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公开(公告)号:CA2932046A1
公开(公告)日:2015-06-18
申请号:CA2932046
申请日:2014-12-04
Applicant: BASF SE
Inventor: HOFF BIRGIT , MOLT ANDREA , HAEFNER STEFAN , ZELDER OSKAR
IPC: C12P25/00
Abstract: The present invention relates to a method of producing riboflavin in a genetically modified organism of the genus Eremothecium, wherein said genetic modification is linked to the fatty acid uptake and/or beta-oxidation pathway of said organism, comprising growing said organisms in a culture medium and isolating riboflavin from the culture medium. The invention further relates to a method of providing a riboflavin accumulating organism belonging to the genus Eremothecium by genetically modifying said organism, to organisms obtained by such a method, as well as the use of such genetically modified organisms for increasing the accumulation of riboflavin.
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公开(公告)号:CL2015000015A1
公开(公告)日:2015-03-06
申请号:CL2015000015
申请日:2015-01-05
Applicant: BASF SE , WINTERSHALL HOLDING GMBH
Inventor: BROCKMANN BEATA , HEROLD ANDREA , ZELDER OSKAR , HAEFNER STEFAN , FLECK CHRISTIAN , SCHRÖDER HARTWIG , GRANSTRÖM MARI , SCHMIDT JULIA KRISTIANE
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公开(公告)号:PT1921150E
公开(公告)日:2013-10-08
申请号:PT07123783
申请日:2004-12-15
Applicant: BASF SE
Inventor: ZELDER OSKAR , SCHROEDER HARTWIG , KROGER BURKHARD , KLOPPROGGE CORINNA , HAEFNER STEFAN
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公开(公告)号:ES2376035T3
公开(公告)日:2012-03-08
申请号:ES07123761
申请日:2005-07-16
Applicant: BASF SE
Inventor: ZELDER OSKAR , KLOPPROGGE CORINNA , KROEGER BURKHARD , SCHROEDER HARTWIG , HAEFNER STEFAN
Abstract: Método para modificar o causar la rata de transcripción de genes en microorganismos en comparación con el tipo silvestre mediante regulación de la transcripción de genes en el microorganismo por ácidos nucleicos con actividad de promotor, que contiene A) la secuencia de ácido nucleico SEQ.ID.NO. 1 o B) una secuencia derivada de esta secuencia por sustitución, inserción o deleción de nucleótidos, que tiene una identidad de al menos 90 % a nivel de ácido nucleico con la secuencia SEQ.ID.NO. 1 o C) una secuencia de ácido nucleico que hibrida con la secuencia de ácido nucleico SEQ.ID.NO. 1 en condiciones estrictas, en cuyo caso los genes respecto de los ácidos nucleicos con actividad de promotor son heterólogos.
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公开(公告)号:BRPI0618080A2
公开(公告)日:2012-02-22
申请号:BRPI0618080
申请日:2006-10-23
Applicant: BASF SE
Inventor: ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE G , YOCUM R ROGERS , PATTERSON THOMAS A , WILLIAMS MARK , HERMANN THERON
Abstract: The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.
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公开(公告)号:ZA201806127B
公开(公告)日:2019-12-18
申请号:ZA201806127
申请日:2018-09-13
Applicant: BASF SE
Inventor: POP CRISTINA , HUSTON DAVENPORT ADRIENNE , LISZKA MICHAEL , TAN XUQIU , FUNKE ANDREAS , KUTSCHER JOCHEN , SEITTER MICHAEL FRIEDRICH HERMANN , HAEFNER STEFAN
Abstract: Lipase enzymes and methods of using the lipases in a baking for improving the volume, stability, tolerance of a baked product and/or reducing and reducing or eliminating the use of DATEM.
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公开(公告)号:ZA201501883B
公开(公告)日:2019-08-28
申请号:ZA201501883
申请日:2015-03-19
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公开(公告)号:CA2696666C
公开(公告)日:2019-07-09
申请号:CA2696666
申请日:2008-08-14
Applicant: BASF SE
Inventor: SCHOLTEN EDZARD , DAEGELE DIRK , HAEFNER STEFAN , SCHROEDER HARTWIG
Abstract: The present invention relates to a novel bacterial strain designated DD1, as deposited with DSMZ under deposit number 18541, which has the ability to produce organic acids, in particular succinic acid (SA), which was originally isolated from bovine rumen, and is capable of utilizing glycerol as a carbon source; and variant strains derived there from retaining said capability, as well as to methods of producing organic acids, in particular succinic acid by making use of said microorganism.
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公开(公告)号:ES2715930T3
公开(公告)日:2019-06-07
申请号:ES10708150
申请日:2010-02-12
Applicant: BASF SE
Inventor: SCHRÖDER HARTWIG , HAEFNER STEFAN , ABENDROTH GREGORY VON , HOLLMANN RAJAN , RADDATZ ALINE , ERNST HANSGEORG , GURSKI HANS
Abstract: Un procedimiento para la producción fermentativa de ácido succínico o una sal o derivado de este, procedimiento que comprende las etapas de: a. incubar una cepa bacteriana en un medio que contenga al menos glicerol como fuente de carbono asimilable y cultivar dicha cepa bajo condiciones que favorezcan la formación del ácido succínico deseado; y b. obtener dicho ácido succínico o sal o derivado de este del medio, en el que dicha cepa bacteriana es una cepa bacteriana de la familia de Pasteurellaceae, capaz de utilizar glicerol como una fuente de carbono para la producción fermentativa de ácido succínico, en el que dicha cepa contiene un gen mutado que codifica una enzima piruvato formato liasa con actividad disminuida o no detectable, cuyo procedimiento comprende la producción fermentativa de ácido succínico y el control del pH con NH4HCO3, (NH4)2CO3, NaOH, Na2CO3, NaHCO3, KOH, K2CO3, KHCO3, Mg(OH)2, MgH(CO3)2, Ca(OH)2, CaCO3, Ca(HCO3)2, CaO, CH6N2O2, C2H7N y/o mezclas de estos.
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公开(公告)号:CA2751280C
公开(公告)日:2019-03-12
申请号:CA2751280
申请日:2010-02-12
Applicant: BASF SE
Inventor: SCHROEDER HARTWIG , HAEFNER STEFAN , ABENDROTH GREGORY VON , HOLLMANN RAJAN , RADDATZ ALINE , ERNST HANSGEORG , GURSKI HANS
Abstract: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.
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