公开(公告)号：DD251750A5

公开(公告)日：1987-11-25

申请号：DD28894586

申请日：1986-04-09

Applicant: DEGUSSA

Inventor： GIRAY GUENES ,  HUTHMACHER KLAUS ,  KLEEMANN AXEL ,  LIED THOMAS

IPC: C07C323/52 ,  A61K31/385 ,  A61P1/16 ,  A61P25/00 ,  C07C67/00 ,  C07C313/00 ,  C07C319/06 ,  C07C319/14 ,  C07C319/20 ,  C07C323/22 ,  C07C327/22 ,  C07D339/04

Abstract: Compounds of forumla XII XII wherein R1 is hydrogen and R2 is phenyl or benzyl are useful as intermediates in the preparation of 1,2-dithiolane-3-pentanoic acid (D,L-thioctic acid) of formula IX IX

公开(公告)号：FI73663C

公开(公告)日：1987-11-09

申请号：FI822399

申请日：1982-07-06

Applicant: DEGUSSA

Inventor： BETHGE HORST ,  KLEEMANN AXEL ,  MARTENS JUERGEN

IPC: C07B57/00 ,  C07B31/00 ,  C07C20060101 ,  C07C67/00 ,  C07C213/00 ,  C07C213/10 ,  C07C215/30 ,  C07C313/00 ,  C07C323/58 ,  C07C91/16 ,  C07C89/04 ,  C07C149/243

公开(公告)号：FI73977B

公开(公告)日：1987-08-31

申请号：FI830037

申请日：1983-01-06

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  MARTENS JUERGEN ,  WEIGEL HORST

IPC: C07B57/00 ,  C07B31/00 ,  C07C20060101 ,  C07C67/00 ,  C07C313/00 ,  C07C319/28 ,  C07C323/58 ,  C07C149/243 ,  C07C148/04

Abstract: The subject matter of the invention is a process for the recovery of S-(carboxymethyl)-(R)-cysteine and S-(carboxymethyl)-(S)-cysteine from a mixture of the two enantiomers. The mixture to be separated is dissolved in water in the presence of sufficient ammonia that the ammonium salt solution formed has a pH between 6 and 9. Then there is brought about in the solution of ammonium salt a state of supersaturation by the addition of seeding crystals of the ammonium salt of one of the two enantiomers, insofar as the starting material contains one of the two enantiomers in excess, the ammonium salt of this enantiomer, the ammonium salt of one of the two enantiomers is brought to crystallization and separated off. Subsequently by addition of seeding crystals of the ammonium salt of the other enantiomers to the remaining mother liquor the ammonium salt of this enantiomer is likewise brought to crystallization and separated off. Finally the respective S-(carboxymethyl)-cysteine is set free from the two ammonium salts.

公开(公告)号：FI73976B

公开(公告)日：1987-08-31

申请号：FI822397

申请日：1982-07-06

Applicant: DEGUSSA

Inventor： BETHGE HORST ,  KLEEMANN AXEL ,  MARTENS JUERGEN

IPC: A61K31/195 ,  C07B57/00 ,  C07C20060101 ,  C07C67/00 ,  C07C319/28 ,  C07C313/00 ,  C07C323/58 ,  C07C149/243 ,  C07C148/04 ,  C07C91/16

Abstract: There is described the resolution of the racemate S-(carboxymethyl)-(RS)-cysteine. It is carried out by means of the optical isomers of 2-amino-1-phenyl-propan-1-ol. This process makes it possible to obtain in a simple manner S-(carboxymethyl)-(R)-cysteine which is important for pharmaceutical purposes and is made from synthetically produced cysteine.

公开(公告)号：FI72314B

公开(公告)日：1987-01-30

申请号：FI824337

申请日：1982-12-16

Applicant: DEGUSSA

Inventor： BETHGE HORST ,  KLEEMANN AXEL ,  MARTENS JUERGEN

IPC: C07B55/00 ,  C07B31/00 ,  C07C20060101 ,  C07C67/00 ,  C07C313/00 ,  C07C319/20 ,  C07C323/58 ,  C07C149/243 ,  C07C148/00

公开(公告)号：HUT40638A

公开(公告)日：1987-01-28

申请号：HU151686

申请日：1986-04-10

Applicant: DEGUSSA

Inventor： GIRAY GUENES ,  HUTHMACHER KLAUS ,  KLEEMANN AXEL ,  LIED THOMAS

IPC: A61K31/385 ,  A61P1/16 ,  C07C323/52 ,  A61P25/00 ,  C07C67/00 ,  C07C313/00 ,  C07C319/06 ,  C07C319/14 ,  C07C319/20 ,  C07C323/22 ,  C07C327/22 ,  C07D339/04 ,  C07C149/20

Abstract: Compounds of forumla XII XII wherein R1 is hydrogen and R2 is phenyl or benzyl are useful as intermediates in the preparation of 1,2-dithiolane-3-pentanoic acid (D,L-thioctic acid) of formula IX IX

公开(公告)号：CA1206741A

公开(公告)日：1986-07-02

申请号：CA449245

申请日：1984-03-09

Applicant: DEGUSSA

Inventor： DRAUZ KARLHEINZ ,  KLEEMANN AXEL ,  WIRTHWEIN ROLF

IPC: C01B15/017

Abstract: The production of hydrogen peroxide solutions extremely low in water in higher boiling solvents by mixing hydrogen peroxide solutions in solvents whose azeotrope boiling points with water lie below the boiling point of hydrogen peroxide with higher boiling solvents which at best form azeotropes with water whose boiling points lie close to or above the boiling point of hydrggen peroxide. The mixture is then freed from water and from the lower boiling solvents by distillation. An in situ method for producing the above mixture is described.

公开(公告)号：CA1178618A

公开(公告)日：1984-11-27

申请号：CA374042

申请日：1981-03-27

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  NYGREN ROBERT ,  WAGNER RUDOLF

IPC: C07C319/14 ,  A61K31/095 ,  A61K47/00 ,  A61K47/20 ,  B01J21/02 ,  B01J23/00 ,  B01J23/02 ,  B01J29/00 ,  B01J29/06 ,  C07C67/00 ,  C07C313/00 ,  C07C323/12 ,  C08K5/37 ,  C11D3/386 ,  G03C5/305 ,  C07C149/18

Abstract: The production of 3-mercapto-propanediol-(1,2) in high yields in a technically simple manner is attained by reacting liquid hydrogen sulphide with glycide under pressure either in the presence of aluminium oxide or in the presence of a sodium aluminium silicate, in a heterogeneous phase.

公开(公告)号：AU525255B2

公开(公告)日：1982-10-28

申请号：AU5060879

申请日：1979-09-05

Applicant: DEGUSSA

Inventor： KLINGLER KARL HEINZ ,  KLEEMANN AXEL ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: A61K31/155 ,  A61K31/403 ,  A61K31/405 ,  A61P25/02 ,  A61P27/02 ,  C07C67/00 ,  C07C239/00 ,  C07C279/04 ,  C07C279/12 ,  C07D209/08 ,  C07D209/43 ,  C07D209/86 ,  C07D209/88 ,  A61K31/40 ,  C07C129/12

Abstract: Compounds corresponding to the formula I are disclosed, wherein Alk represents a C2-C5-alkylene groups optionally substituted by a hydroxy group and Ar represent an optionally substituted phenyl, naphthyl, tetrahydronaphthyl, indanyl or indenyl radical or a monocyclic or condensed bicyclic or tricyclic heterocyclic radical which is optionally substituted, the heterocyclic radical consisting of individual rings having 5 or 6 members and optionally containing from 1 to 4 hetero atoms, and the acid addition salts thereof. A process for producing these compounds is also disclosed. These substituted aminoalkyl guanidines block the beta -receptors of the adrenergic nerve system, and also reduce blood pressure.

公开(公告)号：HU179151B

公开(公告)日：1982-08-28

申请号：HUDE000969

申请日：1978-07-21

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  KLENK HERBERT ,  OFFERMANNS HERIBERT ,  SCHERBERICH PAUL ,  SCHWARZE WERNER

IPC: A01N25/00 ,  A01P3/00 ,  A01P13/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/06 ,  C07C231/08 ,  C07C235/72 ,  C07D307/54 ,  C07C102/08 ,  C07C103/34

Abstract: Compounds are prepared of the formula (I) where R' is a t-alkyl group having 4 to 18 carbon atoms, preferably t-butyl, t-amyl or t-octyl and R is a straight or branched chain alkyl group with 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms or an alkyl group substituted with one or more phenyl group or a halogen atom, particularly a chlorine atom, or a cycloalkyl group with 3 to 8 carbon atoms, particularly cyclopropyl, which can be substituted by one or more 1 to 3 carbon atom alkyl groups or one or more halogen atoms, preferably chlorine, or phenyl or naphthyl or a five membered heterocyclic group or such phenyl, naphthyl or heterocyclic group substituted by halogen atoms, nitro groups, alkyl or alkoxy with 1 to 5 carbon atoms by condensing in acid medium an acyl cyanide of the formula R-CO-CN (II) where R is as defined above with either (a) a tertiary alcohol of the formula HO-R'(III) in which R' is as defined above, or preferably (b) an alkene of the formula (IV) where R1 and R2 are the same or different and are hydrogen or an alkyl group and wherein R3 and R4 are the same or different and wherein the alkyl groups in each case can be 1 to 15 carbon atoms. Some of the compounds are new. They are useful as intermediates for synthesizing herbicides and can be used directly as fungicides.