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    Carboxylic/sulphomic amide prepn
    51.
    发明专利
    Carboxylic/sulphomic amide prepn 未知

    公开(公告)号：DE1914386A1

    公开(公告)日：1970-10-08

    申请号：DE1914386

    申请日：1969-03-21

    Applicant: HOECHST AG

    Inventor： RUDOLF LATTRELL DR ,  LOHAUS GERHARD

    IPC: C07D205/08 ,  C07D205/085 ,  C07D205/09

    Abstract: Carboxylic/sulphonic amide prepn. New cpds. of formula:- (where R1 = halogen, azido or phthalimido; R2 = H, or halogen; R3 = aryl, alkoxy, alkylmercapto or arylmercapto), are prepd. by treating open-chain or cyclic carboxylic or sulphonic amides (whose amide N atom carries an alken-1-yl, a phenyl opt. substd. with an electron donor gp., or a 5-membered heterocyclic gp.) with at least two equivalents of an oxidising agent, at -80 to +100 degrees C.

    57.
    发明专利
    未知

    公开(公告)号：NO170540C

    公开(公告)日：1992-10-28

    申请号：NO871602

    申请日：1987-04-15

    Applicant: HOECHST AG

    Inventor： LOHAUS GERHARD ,  DITTMAR WALTER ,  HAENEL HEINZ ,  RAETHER WOLFGANG ,  REUSCHLING DIETER ,  GROEBEL BENGT-THOMAS

    IPC: A61K31/44 ,  C07D213/89 ,  C07D309/38

    Abstract: New 1-hydroxy-2-pyridones of the general formula I I in which R1, R2 and R3, which are identical or different, denote hydrogen or lower alkyl having 1-4 carbon atoms, R1 and R3 preferably being hydrogen, and R2 preferably being methyl, X denotes S or, preferably, O, Y denotes hydrogen or up to 2 halogen atoms, namely chlorine and/or bromine, Z denotes a single bond or the bivalent radicals O, S, -CR2- (R=H or C1-C4-alkyl) or other 2-valent radicals with 2-10 carbon and, optionally, oxygen and/or sulfur atoms linked to form a chain, it being obligatory when the radicals contain 2 or more oxygen and/or sulfur atoms for the latter to be separated by at least 2 carbon atoms, and it being possible for 2 adjacent carbon atoms also to be linked together by a double bond, and the free valencies of the carbon atoms being saturated by H and/or C1-C4-alkyl groups, Ar denotes an aromatic ring system which has up to two rings and can be substituted by up to three radicals from the group comprising fluorine, chlorine, bromine, methoxy, C1-C4-alkyl, trifluoromethyl and trifluoromethoxy, are prepared by a variety of process variants. The compounds and their physiologically tolerated salts with inorganic or organic bases mainly have antimycotic, anti-bacterial and antiviral activity. The compounds of the formula V V in which R1, R2, R3, X, Y, Z and Ar have the same meaning as in formula I, which occur in the preparation of the compounds of the formula I, are also new.

    1-HYDROXY-2-PYRIDONE DERIVATIVES
    58.
    发明专利
    1-HYDROXY-2-PYRIDONE DERIVATIVES 未知

    公开(公告)号：AU602684B2

    公开(公告)日：1990-10-25

    申请号：AU7171787

    申请日：1987-04-16

    Applicant: HOECHST AG

    Inventor： LOHAUS GERHARD ,  DITTMAR WALTER ,  HANEL HEINZ ,  RAETHER WOLFGANG ,  REUSCHLING DIETER ,  GROBEL BENGT-THOMAS

    IPC: A61K31/44 ,  C07D213/89 ,  C07D309/38 ,  A01N43/40

    Abstract: New 1-hydroxy-2-pyridones of the general formula I I in which R1, R2 and R3, which are identical or different, denote hydrogen or lower alkyl having 1-4 carbon atoms, R1 and R3 preferably being hydrogen, and R2 preferably being methyl, X denotes S or, preferably, O, Y denotes hydrogen or up to 2 halogen atoms, namely chlorine and/or bromine, Z denotes a single bond or the bivalent radicals O, S, -CR2- (R=H or C1-C4-alkyl) or other 2-valent radicals with 2-10 carbon and, optionally, oxygen and/or sulfur atoms linked to form a chain, it being obligatory when the radicals contain 2 or more oxygen and/or sulfur atoms for the latter to be separated by at least 2 carbon atoms, and it being possible for 2 adjacent carbon atoms also to be linked together by a double bond, and the free valencies of the carbon atoms being saturated by H and/or C1-C4-alkyl groups, Ar denotes an aromatic ring system which has up to two rings and can be substituted by up to three radicals from the group comprising fluorine, chlorine, bromine, methoxy, C1-C4-alkyl, trifluoromethyl and trifluoromethoxy, are prepared by a variety of process variants. The compounds and their physiologically tolerated salts with inorganic or organic bases mainly have antimycotic, anti-bacterial and antiviral activity. The compounds of the formula V V in which R1, R2, R3, X, Y, Z and Ar have the same meaning as in formula I, which occur in the preparation of the compounds of the formula I, are also new.

    1-HYDROXY-2-PYRIDONES,MEDICAMENTS WHICH CONTAIN THEM AND METHOD OF USE THEREOF
    59.
    发明专利
    1-HYDROXY-2-PYRIDONES,MEDICAMENTS WHICH CONTAIN THEM AND METHOD OF USE THEREOF 未知

    公开(公告)号：PH24106A

    公开(公告)日：1990-03-05

    申请号：PH35156

    申请日：1987-04-20

    Applicant: HOECHST AG

    Inventor： LOHAUS GERHARD ,  DITTMAR WALTER ,  HANEL HEINZ ,  RAETHER WOLFGANG ,  REUSCHLING DIETER ,  GROBEL BENGT-THOMAS

    IPC: A61K31/44 ,  C07D213/89 ,  C07D309/38 ,  C07D211/86

    Abstract: New 1-hydroxy-2-pyridones of the general formula I I in which R1, R2 and R3, which are identical or different, denote hydrogen or lower alkyl having 1-4 carbon atoms, R1 and R3 preferably being hydrogen, and R2 preferably being methyl, X denotes S or, preferably, O, Y denotes hydrogen or up to 2 halogen atoms, namely chlorine and/or bromine, Z denotes a single bond or the bivalent radicals O, S, -CR2- (R=H or C1-C4-alkyl) or other 2-valent radicals with 2-10 carbon and, optionally, oxygen and/or sulfur atoms linked to form a chain, it being obligatory when the radicals contain 2 or more oxygen and/or sulfur atoms for the latter to be separated by at least 2 carbon atoms, and it being possible for 2 adjacent carbon atoms also to be linked together by a double bond, and the free valencies of the carbon atoms being saturated by H and/or C1-C4-alkyl groups, Ar denotes an aromatic ring system which has up to two rings and can be substituted by up to three radicals from the group comprising fluorine, chlorine, bromine, methoxy, C1-C4-alkyl, trifluoromethyl and trifluoromethoxy, are prepared by a variety of process variants. The compounds and their physiologically tolerated salts with inorganic or organic bases mainly have antimycotic, anti-bacterial and antiviral activity. The compounds of the formula V V in which R1, R2, R3, X, Y, Z and Ar have the same meaning as in formula I, which occur in the preparation of the compounds of the formula I, are also new.

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