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公开(公告)号：KR1020140004607A
公开(公告)日：2014-01-13
申请号：KR1020130144071
申请日：2013-11-25
Applicant: (주)아모레퍼시픽 , 동국대학교 산학협력단
CPC classification number: C12Q1/6883 , C12Q2600/118 , G01N33/53 , G01N33/68
Abstract: The present invention relates to a method for predicting chloasma formation and a diagnostic kit for chloasma formation and, more specifically, to a method for predicting chloasma formation and a diagnostic kit for chloasma formation, capable of diagnosing the possibility of chloasma formation on the skin by confirming the expression levels of genes which are differently expressed between the chloasma tissue and the normal skin tissue, wherein the diagnostic kit comprises: at least one polynucleotide sequence or its complementary polynucleotide as a probe hybridizing with polynucleotide of the gene sequence; a primer pair of the polynucleotide of the gene sequence; or at least one monoclonal antibody having, as a variable region, an amino acid sequence coded by the gene. According to the present invention, 23 high-expression genes and five low-expression genes, which are specific to a chloasma lesion, are used as a chloasma marker gene, thereby precisely and promptly diagnosing the possibility of chloasma formation on the skin. [Reference numerals] (AA) Relative mRNA expression level of a chloasma region as compared with a normal region; (BBC) Normal region
Abstract translation: 本发明涉及一种用于预测黄褐斑形成的方法和用于黄褐斑形成的诊断试剂盒，更具体地，涉及用于预测黄褐斑形成的方法和用于形成黄褐斑的诊断试剂盒，其能够诊断皮肤上形成黄褐斑的可能性 确认在黄褐斑组织和正常皮肤组织之间不同表达的基因的表达水平，其中所述诊断试剂盒包含：至少一种多核苷酸序列或其互补多核苷酸作为与所述基因序列的多核苷酸杂交的探针; 基因序列的多核苷酸的引物对; 或至少一种具有由该基因编码的氨基酸序列作为可变区的单克隆抗体。 根据本发明，将23个高表达基因和5个低度表达基因（其特异性为黄褐斑病变）用作黄褐斑标记基因，从而准确且及时地诊断皮肤上形成黄褐斑的可能性。 （附图标记）（AA）与正常区域相比，黄褐斑区域的相对mRNA表达水平; （BBC）正常区域
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公开(公告)号：KR101199209B1
公开(公告)日：2012-11-07
申请号：KR1020090034997
申请日：2009-04-22
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 천연물의 발효 추출물을 함유하는 화장료 조성물에 관한 것으로, 보다 상세하게는 적소두, 녹두 및 흑두 중 1종 이상의 염장 발효 추출물 또는 적소두, 녹두 및 흑두 중 1종 이상에 해양 심층수를 첨가하여 얻은 염장 발효 추출물을 함유함으로써 항산화 및 항노화 효과를 갖는 화장료 조성물에 관한 것이다.
염장 발효, 항산화, 항노화, 적소두, 녹두, 흑두, 해양 심층수-
公开(公告)号：KR101141907B1
公开(公告)日：2012-05-03
申请号：KR1020050069505
申请日：2005-07-29
Applicant: (주)아모레퍼시픽
Abstract: A method for inhibiting melanosome migration by using prohibitin siRNA(small interference RNA) is provided to inhibit expression of prohibitin in a melanin synthesis cell and uniformed distribution of melanosome in the melanin synthesis cell, so that the skin is whitened. The melanosome migration to the end of melanin synthesis cell is inhibited by administering prohibitin siRNA into the melanin synthesis cell, melan-a, thereby inhibiting binding of prohibitin to melanophilin as a melanosome vehicle and uniformed distribution of melanosome in the melanin synthesis cell.
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公开(公告)号：KR101072641B1
公开(公告)日：2011-10-11
申请号：KR1020040025053
申请日：2004-04-12
Applicant: (주)아모레퍼시픽
Abstract: 본발명은방선균() 균주또는방선균() 배양물추출물을유효성분으로함유하는피부미백용조성물에관한것으로서, 본발명에의한조성물은멜라닌생합성에관여하는효소인타이로시네이즈(tyrosinase)를합성하는글라이코실레이션(glycosylation)의과정에관여하는중요한효소인베타-글루코시다제(beta-glucosidase)의효소활성을억제함으로써, 타이로시네이즈의글라이코실레이션을억제하여멜라닌생성을저해함으로써미백효과를나타내므로, 본발명에의한피부미백용조성물을이용하면, 방선균균주또는방선균배양물추출물의효능으로인해부작용없이멜라닌생성을효과적으로억제할수 있다.
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Patent Agency Ranking
公开(公告)号：KR100998990B1
公开(公告)日：2010-12-09
申请号：KR1020030098859
申请日：2003-12-29
Applicant: (주)아모레퍼시픽
IPC: A61K31/352
Abstract: 본 발명은 슬리밍용 조성물에 관한 것으로, 보다 상세하게는 데아닌(theanine)과 카페인(caffeine), 제니스테인(genistein) 및 카르니틴(L-carnitine)으로 이루어진 군에서 선택된 1종 이상을 함유하는 슬리밍용 조성물에 관한 것이다. 본 발명의 조성물은 데아닌과 카페인, 제니스테인 및 카르니틴을 단독 또는 혼합물의 형태로 함유하여 우수한 지방 분해효과 및 셀룰라이트의 제거 효과를 나타낸다.
데아닌 * 카페인 * 제니스테인 * 카르니틴 * 지방세포 * 지방분해 * 중성지방 * 유리지방산 * 글리세롤 * 비만 * 셀룰라이트 * 다이어트-
公开(公告)号：KR1020100106754A
公开(公告)日：2010-10-04
申请号：KR1020090024900
申请日：2009-03-24
Applicant: (주)아모레퍼시픽
IPC: A61K8/97 , A61Q19/02 , A61K36/185 , A61P17/00
Abstract: PURPOSE: A composition containing Homalium longifolium extract for skin whitening is provided to suppress c-kit protein activation and signal transduction in melanocytes. CONSTITUTION: A composition for skin whitening contains 0.0001-10 weight% of Homalium longifolium extract as an active ingredient. The Homalium longifolium extracts suppresses c-kit activation. The Homalium longifolium extract controls melanocyte function by suppressing signal transduction in melanocytes. The composition for skin whitening is used in the form of emulsion, cream, essence, pack, gel, powder, makeup base, foundation, lotion, ointment, body lotion, body cream, body oil, shampoo, rinse, soap, and hair dye.
Abstract translation: 目的：提供一种含有长白containing提取物用于皮肤美白的组合物，以抑制黑素细胞中的c-kit蛋白激活和信号转导。 构成：用于皮肤美白的组合物含有0.0001-10重量％的枸杞提取物作为活性成分。 枸杞提取物抑制c-kit活化。 Homalium longifolium提取物通过抑制黑素细胞中的信号转导来控制黑素细胞功能。 用于皮肤美白的组合物以乳液，乳膏，精华，包装，凝胶，粉末，化妆底，基础，洗剂，软膏，身体乳液，身体霜，身体油，洗发剂，漂洗剂，肥皂和染发剂的形式使用 。
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公开(公告)号：KR1020100057274A
公开(公告)日：2010-05-31
申请号：KR1020080116244
申请日：2008-11-21
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A cosmetic composition containing 4,4',6-trihydroxyaurone and liposome of phosphatidyl ethanol amine and phosphatidyl choline for skin whitening is provided. CONSTITUTION: A cosmetic composition for skin whitening contains 4,4',6-trihydroxyaurone as an active ingredient and liposome having a phosphatidyl ethanol amine and phosphatidyl choline. The phosphatidyl choline has 12-24 carbon atoms. The cosmetic composition is used in the form of skin, lotion, eye cream, essence, cleansing cream, cleansing lotion, pack, body lotion, body cream, body essence, gel, or cream.
Abstract translation: 目的：提供含有4,4'，6-三羟基甲硅氧烷和磷脂酰乙醇胺脂质体以及用于皮肤美白的磷脂酰胆碱的化妆品组合物。 构成：用于皮肤美白的化妆品组合物含有4,4'，6-三羟基甲龙作为活性成分，脂质体具有磷脂酰乙醇胺和磷脂酰胆碱。 磷脂酰胆碱具有12-24个碳原子。 化妆品组合物以皮肤，洗剂，眼霜，精华液，清洁霜，清洁乳液，包装，身体乳液，身体霜，身体精华，凝胶或霜剂的形式使用。
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公开(公告)号：KR1020100010132A
公开(公告)日：2010-02-01
申请号：KR1020080070987
申请日：2008-07-22
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/73 , A61K8/97 , A61K2800/74 , A61K2800/782 , A61Q19/007 , A61Q19/02 , A61Q19/08
Abstract: PURPOSE: A method for preparing green tea polysaccharide is provided to shorten manufacturing time and improve economic efficiency. CONSTITUTION: A method for preparing green tea polysaccharide comprises: a step of removing chlorophyll and polyphenol of low molecule using solvent; a step of extracting water-soluble active ingredient at 30-40°C from the green tea; and a step of isolating green tea polysaccharide through ultrafiltration and ethanol precipitation. The solvent is hexane, ethanol or methanol. The cosmetic composition is used for skin whitening, moisturization or anti-wrinkle.
Abstract translation: 目的：制备绿茶多糖的方法，缩短生产时间，提高经济效益。 构成：制备绿茶多糖的方法包括：使用溶剂除去低分子的叶绿素和多酚的步骤; 从绿茶中提取30-40℃的水溶性活性成分的步骤; 并通过超滤和乙醇沉淀分离绿茶多糖的步骤。 溶剂是己烷，乙醇或甲醇。 化妆品组合物用于皮肤美白，保湿或抗皱。
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60.发明公开Ｒｈｏ ＧＤＩ-α를 포함하는 멜라닌 생성 조절용 조성물및 Ｒｈｏ ＧＤＩ-α를 이용하여 멜라닌 생성 조절제를스크리닝하는 방법 失效用于控制含有RHO GDI-α的成血作用的组合物，以及使用RHO GDI-α筛选造血调节剂的方法;
公开(公告)号：KR1020090054505A
公开(公告)日：2009-06-01
申请号：KR1020070121200
申请日：2007-11-27
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/64 , A61Q19/02 , G01N33/5008 , G01N2500/04
Abstract: A composition for regulating melanogenesis, which contains RhoGDI-alpha is provided to efficiently promote or inhibit melanogenesis using siRNA gene which suppresses RhoGDI-alpha expression. A composition for regulating melanogenesis comprises a RhoGDI-alpha protein or gene coding the same or a complementary gene of RhoGDI-alpha gene. The composition for regulating melanogenesis inhibits the expressions of MITF and tyrosinase. The composition for regulating melanogenesis promotes the expression of MITF and tyrosinase. A screening method of the composition for regulating melanogenesis includes confirmation of regulation of RhoGDI-alpha expression, activation or function.
Abstract translation: 提供了含有RhoGDI-α的用于调节黑素生成的组合物，用于抑制RhoGDI-α表达的siRNA基因有效促进或抑制黑素生成。 用于调节黑素生成的组合物包含编码RhoGDI-α基因相同或互补基因的RhoGDI-α蛋白或基因。 用于调节黑素生成的组合物抑制MITF和酪氨酸酶的表达。 用于调节黑素生成的组合物促进MITF和酪氨酸酶的表达。 用于调节黑素生成的组合物的筛选方法包括确认RhoGDI-α表达的调节，活化或功能。
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