公开(公告)号：KR1020180027835A

公开(公告)日：2018-03-15

申请号：KR1020160114991

申请日：2016-09-07

Applicant: 현대자동차주식회사 ,  기아자동차주식회사 ,  서울대학교산학협력단

Inventor： 김신정 ,  이은상 ,  이위직 ,  조창민 ,  노종선 ,  김영식

IPC: B60R25/24 ,  B60R25/20 ,  H01Q1/32

CPC classification number: B60R25/24 ,  B60R25/209 ,  B60R25/245 ,  H01Q1/32 ,  H01Q1/3241

Abstract: 차량은원격조작장치를탐색하기위한 LF(Low Frequency)신호를송신하는 LF송신부, LF송신부가송신하는 LF신호의주파수대역보다높은미리설정된주파수대역의신호를수신하는고주파수신부, 및고주파수신부에서수신된신호가변조된 LF신호인경우중계공격으로서판단하는제어부를포함한다.

Abstract translation: 车辆在高频率新娘接收，并且高频新娘接收LF（低频）LF发送部，较高的预定频带比由LF发送部为用于搜索远程控制设备发送的信号发送的LF信号的频带的信号 并且当接收到的信号是调制的LF信号时确定接收到的信号是中继攻击。

公开(公告)号：KR1020140079892A

公开(公告)日：2014-06-30

申请号：KR1020120149054

申请日：2012-12-20

Applicant: 서울대학교산학협력단

Inventor： 김영식 ,  오메르쉐자드

IPC: B01D15/18 ,  G01N30/02 ,  G01N33/00

CPC classification number: B01D15/1807 ,  A61K36/258 ,  C07K1/18 ,  C12P19/00 ,  G01N30/02 ,  G01N33/00

Abstract: The present invention relates to a method for separating ginsenoside from a ginseng extract in one step using a counter-current chromatography. A certain amount and more of high purity of 14 kinds of ginsenoside can be obtained within a short time (100-400 minutes) through one chromatography process without going through a special process. Moreover, an expensive column with a limited reuse is not needed, and the use of a solvent is drastically reduced.

Abstract translation: 本发明涉及一种使用逆流色谱法从人参提取物中分离人参皂甙的方法。 通过一个色谱法可以在短时间内（100-400分钟）内获得一定量的高纯度14种人参皂甙，而不需要经过特殊工艺。 此外，不需要具有有限重复使用的昂贵的塔，并且使用溶剂大大降低。

公开(公告)号：KR101083045B1

公开(公告)日：2011-11-16

申请号：KR1020090087288

申请日：2009-09-16

Applicant: 서울대학교산학협력단

Inventor： 김영식 ,  하인진 ,  이은정

IPC: C12P19/44 ,  A61K31/704 ,  A61K36/346 ,  A61P3/04

Abstract: 길경 추출물로부터 분리되는 길경 사포닌 분획물 및 이 분획물로부터 효소에 의하여 생전환 시킨 고함량의 플라티코딘 D를 유효성분으로 함유하는 지질대사 질환의 예방 및 치료용 조성물에 관한 것으로서, 상세하게는 본 발명의 길경 추출물로부터 분리되는 길경 사포닌 분획물 및 이 분획물로부터 효소에 의하여 생전환 시킨 고함량의 플라티코딘 D 강화 분획물은 지방세포 분화 억제 효과가 탁월하므로, 상기 조성물은 지질대사 질환의 예방 및 치료용 약학조성물 및 건강기능식품으로 유용하게 이용될 수 있다.
길경 추출물, 길경 사포닌 분획물, 플라티코딘 D, 지방세포 분화, 지질대사 질환

公开(公告)号：KR100919134B1

公开(公告)日：2009-09-25

申请号：KR1020080103521

申请日：2008-10-22

Applicant: 에이치엘바이오 주식회사 ,  서울대학교산학협력단

Inventor： 임순성 ,  강일준 ,  김영식

IPC: A61K36/258 ,  A61P3/04

Abstract: PURPOSE: A ginseng extract containing low polarity ginsenoside in high concentration, which has anti-obesity effect is provided to reduce the accumulation of lipid in an adipocyte and used as a composition for anti-obesity. CONSTITUTION: A method for manufacturing a ginseng extract comprises: a step of extracting a ginseng with 20-40 v/v% of methanol or ethanol and 80 ~ 99 v/v% of methanol or ethanol; a step of culturing the extract in pH 1.3-2 of artificial gastric juice; and a step of adding serous fluid and culturing at pH 7-8.

Abstract translation: 目的：提供含有高浓度低极性人参皂苷的人参提取物，其具有抗肥胖作用，以减少脂肪细胞中脂质的积累并用作抗肥胖的组合物。 构成：人参提取物的制造方法，其特征在于，使用20〜40v / v％的甲醇或乙醇和80〜99v / v％的甲醇或乙醇提取人参的步骤; 在人造胃液的pH 1.3-2中培养提取物的步骤; 以及添加浆液并在pH7-8下培养的步骤。

公开(公告)号：KR102218299B1

公开(公告)日：2021-02-22

申请号：KR1020200010063

申请日：2020-01-28

Applicant: 서울대학교산학협력단

Inventor： 김영식 ,  이주희 ,  송광호 ,  백우현 ,  장혜리

IPC: A61K36/28 ,  A61K31/215 ,  A61P17/06 ,  A23L33/105 ,  A61K8/9789 ,  A61K8/37 ,  A61Q19/00

Abstract: 본발명은관동화유래세스퀴테르펜화합물(TG, ECN, TH7, TGN 및 AECN) 또는세스퀴테르펜강화분획(STE)을유효성분으로함유하는건선의예방또는치료용조성물에관한것으로, 본발명의 TG, ECN, TH7, TGN, AECN 및 STE는인간유래각질세포주인 HaCaT 세포에서 TNF-α에의해증가된염증관련인자들의 mRNA 발현을억제하고, IL-6에의해유도된세포과증식(hyperproliferation)을억제하며, 특히 TGN, AECN 및 STE는이미퀴모드유도건선마우스모델에서임상적및 조직학적항건선효과를나타냄으로써, 건선의예방, 치료또는개선용조성물로유용하게사용될수 있다.

公开(公告)号：KR102055322B1

公开(公告)日：2019-12-12

申请号：KR1020180024890

申请日：2018-02-28

Applicant: 서울대학교산학협력단

Inventor： 김영식 ,  강삼식 ,  고혜진 ,  송광호 ,  김지혜

IPC: A61K8/9789 ,  A61K8/49 ,  A61K36/28 ,  A61K31/365 ,  A23L33/105 ,  A61Q19/02 ,  A61P17/00

公开(公告)号：KR1020120137642A

公开(公告)日：2012-12-24

申请号：KR1020110056137

申请日：2011-06-10

Applicant: 서울대학교산학협력단

Inventor： 김영식 ,  박유미 ,  임아랑

IPC: A61K9/16 ,  A61K47/02 ,  A61K31/737

CPC classification number: A61K9/5161 ,  A61K9/06 ,  A61K9/5192 ,  A61K33/38 ,  Y10S514/97

Abstract: PURPOSE: A silver nanoparticle using chondroitin sulfate or acharan sulfate is provided to suppress bacteria without toxicity and to enable quick wound healing. CONSTITUTION: A biocompatible silver nanoparticle improves safety, stability, and wound healing effect using chondroitin sulfate or acharan sulfate. The size of the silver nanoparticle is 5-50 nm. A method for preparing the silver nanoparticles comprises: a step of dissolving chondroitin sulfate or acharan sulfate in 0.01-2.0 mM of distilled water to prepare a reducing agent solution; a step of dissolving 0.01-10.0 mM nitric acid in distilled water to prepare a nitric acid solution; a step of mixing the reducing agent solution and nitric acid solution to prepare a mixture solution; and a step of reacting the mixture solution in an autoclave or microwave.

Abstract translation: 目的：提供使用硫酸软骨素或硫酸沙卡糖的银纳米颗粒，以抑制细菌无毒性，并能快速伤口愈合。 构成：生物相容性银纳米颗粒使用硫酸软骨素或硫酸阿卡拉酸提高安全性，稳定性和伤口愈合效果。 银纳米颗粒的尺寸为5-50nm。 制备银纳米颗粒的方法包括：将硫酸软骨素或硫酸阿卡沙溶解在0.01-2.0mM蒸馏水中以制备还原剂溶液的步骤; 将0.01-10.0mM硝酸溶解在蒸馏水中以制备硝酸溶液的步骤; 将还原剂溶液和硝酸溶液混合以制备混合溶液的步骤; 以及在高压釜或微波炉中使混合溶液反应的步骤。

公开(公告)号：KR1020100135577A

公开(公告)日：2010-12-27

申请号：KR1020090054043

申请日：2009-06-17

Applicant: 주식회사 엘지생활건강 ,  서울대학교산학협력단

Inventor： 김호정 ,  한종섭 ,  이천구 ,  김영식 ,  장세현 ,  신은명

IPC: A61K8/35 ,  A61Q19/08

CPC classification number: A61K8/347 ,  A61K2800/782 ,  A61Q19/08

Abstract: PURPOSE: A cosmetic composition containing demethoxycurcumin or bisdemethoxycurcumin for anti-wrinkling is provided to suppress expression of collaganase without toxicity. CONSTITUTION: A cosmetic composition for anti-wrinkling contains 0.000001-10.0 weight% of demethoxycurcumin of chemical formula 1 or bisdemethoxycurcumin of chemical formula 2 as an active ingredient. The cosmetic composition is used in the form of cream, lotion, essence, gel, ointment, foam, pack, emulsion, foundation, makeup base, soap, or sun screen.

Abstract translation: 目的：提供含有脱甲氧基姜黄素或双脱甲氧基姜黄素抗皱的化妆品组合物，以抑制无毒性的胶原蛋白酶的表达。 构成：抗皱化妆品组合物含有0.000001-10.0重量％的化学式1的脱甲氧基姜黄素或化学式2的二去甲氧基姜黄素作为活性成分。 化妆品组合物以乳膏，洗剂，精华，凝胶，软膏，泡沫，包装，乳液，粉底，化妆底，肥皂或防晒霜的形式使用。

公开(公告)号：KR1020100069202A

公开(公告)日：2010-06-24

申请号：KR1020080127825

申请日：2008-12-16

Applicant: 서울대학교산학협력단 ,  연세대학교 산학협력단

Inventor： 정원윤 ,  박광균 ,  이선경 ,  김영식 ,  하영완 ,  이은정

IPC: A61K31/704 ,  A61P19/10

CPC classification number: A61K31/704 ,  A23L33/105 ,  A61K36/346 ,  A61K2236/33

Abstract: PURPOSE: A composition containing platycodin D for preventing and treating bone diseases is provided to reduce bone absorption and to suppress osteoclasia. CONSTITUTION: A composition for preventing or treating bone diseases contains platycodin D as an active ingredient. The platycodin D is contained in Platycodon grandiflorum extract. The Platycodon grandiflorum extract is obtained by isolating with water, butane, ethyl acetate, or mixture thereof. The bone diseases are bone injury, osteoporosis, richets, malacosteon, or metabolic bone diseases. A pharmaceutical composition for preventing and treating bone diseases contains therapeutically effective amount of the composition and pharmaceutically acceptable carrier.

Abstract translation: 目的：提供含有用于预防和治疗骨病的桔黄素D的组合物以减少骨吸收并抑制骨形成。 构成：用于预防或治疗骨疾病的组合物含有桔黄素D作为活性成分。 桔梗D含有桔梗提取物。 通过用水，丁烷，乙酸乙酯或其混合物分离获得桔梗提取物。 骨骼疾病是骨骼损伤，骨质疏松症，乳头状瘤，马可康多或代谢性骨病。 用于预防和治疗骨疾病的药物组合物含有治疗有效量的组合物和药学上可接受的载体。

公开(公告)号：KR1020080100313A

公开(公告)日：2008-11-17

申请号：KR1020080103893

申请日：2008-10-22

Applicant: 주식회사 한국천연물사이언스 ,  서울대학교산학협력단 ,  주식회사 제마유

Inventor： 이성권 ,  김영식 ,  박영대 ,  이재승 ,  이대성 ,  송주은

IPC: A61K8/98 ,  A61K8/92 ,  A61Q19/00

CPC classification number: A61K8/925 ,  A61K8/14

Abstract: A method for refining horse oil is provided to produce refined horse oil of which a human body absorption property is high, to remove a saturated fatty acid and a free fatty acid using an ultra-precision control crystallization, to increase a validity of the horse oil and the human body absorption property, to enhance an yield while commercial production, to generate no waste water and to cause no color and smell. A method for refining horse oil comprises steps of: i) adding urea in horse oil and reacting it; ii) removing a crystal by filtering the reaction solution of the step i); iii) adding activated charcoal and activated clay in a filtrate of the step ii) and reacting it at a vacuum pressure; iv) removing the activated clay and the activated charcoal using a filtering process; v) cooling the filtrate of the step iv) at a room temperature; vi) adding water to the filtrate of the step v) additionally and performing evaporation of a thin film under the vacuum pressure.

Abstract translation: 提供马油精制方法，制造人体吸收性高的精制马油，利用超精密控制结晶除去饱和脂肪酸和游离脂肪酸，提高马油的有效性 和人体吸收性能，在商业生产时提高产量，不产生废水，不产生颜色和气味。 一种精炼马油的方法包括以下步骤：i）在马油中加入尿素并使其反应; ii）通过过滤步骤i）的反应溶液除去晶体; iii）在步骤ii）的滤液中加入活性炭和活性粘土，并在真空压力下反应; iv）使用过滤方法除去活化的粘土和活性炭; v）在室温下冷却步骤iv）的滤液; vi）另外向步骤v）的滤液中加入水，并在真空压力下进行薄膜的蒸发。