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公开(公告)号：KR1020100131130A
公开(公告)日：2010-12-15
申请号：KR1020090049866
申请日：2009-06-05
Applicant: 한국과학기술연구원
CPC classification number: C07K14/76 , A61K47/643 , C07K14/765 , C07K2319/20
Abstract: PURPOSE: A poly-cysteine peptide-fusion recombinant albumin is provided to improve albumin-drug conjugation efficiency and to reduce side effects of albumin carrier. CONSTITUTION: A recombinant albumin is obtained by fusing poly-cysteine peptide with albumin. The poly-cystein peptide has a sequence of sequence number 1 or 2. The recombinant albumin additionally contains linker peptide between the poly-cysteine peptide and both ends of albumin. The linker peptide is glycine, serine aor alanine. The linker peptide has a sequence of sequence number 3. The drug is anticancer drug, siRNA, or therapeutic agent for incurable diseases. A composition for diagnosing diseases contains albumin-molecule imaging fluorescence complex formed by binding the recombinant albumin with molecule imaging fluorescence.
Abstract translation: 目的：提供多聚半胱氨酸肽融合重组白蛋白，以改善白蛋白 - 药物共轭效率，减少白蛋白载体的副作用。 构成：通过将多聚半胱氨酸肽与白蛋白融合获得重组白蛋白。 多聚半胱氨酸肽具有序列号1或2的序列。重组白蛋白另外含有多聚半胱氨酸肽和白蛋白两端之间的接头肽。 接头肽是甘氨酸，丝氨酸aor丙氨酸。 接头肽具有序列号3的序列。该药物是抗癌药物，siRNA或治疗性疾病的治疗剂。 用于诊断疾病的组合物含有通过用分子成像荧光结合重组白蛋白形成的白蛋白分子成像荧光复合物。
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52.发明公开
公开(公告)号：KR1020100047517A
公开(公告)日：2010-05-10
申请号：KR1020080106450
申请日：2008-10-29
CPC classification number: H01M8/1004 , C23C16/0263 , H01M4/8825 , H01M4/92 , H01M4/921 , H01M4/926 , Y02P70/56
Abstract: PURPOSE: A manufacturing method of a membrane electrode assembly for a fuel cell is provided to simplify the manufacturing process of the membrane electrode assembly, and to reduce the amount of a white pole catalyst. CONSTITUTION: A manufacturing method of a membrane electrode assembly for a fuel cell to form a nano surface structure on a polymer electrolyte membrane comprises the following steps: plasma treating the surface of the polymer electrolyte membrane(30) located in a chamber for plasma treating using PACVD method, while maintaining the pressure range of the chamber into 1.0×10^(-7)~2.75×10^(-3) pascals; forming a nanostructure(40) with hair patterns on the surface of the polymer electrolyte membrane by plasma treating for 1 seconds~60 minutes; and evaporating a catalyst on the surface of the polymer electrolyte membrane.
Abstract translation: 目的：提供一种用于燃料电池的膜电极组件的制造方法，以简化膜电极组件的制造工艺，并减少白极催化剂的量。 构成：在聚合物电解质膜上形成纳米表面结构的燃料电池用膜电极接合体的制造方法包括以下步骤：对位于室内的高分子电解质膜（30）的表面进行等离子体处理， PACVD方法，同时保持室的压力范围为1.0×10 ^（ - 7）〜2.75×10 ^（ - 3）帕斯卡; 通过等离子体处理1秒〜60分钟，在聚合物电解质膜的表面上形成具有毛发图案的纳米结构（40）; 并在聚合物电解质膜的表面上蒸发催化剂。
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Patent Agency Ranking
公开(公告)号：KR1020170039018A
公开(公告)日：2017-04-10
申请号：KR1020150138054
申请日：2015-09-30
Applicant: 경북대학교 산학협력단 , 강릉원주대학교산학협력단 , 한국과학기술연구원 , 울산과학기술원
IPC: H02N11/00
Abstract: 본발명은자성유체를이용한고효율연속발전사이클장치에관한것으로서, 보다상세하게는자성을띄는나노입자인자성유체와, 상기자성유체가내부로통과되어순환되는순환파이프와, 상기순환파이프의외측에상기순환파이프의길이방향을따라소정구간권선되는코일로구성된유도발전부와, 상기순환파이프의상하길이방향을따라상기코일의외측을감싸도록영구자석이복수개배치되되, 상기인접한영구자석은동일한극성끼리상호마주보도록설치되는자화방향변환부를포함하여제공된다. 상기와같은본 발명에따르면, 순환파이프에설치되는영구자석이동일한극성끼리상호마주보도록복수개배치시켜, 자성유체의나노입자가활발하게교란되어발전효율이높아지는효과가있다. 또한, 자성유체에비자성체인기포가비균질적으로흐르도록공급시켜시간에따른자속의변화를유도하여고효율로연속적인발전이가능하도록하는효과가있다.
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公开(公告)号：KR1020150111705A
公开(公告)日：2015-10-06
申请号：KR1020140035407
申请日：2014-03-26
Applicant: 한국과학기술연구원
CPC classification number: A61K41/0057 , A61K9/1075 , A61K9/5123 , A61K9/5146 , A61K49/003 , A61K49/0082 , A61K9/16 , A61K9/127 , A61K47/30 , A61K47/50 , A61K49/04
Abstract: 본발명은생체영상및 광역학치료를위한메틸렌블루나노입자와, 이의암 치료제및 조영제로서의용도에관한것이다. 본발명의국소암표적성광치료제로사용되기위한메틸렌블루나노입자는조성이임상사용중이거나인체유래인물질만으로구성되어, 임상진입장벽이낮고상용화가능성이매우높은나노제제이며, 암표적성, 일항산소발생성능과함께근적외형광을나타내므로광학영상화등 생체영상진단과암 표적광역학치료에동시에사용될수 있다.
Abstract translation: 本发明涉及用于生物成像和光动力学治疗的亚甲蓝纳米颗粒，其抗癌药物，并且用作造影剂。 用于本发明的局部癌症靶向光疗法的亚甲蓝纳米颗粒可以同时用于生物成像诊断例如光学成像等，同时用于癌症靶向光动力学治疗，通过临床使用或仅由 代表人体的物质，代表癌症靶向性，单线态氧的发生能力和近红外荧光，作为具有低临床入门障碍和高商业化可能性的纳米医药。
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公开(公告)号：KR101485389B1
公开(公告)日：2015-01-26
申请号：KR1020130024657
申请日：2013-03-07
Applicant: 한국과학기술연구원
CPC classification number: A61K49/0093 , A61K49/0002 , A61K49/0032 , A61K49/0054
Abstract: 본 발명은 조영제 조성물 및 이를 이용한 바이오 영상화 방법에 관한 것이다. 본 발명의 조영제 조성물은 생분자인 DNA 나노 구조체를 주요 성분으로 포함하기 때문에, 본질적으로 비세포독성 및 비면역성이며, 다른 유기 또는 무기 기반 조영제 조성물에서 관찰될 수 있는 안전성 문제를 야기할 가능성이 낮다. 또한, 본 발명의 조영제 조성물은 우수한 세포 내 섭취 및 안정성을 나타내어 충분한 조영 증강 효과를 통해 질병의 진단을 용이하게 할 뿐만 아니라, 기존에 탐색이 어려웠던 감시림프절까지 영상화할 수 있기 때문에, 암의 전이 여부를 용이하게 판단하고, 저침습적 치료의 임상 적용을 가능하게 한다.
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公开(公告)号：KR1020140110401A
公开(公告)日：2014-09-17
申请号：KR1020130024657
申请日：2013-03-07
Applicant: 한국과학기술연구원
CPC classification number: A61K49/0093 , A61K49/0002 , A61K49/0032 , A61K49/0054
Abstract: The present invention relates to a contrast medium composition and a method of bio imagination using the same. The contrast medium composition of the present invention includes DNA nanostructure, which is a biomolecule, as an active ingredient; is fundamentally non-cytotoxic and non-immunogenic; and is not likely to induce safety problems that may be observed in other organic or inorganic contrast medium composition. In addition, the contrast medium composition of the present invention not only facilitates diagnosis of disease through sufficient contrast enhancement effect by showing excellent cellular uptake and intracellular stability but can visualize even SLNs which is difficult to be visualized traditionally, thus enabling easy examination of cancer metastasis and application of lower invasive treatment.
Abstract translation: 本发明涉及造影剂组合物和使用其的生物想象力的方法。 本发明的造影剂组合物包含作为活性成分的作为生物分子的DNA纳米结构体; 基本上是非细胞毒性和非免疫原性的; 并且不可能引起在其它有机或无机造影剂组合物中可能观察到的安全问题。 此外，本发明的造影剂组合物不仅通过显示优异的细胞摄取和细胞内稳定性而能够通过充分的对比度增强效果来促进疾病的诊断，而且可以使传统上难以显现的SLN甚至可视化，因此能够容易地检查癌症转移 并应用低侵入性治疗。
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公开(公告)号：KR1020140096821A
公开(公告)日：2014-08-06
申请号：KR1020130009894
申请日：2013-01-29
Applicant: 한국과학기술연구원
CPC classification number: A61K49/12 , A61K9/06 , A61K33/24 , A61K47/34 , A61K49/0054 , A61K49/1803 , A61K2121/00 , B82Y5/00
Abstract: The present invention relates to a Gd-PEI nanogel and a contrast agent or a pharmaceutical composition comprising the same. The Gd-PEI nanogel has an amorphous shape and a flexible nature, and thus passes through an RES system. The Gd-PEI nanogel expresses minimum cytotoxin and enables excellent targeting of in-vivo tumor, thereby ensuring high biomedical potential power as the contrast agent and a drug carrier.
Abstract translation: 本发明涉及Gd-PEI纳米凝胶和造影剂或包含其的药物组合物。 Gd-PEI纳米凝胶具有无定形形状和柔性，从而通过RES系统。 Gd-PEI纳米凝胶表达最小的细胞毒素，能够实现体内肿瘤的优异靶向，从而确保作为造影剂和药物载体的高生物医学潜力。
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