film holder. The third element comprises a shutter operatively associated with the window of the film holder and movable between a closed position, wherein the shutter obstructs the window so as to prevent the sample holder from moving into the lowered position, and an opened position, wherein the window is unobstructed by the shutter so as to permit the sample holder to move from the raised position to the lowered position. The production of the permanent photographic record begins when the test sample in the container is placed in direct contact with the photographic film. The production of the photographic record is stopped when the test sample in the container is removed out of direct contact with the photographic film and the slidig shutter is closed. Various test results can be observed by varying the time of direct contact of the test sample in the reactant container with the photographic film. This provides maximal analytical sensitivity. During the entire test, exposure to ambient light is prevented.

公开(公告)号：US4791310A

公开(公告)日：1988-12-13

申请号：US914367

申请日：1986-10-02

Applicant: Arnold Honig ,  James E. Smith

Inventor： Arnold Honig ,  James E. Smith

IPC: G01N21/64 ,  G02B21/00 ,  G01N21/31

CPC classification number: G01N21/6408 ,  G01N2021/178 ,  G01N2021/641 ,  G01N2021/6413 ,  G01N2021/6421 ,  G01N21/6458 ,  G01N2201/0648

Abstract: A multi-chronal fluorescence imaging technique for spatial differentiation and correlation of a plurality of separate sample components tagged with site specific dyes is described. The dyes have decay times that are widely separated and vary by approximately a factor of ten from one dye to the next. These are added to the sample and are excited with a short pulse of ultraviolet light. Between the sample and a detector is placed an adjustable shutter or gate which is opened and closed at predetermined intervals so that the detector can see the approximate maximum intensity output of each dye in a shown ordered sequence without significant interference from the other dyes.

Abstract translation: 描述了用于用位点特异性染料标记的多个单独的样品组分的空间分化和相关性的多次荧光成像技术。 染料具有广泛分离的衰变时间，并且从一种染料到下一种染料变化约十倍。 将它们加入到样品中并用短脉冲的紫外线激发。 在样品和检测器之间放置可调节的快门或门，其以预定间隔打开和关闭，使得检测器可以以所示有序序列看到每种染料的近似最大强度输出，而没有来自其它染料的显着干扰。

公开(公告)号：WO2013014540A2

公开(公告)日：2013-01-31

申请号：PCT/IB2012/001907

申请日：2012-07-20

Applicant: BIOSENSIA PATENTS LIMITED ,  MOYNIHAN, Shane ,  FLAVIN, Diarmuid

Inventor： MOYNIHAN, Shane ,  FLAVIN, Diarmuid

CPC classification number: G01N21/6486 ,  G01N21/278 ,  G01N21/645 ,  G01N21/6452 ,  G01N33/5302 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6471 ,  G01N2201/0624 ,  G01N2201/0627 ,  G01N2201/0648 ,  G01N2201/0693

Abstract: The present disclosure, among other things, describes a reader system comprising a casing, an optical system, en electromechanical motor system, and one or more digital processors.

Abstract translation: 本公开尤其描述了包括壳体，光学系统，机电马达系统和一个或多个数字处理器的读取器系统。

公开(公告)号：WO2007075341A2

公开(公告)日：2007-07-05

申请号：PCT/US2006/047581

申请日：2006-12-13

Applicant: HACH COMPANY

Inventor： MITCHELL, Thomas, Owen

IPC: G01N21/03

CPC classification number: G01N21/643 ,  G01N21/8507 ,  G01N2201/0648

Abstract: A method and apparatus for visually detecting when a luminescent dissolved oxygen sensor is operating is disclosed. In one example embodiment of the invention, a shutter (216) is placed into the light tight container. When the shutter (216) is open, a user can see into the light tight container and verify probe operation. When the shutter (216) is closed, external light is prevented from entering the light tight container and affecting measurement accuracy. In another example embodiment of the invention, one end of a light pipe (526) is placed on the outside of the light tight container, and the other end is positioned to view the light source (504) of the probe. In another example embodiment of the invention a second light source (628), visible on the outside of the light tight container, is used to verify operation of the probe. In another example embodiment of the invention, a predetermined area is left open in the optically opaque hydrostatically transparent (814) on the face of the sensor window, allowing a user to see light from the sensor when the sensor is operating properly.

Abstract translation: 公开了一种用于可视地检测发光溶解氧传感器何时在工作的方法和装置。 在本发明的一个示例性实施例中，快门（216）被放置在不透光的容器中。 当快门（216）打开时，用户可以看到不透光的容器并验证探针操作。 当快门（216）关闭时，防止外部光进入不透光容器并影响测量精度。 在本发明的另一示例性实施例中，光管（526）的一端放置在不透光的容器的外侧，另一端定位成观察探针的光源（504）。 在本发明的另一示例性实施例中，在不透光容器的外侧上可见的第二光源（628）被用于验证探针的操作。 在本发明的另一示例性实施例中，预定区域在传感器窗口的面上的光学不透明流体透明（814）中保持打开，使得用户在传感器正常运行时看到来自传感器的光。

公开(公告)号：WO1980000188A1

公开(公告)日：1980-02-07

申请号：PCT/US1979000339

申请日：1979-05-18

Applicant: BECKMAN INSTR INC

Inventor： BECKMAN INSTR INC ,  GREENE M ,  HAUNOLD O

IPC: G01J03/02

CPC classification number: G01N21/0332 ,  G01N21/763 ,  G01N2201/0648

Abstract: A sample holder and shutter assembly (20) for photometers in which a stationary sample chamber body (40) is mounted in close proximity to a photosensitive device (18). A light path is provided from the sample chamber (53) to the photosensitive device (18) and shutter means is provided for selectively interrupting and opening the light path between the photosensitive device (18) and the sample chamber (53) without moving the sample chamber. Heat exchange means including a heat pump (63) and a heat reservoir (68) are provided for maintaining a desired temperature in the sample chamber (53). The sample chamber body (40) is thermally connected to said heat pump (63) and is preferably thermally isolated from the means mounting it. In one embodiment, the heat pump (63) and heat reservoir (68) are flexibly connected.

公开(公告)号：WO2017194628A1

公开(公告)日：2017-11-16

申请号：PCT/EP2017/061224

申请日：2017-05-10

Applicant: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES

Inventor： HAGUET, Vincent

IPC: G01N21/25 ,  B01L3/00 ,  G02B6/42 ,  G02B6/08

CPC classification number: G01N21/253 ,  B01L3/502715 ,  B01L3/5085 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/255 ,  G01N2201/0461 ,  G01N2201/0626 ,  G01N2201/0631 ,  G01N2201/0634 ,  G01N2201/0648 ,  G01N2201/0806

Abstract: L'invention se rapporte à un système d'observation (15) d'une plaque (10) comportant des puits (20), comportant, pour chaque puits (20): - une source (40) comprenant une diode électroluminescente (60) propre à produire un rayonnement lumineux, un sténopé (70), et un intégrateur de lumière (65) - un capteur optique (185) propre à récolter le signal optique issu du puits (20), le système (15) étant tel que : - un rapport entre la longueur et la dimension transversale moyenne (Dt) de chaque intégrateur de lumière (65) est supérieur ou égal à 2,2, ou - au moins un axe optique est décentré par rapport à la ligne de propagation, le rapport entre la longueur et la dimension transversale moyenne de l'intégrateur étant supérieur ou égal à 1,5.

Abstract translation:

本发明涉及 （20）的板（10）的观察系统（15），所述观察系统包括用于每个孔（20）的：包括清洁电致发光二极管（60）的源（40）; ; 产生一个发光辐射，一个stenopneumer （70）和光积分器（65） - 清洁光学传感器（185）; 从所述井（20）拾取光学信号，所述系统（15）使得： - 每个光积分器的长度和平均横向尺寸（Dt）之间的比率（Dt） 65）高于或低于; 2.2，或者 - 至少一个光轴以eacute居中 关于＆agr; 传播线，积分器的长度与平均横向尺寸之比或以上; 1.5。

公开(公告)号：WO2014144870A2

公开(公告)日：2014-09-18

申请号：PCT/US2014/029462

申请日：2014-03-14

Applicant: ABBOTT LABORATORIES

Inventor： DONOHUE, Joseph, P.

IPC: H04L12/24

CPC classification number: G01N35/021 ,  G01N21/76 ,  G01N35/0099 ,  G01N35/02 ,  G01N35/04 ,  G01N2035/0429 ,  G01N2201/0642 ,  G01N2201/0648 ,  Y10T436/113332 ,  Y10T436/114165

Abstract: A diagnostic analyzer includes a track, a light-blocking member, a motor, and an optical testing device. The track moves a reaction vessel held by the track. The light-blocking member is disposed adjacent to the track. The light-blocking member moves from a first position apart from the track to a second position closer to the track. When the light-blocking member is disposed in the first position a sample contained within the reaction vessel held by the track is exposed to light. When the light-blocking member is disposed in the second position the sample contained within the reaction vessel held by the track is blocked from exposure to the light. The motor moves the light-blocking member between the first and the second positions. The optical testing device is disposed adjacent to the track for optically testing the sample contained within the reaction vessel held by the track when the at least one light- blocking member is disposed in the second position.

Abstract translation: 诊断分析仪包括轨道，遮光构件，电动机和光学测试装置。 轨道移动由轨道保持的反应容器。 遮光构件邻近轨道设置。 遮光构件从远离轨道的第一位置移动到靠近轨道的第二位置。 当遮光构件设置在第一位置时，容纳在由轨道保持的反应容器内的样品暴露于光。 当遮光构件设置在第二位置时，包含在由轨道保持的反应容器内的样品被阻挡以暴露于光。 电动机在第一和第二位置之间移动遮光构件。 当所述至少一个遮光构件设置在所述第二位置时，所述光学测试装置邻近所述轨道布置以光学地测试由所述轨道保持的所述反应容器内的样本。

公开(公告)号：WO02068942A3

公开(公告)日：2003-01-03

申请号：PCT/IB0200590

申请日：2002-02-27

Applicant: IMAGING RES INC ,  ZARATE CARLOS ,  DONDERS PAUL ,  YEKTA AHMED ,  MASOUMI ZAHRA ,  RAMM PETER

Inventor： ZARATE CARLOS ,  DONDERS PAUL ,  YEKTA AHMED ,  MASOUMI ZAHRA ,  RAMM PETER

IPC: G01N21/64 ,  G01N21/78 ,  G01N33/483

CPC classification number: G01N21/6408 ,  G01N2201/0648

Abstract: The present invention relates to an apparatus and method for imaging time resolved fluorescence in biochemical and medical samples. In a primary aspect, the device includes a lens of large aperture, a flash lamp in the illumination path, a fast-acting solid state shutter or a gated detector in the emission path, a device for delivering homogenous monochromatic illumination to a plurality of wells distributed within a microwell plate, a digital camera of high quantum efficiency, and a computer. under computer control, the lamp is pulsed at short intervals. The fast-acting emission shutter or gated detector operates to limit exposure of the camera to a period some microseconds after the extinction of each lamp pulse, during which only delayed fluorescence is transmitted to the camera. The invention achieves simultaneous time resolved imaging of a plurality of samples, with high sensitivity and high throughput.

Abstract translation: 本发明涉及用于在生物化学和医学样品中成像时间分辨荧光的装置和方法。 在主要方面，该装置包括大孔径的透镜，照明路径中的闪光灯，发射路径中的快速固态快门或门控检测器，用于将均匀单色照明传送到多个孔的装置 分布在微孔板，高量子效率的数码相机和计算机中。 在计算机控制下，灯以短时间脉冲。 快速发射快门或门控检测器操作以将相机的曝光限制在每个灯脉冲消失之后几微秒的时段，在此期间仅将延迟的荧光传输到相机。 本发明实现多个样品的同时时间分辨成像，具有高灵敏度和高产量。

公开(公告)号：WO2014144870A3

公开(公告)日：2015-11-26

申请号：PCT/US2014029462

申请日：2014-03-14

Applicant: ABBOTT LAB

Inventor： DONOHUE JOSEPH P

IPC: B01J19/18 ,  C12M1/34 ,  G01N17/02

CPC classification number: G01N35/021 ,  G01N21/76 ,  G01N35/0099 ,  G01N35/02 ,  G01N35/04 ,  G01N2035/0429 ,  G01N2201/0642 ,  G01N2201/0648 ,  Y10T436/113332 ,  Y10T436/114165

Abstract: A diagnostic analyzer includes a track, a light-blocking member, a motor, and an optical testing device. The track moves a reaction vessel held by the track. The light-blocking member is disposed adjacent to the track. The light-blocking member moves from a first position apart from the track to a second position closer to the track. When the light-blocking member is disposed in the first position a sample contained within the reaction vessel held by the track is exposed to light. When the light-blocking member is disposed in the second position the sample contained within the reaction vessel held by the track is blocked from exposure to the light. The motor moves the light-blocking member between the first and the second positions. The optical testing device is disposed adjacent to the track for optically testing the sample contained within the reaction vessel.

Abstract translation: 诊断分析仪包括轨道，遮光构件，电动机和光学测试装置。 轨道移动由轨道保持的反应容器。 遮光构件邻近轨道设置。 遮光构件从远离轨道的第一位置移动到靠近轨道的第二位置。 当遮光构件设置在第一位置时，容纳在由轨道保持的反应容器内的样品暴露于光。 当遮光构件设置在第二位置时，包含在由轨道保持的反应容器内的样品被阻挡以暴露于光。 电动机在第一和第二位置之间移动遮光构件。 光学测试装置邻近轨道设置，用于光学测试包含在反应容器内的样品。

公开(公告)号：WO2013140617A1

公开(公告)日：2013-09-26

申请号：PCT/JP2012/057582

申请日：2012-03-23

Applicant: 株式会社島津製作所 ,  小田 竜太郎

Inventor： 小田　竜太郎

IPC: G01N21/27

CPC classification number: G01N21/05 ,  G01N21/31 ,  G01N2201/0648

Abstract: 光源２からの光を遮光するためのシャッタ１６（遮光用シャッタ）と、光源２から発せられる光の光路上の位置であって光源２と集光ミラー４との間の位置と光路から外れた位置との間でシャッタ１６を移動させるシャッタ駆動機構１８が設けられている。検出器制御部２０は光源２の点灯とシャッタ駆動機構１８によるシャッタの駆動を制御するための光照射制御手段２２を備えている。光照射制御手段２２は、試料の吸光度測定を行なう際にのみシャッタ１６を開くよう構成されている。

Abstract translation: 用于阻挡来自光源（2）的光的快门（16）（遮光快门）和用于将光闸（16）移动到从光发射的光的光路上的位置之间的快门驱动机构（18） 光源（2）和光源（2）和光收集镜（4）之间以及光路以外的位置。 检测器控制单元（20）设置有用于控制光源（2）的点亮和由快门驱动机构（18）驱动快门的光照射控制装置（22）。 光照射控制装置（22）仅在测量样品的吸光度时打开快门（16）。