公开(公告)号：DE19629753A1

公开(公告)日：1998-01-29

申请号：DE19629753

申请日：1996-07-23

Applicant: BASF AG

Inventor： ZETTLER HANS DIETER ,  SCHIESL MICHAEL ,  BREITENBACH JOERG DR ,  ROSENBERG JOERG DR

IPC: A61J3/10 ,  A61J3/06 ,  A61K9/20 ,  B30B11/22

Abstract: Production of solid medicament comprises mixing and melting at least one polymeric binder, at least one pharmaceutical active agent (A) and optionally conventional additives, in the absence of solvents, to give a plastic mixture and shaping the mixture by extrusion. The shaping is carried out in two stages: (i) dividing the extrudate into shaped articles; and (ii) rounding the articles while in a plastic state.

公开(公告)号：CZ185297A3

公开(公告)日：1998-01-14

申请号：CZ185297

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG DR ,  MAIER WERNER ,  GRABOWSKI SVEN DR ,  BREITENBACH JORG DR

IPC: A61J1/03 ,  A61J3/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/28 ,  B30B11/16 ,  B65B9/04

公开(公告)号：DE19539361A1

公开(公告)日：1997-04-24

申请号：DE19539361

申请日：1995-10-23

Applicant: BASF AG

Inventor： BREITENBACH JOERG DR ,  HAERTL AXEL PAUL DR ,  HOFMANN JUERGEN ,  ROSENBERG JOERG DR ,  SCHIESL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60 ,  A61K31/19

Abstract: The invention concerns a method of producing multi-layer medicaments in solid form for oral or rectal administration. At least two substances, which each comprise a thermoplastic, pharmacologically acceptable polymer binder which is soluble or can swell in a physiological environment, at least one of the substances comprising a pharmaceutical active substance, are coextruded and the coextruded multi-layer material is shaped to form the desired medicament.

公开(公告)号：DE19509807A1

公开(公告)日：1996-09-26

申请号：DE19509807

申请日：1995-03-21

Applicant: BASF AG

Inventor： ROSENBERG JOERG DR ,  BREITENBACH JOERG DR

IPC: A61K9/14 ,  A61K9/20 ,  B01J2/20 ,  A61K31/60 ,  A61K31/485

Abstract: A process for producing active agent preparations in the form of a solid solution of the active agent in a polymer matrix in which the active agent is melt-extruded in non-ionic form together with a polymer and a salt.

公开(公告)号：DE19509805A1

公开(公告)日：1996-09-26

申请号：DE19509805

申请日：1995-03-21

Applicant: BASF AG

Inventor： BREITENBACH JOERG DR ,  ROSENBERG JOERG DR ,  SANNER AXEL DR

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K47/30 ,  A61K31/445

Abstract: Transparent rapid-release active agent preparations obtainable by the extrusion of melts containing non-steroid analgesics, homopolymers of N-vinyl pyrrolidone, saccharides or sugar alcohols and sodium or potassium salts.

公开(公告)号：DE19504831A1

公开(公告)日：1996-09-05

申请号：DE19504831

申请日：1995-02-14

Applicant: BASF AG

Inventor： ROSENBERG JOERG DR ,  GRABOWSKI SVEN DR

IPC: A61K9/16 ,  A61K9/20 ,  A61K47/38 ,  A61K9/14

Abstract: Preparations containing active agents obtainable by the melt extrusion of A) a water-soluble thermoplastic hydroxypropyl cellulose, B) one or more active agents, C) if desired, pharmaceutical auxiliaries, in which the proportion of A) is 10 to 30 % wt. in relation to the entire preparation.

公开(公告)号：DE4446468A1

公开(公告)日：1996-06-27

申请号：DE4446468

申请日：1994-12-23

Applicant: BASF AG

Inventor： ROSENBERG JOERG DR ,  MAIER WERNER ,  GRABOWSKI SVEN DR ,  BREITENBACH JOERG DR

IPC: A61J1/03 ,  A61J3/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/28 ,  B30B11/16 ,  B65B9/04

Abstract: The invention concerns a method of producing coated tablets by melt calendering, the melt containing the active substance being introduced into the form cylinders between two films of the coating material.

公开(公告)号：DE4226753A1

公开(公告)日：1994-02-17

申请号：DE4226753

申请日：1992-08-13

Applicant: BASF AG

Inventor： GRABOWSKI SVEN DR ,  SANNER AXEL DR ,  ROSENBERG JOERG DR

IPC: A01N25/10 ,  A01N25/12 ,  A61K9/14 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26

Abstract: Preparations in solid particle form containing active compounds, obtainable by intimate mixing of the active compound with a water-soluble melt of a) 10 to 90% by weight of a water-soluble polymer A of a viscosity Va of 1,000 to 120,000 cps and b) 10 to 90% by weight of a water-soluble polymer B of a viscosity Vb of 1 to 500 cps as a carrier substance, the viscosities Va and Vb being those of a 2% strength by weight aqueous solution at 20@C, measured by the capillary method ASTM D 2363-72 (European Pharmacopoeia, Vol. III, p. 37), and processing of the melt with shaping to give the particles.