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公开(公告)号：UA42733C2
公开(公告)日：2001-11-15
申请号：UA96030964
申请日：1994-08-08
Applicant: BASF AG
Inventor： KEILHAUER GERHARD , ROMERDAHL CYNTHIA , FERNANDEZ BRANA MIGUEL , QIAN XIAO-DONG , BOUSQUET PETER , CASTELLANO BERLANGA JOSE MARIA MORAN , MOSET MARINA , PEREZ DE VEGA MARIA JESUS
IPC: A61K31/47 , A61K31/473 , A61P35/00 , C07D221/14
Abstract: Похіднібіснафталімідузагальноїформули (I): де X, X', X" і X'" ідентичніаборізнітавибраніз групи, щовключаєводень, нітро, аміно, NН-нижчийацил, гідроксил, галоген, алкілз 1-6 атомамивуглецю, абоХ і X' або X" і X"' можутьутворюватиетиленовиймісток, зв'язанийз атомамивуглецюв положеннях 4 і 5 циклічноїсистеми; R і R' - Н, алкілз 1-4 атомамивуглецю; Аі D однаковіаборізній означаютьгрупу -CH 2-CH2-, щоможебутизаміщенаалкіломз 1-4 атомамивуглецю; В - група -(СН2)n-, де n дорівнює 3 або 4 ідеодинатомводнюможебутизаміненийалкільноюгрупоюз 1-4 атомамивуглецю, таїхфармацевтичноприйнятнікислотно-адитивнісолі.
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公开(公告)号：DE69329425T2
公开(公告)日：2001-01-18
申请号：DE69329425
申请日：1993-12-04
Applicant: BASF AG
Inventor： HAUPT ANDREAS , JANSSEN BERND , RITTER KURT , KLINGE DAGMAR , KEILHAUER GERHARD , ROMERDAHL CYNTHIA , BARLOZZARI TERESA , QIAN XIAO-DONG
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公开(公告)号：DE69425882T2
公开(公告)日：2001-01-11
申请号：DE69425882
申请日：1994-03-19
Applicant: BASF AG
Inventor： JANSSEN BERND , KLING ANDREAS , MUELLER STEFAN , RITTER KURT , SCHLECKER RAINER , KEILHAUER GERHARD , ROMERDAHL CYNTHIA , TRAUGOTT ULRICH
IPC: C07D295/08 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/40 , A61K31/403 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/433 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/4418 , A61K31/445 , A61K31/451 , A61K31/47 , A61K31/495 , A61K31/496 , A61P35/00 , C07D207/32 , C07D207/333 , C07D209/52 , C07D211/14 , C07D213/30 , C07D215/14 , C07D261/08 , C07D261/18 , C07D263/14 , C07D263/32 , C07D271/06 , C07D271/10 , C07D277/24 , C07D285/12 , C07D295/092 , C07D307/42 , C07D307/58 , C07D317/58 , C07D317/66 , C07D333/06 , C07D333/16 , C07D413/12 , C07D417/12 , C07D521/00 , C07F9/6509
Abstract: This invention relates to 1-amino-3-phenoxy-propane-derivatives of formula 1: 1 (in which A, B, R, Rx, X and Z are defined as in the specification described) and methods for their preparation. These compounds may be used as modulators of multidrug resistance in cancer chemotherapy and for circumvention of resistance in the treatment of malaria.
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公开(公告)号：DE69329425D1
公开(公告)日：2000-10-19
申请号：DE69329425
申请日：1993-12-04
Applicant: BASF AG
Inventor： HAUPT ANDREAS , JANSSEN BERND , RITTER KURT , KLINGE DAGMAR , KEILHAUER GERHARD , ROMERDAHL CYNTHIA , BARLOZZARI TERESA , QIAN XIAO-DONG
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公开(公告)号：AT196296T
公开(公告)日：2000-09-15
申请号：AT94902676
申请日：1993-12-04
Applicant: BASF AG
Inventor： HAUPT ANDREAS , JANSSEN BERND , RITTER KURT , KLINGE DAGMAR , KEILHAUER GERHARD , ROMERDAHL CYNTHIA , BARLOZZARI TERESA , QIAN XIAO-DONG
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Patent Agency Ranking
公开(公告)号：HRP940458B1
公开(公告)日：2000-02-29
申请号：HRP940458
申请日：1994-08-11
Applicant: BASF AG
Inventor： KEILHAUER GERHARD , ROMERDAHL CYNTHIA , BRANA MIGUEL FERNANDEZ , QUIAN XIAO-DONG , BOSQUET PETER , BERLANGA JOSE MARIA CASTELLANO , MOSET MARINA MORAN , VEGA MARIA JESUS PEREZ DE
IPC: A61K31/47 , A61K31/473 , A61P35/00 , C07D221/14 , C07D211/14 , A61K31/435
Abstract: Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula wherein X, X', X'' and X''', A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutical compositions containing same can be used in the treatment of cancer.
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公开(公告)号：DE69410614D1
公开(公告)日：1998-07-02
申请号：DE69410614
申请日：1994-08-08
Applicant: BASF AG
Inventor： KEILHAUER GERHARD , ROMERDAHL CYNTHIA , FERNANDEZ BRANA MIGUEL , QIAN XIAO-DONG , BOUSQUET PETER , CASTELLANO BERLANGA JOSE , MORAN MOSET MARINA , PEREZ DE VEGA MARIA
IPC: A61K31/47 , A61K31/473 , A61P35/00 , C07D221/14 , A61K31/435
Abstract: Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula wherein X, X', X'' and X''', A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutical compositions containing same can be used in the treatment of cancer.
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公开(公告)号：AT166647T
公开(公告)日：1998-06-15
申请号：AT94924854
申请日：1994-08-08
Applicant: BASF AG
Inventor： KEILHAUER GERHARD , ROMERDAHL CYNTHIA , FERNANDEZ BRANA MIGUEL , QIAN XIAO-DONG , BOUSQUET PETER , CASTELLANO BERLANGA JOSE MARIA , MORAN MOSET MARINA , PEREZ DE VEGA MARIA JESUS
IPC: A61K31/47 , A61K31/473 , A61P35/00 , C07D221/14 , A61K31/435
Abstract: Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula wherein X, X', X'' and X''', A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutical compositions containing same can be used in the treatment of cancer.
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公开(公告)号：AU677696B2
公开(公告)日：1997-05-01
申请号：AU7498494
申请日：1994-08-08
Applicant: BASF AG
Inventor： KEILHAUER GERHARD , ROMERDAHL CYNTHIA , BRANA MIGUEL FERNANDEZ , QIAN XIAO-DONG , BOUSQUET PETER , BERLANGA JOSE MARIA CASTELLANO , MOSET MARINA MORAN , VEGA MARIA JESUS PEREZ DE
IPC: A61K31/47 , A61K31/473 , A61P35/00 , C07D221/14 , A61K31/435
Abstract: Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula wherein X, X', X'' and X''', A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutical compositions containing same can be used in the treatment of cancer.
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公开(公告)号：BR9407257A
公开(公告)日：1996-09-24
申请号：BR9407257
申请日：1994-08-08
Applicant: BASF AG
Inventor： KEILHAUER GERHARD , ROMERDAHL CYNTHIA , FERNANDEZ BRANA MIGUEL , QIAN XIAO-DONG , BOUSQUET PETER , CASTELLANO BERLANGA JOSE MARIA , MORAN MOSET MARINA , PEREZ DE VEGA MARIA JESUS
IPC: A61K31/47 , A61K31/473 , A61P35/00 , C07D221/14 , A61K31/435
Abstract: Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula wherein X, X', X'' and X''', A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutical compositions containing same can be used in the treatment of cancer.
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