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1.发明专利Fertilization production of solid-state nonvolatile microorganism metabolic product 审中-公开固态非挥发性微生物代谢产物的生产
公开(公告)号：JP2013048625A
公开(公告)日：2013-03-14
申请号：JP2012223174
申请日：2012-10-05
Applicant: Basf Se , ビーエーエスエフ ソシエタス・ヨーロピアBasf Se
Inventor： POMPEJUS MARKUS , FREYER STEPHAN , LOHSCHEIDT MARKUS , ZELDER OSKAR , BOY MATTHIAS , SCHOLTEN EDZARD
CPC classification number: C12P13/08 , A23K10/12 , A23L7/104 , C12P7/46 , C12P13/02 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/24 , C12P19/14
Abstract: PROBLEM TO BE SOLVED: To provide a method for producing at least one nonvolatile microorganism metabolic product by performing micororganism-fertilization based on sugar.SOLUTION: In the method, a microorganism culture which produces a desired metabolic product is cultivated by using a sugar-containing liquid culture medium containing a monosaccharide content exceeding 20 wt.% on the basis of the total weight of the liquid culture medium, most of volatile components of fertilization liquids are removed, and the pickles are produced by (a1) a step of powdering a starch supply raw material selected from grains, and (a2) a step of liquefying the powdered material in an aqueous liquid under the existence of at least one starch liquefied enzyme, then saccharifying the material by using saccharified enzyme, adding a partial amount of a crushed raw material to the aqueous liquid continuously or in a batch manner, and performing the liquefaction. Related to a solid preparation of the obtained nonvolatile microorganism metabolic product, the method uses the solid preparation as an additive or a supplementary agent to the food of human beings or animals, or fabric, leather, cellose, paper, or for treating the surface the product.
Abstract translation: 待解决的问题：提供通过基于糖进行微生物施肥来生产至少一种非挥发性微生物代谢产物的方法。 解决方案：在该方法中，通过使用含有超过20重量％的单糖含量的含糖液体培养基，基于液体培养基的总重量培养产生所需代谢产物的微生物培养物 去除受精液体的大部分挥发性成分，并且通过（a1）粉碎选自谷物的淀粉供给原料的工序来制造泡菜，（a2）在水溶液中粉化材料的液化步骤 存在至少一种淀粉液化酶，然后通过使用糖化酶对材料进行糖化，连续地或间歇地向水性液体中分批加入一部分破碎的原料，并进行液化。 与所获得的非挥发性微生物代谢产物的固体制剂相关，该方法使用固体制剂作为人或动物的食物或织物，皮革，纤维素，纸或用于处理表面的添加剂或补充剂 产品。 版权所有（C）2013，JPO＆INPIT
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公开(公告)号：JP2014158474A
公开(公告)日：2014-09-04
申请号：JP2014061610
申请日：2014-03-25
Applicant: Basf Se , ビーエーエスエフ ソシエタス・ヨーロピアBasf Se
Inventor： SCHOLTEN EDZARD , DIRK DAEGELE , HAEFNER STEFAN , SCHROEDER HARTWIG
Abstract: PROBLEM TO BE SOLVED: To provide: a novel bacterial strain designated DD1, which has the ability to produce organic acids, in particular, succinic acid (SA), which has been isolated from bovine rumen, and is capable of utilizing glycerol as a carbon source; and variant strains thereof.SOLUTION: The invention provides a process for producing succinic acid by cultivating a microorganism in the presence of glycerol, glucose, fructose, maltose, sucrose, or the like. The invention also provides a process for the production of tetrahydrofuran and/or 1,4-butanediol and/or γ-butyrolactone, and pyrrolidone from succinic acid. The microorganism is Mannheimia succiniciproducens MBEL belonging to genus Mannheimia, and is a Gram-negative bacillus or coccobacillus.
Abstract translation: 要解决的问题：提供：一种称为DD1的新型细菌菌株，其具有产生有机酸的能力，特别是已经从牛瘤胃中分离的琥珀酸（SA），并且能够利用甘油作为碳 资源; 其变体菌株。本发明提供了通过在甘油，葡萄糖，果糖，麦芽糖，蔗糖等存在下培养微生物来生产琥珀酸的方法。 本发明还提供从琥珀酸生产四氢呋喃和/或1,4-丁二醇和/或γ-丁内酯和吡咯烷酮的方法。 微生物是Mannheimia succiniciproducens MBEL属于Mannheimia属，是革兰氏阴性杆菌或coccobacillus。
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公开(公告)号：WO2009024294A8
公开(公告)日：2009-10-29
申请号：PCT/EP2008006714
申请日：2008-08-14
Applicant: BASF SE , SCHOLTEN EDZARD , DAEGELE DIRK , HAEFNER STEFAN , SCHROEDER HARTWIG
Inventor： SCHOLTEN EDZARD , DAEGELE DIRK , HAEFNER STEFAN , SCHROEDER HARTWIG
Abstract: The present invention relates to a novel bacterial strain designated DD1, which has the ability to produce organic acids, in particular succinic acid (SA), which was originally isolated from bovine rumen, and is capable of utilizing glycerol as a carbon source; and variant strains derived there from retaining said capability; as well as to methods of producing organic acids, in particular succinic acid by making use of said microorganism.
Abstract translation: 本发明涉及一种称为DD1的新型细菌菌株，其具有生产有机酸特别是琥珀酸（SA）的能力，其最初是从牛瘤胃中分离出来的，能够利用甘油作为碳源; 以及由此导致的变异菌株保留所述能力; 以及通过利用所述微生物生产有机酸，特别是琥珀酸的方法。
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公开(公告)号：WO2009024294A9
公开(公告)日：2010-11-04
申请号：PCT/EP2008006714
申请日：2008-08-14
Applicant: BASF SE , SCHOLTEN EDZARD , DAEGELE DIRK , HAEFNER STEFAN , SCHROEDER HARTWIG
Inventor： SCHOLTEN EDZARD , DAEGELE DIRK , HAEFNER STEFAN , SCHROEDER HARTWIG
Abstract: The present invention relates to a novel bacterial strain designated DD1, which has the ability to produce organic acids, in particular succinic acid (SA), which was originally isolated from bovine rumen, and is capable of utilizing glycerol as a carbon source; and variant strains derived there from retaining said capability; as well as to methods of producing organic acids, in particular succinic acid by making use of said microorganism.
Abstract translation: 本发明涉及一种称为DD1的新型细菌菌株，其具有生产有机酸特别是琥珀酸（SA）的能力，其最初是从牛瘤胃中分离出来的，并能够利用甘油作为碳源; 和来自保留所述能力的变体菌株; 以及通过利用所述微生物生产有机酸，特别是琥珀酸的方法。
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公开(公告)号：DK3230435T5
公开(公告)日：2024-10-14
申请号：DK15817104
申请日：2015-12-09
Applicant: BASF SE
Inventor： HOFF BIRGIT , HAEFNER STEFAN , JEONG WEOL KYU , SCHOLTEN EDZARD
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Patent Agency Ranking
公开(公告)号：ES2688949T3
公开(公告)日：2018-11-07
申请号：ES07727808
申请日：2007-04-04
Applicant: BASF SE
Inventor： BAUDUIN CHRISTOPHE , FISCHER WOLFGANG , PINKOS ROLF , SCHOLTEN EDZARD
IPC: C07C67/08 , C07C29/149 , C07C31/20 , C07C69/40 , C07D307/08 , C07D307/32
Abstract: Procedimiento para la preparación al menos de un éster alquílico de un ácido policarboxílico, en el que se realiza una destilación reactiva, poniendo en contacto en contracorriente una muestra, que comprende una solución acuosa libre de alcanol de una sal de amonio de al menos un ácido policarboxílico, en una columna de destilación con al menos un alcanol y separándose el amoníaco y el agua que se producen durante la esterificación de manera destilativa de la reacción, en donde se alimentan la solución acuosa que contiene sal de ácido carboxílico y el alcanol en al menos dos flujos de productos de partida separados uno de otro a la columna de destilación, de modo que la alimentación del alcanol se realiza al menos en una etapa de separación teórica o al menos en un plato por debajo de la alimentación de la solución acuosa que contiene sal de ácido carboxílico.
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公开(公告)号：CA2623588C
公开(公告)日：2016-06-28
申请号：CA2623588
申请日：2006-09-06
Applicant: BASF SE
Inventor： POMPEJUS MARKUS , FREYER STEPHAN , LOHSCHEIDT MARKUS , ZELDER OSKAR , BOY MATTHIAS , SCHOLTEN EDZARD
Abstract: The invention relates to a method for production of at least one non-volatile microbial metabolism product in solid form by sugar-based microbial fermentation, wherein a microbial strain producing the required metabolism product is cultivated with a sugary liquid medium with a monosaccharide content of more than 20 wt. %, based on the total weight of the liquid medium, the volatile components of the fermentation brew are mostly removed, the sugary liquid medium being produced by: a1) milling a starch source selected from cereal grains, a2) liquefying the milled material in an aqueous liquid in the presence of at least one starch-digesting enzyme and subsequent saccharification using at least one saccharifying enzyme, wherein the liquefying is carried out with addition of a partial amount of the milled material to the aqueous fluid continuously or batch-wise. The invention further relates to a solid formulation obtained by the above method of a non-volatile microbial metabolism product and the use of such a solid formulation as additive or supplement to animal or human food or for textile, leather, cellulose, paper or surface treatments.
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8.发明专利
公开(公告)号：ES2559385T3
公开(公告)日：2016-02-11
申请号：ES09178048
申请日：2009-12-04
Applicant: BASF SE
Inventor： SCHOLTEN EDZARD , HAEFNER STEFAN , SCHRÖDER HARTWIG
Abstract: Una célula bacteriana del género Pasteurella que comprende un polipéptido heterólogo que tiene actividad isocitrato liasa y un polipéptido heterólogo que tiene actividad malato sintasa.
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公开(公告)号：NO20080932L
公开(公告)日：2008-06-03
申请号：NO20080932
申请日：2008-02-25
Applicant: BASF SE
Inventor： ZELDER OSKAR , BOY MATTHIAS , POMPEJUS MARKUS , FREYER STEPHAN , LOHSCHEIDT MARKUS , SCHOLTEN EDZARD
Abstract: The present invention relates to a method for the production of at least one nonvolatile microbial metabolite in solid form by sugar-based microbial fermentation, in which process a microorganism strain which produces the desired metabolites is grown using a sugar-containing liquid medium with a monosaccharide content of more than 20% by weight based on the total weight of the liquid medium, and the volatile constituents of the fermentation liquor are subsequently largely removed, the sugar-containing liquid medium being prepared by: a1) milling selected starch feedstock from cereal grains; and a2) liquefying the millbase in an aqueous liquid in the presence of at least one starch-liquefying enzyme, followed by saccharification using at least one saccharifying enzyme, where, for liquefaction purposes, at least a portion of the millbase is liquefied by continuous or batchwise addition to the aqueous liquid. Furthermore, the invention relates to a solid formulation, of a nonvolatile microbial metabolite, obtainable by the method according to the invention; and to the use of such a solid formulation as additive or supplement for human or animal nutrition or for the treatment of textiles, leather, cellulose, paper or surfaces.
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公开(公告)号：ES2764410T3
公开(公告)日：2020-06-03
申请号：ES12162854
申请日：2008-08-14
Applicant: BASF SE
Inventor： SCHOLTEN EDZARD , DAEGELE DIRK , HAEFNER STEFAN , SCHROEDER HARTWIG
Abstract: Una cepa mutante de una cepa bacteriana DD1 como la depositada en el DSMZ que tiene el número de depósito DSM 18541, que tiene la capacidad de producir ácido succínico a partir de glicerol y en la que dicha cepa mutante tiene un ADNr 16S de SEQ ID NO: 1; o una secuencia, que muestra una homología de secuencia de al menos 99,9 % con la SEQ ID NO: 1.
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