公开(公告)号：GB1300166A

公开(公告)日：1972-12-20

申请号：GB1980270

申请日：1970-04-24

Applicant: BASF AG

Inventor： REIF WERNER ,  NUERRENBACH AXEL ,  FREYSCHLAG HERWIG

IPC: C07C403/00

Abstract: 1300166 Granular Vitamin A esters BADISCHE ANILIN- & SODA-FABRIK AG 24 April 1970 19802/70 Heading C2V Granular Vitamin A esters are prepared by dripping molten Vitamin A ester into an organic liquid at -10 to -70‹ C., the liquid being one in which the ester is insoluble and which has a lower density than the esters, the resultant granules then being separated and dried. The liquid may be an alcohol or a gasoline. An antioxidant may be added to the melt. In examples, molten Vitamin A acetate and Vitamin A palmitate are dripped into cooled methanol to form granules.

公开(公告)号：CA905980A

公开(公告)日：1972-07-25

申请号：CA905980D

Applicant: BASF AG

Inventor： GRASSNER HANS ,  NUERRENBACH AXEL ,  POMMER HORST ,  KLOTMANN GEORG

公开(公告)号：CA797871A

公开(公告)日：1968-10-29

申请号：CA797871D

Applicant: BASF AG

Inventor： REIF WERNER ,  FREYSCHLAG HERWIG ,  NUERRENBACH AXEL ,  POMMER HORST

公开(公告)号：GB1079216A

公开(公告)日：1967-08-16

申请号：GB4822664

申请日：1964-11-27

Applicant: BASF AG

Inventor： FREYSCHLAG HERWIG ,  REIF WERNER ,  NUERRENBACH AXEL ,  SARNECKI WILHELM

IPC: A01N57/22 ,  C07F9/535

Abstract: The invention comprises ylenals, (i.e. compounds which in the same molecule contain a phosphorylene group and an aldehyde group in conjunction) of the formula where Ar is an aryl radical which may be substituted by alkyl or alkoxy groups; R1, R2 and R3 are H or alkyl groups and n is an integer from 1 to 6. They may be obtained by reacting a proton acceptor in liquid phase with a quaternary phosphonium salt of the formula where X(-) is a monovalent anion. Suitable proton acceptors are bases having a pK value below or about 9 such as alcoholates, ammonia, amines, e.g. alkylamines or heterocyclic amines, or aqueous alkali. Suitable solvents are water, dimethyl-formamide or sulphoxide, acetonitrile, alcohol, hydrocarbons, halogenated hydrocarbons or mixtures thereof. Specified products are triphenylphosphine-2-formylpropen-1-yl-1-methylene, triphenylphosphine-3-formylpropen-(2)-yl-2-methylene, triphenylphosphine-2 - methyl - 4 - formylbutadien - (1,3) - yl - 1 - methylene, triphenylphosphine-1-methyl-4-formylbutadiene - (1,3) - yl - 1 - methylene, and triphenylphosphine - 2,6 - dimethyl - 6 - formylhexatrien - (1,3,5) - yl - 1 - methylene. Examples are given for the preparation of triphenylphosphine - 2 - formylpropen - 1 - yl-methylene. The products are intermediates for the synthesis of dyes, pharmaceuticals, plant protection agents, food dyes and carolenoids. The phosphonium salts of Formula I may be obtained by reacting a suitable halogen compound with a triarylphosphine in an organic solvent.

公开(公告)号：FR1395458A

公开(公告)日：1965-04-09

申请号：FR975628

申请日：1964-05-23

Applicant: BASF AG

Inventor： NUERRENBACH AXEL ,  SARNECKI WILHELM ,  REIF WERNER

IPC: C07F9/54

公开(公告)号：FI88025C

公开(公告)日：1993-03-25

申请号：FI870356

申请日：1987-01-27

Applicant: BASF AG

Inventor： WUEST HANS-HEINER ,  JANSSEN BERND ,  FRICKEL FRITZ-FRIEDER ,  NUERRENBACH AXEL

IPC: A61K31/05 ,  A61K31/047 ,  A61K31/085 ,  A61K31/135 ,  A61K31/16 ,  A61K31/19 ,  A61K31/195 ,  A61K31/215 ,  A61K31/22 ,  A61K31/357 ,  A61K31/36 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  C07C27/00 ,  C07C39/23 ,  C07C39/42 ,  C07C41/00 ,  C07C43/168 ,  C07C43/20 ,  C07C43/215 ,  C07C51/00 ,  C07C59/125 ,  C07C59/68 ,  C07C59/72 ,  C07C62/38 ,  C07C67/00 ,  C07C69/07 ,  C07C69/157 ,  C07C69/24 ,  C07C69/712 ,  C07C69/78 ,  C07C213/00 ,  C07C217/18 ,  C07D317/50 ,  C07D325/00 ,  C07C69/035 ,  C07C69/16

公开(公告)号：CA1266672A

公开(公告)日：1990-03-13

申请号：CA491249

申请日：1985-09-20

Applicant: BASF AG

Inventor： WUEST HANS-HEINER ,  FRICKEL FRITZ-FRIEDER ,  NUERRENBACH AXEL

IPC: C07D263/10 ,  A61K31/015 ,  A61K31/03 ,  A61K31/075 ,  A61K31/085 ,  A61K31/11 ,  A61K31/115 ,  A61K31/12 ,  A61K31/135 ,  A61K31/16 ,  A61K31/165 ,  A61K31/19 ,  A61K31/215 ,  A61K31/22 ,  A61K31/275 ,  A61K31/41 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  C07C1/00 ,  C07C13/465 ,  C07C13/48 ,  C07C17/00 ,  C07C25/24 ,  C07C27/00 ,  C07C33/38 ,  C07C39/23 ,  C07C39/38 ,  C07C43/168 ,  C07C43/176 ,  C07C43/215 ,  C07C43/23 ,  C07C45/00 ,  C07C45/44 ,  C07C45/68 ,  C07C47/548 ,  C07C47/55 ,  C07C47/57 ,  C07C47/575 ,  C07C49/683 ,  C07C49/747 ,  C07C49/757 ,  C07C49/798 ,  C07C49/813 ,  C07C49/835 ,  C07C49/84 ,  C07C57/50 ,  C07C57/62 ,  C07C59/72 ,  C07C63/66 ,  C07C63/74 ,  C07C65/19 ,  C07C65/28 ,  C07C65/38 ,  C07C67/00 ,  C07C69/157 ,  C07C69/618 ,  C07C69/65 ,  C07C69/734 ,  C07C69/76 ,  C07C69/78 ,  C07C209/00 ,  C07C209/48 ,  C07C211/44 ,  C07C211/52 ,  C07C215/74 ,  C07C233/05 ,  C07C233/11 ,  C07C233/22 ,  C07C233/29 ,  C07C233/65 ,  C07C235/34 ,  C07C235/38 ,  C07C235/42 ,  C07C255/50 ,  C07C255/51 ,  C07C255/54 ,  C07C255/56 ,  C07D257/04 ,  C07C69/94 ,  C07C121/75

Abstract: Disclosed are novel diarylacetylene of the formula I: I where R1 and R2 are each hydrogen or methyl, R3 is hydrogen, methyl, hydroxyl or C1-C6-alkoxy, R4 is hydrogen, methyl or methoxy, R5 is hydrogen, halogen, methoxy or C1-C4-alkyl, A is a methylene or ethylene radical which is unsubstituted or substituted by C1-C4-alkyl or is -CH=CH-, -CHOH-CH2- or -CO-CH2-, and R is hydrogen, methyl, nitrile, tetrazolyl, C2-C10-ketal or a radical -CHR7-OR8, -CHR7-NR9R10, -COR11, -CR12=CH-COOR13 or -CR12=CH-CO-NR14R15, where R7 is hydrogen or C1-C4-alkyl, R8 is hydrogen, C1-C4-alkyl, C1-C20-alkanoyl, unsubstituted or substituted benzoyl or a radical -P(0) (OR13)2 or -P(0) (NR14R15)2 (where R13 is hydrogen, unsubstituted or hydroxyl-substituted C1-C8-alkyl, unsubstituted or substituted aryl, or aralkyl which is unsubstituted or substituted in the aryl moiety, and R14 and R15 are each hydrogen, unsubstituted or hydroxyl-substituted C1-C6-alkyl, or an unsubstituted or substituted aralkyl or aryl group), R9 and R10 are each hydrogen, C1-C4-alkyl, C1C6-unsubstituted or substituted benzoyl, R11 is hydrogen, halogen, C1-C4-alkyl or a radical NR14R15 or -OR13 (where R13, R14 and R15 have the above meanings) and R12 is hydrogen or methyl, and, where relevant, its physiologically tolerated salts. These derivatives are useful for the treatment of dermatological disorders and the prophylactic and therapeutic treatment of precanceroses and tumors.

公开(公告)号：AU578739B2

公开(公告)日：1988-11-03

申请号：AU4783485

申请日：1985-09-24

Applicant: BASF AG

Inventor： FRICKEL FRITZ FRIEDER ,  NUERRENBACH AXEL ,  THYES MARCO

IPC: A61K31/41 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  C07D20060101 ,  C07D257/04

公开(公告)号：HUT43985A

公开(公告)日：1988-01-28

申请号：HU24387

申请日：1987-01-27

Applicant: BASF AG

Inventor： WUEST HANS-HEINER ,  JANSSEN BERND ,  FRICKEL FRITZ-FRIEDER ,  NUERRENBACH AXEL

IPC: A61K31/05 ,  A61K31/047 ,  A61K31/085 ,  A61K31/135 ,  A61K31/16 ,  A61K31/19 ,  A61K31/195 ,  A61K31/215 ,  A61K31/22 ,  A61K31/357 ,  A61K31/36 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  C07C27/00 ,  C07C39/23 ,  C07C39/42 ,  C07C41/00 ,  C07C43/168 ,  C07C43/20 ,  C07C43/215 ,  C07C51/00 ,  C07C59/125 ,  C07C59/68 ,  C07C59/72 ,  C07C62/38 ,  C07C67/00 ,  C07C69/07 ,  C07C69/157 ,  C07C69/24 ,  C07C69/712 ,  C07C69/78 ,  C07C213/00 ,  C07C217/18 ,  C07D317/50 ,  C07D325/00

公开(公告)号：HU193818B

公开(公告)日：1987-12-28

申请号：HU355185

申请日：1985-09-20

Applicant: BASF AG

Inventor： WUEST HANS-HEINER ,  FRICKEL FRITZ-FRIEDER ,  NUERRENBACH AXEL

IPC: C07F9/09 ,  A61K20060101 ,  A61K31/66 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  C07F20060101 ,  C07F9/11 ,  C07F9/12 ,  C07F9/24 ,  C07F9/59 ,  C07F9/6533 ,  C07F9/6574 ,  C07F9/6584

Abstract: A vinylbenzyl phosphate of the formula I where A, R1, R2, R3, R4, R5, R6, R7, R8 and R9 have the meanings stated in the description, and their preparation are described. The substances are useful for the treatment of disorders.