公开(公告)号：AU564272B2

公开(公告)日：1987-08-06

申请号：AU3352784

申请日：1984-09-26

Applicant: DEGUSSA

Inventor： KLINGLER KARL-HEINZ ,  ENGEL JURGEN ,  OEPEN GERHARD ,  STROMAN FRITZ ,  THIEMER KLAUS ,  METZENAUER PETER

IPC: C07C45/63 ,  C07C45/71 ,  C07C217/62 ,  A61K31/135 ,  C07C91/34 ,  C07C93/14

公开(公告)号：AU525255B2

公开(公告)日：1982-10-28

申请号：AU5060879

申请日：1979-09-05

Applicant: DEGUSSA

Inventor： KLINGLER KARL HEINZ ,  KLEEMANN AXEL ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: A61K31/155 ,  A61K31/403 ,  A61K31/405 ,  A61P25/02 ,  A61P27/02 ,  C07C67/00 ,  C07C239/00 ,  C07C279/04 ,  C07C279/12 ,  C07D209/08 ,  C07D209/43 ,  C07D209/86 ,  C07D209/88 ,  A61K31/40 ,  C07C129/12

Abstract: Compounds corresponding to the formula I are disclosed, wherein Alk represents a C2-C5-alkylene groups optionally substituted by a hydroxy group and Ar represent an optionally substituted phenyl, naphthyl, tetrahydronaphthyl, indanyl or indenyl radical or a monocyclic or condensed bicyclic or tricyclic heterocyclic radical which is optionally substituted, the heterocyclic radical consisting of individual rings having 5 or 6 members and optionally containing from 1 to 4 hetero atoms, and the acid addition salts thereof. A process for producing these compounds is also disclosed. These substituted aminoalkyl guanidines block the beta -receptors of the adrenergic nerve system, and also reduce blood pressure.

公开(公告)号：FI61900B

公开(公告)日：1982-06-30

申请号：FI771187

申请日：1977-04-14

Applicant: DEGUSSA

Inventor： OFFERMANNS HERIBERT ,  KLINGLER KARL HEINZ ,  THIEMER KLAUS ,  STROMAN FRITZ

IPC: A61K31/52 ,  A61K31/522 ,  A61P25/02 ,  C07D473/08 ,  C07D473/10

公开(公告)号：HU178208B

公开(公告)日：1982-03-28

申请号：HUDE000949

申请日：1978-01-11

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  NUBERT INGOMAR ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: C07D333/24 ,  A61K31/38 ,  A61K31/381 ,  A61P9/08 ,  C07D333/16 ,  C07D333/20 ,  C07D409/06

Abstract: There are prepared compounds of the formula (I) where >A-B- has either the structure >C(OH)-CH2- or the structure >C=CH, Alk is a straight or branched chain C1-C5-alkylene group and Y is where R is hydrogen or a C1-C4-alkyl group and T is hydrogen or a C2-C6-alkanoyl group where R' is hydrogen, phenyl, phenyl substituted once or twice. The compounds are effective in improving peripheral and cerebral circulation. There are also produced intermediate compounds of formula (II) where NHY is replaced by chlorine, bromine or iodine.

公开(公告)号：CA1116173A

公开(公告)日：1982-01-12

申请号：CA335022

申请日：1979-09-05

Applicant: DEGUSSA

Inventor： KLINGLER KARL-HEINZ ,  KLEEMANN AXEL ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: A61K31/155 ,  A61K31/403 ,  A61K31/405 ,  A61P25/02 ,  A61P27/02 ,  C07C67/00 ,  C07C239/00 ,  C07C279/04 ,  C07C279/12 ,  C07D209/08 ,  C07D209/43 ,  C07D209/86 ,  C07D209/88 ,  C07C129/12 ,  C07D209/20

Abstract: Compounds corresponding to the formula (I) are disclosed, wherein Alk represents a C2-C5-alkylene group which may be substituted by a hydroxy group and Ar represents unsubstituted phenyl, naphthyl or indolyl radical or a phenyl, naphthyl or indolyl radical substituted one or more times by a Cl-C6-alkyl group, a C2-C6-alkenyl group, a Cl-C6-alkoxy group, a C2-C6-alkenoxy group, or a halogen atom and pharmaceutically acceptable acid addition salts thereof. A process for producing these compounds is also disclosed. These substituted aminoalkyi guanidines block the .beta.-receptors of the adrenergic nerve system, and also reduce blood pressure.

公开(公告)号：CA1108629A

公开(公告)日：1981-09-08

申请号：CA318131

申请日：1978-12-18

Applicant: DEGUSSA

Inventor： KLINGLER KARL H ,  THIEMER KLAUS ,  STROMAN FRITZ

IPC: A61K31/19 ,  A61K31/16 ,  A61K31/194 ,  A61K31/195 ,  A61K31/205 ,  A61P9/02 ,  C07C20060101 ,  C07C233/20 ,  C07D317/60 ,  C07C103/60

Abstract: The present invention provides hemiamides of unsaturated aliphatic dicarboxylic acids having the general formula (I) wherein R1, R2 and R3 are identical or different and represent hydrogen, a halogen atom, a hydroxy group, a methyl group or a methoxy group or two of those radicals together represent a methylene-dioxy group, R4 represents hydrogen or a methyl group, the radicals R6 and R7 represent, independently of each other, hydrogen or C1-C4-alkyl groups, and n is 0 or 1, and their salts, the N-(2-(3-hydroxy-phenyl)-2-hydroxy-ethyl)- maleic monoamide being excluded in the case of the free acids. The hemiamides have pharmacological properties.

公开(公告)号：DD142883A5

公开(公告)日：1980-07-16

申请号：DD21212778

申请日：1978-01-10

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  NUBERT INGOMAR ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: C07D333/24 ,  A61K31/38 ,  A61K31/381 ,  A61P9/08 ,  C07D333/16 ,  C07D333/20 ,  C07D409/06

Abstract: There are prepared compounds of the formula (I) where >A-B- has either the structure >C(OH)-CH2- or the structure >C=CH, Alk is a straight or branched chain C1-C5-alkylene group and Y is where R is hydrogen or a C1-C4-alkyl group and T is hydrogen or a C2-C6-alkanoyl group where R' is hydrogen, phenyl, phenyl substituted once or twice. The compounds are effective in improving peripheral and cerebral circulation. There are also produced intermediate compounds of formula (II) where NHY is replaced by chlorine, bromine or iodine.

公开(公告)号：FI792755A

公开(公告)日：1980-03-07

申请号：FI792755

申请日：1979-09-05

Applicant: DEGUSSA

Inventor： KLINGER KARL-HEINZ ,  KLEEMANN AXEL ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: A61K31/403 ,  A61K31/155 ,  A61K31/405 ,  A61P25/02 ,  A61P27/02 ,  C07C67/00 ,  C07C239/00 ,  C07C279/04 ,  C07C279/12 ,  C07D209/08 ,  C07D209/43 ,  C07D209/86 ,  C07D209/88 ,  C07C

Abstract: Compounds corresponding to the formula I are disclosed, wherein Alk represents a C2-C5-alkylene groups optionally substituted by a hydroxy group and Ar represent an optionally substituted phenyl, naphthyl, tetrahydronaphthyl, indanyl or indenyl radical or a monocyclic or condensed bicyclic or tricyclic heterocyclic radical which is optionally substituted, the heterocyclic radical consisting of individual rings having 5 or 6 members and optionally containing from 1 to 4 hetero atoms, and the acid addition salts thereof. A process for producing these compounds is also disclosed. These substituted aminoalkyl guanidines block the beta -receptors of the adrenergic nerve system, and also reduce blood pressure.

公开(公告)号：AU4709479A

公开(公告)日：1979-11-22

申请号：AU4709479

申请日：1979-05-16

Applicant: DEGUSSA

Inventor： ENGEL JURGEN ,  KLEEMANN AXEL ,  POSSELT KLAUS ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: A61K31/135 ,  A61K20060101 ,  A61K31/13 ,  A61K31/137 ,  A61K31/43 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P29/00 ,  C07C20060101 ,  C07C67/00 ,  C07C213/00 ,  C07C213/02 ,  C07C213/08 ,  C07C215/30 ,  C07C215/60 ,  C07C221/00 ,  C07C225/06 ,  C07C225/10 ,  C07C225/14 ,  C07C97/10

Abstract: There are prepared compounds of the formula: wherein X is the group >C=O or >CH(OH), Y is the group R2 is hydrogen or C1 to C6 alkyl, R3 is hydrogen or a hydroxy group and R1 is the adamantyl group or a saturated or single unsaturated C3 to C16 cycloalkyl group where the C3 to C16 cycloalkyl group can be substituted by a C1-C4 alkyl group or a halogen atom and their salts. The compounds are useful in dilating the peripheral blood vessels and in lowering blood pressure.

公开(公告)号：DD133331A5

公开(公告)日：1978-12-27

申请号：DD20255577

申请日：1977-12-12

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  KLINGLER KARL H ,  VON SCHLICHTEGROLL ANSGAR ,  STROMAN FRITZ ,  THIEMER KLAUS ,  WESTERMANN ERIK

IPC: A61K31/52 ,  A61K31/522 ,  A61P9/00 ,  C07D473/08