公开(公告)号：DE69330785T2

公开(公告)日：2002-06-20

申请号：DE69330785

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： SCHMIDT LINDA S ,  SPRONK ADRIAN M ,  CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  KANEWSKE III ,  LAGOCKI PETER A ,  MITCHELL JAMES E ,  MARTIN RICHARD R ,  MOORE LARRY E ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH JANE B ,  TAYI APPARAO ,  VAUGHT JAMES A ,  YOST DAVID A

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  G01N1/00 ,  G01N21/25 ,  G01N33/53 ,  G01N33/536 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  G01N33/02 ,  G01N33/483

公开(公告)号：ES2150942T3

公开(公告)日：2000-12-16

申请号：ES93909167

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： RAYMOURE WILLIAM J ,  CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  G01N1/00 ,  G01N21/25 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  G01N33/546 ,  G01N33/483

公开(公告)号：CA2172363A1

公开(公告)日：1995-03-31

申请号：CA2172363

申请日：1994-09-22

Applicant: ABBOTT LAB

Inventor： CLARK FREDERICK L ,  CLEMENS JOHN M ,  HANCE ROBERT B ,  HENDRICK KENDALL B ,  TAYI APPARAO ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MCDOWELL DOUGLAS D ,  MERRIAM RICHARD A ,  MOORE LARRY W ,  OLEKSAK CARL M ,  PENNINGTON CHARLES D ,  RAYMOURE WILLIAM J ,  RUMBAUGH WILLIAM D ,  SCHMIDT LINDA S ,  SCHRIER PAUL R ,  SMITH B JANE ,  SPRONK ADRIAN M ,  WALKER EDNA S ,  VAUGHT JAMES A ,  VICKSTROM RICHARD L ,  WALKER DONNY RAY ,  WATKINS WILLIAM E III ,  WINTER GARY E ,  WOHLFORD ROBERT A ,  CLIFT GILBERT ,  CLOONAN KEVIN M ,  MITCHELL JAMES E ,  STANTON ALYN K ,  YOST DAVID A ,  HILLS DAVID B

IPC: G01N33/483 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  G01N37/00

Abstract: An automated, continuous and random access analytical system, having apparat us and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodolo gies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is a lso disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assa ys of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a u nit dose disposable and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reacti on sequence, followed by physical transfer of the unit dose disposable to a processing wo rkstation, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation. The system is capable of performi ng more than one scheduled assay in any order, and assay s where more than such scheduled assays are presented. The automated, continuo us and random access analytical system is also capable o f analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

公开(公告)号：CA2650259A1

公开(公告)日：1995-03-30

申请号：CA2650259

申请日：1994-09-22

Applicant: ABBOTT LAB

Inventor： HENDRICK KENDALL B ,  MOORE LARRY W ,  CLOONAN KEVIN M ,  CLARK FREDERICK L ,  CLIFT GILBERT ,  WATKINS WILLIAM E III ,  KANEWSKE WILLIAM J III ,  VICKSTROM RICHARD L ,  MCDOWELL DOUGLAS D

IPC: B65D47/08 ,  G01N33/483 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04

Abstract: A capped-closure mounted on a container for storing reagents for use in an automated analytical instrument having an actuating device mounted thereon. The capped-closure comprises a base being generally cylindrical, wherein the bas e has one end opening to the container and the other end having an opening through whi ch the reagents can be aspirated. The capped-closure further comprises a lever assembly pivotally mounted on the base. The lever assembly has one end which forms a cap operable to seal the opening the base sufficiently tightly to prevent evaporation from the container. The other end of the lever assembly forms a tab operable to pivot the lever assembly to a substantially perpendicular position with opening of the base when depressed for exposing the opening of the base to a device for aspirating th e reagent from the container. The capped-closure finally comprises spring mechanism connect ed between the base and the lever assembly for urging the lever assembly to the substantially perpendicular position.

公开(公告)号：CA2613156A1

公开(公告)日：1995-03-30

申请号：CA2613156

申请日：1994-09-22

Applicant: ABBOTT LAB

Inventor： TAYI APPARAO ,  KANEWSKE WILLIAM J III ,  VAUGHT JAMES A ,  YOST DAVID A ,  HILLS DAVID B ,  LAGOCKI PETER A ,  WINTER GARY E ,  VICKSTROM RICHARD L ,  STANTON ALYN K ,  PENNINGTON CHARLES D ,  RAYMOURE WILLIAM J ,  MARTIN RICHARD R ,  OLEKSAK CARL M ,  MITCHELL JAMES E ,  SCHMIDT LINDA S ,  WALKER DONNY RAY ,  WATKINS WILLIAM E III ,  HENDRICK KENDALL B ,  WALKER EDNA S ,  SPRONK ADRIAN M ,  WOHLFORD ROBERT A ,  SMITH JANE B ,  RUMBAUGH WILLIAM D ,  MOORE LARRY W ,  MERRIAM RICHARD A ,  CLOONAN KEVIN M ,  SCHRIER PAUL R ,  CLARK FREDERICK L ,  CLEMENS JOHN M ,  MCDOWELL DOUGLAS D ,  HANCE ROBERT B ,  CLIFT GILBERT

IPC: G01N33/483 ,  G01N35/00 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N1/44 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N37/00 ,  H01J49/04

Abstract: The invention discloses an automated liquid level sensing system for detecting the presence of liquid in a container, comprising an electrically conductive and movable probe positioned above said container; a signal source electrically connected to said probe, said signal source capable of energizing said probe thereby causing said probe to transmit said electrical signal at a given frequency; a receiving antenna and means for transferring said received electrical signal from said receiving antenna to an analyzing means; wherein analyzing said received electrical signal includes: (1) means for detecting changes in received signal amplitude, wherein said means for detecting changes in received signal amplitude includes:(a) means for multiplying said received signal by a reference signal, said reference signal having a frequency substantially equal to the frequency of the transmitted signal; and (b) a low pass filter through which is passed said multiplied received signal; and (2) means for measuring rate of change of said change in received signal amplitude; and means connected to said analyzing means for indicating that liquid has been detected. The invention further discloses a method of automatically detecting the presence of liquid in a container using the system of the invention. An automated liquid sensing system for use in a clinical analysis system having a pipettor for dispensing or aspirating liquid in a container, the pipettor being electrically conductive and moveable vertically into the container, using the automated liquid sensing system of the invention further comprising a means electrically connected to the pipettor for applying a RF signal thereto and causing the pipettor to radiate an electromagnetic field, the propagation of which changes when the pipettor contacts the surface of the liquid in the container is further disclosed.

公开(公告)号：AU3934993A

公开(公告)日：1993-11-08

申请号：AU3934993

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： KANEWSKE WILLIAM J III ,  VAUGHT JAMES A ,  VICKSTROM RICHARD L ,  CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  LAGOCKI PETER A ,  MARTIN RICHARD E ,  MITCHELL JAMES E ,  MOORE LARRY E ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH JANE B ,  TAYI APPARAO ,  YOST DAVID A

IPC: B29C45/00 ,  B29C45/42 ,  G01N21/03 ,  G01N21/64 ,  G01N33/53 ,  G01N35/02 ,  B29D23/22 ,  G01N35/06

公开(公告)号：CA2132960A1

公开(公告)日：1993-10-14

申请号：CA2132960

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  KANEWSKE WILLIAM J III ,  LOGOCKI PETER A ,  MARTIN RICHARD R ,  MITCHELL JAMES E ,  MOORE LARRY W ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH B JANE ,  TAYI APPARAO ,  VAUGHT JAMES A ,  YOST DAVID A ,  MERRIAM RICHARD A ,  WALKER DONNY R ,  RUMBAUGH WILLIAM ,  CLEMENS JOHN M

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  B29C45/00 ,  B67D99/00 ,  C12M1/34 ,  G01F23/284 ,  G01N1/00 ,  G01N1/14 ,  G01N1/28 ,  G01N21/03 ,  G01N21/25 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G05D23/19 ,  H01J49/04 ,  H05B1/02

Abstract: 2132960 9320440 PCTABS00027 An automated, continuous and random access analytical system, havin apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample (26), reagents (30) to a reaction vessel (34) without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable (34) to a process work station (46), whereby a mixture of the unit dose disposable reagents and sample (34) are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

公开(公告)号：CA2129246A1

公开(公告)日：1993-10-14

申请号：CA2129246

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： KANEWSKE WILLIAM J III ,  VAUGHT JAMES A ,  VICKSTROM RICHARD L ,  CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MITCHELL JAMES E ,  MOORE LARRY W ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH JANE B ,  TAYI APPARAO ,  YOST DAVID A

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  B29C45/00 ,  B29C45/26 ,  B29C45/42 ,  B29D11/00 ,  B29D23/00 ,  G01N1/00 ,  G01N21/03 ,  G01N21/25 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  B29D23/22

公开(公告)号：ES2351337T3

公开(公告)日：2011-02-03

申请号：ES04010960

申请日：1994-09-22

Applicant: ABBOTT LAB

Inventor： TAYI APPARAO ,  MITCHELL JAMES E ,  HANCE ROBERT B ,  WATKINS WILLIAM E III ,  CLARK FREDERICK L ,  MCDOWELL DOUGLAS D ,  RAYMOURE WILLIAM J ,  HILLS DAVID B ,  CLIFT GILBERT ,  STANTON ALYN K ,  SPRONK ADRIAN M ,  KANEWSKE WILLIAM J III ,  MARTIN RICHARD R ,  VAUGHT JAMES A ,  OLEKSAK CARL M ,  HENDRICK KENDALL B ,  SCHRIER PAUL R ,  PENNINGTON CHARLES D ,  MOORE LARRY W ,  CLEMENS JOHN M ,  WALKER EDNA S ,  SMITH JANE B ,  CLOONAN KEVIN M ,  WOHLFORD ROBERT A ,  WALKER DONNY RAY ,  YOST DAVID A ,  MERRIAM RICHARD A ,  SCHMIDT LINDA S ,  VICKSTROM RICHARD L ,  LAGOCKI PETER A ,  WINTER GARY E ,  RUMBAUGH WILLIAM D

IPC: G01N33/483 ,  G01N35/02 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04

Abstract: Un método para realizar simultáneamente al menos dos análisis, comprendiendo dichos análisis una pluralidad de actividades, para una pluralidad de muestras líquidas en un sistema analítico continuo, comprendiendo dicho método las etapas de: combinar una alícuota de una primera muestra líquida con al menos un reactivo en un primer contenedor de reacción para formar una primera mezcla de reacción de análisis para dicha primera muestra líquida; combinar una alícuota de una segunda muestra líquida con al menos un reactivo en un segundo contenedor de reacción para formar una segunda mezcla de reacción de análisis para dicha segunda muestra líquida; incubar dichas primera y dicha segunda mezcla de reacción de análisis al menos un tiempo; realizar las actividades asociadas con cada análisis distintas de dicha combinación y dicha incubación de la primera y la segunda mezclas de reacción de análisis para completar cada análisis, incluyendo dichas otras actividades analizar las mezclas de reacción de análisis incubadas; y programar las etapas de dicha combinación, dicha incubación, y dichas actividades de realización distintas de dicha combinación y dicha incubación asociadas con cada uno de los análisis de acuerdo con un protocolo predeterminado, especificando dicho protocolo: (a) qué actividades se van a realizar para un análisis dado; (b) el orden en el que se van a realizar dichas actividades de (a); (c) al menos un período de incubación entre dichas actividades de (a), comprendiendo dicho al menos un período de incubación un período nominal de tiempo para la realización de una etapa de incubación entre las actividades de (a) y una ventana de tiempo especificada para añadirla o restarla al período de incubación nominal para variar la duración del período nominal entre las actividades de (a) para optimizar el funcionamiento; (d) cómo se van a realizar dichas actividades de (a); y (e) la duración de dichas actividades de (a).

公开(公告)号：CA2650259C

公开(公告)日：2010-01-12

申请号：CA2650259

申请日：1994-09-22

Applicant: ABBOTT LAB

Inventor： WATKINS WILLIAM E III ,  VICKSTROM RICHARD L ,  KANEWSKE WILLIAM J III ,  MCDOWELL DOUGLAS D ,  CLOONAN KEVIN M ,  CLARK FREDERICK L ,  MOORE LARRY W ,  HENDRICK KENDALL B ,  CLIFT GILBERT

IPC: B65D47/08 ,  G01N33/483 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04

Abstract: A capped-closure mounted on a container for storing reagents for use in an automated analytical instrument having an actuating device mounted thereon. The capped-closure comprises a base being generally cylindrical, wherein the bas e has one end opening to the container and the other end having an opening through whi ch the reagents can be aspirated. The capped-closure further comprises a lever assembly pivotally mounted on the base. The lever assembly has one end which forms a cap operable to seal the opening the base sufficiently tightly to prevent evaporation from the container. The other end of the lever assembly forms a tab operable to pivot the lever assembly to a substantially perpendicular position with opening of the base when depressed for exposing the opening of the base to a device for aspirating th e reagent from the container. The capped-closure finally comprises spring mechanism connect ed between the base and the lever assembly for urging the lever assembly to the substantially perpendicular position.